NEW PYRIDINE DERIVATIVES OF BENZIMIDAZOLE
Patent Information
- Authority / Receiving Office
- RU · RU
- Patent Type
- Applications
- Current Assignee / Owner
- F HOFFMANN LA ROCHE & CO AG
- Filing Date
- 2023-01-18
- Publication Date
- 2026-06-30
Claims
1. Compound of formula (I) (I), where R 1 is hydrogen or halogen; R 2 and R 2 ' are independently selected from hydrogen, alkyl, cyclopropyl, haloalkyl and alkoxyalkyl; A1 is -O-, -NR 6 -, -(C=O)- or bond; R 6 is hydrogen or alkyl; R 3 is hydroxyalkyl, heterocycloalkyl, heteroaryl, phenyl or cycloalkylalkyl, wherein heterocycloalkyl, heteroaryl, phenyl and cycloalkylalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R 7 ; if A1 is -(C=O)-, then R 3 may also be a haloalkylamino; each R 7independently selected from alkoxy, alkylamino, alkyl, aminocarbonyl, amino, cyano, cycloalkylamino, haloalkyl, halocycloalkyl, halogen, heteroaryl, hydroxycarbonylamino, alkoxyalkyl, alkylaminocarbonyl, alkylsulfonyl, alkoxycarbonimidoyl, aminocarbonyl, hydroxy, cycloalkylalkyl, haloalkoxy, heterocycloalkyl, and cycloalkyl; A2 represents -O-, -NH- or a bond; R 4 represents hydrogen, alkyl, haloalkyl, alkoxyalkyl, dialkylaminoalkyl, cycloalkyl, cycloalkylcarbonyl, aryl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; wherein aryl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl and heterocycloalkylalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R 8 ; if A2 is a bond, then R 4 may also be halogen or cyano; each R 8independently selected from alkyl, halogen, cyano, alkylsulfonyl, alkylaminocarbonyl, heterocycloalkyl, and alkoxyheterocycloalkylalkyl; A3 represents -O-, -NR 10 - or connection; R 5 represents hydrogen, alkyl, alkylsulfonyl, cycloalkylcarbonyl, heterocycloalkylalkyl, heterocycloalkylalkylcarbonyl, aryl, heteroaryl or heterocycloalkyl, wherein the cycloalkylcarbonyl, aryl, heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R 9 ; if A3 is a bond, then R 5 may also be halogen or cyano; every R 9independently selected from alkoxy, halogen, dialkylaminocarbonyl, alkyl, alkoxyalkoxy, alkoxyheterocycloalkylalkyl, alkoxyheterocycloalkylcarbonyl, haloalkyl, haloalkoxy, heterocycloalkylalkoxy, heterocycloalkyl, heterocycloalkyloxy, hydroxy, hydroxyalkyl, alkylheterocycloalkyl, (haloalkyl)cycloalkyl, alkylheterocycloalkylalkyl, heterocycloalkylalkyl, alkylsulfonyl, (alkyl)heterocycloalkyl, alkylheterocycloalkyloxy, heterocycloalkylheterocycloalkyl, heterocycloalkylheterocycloalkyl, CH3-O-(CH2-CH2-O) n -, alkylaminocarbonyl and cyano; where n is selected from 5, 6, 7, 8 and 9; and R 10 represents hydrogen or alkylcarbonyl; or a pharmaceutically acceptable salt thereof.
2. The compound according to item 1, where R 1 represents hydrogen or chlorine.
3. The compound according to item 1 or 2, where R 2 and R 2' are independently selected from hydrogen, methyl, ethyl, cyclopropyl, difluoromethyl, trifluoromethyl and methoxymethyl.
4. A compound according to any one of claims 1 to 3, wherein A1 is -O-, -NR 6 - or connection; and where R 6 represents hydrogen or methyl.
5. A connection according to any of paragraphs 1-4, where R 3 represents hydroxypentyl, hydroxybutyl, phenyl, cyclopropylmethyl, heterocycloalkyl or heteroaryl, and wherein phenyl, heterocycloalkyl and heteroaryl are optionally substituted with 1, 2 or 3 substituents independently selected from R 7 ; if A1 is -(C=O)-, then R 3 may also be trifluoroethylamino; each R 7independently selected from aminocarbonyl, amino, cyano, methoxy, ethoxy, chloro, fluoro, hydroxy, trifluoromethyl, trifluoroethyl, difluoromethyl, methylsulfonyl, methylaminocarbonyl, methoxyethyl, cyclopropylamino, difluoromethoxy, oxetan-3-yl, methylamino, 1H-pyrazol-4-yl, difluorocyclopropyl, methyl, ethyl, cyclopropylmethyl, and cyclobutylmethyl.
6. A compound according to any one of claims 1 to 5, wherein A2 is -O-, -NH- or a bond; R 4 represents hydrogen, haloalkyl, alkoxyalkyl, dialkylaminoalkyl, cycloalkyl, cycloalkylcarbonyl, aryl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; wherein aryl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl and heterocycloalkylalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R 8 ; if A2 is a bond, then R 4 may also be halogen or cyano; if A2 is -O- or -NH-, then R 4may also be alkyl; every R 8 independently selected from alkyl, halogen, cyano, alkylsulfonyl, alkylaminocarbonyl, heterocycloalkyl, and alkoxyheterocycloalkylalkyl; A3 represents -O-, -NH- or a bond; R 5 represents hydrogen, alkylsulfonyl, cycloalkylcarbonyl, heterocycloalkylalkyl, heterocycloalkylalkylcarbonyl, aryl, heteroaryl or heterocycloalkyl, wherein aryl, cycloalkylcarbonyl, heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R 9 ; if A3 is a bond, then R 5 may also represent halogen or cyano; if A3 is -O- or -NH-, then R 5 may also be alkyl; every R 9independently selected from alkoxy, halogen, dialkylaminocarbonyl, alkyl, alkoxyalkoxy, alkoxyheterocycloalkylalkyl, alkoxyheterocycloalkylcarbonyl, haloalkyl, haloalkoxy, heterocycloalkylalkoxy, heterocycloalkyl, heterocycloalkyloxy, hydroxy, alkylheterocycloalkyl, alkylheterocycloalkylalkyl, heterocycloalkylalkyl, alkylsulfonyl, (alkyl)heterocycloalkyl, alkylheterocycloalkyloxy, heterocycloalkylheterocycloalkyl, heterocycloalkylheterocycloalkyl, CH3-O-(CH2-CH2-O) n -, alkylaminocarbonyl and cyano; where n is selected from 5, 6, 7, 8 and 9; provided that only one of R 4 and R 5 may represent hydrogen.
7. A compound according to any one of claims 1 to 6, wherein A2 is -O- or a bond.
8. A connection according to any of paragraphs 1-7, where R 4represents hydrogen, trifluoromethyl, methoxyethyl, dimethylaminoethyl, cyclopropylcarbonyl, morpholinoethyl, (1,1-dioxo-1,2-thiazolidin-2-yl)methyl, (2-oxopyrrolidin-1-yl)methyl, (2-oxo-1-piperidyl)methyl, heteroaryl or heterocycloalkyl, and wherein heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R 8 ; if A2 is a bond, then R 4 may also represent fluorine, bromine, or cyano; if A2 represents -O- or -NH-, then R 4 may also represent methyl; every R 8 independently selected from methyl, fluoro, cyano, methylsulfonyl, oxetan-3-yl, and (3-methoxyazetidin-1-yl)methyl.
9. A compound according to any one of claims 1 to 8, wherein A3 is -O- or -NH-.
10. A connection according to any one of paragraphs 1-9, where R 5represents hydrogen, methylsulfonyl, morpholinoethyl, (2-oxopyrrolidin-1-yl)methyl, (2-oxo-1-piperidyl)methyl, (oxetan-3-yl)methyl, 1-piperidylethylcarbonyl, phenyl, heteroaryl or heterocycloalkyl; wherein phenyl, heteroaryl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents independently selected from R 9 ; if A3 is a bond, then R 5 may also represent fluorine or cyano; if A3 represents -O- or -NH-, then R 5 may also represent methyl; and where each R 9is independently selected from methyl, methoxy, oxetan-3-yl, azetidin-3-yl, azetidin-1-yl, 3,3-difluoroazetidin-1-yl, 2-oxopyrrolidin-1-yl, hydroxy, difluoromethyl, trifluoromethyl, (3-methoxyazetidin-1-yl)methyl, 3-methoxyazetidine-1-carbonyl, methoxyethoxy, difluoroethoxy, difluoromethoxy, [2-(1,1-dioxo-1,4-thiazinan-4-yl)ethoxy], oxetan-3-yloxy, chloro, dimethylaminocarbonyl, cyano, methylsulfonyl, morpholinomethyl, morpholino, (4-methylpiperazin-1-yl)methyl, CH3-O-(CH2-CH2-O)7-, oxetan-3-yl, [1-(oxetan-3-yl)pyrrolidin-2-yl] and (2-methyl-1,3-dioxolan-2-yl).
11. A compound according to any one of paragraphs 1-10, selected from [2-(3-chlorophenyl)-6-(5,6-dimethoxybenzimidazol-1-yl)-3-pyridyl]methanol; (2-(3-chloro-2-fluorophenyl)-6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)pyridin-3-yl)methanol; (6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-2-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)methanol; 1-(6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-2-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)ethan-1-ol; 1-(6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-2-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)propan-1-ol; 1-(2-(3-chlorophenyl)-6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)pyridin-3-yl)ethan-1-ol; 1-(2-(3-chloro-2-fluorophenyl)-6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)pyridin-3-yl)ethan-1-ol; (S)-1-(6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-2-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)ethan-1-ol; (R)-1-(6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-2-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)ethan-1-ol; cyclopropyl(6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-2-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)methanol; 1-(2-(3-chlorophenyl)-6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)pyridin-3-yl)propan-1-ol; (2-(3-chlorophenyl)-6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)pyridin-3-yl)(cyclopropyl)methanol; (6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-2-morpholinopyridin-3-yl)methanol; (6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-2-(pyrrolidin-1-yl)pyridin-3-yl)methanol; (6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-2-(piperidin-1-yl)pyridin-3-yl)methanol; 5-((6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-(hydroxymethyl)pyridin-2-yl)amino)pentan-1-ol; 1-(6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-(hydroxymethyl)pyridin-2-yl)pyrrolidin-2-one; 4-((6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-(hydroxymethyl)pyridin-2-yl)amino)butan-1-ol; (S)-2-(6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-(1-hydroxyethyl)pyridin-2-yl)benzamide; (R)-2-(6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-(1-hydroxyethyl)pyridin-2-yl)benzamide; (S)-3-(6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-(1-hydroxyethyl)pyridin-2-yl)benzonitrile; (R)-3-(6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-(1-hydroxyethyl)pyridin-2-yl)benzonitrile; (S)-4-(6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-(1-hydroxyethyl)pyridin-2-yl)benzonitrile; (R)-4-(6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-(1-hydroxyethyl)pyridin-2-yl)benzonitrile; (S)-6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-(1-hydroxyethyl)-1'-methyl-[2,4'-bipyridin]-2'(1'H)-one; (R)-6-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-(1-hydroxyethyl)-1'-methyl-[2,4'-bipyridin]-2'(1'H)-one; 1-[6-[5-(2-morpholinoethoxy)benzimidazol-1-yl]-2-phenoxy-3-pyridyl]ethanol; 1-[2-anilino-6-[5-(2-morpholinoethoxy)benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[5-(2-morpholinoethoxy)benzimidazol-1-yl]-2-[3-(trifluoromethyl)pyrazol-1-yl]-3-pyridyl]ethanol; 1-[6-(5,6-dimethoxybenzimidazol-1-yl)-2-[3-(trifluoromethyl)pyrazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-(4-methylpiperazin-1-yl)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[4-(oxetan-3-yl)piperazin-1-yl]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-(2-morpholinoethoxy)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[[1-(oxetan-3-yl)pyrazol-4-yl]amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[[1-(azetidin-3-yl)pyrazol-4-yl]amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[6-(6-methylpyridazin-3-yl)oxybenzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-(6-methylpyridazin-3-yl)oxybenzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 5-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-1-methylpyrazole-4-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[para-(3R)-3-hydroxypyrrolidin-1-yl]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(3S)-3-hydroxypyrrolidin-1-yl]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methyl-3-pyridyl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(5-methylpyrazin-2-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(5-methylpyrimidin-2-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(5-methyl-2-pyridyl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-(1,1-dioxo-1,2-thiazolidin-2-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[(2-methylpyrimidin-5-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-(pyridazin-4-ylamino)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methoxypyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-(pyridazin-3-ylamino)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[[6-(difluoromethyl)pyridazin-3-yl]amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-fluoro-6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl]-3-pyridyl]ethanol; 1-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[(5-methyl-1,3,4-oxadiazol-2-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 2-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; (3R)-1-[3-(1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]pyrrolidine-3-carbonitrile; rac-(3R)-1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]pyrrolidine-3-carbonitrile; 1-[2-(3,5-dimethylpyrazol-1-yl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-(3,5-dimethylpyrazol-1-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 5-methyl-1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-[rac-(1R)-1-hydroxyethyl]-2-pyridyl]pyrazole-3-carbonitrile; 5-methyl-1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-[rac-(1S)-1-hydroxyethyl]-2-pyridyl]pyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(5-methyl-1,3,4-thiadiazol-2-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[[1-(oxetan-3-yl)-4-piperidyl]oxy]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[6-[[1-(oxetan-3-yl)-4-piperidyl]oxy]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]pyrazole-3-carbonitrile; 1-[[[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]amino]methyl]cyclopropanecarbonitrile; 1-[[[3-(1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]amino]methyl]cyclopropanecarbonitrile; 5-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]pyridine-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-(1,2,4-triazin-3-ylamino)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-3-methylpyrrolidine-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-3-methylpyrrolidine-3-carbonitrile; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-(isoxazol-3-ylamino)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-N-(2,2,2-trifluoroethyl)pyridine-2-carboxamide; 1-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[rac-(3aR,6aS)-2,3,3a,5,6,6a-hexahydro-1H-pyrrolo[3,2-b]pyrrol-4-yl]-3-pyridyl]ethanol; 1-[6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[rac-(3aS,6aR)-2,3,3a,5,6,6a-hexahydro-1H-pyrrolo[3,2-b]pyrrol-4-yl]-3-pyridyl]ethanol; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[rac-(3aR,6aS)-2,3,3a,5,6,6a-hexahydro-1H-pyrrolo[3,2-b]pyrrol-4-yl]-3-pyridyl]ethanol; 1-[2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[6-bromo-5-[4-(oxetan-3-yl)piperazin-1-yl]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-(3-ethoxy-5-methylpyrazol-1-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-(3-ethoxy-5-methylpyrazol-1-yl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-(6-methylpyridazin-4-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 4-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-1-(2,2,2-trifluoroethyl)piperazin-2-one; 4-[3-(1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-1-(2,2,2-trifluoroethyl)piperazin-2-one; 1-[[3-(1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]oxymethyl]cyclopropanecarbonitrile; 1-[[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]oxymethyl]cyclopropanecarbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-methoxy-6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-N,5-dimethylpyrazole-3-carboxamide; 1-[2-(5-methyl-3-methylsulfonylpyrazol-1-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[(2-keto-1-methylpyrimidin-4-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 5-methyl-1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-(2,2,2-trifluoro-1-hydroxyethyl)-2-pyridyl]pyrazole-3-carbonitrile; 1-[2-[1-(difluoromethyl)-3-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-4-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-4-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-N,5-dimethylpyrazole-3-carboxamide; 1-[3-(1-hydroxyethyl)-6-[5-[(2-keto-1-methyl-4-piperidyl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; [2-(3-methoxy-5-methylpyrazol-1-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]methanol; 1-[2-(3,5-dimethylisoxazol-4-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[(4-methoxypyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(5-keto-1-methylpyrrolidin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-(3-methyl-4-pyridyl)-3-pyridyl]ethanol; 1-[2-[4-(cyclopropylamino)pyrimidin-5-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 5-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-4-(trifluoromethyl)pyridin-2-ol; 3-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one; 1-[6-[6-fluoro-5-[[(3S,4R)-4-fluoropyrrolidin-3-yl]amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-[2-(difluoromethoxy)-5-methyl-4-pyridyl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-(2-fluoro-5-methyl-4-pyridyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-4-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-4-methylpyrazole-3-carbonitrile; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[5-methyl-3-(trifluoromethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-pyridyl]ethanol; 1-[[[3-(1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]methylamino]methyl]cyclopropanecarbonitrile; 1-[[[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]methylamino]methyl]cyclopropanecarbonitrile; 1-[2-(2-chloro-5-fluoro-3-pyridyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[6-[[6-[(3-methoxyazetidin-1-yl)methyl]pyridazin-3-yl]amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[[6-[(3-methoxyazetidin-1-yl)methyl]pyridazin-3-yl]amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[5-(oxetan-3-yl)-3-(trifluoromethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-3-methylpyrazole-4-carbonitrile; 1-[2-[2-(methylamino)-3-pyridyl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-3-methylpyrazole-4-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-3-methylazetidine-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-3-methylazetidine-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[6-methoxy-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[2-(1H-pyrazol-4-yl)-3-pyridyl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[6-(2-methoxyethoxy)-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-fluoro-6-[[rac-(3R,4S)-4-fluoropyrrolidin-3-yl]amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)pyridin-2-yl]-5-methylpyrazole-3-carbonitrile; 1-[6-[6-[2-(dimethylamino)ethoxy]-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-bromo-6-[4-(oxetan-3-yl)piperazino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[[6-(3-methoxyazetidin-1-carbonyl)pyridazin-3-yl]amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]-6-pyrrolidin-3-yloxybenzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[[6-(2-methoxyethoxy)pyridazin-3-yl]amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-(1H-benzotriazol-4-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[5-[[6-(2,2-difluoroethoxy)pyridazin-3-yl]amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[[6-(difluoromethoxy)pyridazin-3-yl]amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(2,2-difluoro-1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(2,2-difluoro-1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[6-[(1,1-dioxo-1,2-thiazolidin-2-yl)methyl]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[(1,1-dioxo-1,2-thiazolidin-2-yl)methyl]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 3-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-2-methoxyphenol; 3-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]furan-2-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]pyridin-2-yl]-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridine-3-carbonitrile; 1-[6-[5-[[6-[2-(1,1-diketo-1,4-thiazinan-4-yl)ethoxy]pyridazin-3-yl]amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[[6-(oxetan-3-yloxy)pyridazin-3-yl]amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[(3S)-pyrrolidin-3-yl]oxy-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[6-[(2-oxopyrrolidin-1-yl)methyl]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(2-oxopyrrolidin-1-yl)methyl]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-(3-methoxy-5-methylpyrazol-1-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[6-[(2-oxo-1-piperidyl)methyl]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(2-oxo-1-piperidyl)methyl]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 3-[[1-[6-(3-cyano-5-methylpyrazol-1-yl)-5-(1-hydroxyethyl)-2-pyridyl]benzimidazol-5-yl]amino]-N,N,6-trimethylpyridazine-4-carboxamide; 5-hydroxy-2-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]benzonitrile; 5-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-3-(trifluoromethyl)-1H-pyridazin-6-one; 2-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]furan-3-carbonitrile; 1-[2-[2-(2,2-difluorocyclopropyl)pyrazol-3-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[[6-(oxetan-3-yl)pyridazin-3-yl]amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; (1S)-1-[2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; (1R)-1-[2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[5-(difluoromethyl)-3-methylpyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxy-2-methoxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxy-2-methoxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-[(1S)-1-hydroxyethyl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-[(1R)-1-hydroxyethyl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[5-chloro-3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]pyrazole-3-carbonitrile; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[5-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; 1-[6-[5-[(6-chloro-4-methoxypyridazin-3-yl)amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazol-3-carbonitrile; rac-(3R,5S)-1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrrolidine-3-carbonitrile; 1-[5-chloro-3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 5-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-2-methylpyrazole-3-carbonitrile; 1-[3-[(1R)-1-hydroxyethyl]-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-[3,5-bis(difluoromethyl)pyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]pyridin-3-yl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[[6-(trifluoromethyl)pyridazin-3-yl]amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-[2-ethyl-5-(trifluoromethyl)pyrazol-3-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; rac-(1S)-1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; rac-(1R)-1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]triazole-4-carbonitrile; (3S,5R)-1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrrolidine-3-carbonitrile; 5-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-1-methylpyrazole-3-carbonitrile; 2-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]triazole-4-carbonitrile; 1-[6-(3-cyano-5-methylpyrazol-1-yl)-5-(1-hydroxyethyl)pyridin-2-yl]benzimidazole-5-carbonitrile; 1-[2-(1-ethyl-3-methylpyrazol-4-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[1-(2-methoxyethyl)-3-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[1-(cyclopropylmethyl)-3-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 5-methyl-1-[3-methylol-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]pyrazole-3-carbonitrile; 5-methyl-1-[3-methylol-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]pyrazole-3-carbonitrile; 1-[2-(1-ethyl-5-methylpyrazol-4-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[1-(cyclopropylmethyl)-5-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[1-(cyclobutylmethyl)-3-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[1-(cyclobutylmethyl)-5-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]-6-(trifluoromethyl)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-[(1S)-1-hydroxyethyl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carboximidic acid methyl ester; 1-[2-[1-(2,2-difluorocyclopropyl)-3-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[1-(2-methoxypropyl)-3-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[1-(2-methoxypropyl)-5-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-[(1S)-1-hydroxyethyl]-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-[1-(2,2-difluoropropyl)-3-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]-6-(oxetan-3-yloxy)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-(2-ethyl-5-methyl-4-pyridyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[1-(2,2-difluoropropyl)-5-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-(2-methoxy-5-methyl-4-pyridyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; (1S)-1-[2-[3,5-bis(difluoromethyl)pyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; (1R)-1-[2-[3,5-bis(difluoromethyl)pyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-(2-cyclopropyl-5-methyl-4-pyridyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[3-(difluoromethoxy)-5-methylpyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methyl-4-methylsulfonylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[[6-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy] ethoxy]ethoxy]pyridazine-3-yl]amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[6-[(6-methyl-3-pyridyl)amino]-5-(2-morpholinoethoxy)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[6-(2-oxa-5-azaspiro[3.4]octan-5-yl)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-(2-oxa-5-azaspiro[3.4]octan-5-yl)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methyl-3-pyridyl)amino]-6-(2-morpholinoethoxy)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-[3-(difluoromethyl)pyrrolidin-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-(2,2-difluoro-5-azaspiro[2.4]heptan-5-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; (1S)-1-[2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; 5-(difluoromethyl)-2-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]pyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[[6-[1-(oxetan-3-yl)pyrrolidin-2-yl]pyridazin-3-yl]amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 7,7-difluoro-1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5,6-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carbonitrile; 5-(difluoromethyl)-1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]pyrazole-3-carbonitrile; (1S)-1-[2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-6-[6-fluoro-5-(pyridazin-3-ylamino)benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[5-methyl-2-(2,2,2-trifluoroethyl)triazol-4-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-4,5-dimethylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[(4-methyl-2,3-dihydropyridazino[4,5-b][1,4]oxazin-8-yl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[5-methyl-1-(2,2,2-trifluoroethyl)triazol-4-yl]-3-pyridyl]ethanol; 1-[1-[6-(3-cyano-5-methylpyrazol-1-yl)-5-(1-hydroxyethyl)-2-pyridyl]benzimidazol-5-yl]-N,N-dimethylpyrrolidine-2-carboxamide; 1-[2-[1-(2,2-difluoroethyl)-3-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[5-fluoro-6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-(hydroxymethyl)-2-pyridyl]-5-methylpyrazol-3-carbonitrile; [6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]methanol; [6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[5-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]methanol; [2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-6-[5-(7,8-dihydro-5H-pyrano[4,3-c]pyridazin-3-ylamino)benzimidazol-1-yl]-3-pyridyl]methanol; [6-[5-[(4aS,7aR)-4-methyl-2,3,4a,5,7,7a-hexahydropyrrolo[3,4-b][1,4]oxazin-6-yl]benzimidazol-1-yl]-2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-3-pyridyl]methanol; [2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]methanol; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[2-(trifluoromethyl)morpholin-4-yl]-3-pyridyl]ethanol; 3-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-3-azabicyclo[3.1.0]hexane-1-carbonitrile; 1-[2-(5,5-difluoro-2-azabicyclo[2.2.1]heptan-2-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[2-(difluoromethyl)morpholin-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-(6,6-difluoro-2-azabicyclo[2.2.1]heptan-2-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[7-(difluoromethyl)-5-azaspiro[2.4]heptan-5-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-(6,6-difluoro-3-azabicyclo[3.2.0]heptan-3-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; N-[1-[6-(3-cyano-5-methylpyrazol-1-yl)-5-(1-hydroxyethyl)-2-pyridyl]benzimidazol-5-yl]cyclopropanecarboxamide; N-[3-[6-(3-cyano-5-methylpyrazol-1-yl)-5-(1-hydroxyethyl)-2-pyridyl]benzimidazol-5-yl]cyclopropanecarboxamide; 1-[2-(4,7-diazaspiro[2.5]octan-7-yl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[5-[(3aS,6aS)-6-oxo-2,3,3a,4,5,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[3-(trifluoromethyl)piperazin-1-yl]-3-pyridyl]ethanol; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[5-methyl-2-(trifluoromethyl)-4-pyridyl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-[(2-keto-1-methyl-3-pyridyl)amino]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-(3-methoxy-1-methylpyrazol-4-yl)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazol-3-carbonitrile; 1-[2-[2-(difluoromethyl)-5-methyl-4-pyridyl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[6-(1-methyl-2-oxopyrimidin-4-yl)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-6-[6-fluoro-5-[[6-(2-methyl-1,3-dioxolan-2-yl)pyridazin-3-yl]amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[5-(1-methyl-2-oxopyrimidin-4-yl)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[6-(6-methylpyridazin-3-yl)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-(6-methylpyridazin-3-yl)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[6-[(2S)-2-cyanopyrrolidin-1-yl]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[(2S)-2-cyanopyrrolidin-1-yl]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[6-[(3aS,6aS)-6-oxo-2,3,3a,4,5,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-[3-(difluoromethyl)-5-methyl-1,2,4-triazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 3-[[1-[6-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-5-[(1~{S})-1-hydroxyethyl]-2-pyridyl]-6-fluorobenzimidazol-5-yl]amino]-~{N},~{N},6-trimethylpyridazine-4-carboxamide; 1-[2-[2-(difluoromethoxy)-5-methyl-4-pyridyl]-6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-(hydroxymethyl)-2-pyridyl]-5-methylpyrazol-3-carbonitrile; 3-[[1-[6-[3,5-bis(difluoromethyl)pyrazol-1-yl]-5-(hydroxymethyl)-2-pyridyl]benzimidazol-5-yl]amino]-N,N,6-trimethylpyridazine-4-carboxamide; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[4-methyl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]-3-pyridyl]ethanol; 1-[2-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-6-[5-[6-(morpholinomethyl)pyridazin-3-yl]oxybenzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[5-(6-methylpyridazin-3-yl)oxybenzimidazol-1-yl]-2-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; 1-[6-[5-[6-[(4-methylpiperazin-1-yl)methyl]pyridazin-3-yl]oxybenzimidazol-1-yl]-2-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-3-pyridyl]ethanol; 1-[2-[3-(difluoromethoxy)-5-methylpyrazol-1-yl]-6-[6-[(6-methylpyridazin-3-yl)amino]-5-(oxetan-3-yloxy)benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-(3-chloro-5-methylpyrazol-1-yl)-6-[5-fluoro-6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-(3-chloro-5-methylpyrazol-1-yl)-6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[1-(cyclopropylmethyl)-3-methylpyrazol-4-yl]-6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[3-(difluoromethoxy)-5-methylpyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]-6-(oxetan-3-yloxy)benzimidazol-1-yl]-3-pyridyl]ethanol; N-[1-[5-(1-hydroxyethyl)-6-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-pyridyl]benzimidazol-5-yl]-2-(1-piperidyl)acetamide; 6-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-6-azaspiro[3.4]octane-8-carbonitrile; 4-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]morpholine-2-carbonitrile; N-[1-[6-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-5-(1-hydroxyethyl)-2-pyridyl]-6-fluorobenzimidazol-5-yl]cyclopropanecarboxamide; 1-[6-[6-(2,3-difluoro-4-methylanilino)-5-fluorobenzimidazol-1-yl]-2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-3-pyridyl]ethanol; 1-[2-[1-(difluoromethyl)-4-methylpyrazol-3-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-6-[5-fluoro-6-(2,3,4-trifluoroanilino)benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[3-(1-hydroxyethyl)-6-[6-(6-methyl-7-oxo-5H-pyrrolo[3,4-b]pyridin-2-yl)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-(6-methyl-7-oxo-5H-pyrrolo[3,4-b]pyridin-2-yl)benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-[3-(difluoromethoxy)-5-methylpyrazol-1-yl]-6-[5-[[6-(difluoromethyl)pyridazin-3-yl]amino]benzimidazol-1-yl]pyridin-3-yl]ethanol; 1-[2-[3-(difluoromethyl)-5-ethylpyrazol-1-yl]-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[3-(difluoromethyl)-4,5-dimethylpyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[3-(difluoromethyl)-5-ethylpyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[6-[(6-chloropyridazin-3-yl)amino]-5-fluorobenzimidazol-1-yl]-2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-3-pyridyl]ethanol; 1-[6-[5-[(6-chloropyridazin-3-yl)amino]-6-fluorobenzimidazol-1-yl]-2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-3-pyridyl]ethanol; (1S)-1-[2-[3-(difluoromethoxy)-5-methylpyrazol-1-yl]-6-[6-fluoro-5-(pyridazin-3-ylamino)benzimidazol-1-yl]-3-pyridyl]ethanol; (1S)-1-[2-[3-(difluoromethoxy)-5-methylpyrazol-1-yl]-6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; (1R)-1-[2-[3-(difluoromethoxy)-5-methylpyrazol-1-yl]-6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[5-fluoro-6-[(5-methyl-1,3,4-oxadiazol-2-yl)amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[6-fluoro-5-[(5-methyl-1,3,4-oxadiazol-2-yl)amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[6-fluoro-5-(2,3,4-trifluoroanilino)benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-fluoro-6-(2,3,4-trifluoroanilino)benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; N-[1-[6-(3-cyano-5-methylpyrazol-1-yl)-5-(1-hydroxyethyl)-2-pyridyl]benzimidazol-5-yl]-1-fluorocyclopropanecarboxamide; 1-[6-[6-(6,7-dihydro-5~{H}-cyclopenta[c]pyridazin-3-ylamino)-5-fluorobenzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-(6,7-dihydro-5~{H}-cyclopenta[c]pyridazin-3-ylamino)-6-fluorobenzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; (1S)-1-[2-[3-(difluoromethoxy)-5-methylpyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]-6-(oxetan-3-yloxy)benzimidazol-1-yl]-3-pyridyl]ethanol; (1R)-1-[2-[3-(difluoromethoxy)-5-methylpyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]-6-(oxetan-3-yloxy)benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[6-fluoro-5-[(5-methyl-1,3,4-thiadiazol-2-yl)amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 3-fluoro-4-[3-(1-hydroxyethyl)-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-pyridyl]-1-(2,2,2-trifluoroethyl)pyridin-2-one; 1-[2-[3,5-bis(difluoromethyl)pyrazol-1-yl]-6-[6-fluoro-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[6-(difluoromethoxy)-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazol-3-carbonitrile; 1-[6-[6-fluoro-5-[(5-fluoro-6-methyl-3-pyridyl)amino]benzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[5-[[5-(azetidin-1-yl)pyridazin-3-yl]amino]-6-fluorobenzimidazol-1-yl]-2-[3-(difluoromethyl)-5-methylpyrazol-1-yl]-3-pyridyl]ethanol; 1-[6-[6-fluoro-5-[(5-fluoro-6-methyl-3-pyridyl)amino]benzimidazol-1-yl]-3-[(1S)-1-hydroxyethyl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[5-[2-(2-oxopyrrolidin-1-yl)oxazol-5-yl]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-(4,4-difluoropyrrolidin-3-yl)oxy-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[5-(7,8-dihydro-5~{H}-pyrano[4,3-c]pyridazin-3-ylamino)-6-methoxybenzimidazol-1-yl]-3-(1-hydroxyethyl)-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[3-(1-hydroxyethyl)-6-[6-[2-(2-oxopyrrolidin-1-yl)oxazol-5-yl]benzimidazol-1-yl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-[6-(difluoromethoxy)-3-methylpyridazin-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[3-(difluoromethyl)-5-methoxypyrazol-1-yl]-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[3-(difluoromethyl)-5-methoxypyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[1-(2,3-difluoropropyl)-3-methylpyrazol-4-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; (1S)-1-[2-[3-(difluoromethoxy)-5-methylpyrazol-1-yl]-6-[6-methoxy-5-[(2-methylpyrimidin-5-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-2-[2-methyl-5-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]-3-pyridyl]ethanol; 1-[6-[6-(difluoromethoxy)-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-[(1S)-1-hydroxyethyl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[6-[6-(difluoromethoxy)-5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-[(1R)-1-hydroxyethyl]-2-pyridyl]-5-methylpyrazole-3-carbonitrile; 1-[2-[3-(difluoromethoxy)-5-(difluoromethyl)pyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[3-(difluoromethoxy)-5-(difluoromethyl)pyrazol-1-yl]-6-[6-[(6-methylpyridazin-3-yl)amino]benzimidazol-1-yl]-3-pyridyl]ethanol; 1-[2-[3-(difluoromethoxy)-5-methylpyrazol-1-yl]-6-[6-[(6-methylpyridazin-3-yl)amino]-5-(oxetan-3-ylmethyl)benzimidazol-1-yl]-3-pyridyl]ethanol; and 1-[2-[3-(difluoromethoxy)-5-methylpyrazol-1-yl]-6-[5-[(6-methylpyridazin-3-yl)amino]-6-(oxetan-3-ylmethyl)benzimidazol-1-yl]-3-pyridyl]ethanol; or a pharmaceutically acceptable salt thereof.
12. A method for producing a compound according to any of paragraphs 1-11, comprising one of the following steps: (a) the reaction of a compound of formula (B1) (B1), with a restorative agent; (b) the reaction of a compound of formula (C1) (C1) with a restorative; or (c) reaction of the compound (D1) (D1) with a compound of formula R c MgX, where A1, A2, A3, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in any of paragraphs 1-11, R a is alkyl or cycloalkyl, R b represents hydrogen or alkyl, R c represents alkyl or cycloalkyl, and X represents halogen.
13. A connection according to any one of paragraphs 1-11, produced in accordance with the method according to paragraph 12.
14. A compound of formula (I) according to any one of claims 1 to 11, or a pharmaceutically acceptable salt thereof, for use as a therapeutically active substance.
15. A pharmaceutical composition comprising a compound of formula (I) according to any one of claims 1-11 or a pharmaceutically acceptable salt thereof and a therapeutically inert carrier.
16. Use of a compound of formula (I) according to any one of claims 1 to 11, or a pharmaceutically acceptable salt thereof, for the treatment or prevention of rheumatoid arthritis, juvenile rheumatoid arthritis, non-alcoholic steatohepatitis (NASH), primary sclerosing cholangitis, giant cell vasculitis, inflammatory bowel disease (IBD), atherosclerosis, type 2 diabetes mellitus or glomerulonephritis.
17. Use of a compound of formula (I) according to any one of claims 1 to 11 or a pharmaceutically acceptable salt thereof for the preparation of a medicinal product for the treatment or prevention of rheumatoid arthritis, juvenile rheumatoid arthritis, non-alcoholic steatohepatitis (NASH), primary sclerosing cholangitis, giant cell vasculitis, inflammatory bowel disease (IBD), atherosclerosis, type 2 diabetes mellitus or glomerulonephritis.
18. A compound of formula (I) according to any one of claims 1 to 11, or a pharmaceutically acceptable salt thereof, for use in the treatment or prevention of rheumatoid arthritis, juvenile rheumatoid arthritis, non-alcoholic steatohepatitis (NASH), primary sclerosing cholangitis, giant cell vasculitis, inflammatory bowel disease (IBD), atherosclerosis, type 2 diabetes mellitus or glomerulonephritis.
19. A method for the treatment or prevention of rheumatoid arthritis, juvenile rheumatoid arthritis, non-alcoholic steatohepatitis (NASH), primary sclerosing cholangitis, giant cell vasculitis, inflammatory bowel disease (IBD), atherosclerosis, type 2 diabetes mellitus or glomerulonephritis, comprising administering an effective amount of a compound of formula (I) according to any one of claims 1 to 11 or a pharmaceutically acceptable salt thereof to a patient in need thereof.
20. The invention as described above in this document.