Method for the treatment of post-radiation cystitis by multiple intravesicular instillations of hyaluronic acid

The method of continuous intravesical instillations of hyaluronic acid and chondroitin sulfate through a silicone catheter addresses the limitations of current treatments by ensuring prolonged drug contact and tissue regeneration, effectively managing post-radiation cystitis with improved patient comfort and efficacy.

RU2865429C1Active Publication Date: 2026-07-02ЛИР ЯНА ВЛАДИМИРОВНА +1
View PDF 3 Cites 0 Cited by

Patent Information

Application Number
RU2025115065
Authority / Receiving Office
RU · RU
Patent Type
Patents
Current Assignee / Owner
Filing Date
2025-06-02
Publication Date
2026-07-02
Estimated Expiration
2045-06-02

AI Technical Summary

Technical Problem

Current treatments for post-radiation cystitis, such as intravesical installations of hyaluronic acid and gel formulations, suffer from short-lived therapeutic effects, frequent painful catheterizations, high risk of infectious complications, and low patient compliance, due to the rapid washout of drugs during urination and the need for complex regimens.

Method used

A method involving multiple daily intravesical instillations of hyaluronic acid and chondroitin sulfate through a silicone urethral catheter, combined with antibiotics and hemostatic therapy, to maintain a continuous therapeutic concentration and stimulate tissue regeneration, using a specially designed catheter for outpatient treatment.

Benefits of technology

Achieves rapid relief of symptoms, reduces urination frequency, stops hematuria, and promotes epithelialization, with minimal infectious risk and patient discomfort, providing a stable therapeutic effect lasting up to 6-12 months.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 00000001
    Figure 00000001
  • Figure 00000002
    Figure 00000002
  • Figure 00000004
    Figure 00000004
Patent Text Reader

Abstract

FIELD: medicine; urology.SUBSTANCE: used in the treatment of post-radiation cystitis. The method involves intravesical instillation of hyaluronic acid. A three-way 22 Ch catheter is installed, the bladder is washed with sterile saline solution and then instillations are performed for 14 days every 4 hours, starting from 8.00 to 0.00 for 60–90 minutes. The first instillation is made with 50 ml of 0.2% hyaluronic acid, the second – 50 ml of 0.5% chondroitin sulfate, the third - 50 ml of 0.2% hyaluronic acid, the fourth – 50 ml of a combined solution of 0.2% hyaluronic acid and 0.5% chondroitin sulfate, the fifth – 50 ml of 0.2% hyaluronic acid. In parallel with this, ceftriaxone 2 g is used once a day intravenously for 7 days, as well as tranexamic acid 1 g intravenously 2 times a day for 5 days.EFFECT: creating a protective barrier on the urothelium, stimulating tissue regeneration, relieving pain, and restoring the functional capacity of the bladder through the constant therapeutic effect of hyaluronic acid on the damaged bladder mucosa through multiple instillations through an installed urethral catheter.1 cl, 2 ex
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Method of treating radiation and interstitial cystitis

    RU2557949C1

  • Aqueous composition for instillation in bladder

    RU2586285C1

  • Method for treatment and prevention of cystitis

    RU2751649C1