Methods of delivering a viral vector to a kidney
Patent Information
- Authority / Receiving Office
- PT · PT
- Patent Type
- Patents
- Current Assignee / Owner
- UNIV OF BRISTOL
- Filing Date
- 2023-11-17
- Publication Date
- 2026-06-05
AI Technical Summary
Existing methods for delivering viral vectors to glomerular cells, such as podocytes, in the kidney are inefficient and often result in inconsistent gene delivery, with most molecular therapies being prevented by the permselectivity of the glomerulus and conventional intravenous or direct kidney injection methods failing to effectively treat diseases like Alport syndrome.
A minimally invasive method involving direct renal artery injection of a viral vector using a catheter, which does not require occluding the renal vein or clamping the renal artery or aorta, allowing for improved delivery and increased transgene expression in glomeruli and podocytes.
This method results in localized transgene expression in the kidney with minimal expression in other tissues, achieving a marked increase in viral copy number and efficiency compared to intravenous injection.