Disubstituted phthalazine hedgehog pathway antagonists
PK201000500A0Undetermined Publication Date: 2010-06-28ELI LILLY & CO
0 Cites 0 Cited by
Patent Information
- Application Number
- PK201000500
- Authority / Receiving Office
- PK · PK
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2010-06-08
- Publication Date
- 2010-06-28
Abstract
The hedgehog (Hh) signaling pathway plays an important role in embryonic pattern formation and adult tissue maintenance by directing cell differentiation and proliferation. The present invention relates to Hedgehog pathway antagonists and more specifically to novel 1,4-disubstituted phthalazines, like 4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide of the formula I given below:
Need to check novelty before this filing date? Find Prior Art