Carboxamide compounds and their use as calpain inhibitors

Abstract

The present invention relates to novel carboxamide compound which is an inhibitor of calpain (calcium dependant cysteine proteases). Also provided is a pharmaceutical composition comprising said carboxamide compound for treating a disorder associated with an elevated calpain activity. The carboxamide compound is of the general formula I in which R1 , R2 , R3a, R3b, R4, Q, Y, A and X have meanings as defined in the claims and the description. In particular, the compound has the general formula la and Ib in which R1 , r, R2b, R3a, R3b, R4 , Y and X have meanings as defined in the claims. Of this compound that is preferred wherein Y is a moiety CH2, CH2-CH2, CH2-CH2-CH2, N(Ry#)-CH2, N(Ry#)-CH2-CH2, each optionally having 1 or 2 H-atoms replaced with identical or different radicals Ry , wherein Ry and Ry# have meanings as defined in the claims.