Method for treating chronic periodontitis in experiment with laboratory rats

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Topical application of adenosine triphosphate disodium salt addresses the limitations of existing treatments by effectively reducing inflammation and restoring periodontal structures in periodontitis, achieving a normal histological structure and eliminating residual signs.

RU2865262C1Active Publication Date: 2026-07-01FEDERALNOE GOSUDARSTVENNOE BYUDZHETNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO OBRAZOVANIYA KAZANSKIJ GOSUDARSTVENNYJ MEDITSINSKIJ UNIV MINISTSTVA ZDRAVOOKHRANENIYA ROSSIJSKOJ FEDERATSII

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Patent Information

Authority / Receiving Office: RU · RU
Patent Type: Patents
Current Assignee / Owner: FEDERALNOE GOSUDARSTVENNOE BYUDZHETNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO OBRAZOVANIYA KAZANSKIJ GOSUDARSTVENNYJ MEDITSINSKIJ UNIV MINISTSTVA ZDRAVOOKHRANENIYA ROSSIJSKOJ FEDERATSII
Filing Date: 2025-12-01
Publication Date: 2026-07-01

AI Technical Summary

Technical Problem

Existing treatments for chronic inflammatory periodontal diseases, such as periodontitis, face challenges including diffusion of drugs beyond the lesion site, lack of local effect, mechanical strength, unpleasant odor, allergic reactions, contraindications due to metal structures, and insufficient tissue restoration effects.

Method used

The use of an aqueous solution of adenosine triphosphate disodium salt (ATP) for topical application in treating periodontitis, combined with scaling, curettage, and irrigation, to address the etiopathogenesis of the disease.

Benefits of technology

Reduces signs of chronic inflammation, restores tooth-gingival attachment, and achieves a normal histological structure of the periodontium without residual inflammation.

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Abstract

FIELD: dentistry.SUBSTANCE: laboratory rats undergo dental calculus removal, closed curettage, and antiseptic treatment of periodontal pockets using the drug. In this case, an aqueous solution of adenosine triphosphate adisodium salt with a concentration of 25% is used as a drug at intervals of 7 days from the start of treatment.EFFECT: method allows to reduce and eliminate signs of chronic inflammation: swelling, bleeding, hyperemia, and restore gingival attachment.1 cl, 2 dwg, 1 ex

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