Liquid cosmetic composition for stimulating hair growth

Abstract

FIELD: cosmetics.SUBSTANCE: liquid cosmetic composition for stimulating hair growth comprises a peptide complex comprising purified water, butylene glycol, glycerin, PEG-40 hydrogenated castor oil, PPG-26-buteth-26, caprylyl glycol, 1,2-hexanediol, alanine / histidine / lysine copper polypeptide HCl; a peptide complex comprising purified water, butylene glycol, PPG-36-buteth-26, PEG-40 hydrogenated castor oil, apigenin, oleanolic acid, biotinoyl tripeptide; a peptide complex comprising purified water, glycerin, acetyl tetrapeptide-3; Peptide complex including purified water, butylene glycol, glycerin, PEG-40 hydrogenated castor oil, PPG-26-buteth-26, 1,2-hexanediol, caprylyl glycol, copper tripeptide-1; butylene glycol; ethoxydiglycol; Amino acid complex including purified water, betaine, sodium PCA, sorbitol, 1,2-hexanediol, serine, glycine, glutamic acid, alanine, arginine, lysine, threonine, proline; glycerin; niacinamide; Extract complex including Houttuynia cordata extract, green tea extract, Perilla fertiliser leaf extract, 1,2-hexanediol; sodium PCA; Red clover extract, including purified water, glycerin, red clover flower extract, sodium benzoate, potassium sorbate, citric acid; phenoxyethanol; PEG-40 hydrogenated castor oil; ethylhexylglycerin; lactic acid; fragrance; purified water, at a certain ratio of components, wt.%.EFFECT: increase in the density and thickness of hair, acceleration of its growth, reduction of inflammatory phenomena on the scalp, reduction of hair loss by increasing the active growth phase (anagen) and prevention of degradation of the hair follicle.1 cl, 3 tbl, 4 ex

Description

[0001] The invention relates to cosmetics and can be used to stimulate hair growth.

[0002] These days, people are increasingly faced with the problem of hair loss. Hair loss can be considered a pathological, complete or partial loss of hair due to damage to the hair follicle. This phenomenon is one of the most common clinical scenarios. The causes can range from genetic factors to severe anxiety.

[0003] Modern medicine and cosmetology are focused on finding solutions to these problems. This has led to the development of new therapies, medications, and cosmetic products that improve scalp condition, target hair follicles, and improve hair structure.

[0004] From the prior art CN111329779A (published on June 26, 2020, IPC A61K8 / 64; A61K8 / 9706; A61K8 / 9789; A61Q7 / 00), an active peptide composition that promotes hair growth is known, characterized in that it contains a peptide for stimulating keratin genes and a synergistic short peptide. The peptides that stimulate keratin genes are one or more copper peptides, myristoyl pentapeptide-17, myristoyl hexapeptide-16 and biotin tripeptide-1. The weight ratio of the keratin gene stimulating peptide to the synergistic short peptide is (5-20): (0.05-5).

[0005] From source CN105106028A (published 02.12.2015, IPC A61K38 / 06; A61K38 / 07; A61K38 / 08; A61K8 / 64; A61K8 / 73; A61P17 / 14; A61Q7 / 00), a polypeptide composition for hair growth is known, characterized in that it contains a polypeptide that stimulates the production of collagen, and a polypeptide that promotes the production of keratin. The polypeptide composition is a combination of myristoyl pentapeptide-17 and biotin tripeptide-1, or a combination of myristoyl pentapeptide-17 and acetyl tetrapeptide-3, or a combination of myristoyl pentapeptide-17 and biotin tripeptide-1 and a copper peptide, or a combination of myristoyl pentapeptide-17, myristoyl hexapeptide-16 and biotin tripeptide-1 and a copper peptide, or a combination of myristoyl pentapeptide-17, myristoyl hexapeptide-16 and biotin tripeptide-1, acetyl tetrapeptide-3 and a copper peptide. The concentration of each polypeptide component is 0.01 ppm-50,000 ppm (w / w), and the solvent is water.Some other ingredients beneficial for hair growth may be added, selected from one or more of the following substances: biotin, 5,7,4'-trihydroxyflavone, oleanolic acid, with the concentration of each substance being from 0.01 ppm to 50,000 ppm (w / w).

[0006] Source CN115227804A (published October 25, 2022, IPC A61K31 / 164; A61K33 / 44; A61K38 / 06; A61K38 / 07; A61K38 / 08; A61P17 / 14) discloses a liquid composition for hair growth and for the prevention of seborrheic alopecia, stimulating hair growth, characterized in that it contains the following raw materials in a weight percentage ratio: 0.005-0.03% acetyl tetrapeptide-3, 0.01-0.1% myristoyl pentapeptide-17, 0.005-0.025% biotin 3-1 peptide, 1-6% immortelle extract, 1-6% Platycladus leaf extract orientalis, 0.2-2% Chinese medicine estrogen extract, 0.2-2% panthenol, 0.2-0.5% phenoxyethanol, 0.5-3% cornflower extract, 0.01-0.02% fullerene derivatives, and the remainder is an alcohol-water buffer solution.

[0007] Source CN114288221A (published 08.04.2022, IPC A61K8 / 49; A61K8 / 64; A61K8 / 65; A61K8 / 9761; A61K8 / 9789; A61Q7 / 00) describes a method for preparing an essence containing polypeptides and plant extracts with a hair growth effect, characterized in that the essence contains the following raw materials in parts by weight: 0.1-1 part of tripeptide-1, 0.01-0.05 parts of copper tripeptide-1, 1-6 parts of acetyl tetrapeptide-3, 0.5-3 parts of octapeptide-2, 1-8 parts of nutmeg pentapeptide-17, 0.1-3 parts of oligopeptide-1, 0.1-3 parts oligopeptide-3, 1-4 parts oligopeptide-5, 0.01-0.1 soluble collagen peptide, 50-80 parts traditional Chinese medicine extract and 3-12 parts deionized water.

[0008] From the source US2024156707A1 (published on 16.05.2024, IPC A61K8 / 34; A61K8 / 44; A61K8 / 46; A61K8 / 58; A61K8 / 64; A61K8 / 67; A61K8 / 73; A61K8 / 86; A61Q5 / 02; A61Q7 / 00) a hair growth essence is known, characterized in that it contains the following weight percentages of each component: Water 89.24%, PEG-400 7%, Dextran 1%, Citrulline 0.5%, MSM 1%, Biotin tripeptide-1 0.01%, Blue copper peptide 0.35%, Panthenol 0.5%, Zinc gluconate 0.1%, Phenoxyethanol 0.15%, Chlorphenesin 0.15%.

[0009] The source CN118370806A (published on July 23, 2024, IPC A61K31 / 7076; A61K36 / 535; A61K36 / 638; A61K36 / 704; A61K38 / 06; A61K38 / 07; A61K38 / 08; A61K38 / 39; A61K47 / 10; A61K47 / 18; A61K47 / 32; A61K47 / 36; A61K9 / 06; A61P17 / 14) describes a hair growth composition for the treatment of hair loss or baldness, characterized in that it includes a preparation made from the following raw materials: Ligustrum lucidum fruits, multi-flowered knotweed, Perilla leaf frutescens. The drug also contains 0.04-0.08 g / l acetylhexapeptide-8, 1-3 g / l collagen type 17, 3-7 g / l adenosine, 0.04-0.08 g / l tetrapeptide, 0.01-0.02 g / l biotin tripeptide-1, 0.04-0.08 g / l octapeptide, 15-25 g / l sodium hyaluronate, 14-18 g / l pentylene glycol, 1.0-1.4 g / l caprylhydroxamic acid, and 6-10 g / l hexylene glycol.

[0010] From source CN118717561A (published on 01.10.2024, IPC A61K8 / 19; A61K8 / 34; A61K8 / 64; A61K8 / 73; A61P17 / 14; A61Q7 / 00), a hair growth essence is known, containing a blue copper peptide and a biotin tripeptide, characterized in that the ingredients of the hair growth essence include: a phase A component, a phase B component, a phase C component, biotin-1 tripeptide, a blue copper peptide and water. The phase A component includes glycerin and sodium hyaluronate. The B-phase component includes propylene glycol, 1,2-hexanediol, ethylhexylglycerin and phenoxyethanol. The C-phase component includes any one or more of α-glucans, β-glucan, and maltitol. The ingredients of the hair growth essence, by weight, include: 0.015-0.025 parts biotin tripeptide-1, 0.4-0.6 parts blue copper peptide, 5.5-7 parts glycerin, 6.5-7.5 parts propylene glycol, 0.1-0.15 parts sodium hyaluronate, 0.55-0.65 parts 1,2-hexanediol, 0.2-0.3 parts ethylhexylglycerin, and 0.3-0.4 parts phenoxyethanol.The ingredients of hair growth essence are added with purified water to a weight of 100 parts.

[0011] The source CN111658580A (published on September 15, 2020, IPC A61K31 / 045; A61K33 / 34; A61K36 / 14; A61K38 / 06; A61K38 / 07; A61K8 / 19; A61K8 / 34; A61K8 / 64; A61K8 / 92; A61K8 / 9706; A61K8 / 9761; A61P17 / 00; A61P17 / 14; A61Q5 / 12; A61Q7 / 00) discloses a hair growth essence containing multiple peptides and plant extracts, characterized in that it consists of the following raw materials in percentage by weight: Tripeptide-1: 0.01-0.1%; Copper Tripeptide-1: 0.01-0.05%; Acetyl Tetrapeptide-3: 2-5%; Platycladus orientalis Leaf Extract: 50-70% , Zona Algae Extract: 5-20%, Bisabolol: 0.2-1%; Ethylene Glycol: 1-5%; The rest was deionized water.

[0012] The closest source selected as a prototype is source CN109568169A (published on 05.04.2019, IPC A61K8 / 11; A61K8 / 64; A61Q7 / 00), which proposes an active polypeptide with a hair growth effect, characterized in that the active polypeptide with a hair growth effect is encapsulated in a nanoinclusion. The active polypeptide with a hair growth effect is biotin tripeptide-1, myristoyl pentapeptide-17, myristoyl hexapeptide-16, copper tripeptide-1, acetyl tetrapeptide-3, and the mass percentage concentration of each component is 0.0001%-5%. Encapsulation is carried out using lipid components.The lipid component is one or a combination of soy lecithin, egg yolk lecithin, osphatidylethanolamine, lysophosphatidylcholine, lauric acid, myristic acid, palmitic acid, stearic acid, isopropyl myristate, isopropyl palmitate, oleic acid, linoleic acid glyceride, and vitamin E, and the weight percentage concentration of each component is 2%-20%. The nanoinclusions also include the following components: polyol, surfactant, pH buffer. The polyol is one or a combination of propylene glycol, glycerin, 1,2-hexanediol, and 1,3-butanediol, and the weight percentage concentration of each component is 2%-20%. The surfactant is Tween 20, Tween 40, Tween 60, Tween 80, poloxamer and tyloxamer, and the mass percentage concentration of each component is 0.1%-10%.The pH buffer is a combination of sodium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, or potassium dihydrogen phosphate, and the mass percentage concentration of each component is 0.001%-1%. The product form of the active polypeptide with a hair growth effect includes, but is not limited to, hair care essence, shampoo, lotion, etc.

[0013] The disadvantage of known analogs is the insufficient effectiveness of known compositions in terms of increasing the density and thickness of hair, as well as reducing inflammatory phenomena on the scalp.

[0014] The technical result, which the claimed solution is aimed at achieving, is to increase the density and thickness of hair, accelerate its growth, reduce inflammation on the scalp, reduce hair loss by increasing the active growth phase (anagen) and preventing degradation of the hair follicle.

[0015] In order to achieve the above technical result, a liquid cosmetic composition for stimulating hair growth is proposed, comprising a peptide complex comprising purified water, butylene glycol, glycerin, PEG-40 hydrogenated castor oil, PPG-26-buteth-26, caprylyl glycol, 1,2-hexanediol, alanine / histidine / lysine copper polypeptide HCl; a peptide complex comprising purified water, butylene glycol, PPG-36-buteth-26, PEG-40 hydrogenated castor oil, apigenin, oleanolic acid, biotinoyl tripeptide; a peptide complex comprising purified water, glycerin, acetyl tetrapeptide-3; Peptide complex including purified water, butylene glycol, glycerin, PEG-40 hydrogenated castor oil, PPG-26-buteth-26, 1,2-hexanediol, caprylyl glycol, copper tripeptide-1; butylene glycol; ethoxydiglycol;amino acid complex including purified water, betaine, sodium PCA, sorbitol, 1,2-hexanediol, serine, glycine, glutamic acid, alanine, arginine, lysine, threonine, proline; glycerin; niacinamide; extract complex including houttuynia cordata extract, green tea extract, perilla fertiliser leaf extract, 1,2-hexanediol; sodium PCA; red clover extract including purified water, glycerin, red clover flower extract, sodium benzoate, potassium sorbate, citric acid; phenoxyethanol; PEG-40 hydrogenated castor oil; ethylhexylglycerin; lactic acid; fragrance; purified water, in the following ratio of components, wt.%:;

[0016] peptide complex, including purified water, butylene glycol, glycerin, PEG-40 hydrogenated castor oil, PPG-26-buteth-26,

[0017] Caprylyl glycol, 1,2-hexanediol, alanine / histidine / lysine copper polypeptide HCl - 6.0-9.0;

[0018] peptide complex including purified water, butylene glycol, PPG-36-buteth-26, PEG-40 hydrogenated castor oil, apigenin, oleanolic acid, biotinoyl tripeptide-1 - 4.0-7.0;

[0019] peptide complex, including purified water, glycerin, acetyl tetrapeptide-3 - 4.0-7.0;

[0020] peptide complex including purified water, butylene glycol, glycerin, PEG-40 hydrogenated castor oil, PPG-26-buteth-26, 1,2-hexanediol, caprylyl glycol, copper tripeptide-1 - 1.0-4.0;

[0021] butylene glycol - 4.0-7.0;

[0022] ethoxydiglycol - 1.0-2.6;

[0023] amino acid complex, including purified water, betaine, sodium PCA, sorbitol, 1,2-hexanediol, serine, glycine, glutamic acid, alanine, arginine, lysine, threonine, proline - 1.0-3.0;

[0024] glycerin - 1.0-3.0;

[0025] niacinamide - 1.0-3.0;

[0026] a complex of extracts including Houttuynia cordata extract, green tea extract, Perilla fertiliser leaf extract, 1,2-hexanediol - 0.5-2.0;

[0027] Sodium PCA - 0.5-2.0;

[0028] red clover extract, including purified water, glycerin, red clover flower extract, sodium benzoate, potassium sorbate, citric acid - 0.5-2.0;

[0029] phenoxyethanol - 0.7-0.9;

[0030] PEG-40 hydrogenated castor oil - 0.1-1.0;

[0031] ethylhexylglycerin - 0.05-0.3;

[0032] lactic acid - 0.01-0.07;

[0033] fragrance - 0.01-0.05;

[0034] purified water - up to 100%.

[0035] One of the active ingredients is a peptide complex containing purified water, butylene glycol, glycerin, PEG-40 hydrogenated castor oil, PPG-26-buteth-26, caprylyl glycol, 1,2-hexanediol, and alanine / histidine / lysine copper polypeptide HCl. It prolongs the growth phase and promotes hair diameter growth. It inhibits 5-α-reductase and helps protect the follicle from aging and death.

[0036] Also added is a peptide complex containing purified water, butylene glycol, PPG-36-buteth-26, PEG-40 hydrogenated castor oil, apigenin, oleanolic acid, and biotinoyl tripeptide-1, which prevents hair loss. It stimulates cell proliferation and differentiation, promoting hair growth.

[0037] Additionally, a peptide complex has been added, including purified water, glycerin, and acetyl tetrapeptide-3, which stimulates hair growth and increases hair density. This complex inhibits 5-α-reductase activity, triggering hair follicle regeneration processes. It also reduces hair loss.

[0038] Also added is a peptide complex containing purified water, butylene glycol, glycerin, PEG-40 hydrogenated castor oil, PPG-26-buteth-26, 1,2-hexanediol, caprylyl glycol, and copper tripeptide-1. Supports the anagen phase of hair growth, promoting hair growth.

[0039] The serum's botanical components work synergistically with peptides: Perilla ferns and Houttuynia cordata extracts provide anti-inflammatory effects, while green tea extract acts as an antioxidant and immunostimulant, preventing dandruff. Clover flower extract reduces the negative impact of androgens on hair follicles.

[0040] Sodium PCA and amino acid complex, including purified water, betaine, sodium PCA, sorbitol, 1,2-hexanediol, serine, glycine, glutamic acid, alanine, arginine, lysine, threonine, proline, has a beneficial effect on the condition of the epidermis of the scalp.

[0041] Niacinamide improves microcirculation and has a sebum-regulating effect.

[0042] Butylene glycol, ethoxydiglycol, glycerin and PEG-40 hydrogenated castor oil are added as solvents.

[0043] The serum is protected by adding preservatives: phenoxyethanol and ethylhexylglycerin.

[0044] Fragrance is used to give the serum a pleasant aroma.

[0045] Lactic acid is added as a pH adjuster.

[0046] The feasibility of the claimed invention is supported by specific implementation examples. Cosmetic formulations are presented in Table 1.

[0047] Table 1

[0048] Composition 1 Composition 2 Composition 3 Composition 4 INCI % % % % purified water Up to 100.0 Up to 100.0 Up to 100.0 Up to 100.0 Purified water, butylene glycol, glycerin, PEG-40 hydrogenated castor oil, PPG-26-buteth-26, caprylyl glycol, 1,2-hexanediol, alanine / histidine / lysine copper polypeptide HCl 8,0 9,0 6,0 7,0 Purified water, butylene glycol, PPG-36-buteth-26, PEG-40 hydrogenated castor oil, apigenin, oleanolic acid, biotinoyl tripeptide-1 5,0 6,0 7,0 4,0 purified water, glycerin, acetyl tetrapeptide-3 5,0 4,0 6,0 7,0 Purified water, butylene glycol, glycerin, PEG-40 hydrogenated castor oil, PPG-26-buteth-26, 1,2-hexanediol, caprylyl glycol, copper tripeptide-1 3,0 4,0 2,0 1,0 butylene glycol 5,0 6,0 7,0 4,0 ethoxydiglycol 2,5 2,6 2,0 1,0 Purified water, betaine, sodium PCA, sorbitol, 1,2-hexanediol, serine, glycine, glutamic acid, alanine, arginine, lysine, threonine, proline 2,0 1,0 1,0 3,0 glycerol 2,0 1,0 2,0 3,0 niacinamide 2,0 1,0 2,0 3,0 Houttuynia cordata extract, green tea extract, perilla fern leaf extract, 1,2-hexanediol 1,0 0,5 1,5 2,0 sodium PCA 1,0 0,5 1,5 2,0 Purified water, glycerin, red clover flower extract, sodium benzoate, potassium sorbate, citric acid 1,0 0,5 1,5 2,0 phenoxyethanol 0,81 0,7 0,9 0,85 ethylhexylglycerin 0,09 0,05 0,20 0,30 lactic acid 0,05 0,07 0,03 0,01 PEG-40 hydrogenated castor oil 0,5 0,1 1,0 0,3 fragrance 0,02 0,01 0,05 0,04

[0049] Technology for preparing liquid cosmetic composition for stimulating hair growth.

[0050] Add the prescribed amount of warm purified water to a mixing bowl with a stirrer. Turn on the stirrer at 20-60 rpm. Next, weigh out the glycerin, butylene glycol, ethoxydiglycol, phenoxyethanol, and glycerin. Transfer these ingredients to the mixing bowl. Next, add the niacinamide solution. Finally, add the prepared mixture of PEG-40 hydrogenated castor oil and fragrance.

[0051] Next, a peptide complex is added, including purified water, butylene glycol, glycerin, PEG-40 hydrogenated castor oil, PPG-26-buteth-26, caprylyl glycol, 1,2-hexanediol, alanine / histidine / lysine copper polypeptide HCl. After this, a peptide complex is added, including purified water, butylene glycol, PPG-36-buteth-26, PEG-40 hydrogenated castor oil, apigenin, oleanolic acid, and biotinoyl tripeptide-1.

[0052] Also added is a peptide complex, which includes purified water, glycerin, and acetyl tetrapeptide-3.

[0053] Add a peptide complex, including purified water, butylene glycol, glycerin, PEG-40 hydrogenated castor oil, PPG-26-buteth-26, 1,2-hexanediol, caprylyl glycol, copper tripeptide-1.

[0054] Adds an amino acid complex, including purified water, betaine, sodium PCA, sorbitol, 1,2-hexanediol, serine, glycine, glutamic acid, alanine, arginine, lysine, threonine, proline.

[0055] Also added is a complex of extracts, including Houttuynia cordata extract, green tea extract, Perilla fern leaf extract, and 1,2-hexanediol. Additionally, clover extract and sodium PCA are added. A lactic acid solution is also added.

[0056] Stir until smooth.

[0057] To confirm the declared technical result, the obtained samples of the liquid cosmetic composition for stimulating hair growth were subjected to an assessment of consumer properties and physicochemical indicators.

[0058] The following parameters were selected to evaluate consumer properties: odor, oiliness, and stickiness. Average parameter values ​​are presented in Table 2 (values ​​are given on a 10-point scale).

[0059] Table 2

[0060] Average values ​​of consumer properties indicators Parameter name Composition 1, points Composition 2, points Composition 3, points Composition 4, points Smell 10 9 8 9 Fat content 0 1 2 1 Stickiness 0 1 1 1

[0061] Composition 1 of liquid cosmetic composition for stimulating hair growth is optimal.

[0062] According to the organoleptic and physicochemical indicators, compositions 1-4 of the liquid cosmetic composition for stimulating hair growth comply with the requirements and standards of GOST 31679-2012, specified in Table 3.

[0063] Table 3

[0064] Organoleptic and physicochemical indicators Name of the indicator Acceptable standards Characteristics and norms of Composition 1 Characteristics and norms of Composition 2 Characteristics and norms of Composition 3 Characteristics and norms of Composition 4 Appearance A homogeneous single-phase or multiphase liquid (emulsion, suspension) without foreign impurities Homogeneous single-phase liquid without foreign impurities Homogeneous single-phase liquid without foreign impurities Homogeneous single-phase liquid without foreign impurities Homogeneous single-phase liquid without foreign impurities Color Characteristic of the color of the product of a specific name Greenish-yellow Greenish-yellow Greenish-yellow Greenish-yellow Smell Characteristic of the smell of a product of a specific name Fantasy Fantasy Fantasy Fantasy pH 1,2-8,5 5,0 4,6 5,2 5,6

[0065] Toxicological studies have shown that the declared liquid cosmetic composition for stimulating hair growth is safe and does not have a general toxic effect.

[0066] Clinical studies have shown that the liquid cosmetic composition for stimulating hair growth does not have an irritating or sensitizing effect.

[0067] Regular use of the liquid cosmetic composition for stimulating hair growth increases the density and thickness of hair, accelerates its growth, reduces inflammation on the scalp, stops hair loss by increasing the active growth phase (anagen) and prevents degradation of the hair follicle.