New benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them

Abstract

Compound of formula (I): wherein:  R1 and R2, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, acyl, alkoxycarbonyl, carboxy, hydroxy, hydroxyalkyl, cyano, nitro, amino, substituted or unsubstituted aminocarbonyl, aminosulphonyl, alkylsulphonylaminoalkyl, Nhydroxy-carboximidamide or benzyloxy group,  R3 represents a hydrogen atom or an alkyl, cycloalkyl or cycloalkylalkyl group,  R4 represents a hydrogen atom or a substituted or unsubstituted alkyl group. Also provided is a pharmaceutical composition comprising the said compound for the treatment or prevention of progressive neurodegenerative diseases, Alzheimer's disease, Parkinson’s disease, Pick’s disease, Huntington’s chorea, Korsakoff’s disease, schizophrenia, acute neurodegenerative diseases, frontal lobe and subcortical dementias, vascular dementias, epilepsy, cerebral vascular accidents and also depressive and anxious states.