Pyrazole derivatives

Abstract

The invention relates to compound of formulaswherein R 1 is hydrogen or phenyl, optionally substitutes by halogen, CN or lower alkoxy or lower alkoxy substituted by halogen; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl or is phenyl optionally substituted by one or more substituents, selected from halogen, cyano or lower alkoxy substituted by halogen, or is pyridinyl, optionally substituted by halogen or lower alkyl substituted by halogen, or is pyrimidinyl, optionally substituted by lower alkyl substituted by halogen, or is pyrazinyl, optionally substituted by halogen, cyano or lower alkyl substituted by halogen; R 4 is hydrogen, lower alkyl or phenyl; Z is a bond, -C H2- or —O-; It has now been found that the compound of formulas IA and lB have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1 .The compound may be used for the treatment of depression, psychosis, Parkinson's disease, anxiety and attention deficit hyperactivity disorder (ADHD) and diabetes.