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RU2024113322A3Pending Publication Date: 2026-06-29ASSEMBLY BIOSCIENCES INC

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Patent Information

Authority / Receiving Office: RU · RU
Patent Type: Applications
Current Assignee / Owner: ASSEMBLY BIOSCIENCES INC
Filing Date: 2022-10-19
Publication Date: 2026-06-29

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Claims

1. A method for producing compound I or its salt, comprising the step of converting compound 3.4 into compound I or its salt: .

2. The method according to claim 1, further comprising the step of converting compound 3.3 into compound 3.4: .

3. The method according to claim 2, further comprising the step of converting compound 3.2 into compound 3.3: .

4. The method according to claim 3, further comprising the step of converting compound 3.1 into compound 3.2: .

5. The method according to claim 4, further comprising the step of converting compound 3 into compound 3.1: .

6. The method according to claim 5, further comprising the step of converting compound 2 into compound 3: .

7. The method according to claim 6, further comprising the step of converting compound 1 into compound 2: .

8. A method for producing compound Ia or its salt, comprising the step of converting compound 3.4a into compound Ia or its salt: .

9. The method according to claim 8, further comprising the step of converting compound 3.3a into compound 3.4a: .

10. The method according to claim 9, further comprising the step of converting compound 3.2a into compound 3.3a: .

11. The method according to claim 10, further comprising the step of converting compound 3.1a into compound 3.2a: .

12. The method according to claim 11, further comprising the step of converting compound 3a into compound 3.1a: .

13. The method according to claim 12, further comprising the step of converting compound 2a into compound 3a: .

14. The method according to claim 13, further comprising the step of converting compound 1a into compound 2a: .

15. Compound I or its salt, obtained or obtainable by the method of any of paragraphs 1-7.

16. Compound I or a salt thereof according to claim 15, wherein compound I is essentially compound I(a).

17. Compound I or a salt thereof according to claim 16, wherein compound I contains compound I(a) and less than 10% (such as less than 5%, less than 2% or less than 1%) by HPLC area of other stereoisomers.

18. Compound Ia or its salt, obtained or obtainable by the method according to any of paragraphs 8-14.

19. Compound Ia or its salt according to claim 18, wherein compound Ia is stereochemically pure.

20. Compound 3.4 or compound 3.4a or its salt:

21. Compound VIII: , where R5 represents C 1-4 alkyl or phenyl.

22. A compound selected from one of the following compounds or a salt thereof: , where each R2 is independently hydrogen, alkyl, or phenyl, or both R2 are joined to form a cyclic boronic ether; R3 is C 1-4 alkyl; and R5 is C 1-4 alkyl or phenyl.

23. The compound according to claim 22, wherein both R2 are joined to form a pinacolboronic ester.

24. The compound according to claim 22, wherein R3 is methyl or ethyl.

25. A compound according to any one of claims 21 to 24, wherein R5 is phenyl.

26. Use of a compound according to any one of claims 20 to 25 in the preparation of compound I or compound Ia.