Humanized antibodies specific for the protofibrillar form of beta-amyloid peptide
PK201000393A0Active Publication Date: 2010-05-31SANOFI AVENTIS SA
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Patent Information
- Application Number
- PK201000393
- Authority / Receiving Office
- PK · PK
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2010-05-10
- Publication Date
- 2010-05-31
Abstract
The present invention provides a humanized antibody specific for the protofibrillar form of the Α-β peptide characterized in that said antibody comprises CDRs having the sequence identical to the sequences SEQ ID NO: 10, 12, 14, 16, 18 and 2 0 , or differs by one amino acid relative to one of the sequences SEQ ID NO: 10, 12, 14, 16, 18 and 2 0 and antibody of the present invention binds to the A- β peptide aggregated in senile plaques and not to the diffuse deposits of A- β peptides. The antibody of the present invention is therapeutically effective for use in the area of Alzheimer’s disease.
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