Method of producing 4'-O-β-D-(4'''-O-methylglucopyranosyl)-4"-hydroxyxanthohumol

Abstract

The subject of the application is a method for producing 4'-O-β-D-(4"'-O-methylglucopyranosyl)-4"-hydroxyxanthohumol of formula 1, characterized in that the strain Isaria farinosa KCh KW 1.1 is introduced into a medium suitable for filamentous fungi, then after at least 72 hours a substrate, which is xanthohumol of formula 1, dissolved in an organic solvent miscible with water, is introduced into the culture, the transformation is carried out at a temperature of 20 to 30 degrees Celsius, with continuous shaking, for at least 24 hours, after which the product is extracted with an organic solvent immiscible with water and purified chromatographically.