Novel substituted 1-amino-1,2,3,4,-tetrahydronaphthalene-2-o1 and 5,6,7,8-tetrahydronaphthalene-1,6-diol compound.

Abstract

Compound of formula (la), in which 1) the radicals R1, R2 and R3 independently of one another are selected from -0H, 0-CH3, Cl, F, H, II) the radical R4 is selected from 2-methylquinolin-5-y1 2-methylquinazolin-5-y1 2-ethylquinazolin-5-y1 7-fluoroo-2-methylquinazolin-5-yl, 8-fluoro-2-methylquinazolin-5-yl, 7,8-difluoro-2-methylquinazolin-5-yl, quinolin-2(1H)-on-5-yl. 8-fluoroquinolin-2(1 H)-on-5-yl, isochromen-1-on-5-yl 2-methylphthalazin- 1- on-5-y1 isoquinolin-2(1 H)-on-5-yl, III) the radical R5 is -CF3 and IV) the radical R6 is selected from -CH3, CH2-CH3, -(CH2)2-CH3, or as well as their stereoisomers with physiologically tolerated anions, characterized in that the enantiomeric compounds are present in the 1α,2α,4β configuration of the 1-amino-1,2,3,4- tetrahydronaphthalen-2-ol parent structure or 5α,6α,8β configuration of the 5,6,7,8-tetrahydronaphthalen-1,6-diol parent structure.