Method for determining the degree of polymerization of microcrystalline cellulose
RU2024124872A3Pending Publication Date: 2026-09-10ТРУБИЦЫНА ДАРЬЯ АЛЕКСАНДРОВНА
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Patent Information
- Application Number
- RU2024124872
- Authority / Receiving Office
- RU · RU
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2024-08-26
- Publication Date
- 2026-09-10
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Claims
A method for determining the quality of pharmacopoeial microcrystalline cellulose, consisting of excitation and recording of characteristic NMR signals 13 From the sample under study, determining the signal parameters by which the average number degree of polymerization (DP) is calculated, characterized in that the NMR spectrum is recorded 13 From a solid-state sample using cross-polarization (CP) and magic angle spinning (MAS), the integral intensities of the signals of acetal (chemical shift 100-110 ppm) and hemiacetal (chemical shift 93-99 ppm) carbon atoms are determined and the number-average degree of polymerization is calculated from their ratio.