Substituted n-(arylalkyl)-1h-pyrrolopyridine-2 carboxamide compound

Abstract

The invention relates to compounds of general formula (I): in which n is equal to 0, 1, 2 or 3; the pyrrolopyridine nucleus is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridine group or a pyrrolo[2,3b]pyridine group; the pyrrolopyridine nucleus being optionally substituted in the carbon position 4, 5, 6 and / or 7 with one or more substituents X, which may be identical or different; Z1, Z2, Z3, Z4 and Z5 represent, independently of each other, a hydrogen or halogen atom or a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C1-C6-fluoroalkoxyl, cyano, C(O)NR1R2, nitro, NR1R2, C1-C6-thioalkyl, -S(O) C1-C6-alkyl, -S(O)2-C1-C6-alkyl, SO2NR1R2, NR3COR4, NR3S02R5 aryl-C1-C6-alkylene or aryl group, the aryl and the aryl-C1-C6-alkylene being optionally substituted; W represents a fused bicyclic group of formula:bonded to the nitrogen atom via positions 1, 2, 3 or 4; A represents an optionally substituted 5- to 7 membered heterocycle comprising from one to three heteroatoms chosen from O, S and N; Preparation process and therapeutic use.