A Pharmaceutically acceptable salt of 2-Alkylurea-4-aryl-5-cyclyl-pyridine and 2-alkylurea-4-aryl-5-cyclyl pyrimidine compound

Abstract

A pharmaceutically acceptable salt of compound of formula (XVIII):wherein: X is CH or N; and R29 is a 6-membered aryl or a 5- or 6 membered heteroaryl, wherein the aryl or heteroaryl is optionally substituted on one or more carbon atom with one or more R11; and wherein if the heteroaryl comprises a NH- moiety the hydrogen may be optionally substituted with a group selected from R8; R1 is selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl or C3-6cycloalkyl; wherein R1 may be optionally substituted on carbon by one or more R6; Ring B is carbocyclyl or heterocyclyl; wherein if said heterocyclyl contains an NH- moiety that nitrogen may be optionally substituted by a group selected from R14; R5 is selected from hydroxy, C1-6alkoxy, N(R15)(R16) and a nitrogen linked heterocyclyl; wherein said C1-6alkoxy may be optionally substituted on carbon by one or more R17; and wherein if said nitrogen linked heterocyclyl contains an -NHmoiety that nitrogen may be optionally substituted by a group selected from R18; R6, R11 and R17 are substituents on carbon and are each independently selected from halo, nitro, cyano, hydroxy, amino, carboxy, carbamoyl, mercapto, sulphamoyl, C1 6alkyl, C7-6alkenyl, C2-6alkynyl, C1-6alkoxy, C1-6alkanoyl, C1-6alkanoyloxy, N-(C1 6a1ky1)amino, N,N-(C1-6alky1)2amino, C1 6alkanoylamino, N-(C1-6alkyl)carbamoyl, N,N-(C1-6alky1)2carbamoyl, Cl-6alkylS(O)a wherein a is 0 to 2, C1-6alkoxycarbonyl, C1 6alkoxycarbonylamino, N-(C1 6alkyl)sulphamoyl, N,N-(C1 6alkyl)2sulphamoyl, C1 6alkylsulphonylamino, carbocyclyl or heterocyclyl; wherein R6, R7,R11 and R17 independently of each other may be optionally substituted on carbon by one or more R19; and wherein if said heterocyclyl contains an -NH- moiety that nitrogen may be optionally substituted by a group selected from R20; R15 and R16 are independently selected from hydrogen, C1-6alkyl, C1-6alkoxy, C1 6alkanoyl, carbocyclyl or heterocyclyl; wherein R15 and R16 independently of each other may be optionally substituted on carbon by one or more R21; and wherein if said heterocyclyl contains an -NH- moiety that nitrogen may be optionally substituted by a group selected from R22; R8, R14, R18, R20 and R22 are independently selected from C1-6a1ky1, C3-6cycloalkyl, C1-6alkanoyl, C1-6alkylsulphonyl, C1 6alkoxycarbonyl, carbamoyl, N-(C1 6alkyl)carbamoyl, N,N-(C1 6alkyl)carbamoyl, benzyl,benzyloxycarbonyl, benzoyl and phenylsulphonyl; wherein R8, R12, R13, R14, R18, R20 and R22 independently of each other may be optionally substituted on carbon by one or more R23; and R19, R21 and R23 are independently selected from halo. nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, carboxy, carbamoyl, mercapto, sulphamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N ethylamino, acetylamino, N methylcarbamoyl, N-ethylcarbamoyl, N,N dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulphinyl, ethylsulphinyl, mesyl, ethylsulphonyl. methoxycarbonyl, ethoxycarbonyl. N-methylsulphamoyl, N ethylsulphamoyl. N,N-dimethylsulphamoyl, N, N-diethylsulphamoyl or N-methyl-N ethylsulphamoyl.