A TWO-STEP METHOD FOR ISOLATION OF LOW-DENSITY NEUTROPHILS FROM HUMAN BLOOD
RU2026100343A3Pending Publication Date: 2026-06-29FEDERALNOE GOSUDARSTVENNOE BYUDZHETNOE NAUCHNOE UCHREZHDENIE NAUCHNO ISSLEDOVATELSKIJ INST KLINICHESKOJ I EKSPERIMENTALNOJ REVMATOLOGII IMENI A B ZBOROVSKOGO
Patent Information
- Authority / Receiving Office
- RU · RU
- Patent Type
- Applications
- Current Assignee / Owner
- FEDERALNOE GOSUDARSTVENNOE BYUDZHETNOE NAUCHNOE UCHREZHDENIE NAUCHNO ISSLEDOVATELSKIJ INST KLINICHESKOJ I EKSPERIMENTALNOJ REVMATOLOGII IMENI A B ZBOROVSKOGO
- Filing Date
- 2026-01-12
- Publication Date
- 2026-06-29
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Claims
A method for isolating low-density neutrophils from human blood, comprising separating blood leukocytes into fractions of varying density by centrifugation in a density gradient, followed by extraction of non-neutrophil cells from the cell mixture using magnetically controlled particles that selectively bind to such cells, characterized in that the gradient component providing the required density is iohexol, and iohexol-containing gradients with densities of 1072 kg / m are used for centrifugation. 3 and 1080 kg / m 3 , and the main structural component of the surface of magnetically controlled particles used to extract non-neutrophil cells is polyacrylamide.