Substituted benzamide derivatives

Abstract

The present invention relates to compound of formulawherein R 1 is hydrogen, halogen, cyano, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen or C(O)NH2, or is phenyl optionally substituted by halogen, cyano or lower alkoxy substituted by halogen, or is 2,2-difluorobenzo[d][1,3]dioxol-5-yl, or is 6(trifluoromethyl)pyrazin-2-yl or 5(trifluoromethyl)pyrazin-2-yl or is 6(trifluoromethyl)pyrimidin-4-yl, or is 6(trifluoromethyl)pyridin-3-yl, or is 5cyanopyrazin-2-yl or is 2(trifluoromethyl)pyrimidin-4-yl; n is 1 or 2 R 2 is halogen, lower alkyl or cyano and R3 is hydrogen, or R 2 is hydrogen and R3 is halogen, lower alkyl or cyano; X is a bond, -NR'-, -CH2NH- or -CHR'-; R’ is hydrogen or lower alkyl; Z is a bond, -CH2- or —O-; Ar is phenyl or is heteroaryl, selected from the group consisting of 1H-indazole-3yl, pyridine-2yl, pyridine-3-yl, pyridine-4-yl, pyrimidine-5-yl, 1H-pyrazole-3-yl, 1H-pyrazole-4-yl or 1Hpyrazole-5-yl; Which may be used for the treatment of depression, psychosis, Parkinson's disease, anxiety, attention deficit hyperactivity disorder (ADHD) and diabetes.