3-phenylpyrazolo[5,1-b]thiazole compound and pharmacetical composition comprising thereof

Abstract

The present invention provides a compound of formula (I). wherein R1 represents the formula -A11-A12; R2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A11 represents a single bond, methylene or 1,2-ethylene; A12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R4 represents methoxy or chlorine. The invention further provides a pharmaceutical composition comprising the compound as an active ingredient which is a therapeutic or prophylactic agent for depression, depressive symptoms, anxiety, irritable bowel syndrome, sleep disorder, insomnia, alcohol dependence, alcohol withdrawal symptoms, drug dependence, drug withdrawal symptoms, stress-related gastrointestinal dysfunction, anorexia nervosa, eating disorder, postoperative ileus, ischemic neuropathy, apoplexy, Excitotoxicneuropathy,convulsion,epilepsy, hypertension, schizophrenia, bipolar disorder or dementia.