Κ-opioid receptor agonist and its use

Abstract

FIELD: pharmaceutical composition.SUBSTANCE: invention relates to an agonist of κ-opioid receptors or its pharmaceutically acceptable salt. Agonist of κ-opioid receptors is proposed, which has high selectivity for κ-opioid receptors, with activity of agonist of κ-opioid receptors 3–15 times higher than diphelikephalin.EFFECT: agonistκ -opioid receptors can be used to treat and / or relieve itching and / or pain.8 cl, 3 tbl, 2 ex

Description

[0001] This application claims priority to Chinese Patent Application No. 202310371594.6, filed with the National Intellectual Property Administration of China on April 10, 2023, entitled “LONG-ACTING K-OPIOID RECEPTOR AGONIST”, and Chinese Patent Application No. 202410112984.6, filed with the National Intellectual Property Administration of China on January 26, 2024, entitled “LONG-ACTING K-OPIOID RECEPTOR AGONIST”, which are incorporated herein by reference in their entirety.SCOPE

[0002] The present invention relates to the field of biomedical technology, and in particular, to a highly selective κ-opioid receptor agonist and its use. BACKGROUND

[0003] Opioid drugs exert their physiological effects primarily through binding to three known classical opioid receptors: μ, δ, and κ. All three of these receptors are members of the G protein-coupled receptor family and are primarily distributed in the central nervous system but are also present in many peripheral tissues.

[0004] The most classic of these drugs is morphine, which exerts its analgesic effect primarily through μ-opioid receptors. Clinically common analgesics also include other drugs that act on μ-opioid receptors, such as traditional opioid medications such as dihydromorphinone and fentanyl. However, long-term use of drugs that act on μ-opioid receptors can lead to the development of multiple side effects, such as tolerance, dependence, respiratory depression, effects on gastrointestinal motility, etc., which not only increase the cost of treatment but also impact patient recovery time.Some non-opioid injectables, such as acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs), have limited uses and dosages due to their weak analgesic effect. Furthermore, they also have certain side effects, such as acetaminophen increasing hepatotoxicity, and NSAIDs can cause various gastrointestinal problems.

[0005] κ-opioid receptors are present in the brain, spinal cord, central and peripheral nerve endings, somatic and visceral sensory afferent nerve cell bodies, and immune cells. Studies using κ-opioid receptor agonists have shown that κ-opioid receptors can be used as a therapeutic target for the treatment of pain and the prevention of a wide range of diseases and conditions, such as pain, including hyperalgesia, in eye diseases and eye pain, and in the treatment of itching caused by uremia and opioids.

[0006] Difelikephalin (trade name KORSUVA) is a first-in-class, highly selective κ-opioid receptor (KOR) full agonist that can inhibit the activity of itch-inducing peripheral neurons without significantly affecting other receptors (including μ- or δ-opioid receptors), ion channels, or transporters. Furthermore, unlike small molecule KOR agonists, KORSUVA is a small synthetic peptide that primarily activates KORs expressed by peripheral neurons (PNS) and immune cells. The US FDA has approved difelikephalin for marketing for the treatment of moderate to severe pruritus associated with chronic kidney disease in adults (CKD-aP) on hemodialysis (HD).Diphelikephalin has demonstrated antipruritic and analgesic properties, as well as suppression of acute postoperative pain (IV drugs in laparoscopic hysterectomy and resection of ventral hernia and bunion) in several different phase II or III trials.

[0007] The present invention is directed to providing a highly active κ-opioid receptor agonist. SUMMARY OF THE INVENTION

[0008] The aim of the present invention is to provide a class of peptide compounds that exhibit high selectivity for κ-opioid receptors and are novel, highly active κ-opioid receptor agonists. Another aim of the present invention is to provide a pharmaceutical composition. Another aim of the present invention is to provide the use of the compounds and the pharmaceutical composition.

[0009] In order to achieve the above objectives, the present invention provides the following technical solutions:

[0010] In a first aspect, the present invention relates to a κ-opioid receptor agonist having a structure corresponding to formula I, a stereoisomer thereof, and a pharmaceutically acceptable salt thereof: D-Phe-AA1-AA2-D-Lys-1-(4-aminopiperidine-4-carbonyl)-AA3-AA4-AA5(formula I)

[0011] wherein AA1 is modified or unmodified D-Phe, or modified or unmodified D-Tyr;

[0012] AA2 is D-Leu or D-cyclopropylalanine;

[0013] AA3 is -(PEG m1 (CH2) m2 CO) m3 -, or (AA6) m4 , or absent, where:

[0014] m1 represents an integer ranging from 1 to 10;

[0015] m2is an integer ranging from 1 to 5;

[0016] m3represents an integer ranging from 1 to 5;

[0017] m4represents an integer ranging from 1 to 5;

[0018] AA6 is AEEA or Gly or D-Ala or L-Ala or D-Leu or L-Leu or D-Phe or L-Phe or D-Ser or L-Ser or D-Thr or L-Thr or D-Tyr or L-Tyr or D-Asp or L-Asp or D-Glu or L-Glu or D-Gln or L-Gln or D-Lys or L-Lys or D-Arg or L-Arg or D-His or L-His;

[0019] AA4 is (AA7) n or absent, where:

[0020] n represents an integer ranging from 1 to 10;

[0021] AA7 represents D-Lys or L-Lys or D-Dap or L-Dap or D-Dab or L-Dab or D-Orn or L-Orn or D-Dah or L-Dah or D-Dao or L-Dao;

[0022] AA5 represents OH or NH2.

[0023] Preferably, AA1 is a modified D-Phe, and the modified D-Phe is selected from the group consisting of D-Phe(2-F), D-Phe(4-F), D-Phe(2-Cl), D-Phe(4-Cl), D-Phe(2-Br), D-Phe(4-Br), D-Phe(2-I), D-Phe(4-I), D-Phe(4-Me), D-Phe(4-Et), D-Phe(4-Ipr), D-Phe(4-NH2), D-Phe(4-NHCH3), D-Phe(4-NHCH2CH3), D-Phe(4-NHCH(CH3)2), D-Phe(4-N(CH3)2) and D-Phe(4-N(CH3)CH2CH3).

[0024] Preferably, AA1 is a modified D-Tyr, and the modified D-Tyr is selected from the group consisting of D-Tyr(Me), D-Tyr(Et), D-Tyr(CH2CF3), and D-Tyr(Ipr).

[0025] In addition, the κ-opioid receptor agonist is a compound having a structure corresponding to formula II, its stereoisomer and a pharmaceutically acceptable salt thereof: D-Phe-AA1-AA2-D-Lys-1-(4-aminopiperidine-4-carbonyl)-R-(AA8) P -NH2(OH)(formula II)

[0026] Unless otherwise indicated, in the structural formulas of this description, “-NH2(OH)” means -NH2 or -OH.

[0027] AA1 is modified D-Phe or modified D-Tyr, wherein the specific modifications are as described above;

[0028] AA2 is D-Leu or D-cyclopropylalanine;

[0029] R is present or absent and, when R is present, R is selected from the group consisting of -PEG m1 CH2CO-, AEEA n1 - and -Gly n2 -; Where:

[0030] m1 is an integer in the range of 1 to 5, and in particular is selected from the group consisting of 1, 2, 3, 4, and 5;

[0031] n1 is an integer in the range of 1 to 5, and in particular is selected from the group consisting of 1, 2, 3, 4, and 5;

[0032] n2 is an integer ranging from 1 to 5, and in particular is selected from the group consisting of 1, 2, 3, 4, and 5;

[0033] AA8 is Lys or D-Lys; p is an integer ranging from 0 to 6, and in particular is selected from the group consisting of 0, 1, 2, 3, 4, 5, and 6; when p is 0, AA8 is absent.

[0034] In one optional embodiment of the present invention, the κ-opioid receptor agonist is a compound having a structure corresponding to formula III, a stereoisomer thereof, and a pharmaceutically acceptable salt thereof: D-Phe-D-Tyr(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-R1- (AA8) p1 -NH2(OH)(formula III)

[0035] wherein D-tyr(X) represents modified D-Tyr; the modified D-Tyr is selected from the group consisting of D-Tyr(Me), D-Tyr(Et), D-Tyr(CH2CF3), and D-Tyr(Ipr);

[0036] R1 is present or absent; when R1 is present, R1 is selected from the group consisting of -PEG k1 CH2CO- and -Gly n2 -; Where:

[0037] k1 is an integer ranging from 1 to 5, and in particular is selected from the group consisting of 1, 2, 3, 4, and 5;

[0038] n2 is an integer ranging from 1 to 5, and is specifically selected from the group consisting of 1, 2, 3, 4, and 5;

[0039] AA8 is Lys or D-Lys; p1 is an integer ranging from 0 to 6, and in particular is selected from the group consisting of 0, 1, 2, 3, 4, 5, and 6; when p1 is 0, AA8 is absent.

[0040] In one optional embodiment of the present invention, the κ-opioid receptor agonist is a compound having a structure corresponding to formula IV, a stereoisomer thereof, and a pharmaceutically acceptable salt thereof: D-Phe-D-Tyr(X)-D-cyclopropylalanine-D-Lys-1-(4-aminopiperidine-4-carbonyl)-R2-(AA8) p2 -NH2(OH)(formula IV)

[0041] where D-tyr(X) represents modified D-Tyr; the modified D-Tyr is selected from the group consisting of D-Tyr(Me), D-Tyr(Et), and D-Tyr(Ipr).

[0042] R2 is present or absent; when R2 is present, R2 is - PEG k2 CH2CO-; where:

[0043] k2 is an integer ranging from 1 to 5, and in particular is selected from the group consisting of 1, 2, 3, 4, and 5;

[0044] in the most preferred embodiments of the present invention, k2 is 1, 2 or 3;

[0045] AA8 is Lys or D-Lys; p2 is an integer ranging from 0 to 6, and in particular is selected from the group consisting of 0, 1, 2, 3, 4, 56; when p2 is 0, AA8 is absent;

[0046] in the most preferred embodiments of the present invention, p2 is 0 or 1.

[0047] In an optional embodiment of the present invention, the κ-opioid receptor agonist is a compound having a structure corresponding to formula V, a stereoiomer thereof, and a pharmaceutically acceptable salt thereof: D-Phe-D-Phe(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-(AA8) p3 -NH2(OH)(formula V)

[0048] wherein D-Phe(X) represents a modified D-Phe; the modified D-Phe is selected from the group consisting of D-Phe(2-F), D-Phe(4-F), D-Phe(2-Cl), D-Phe(4-Cl), D-Phe(2-Br), D-Phe(4-Br), D-Phe(2-I), D-Phe(4-I), D-Phe(4-Me), D-Phe(4-Et), D-Phe(4-Ipr), D-Phe(4-NH2).

[0049] AA8 is Lys or D-Lys; p3 is an integer ranging from 0 to 6, and in particular is selected from the group consisting of 0, 1, 2, 3, 4, 5, and 6; when p3 is 0, AA8 is absent;

[0050] in the most preferred embodiments of the present invention, p3 is 0 or 1.

[0051] Furthermore, preferably, the κ-opioid receptor agonist has one or more structural formulas selected from the group consisting of 1) to 10):

[0052] 1) D-Phe-D-Tyr(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-NH2

[0053] 2) D-Phe-D-Tyr(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl-OH

[0054] 3) D-Phe-D-Tyr(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-(AA8) q -NH2(OH)

[0055] 4) D-Phe-D-Tyr(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-PEG k1 CH2CO-AA8-NH2(OH)

[0056] 5) D-Phe-D-Tyr(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-Gly n2 -AA8-NH2(OH)

[0057] 6) D-Phe-D-Tyr(X)-O-cyclopropylalanine-D-Lys-l-(4-aminopiperidine-4-carbonyl)-NH2(OH)

[0058] 7) D-Phe-D-Tyr(X)-O-cyclopropylalanine-D-Lys-l-(4-aminopiperidine-4-carbonyl)-AA8-NH2(OH)

[0059] 8) D-Phe-D-Tyr(X)-D-cyclopropylalanine-D-Lys-1-(4-aminopiperidine-4-carbonyl) - PEG k2 CH2CO-AA8-NH2(OH)

[0060] 9) D-Phe-D-Phe(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-NH2(OH)

[0061] 10) D-Phe-D-Phe(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-AA8-NH2(OH),

[0062] in the above structural formulas, AA8 represents Lys or D-Lys; where:

[0063] in formula 1) D-Tyr(X) represents D-Tyr(Et);

[0064] in formulas 2)-3) D-Tyr(X) is D-Tyr(Me) or D-Tyr(Et) or D-Tyr(CH2CF3) or D-Tyr(Ipr), and q is 1 or 2 or 3 or 4 or 5 or 6;

[0065] in formulas 4)-8), D-Tyr(X) represents D-Tyr(Et),

[0066] k1 is 1, or 2, or 3, or 4, or 5;

[0067] n2 is 1, or 2, or 3, or 4, or 5;

[0068] k2 is 1, or 2, or 3;

[0069] in formula 9) D-Phe(X) represents D-Phe(4-F), or D-Phe(4-Cl), or D-Phe(4-Br), or D-Phe(4-I);

[0070] in formula 10) D-Phe(X) represents D-Phe(4-F) or D-Phe(4-Cl) or D-Phe(4-Br) or D-Phe(4-I) or D-Phe(4-Me) or D-Phe(4-Et) or D-Phe(4-Ipr) or D-Phe(4-NH2);

[0071] In a second aspect, the present invention relates to a pharmaceutical composition, wherein the pharmaceutical composition comprises a κ-opioid receptor agonist of the present invention, a stereoisomer thereof, and a pharmaceutically acceptable salt thereof.

[0072] In addition, the pharmaceutical composition further contains a pharmaceutically acceptable carrier.

[0073] In a third aspect, the present invention relates to the use of a κ-opioid receptor agonist, a stereoisomer thereof and a pharmaceutically acceptable salt, and / or a pharmaceutical composition, for the manufacture of a medicament for the prevention and / or relief of itching and / or pain relief.

[0074] The κ-opioid receptor agonist described herein exhibits high selectivity for κ-opioid receptors with an activity 3-15 times greater than that of the marketed drug diphelikephalin. This high activity makes the drug suitable for the treatment, prevention, and / or relief of itching and / or pain. DETAILED DESCRIPTION

[0075] As used herein, the term "stereoisomer" refers to compounds that have the same chemical structure but differ in the spatial arrangement of atoms or groups. Stereoisomers include, but are not limited to, enantiomers, diastereomers, conformational isomers (rotamers), geometric (cis / trans) isomers, and atropisomers.

[0076] A "pharmaceutical composition," as described herein, may refer to a composition for treating a disease or for use in in vitro cell culture experiments. When used for treating a disease, the term "pharmaceutical composition" typically refers to a unit dosage form and can be prepared by any method well known in the pharmaceutical art. Generally, all such methods include the step of combining the active ingredient with an excipient, which is one or more auxiliary components.

[0077] As used herein, the term "pharmaceutically acceptable" refers to a substance or composition that is chemically and / or toxicologically compatible with the other ingredients of the formulation and / or the mammal being treated. Preferably, the term "pharmaceutically acceptable" refers to one that is approved by a regulatory agency of the federal or national government or listed in the United States Pharmacopeia or other generally recognized pharmacopeia for use in animals, and particularly in humans.

[0078] In particular, the term "pharmaceutically acceptable carrier" may include any and all solvents, solid excipients, diluents, liquid carriers, and the like suitable for the particular desired dosage form. The present invention also contemplates the use of any conventional carriers, except in cases where they are incompatible with the κ-opioid receptor agonist described herein, for example, due to the occurrence of any undesirable biological effect or other unfavorable interaction with any other component of the pharmaceutically acceptable composition.

[0079] The technical solutions in the embodiments of the present invention will be clearly and fully described below. It should be understood that the described embodiments represent only some, but not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by a person skilled in the art without creative efforts fall within the scope of protection of the present invention.

[0080] As used herein, the terms "alleviate," "ameliorate," or "mitigate" may be used interchangeably. These terms refer to the method of achieving a beneficial or desired result, including, but not limited to, therapeutic benefit. "Therapeutic benefit" means the elimination or alleviation of the underlying disorder being treated. As used herein, therapeutic benefit is achieved by eliminating or alleviating one or more physiological symptoms associated with the underlying disorder, such that the individual experiences improvement, although the individual may still suffer from the underlying disorder.

[0081] The present invention relates to a κ-opioid receptor agonist and its use. One skilled in the art can, by referring to the content of the present description, appropriately modify the relevant parameters for the practical application of the present invention. Although the methods of the present invention are described using preferred examples, it will be obvious to those skilled in the art that modifications or suitable variations and combinations can be made to the compounds and production methods described in the present description without departing from the content, spirit and scope of the present invention for the implementation and application of the technology of the present invention.

[0082] The full names corresponding to the English abbreviations used in this description are shown in the table below.

[0083] Example 1: Getting a connection

[0084] The production method is a solid-phase polypeptide synthesis, which includes: obtaining a peptide resin by solid-phase polypeptide synthesis, cleaving the peptide resin with acid to obtain a crude product, and finally purifying the crude product to obtain a pure product. The step of obtaining the peptide resin by solid-phase polypeptide synthesis involves the sequential addition of the corresponding protected amino acids of the future sequence to the carrier resin by solid-phase addition to obtain the peptide resin:

[0085] In the above production method, the Fmoc-protected amino acid is used in an amount of 1.2 to 6 times the total molar amount of the resin used; preferably 2.5 to 3.5 times.

[0086] In the above-mentioned production method, the substitution degree of the carrier resin is from 0.3 to 1.5 mmol / g resin, preferably from 0.6 to 1.0 mmol / g resin.

[0087] In a preferred embodiment of the present invention, the solid-phase addition synthesis method comprises removing the Fmoc protecting group from the protected amino acid resin obtained in the preceding step, followed by an addition reaction of the next protected amino acid. The deprotection step, consisting of removing Fmoc, lasts from 10 to 60 minutes, preferably from 15 to 25 minutes. The addition reaction lasts from 60 to 300 minutes, preferably from 100 to 140 minutes.

[0088] The addition reaction requires the addition of a condensing reagent. The condensing reagent is selected from the group consisting of DIC (N,N-diisopropylcarbodiimide), N,N-dicyclohexylcarbodiimide, benzotriazol-1-yl-oxy-tripyrrolidinophosphonium hexafluorophosphate, 2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, benzotriazole-N,N,N',N'-tetramethyluronium hexafluorophosphate, and O-(benzotriazole)-N,N,N',N'-tetramethyluronium tetrafluoroborate. N,N-diisopropylcarbodiimide is preferred. The condensing reagent is used in a molar amount exceeding the total molar amount of amino groups in the amino resin by 1.2-6 times, preferably by 2.5-3.5 times.

[0089] The addition reaction requires the addition of an activating agent. The activating agent is selected from the group consisting of 1-hydroxybenzotriazole and N-hydroxy-7-azabenzotriazole, preferably 1-hydroxybenzotriazole. The activating agent is used in an amount 1.2-6 times greater than the total molar amount of amino groups in the amino resin, preferably 2.5-3.5 times.

[0090] In a preferred embodiment of the present invention, the Fmoc deprotecting reagent is a PIP / DMF (piperidine / N,N-dimethylformamide) mixed solution containing 10% to 30% (volume) of piperidine. The amount of the Fmoc deprotecting reagent used is 5 to 15 ml per gram of amino resin, preferably 8 to 12 ml per gram of amino resin.

[0091] More preferably, the acidolysis agent used in the step of acidolysis of the peptide resin is a mixed solvent of trifluoroacetic acid (TFA), 1,2-ethanedithiol (EDT) and water, and the volume ratio of the mixed solvent is as follows: 80% to 95% TFA, 1% to 10% EDT, and the rest is water.

[0092] Even more preferably, the mixed solvent has the following volume ratio: 89% to 91% TFA, 4% to 6% EDT, and the balance is water. Most preferably, the mixed solvent has the following volume ratio: 90% TFA, 5% EDT, and the balance is water.

[0093] The acidolysis agent is used in an amount of 4 to 15 ml per gram of the peptide resin; preferably 7 to 10 ml per gram of the peptide resin.

[0094] The digestion step using an acidolysis agent lasts for 1 to 6 hours, preferably 3 to 4 hours, at room temperature.

[0095] Moreover, the crude product is purified by high performance liquid chromatography and then lyophilized to obtain the pure product.

[0096] 1. Synthesis of peptide resin

[0097] The peptide resin was prepared by sequentially attaching the corresponding protected amino acids of the sequence to the carrier resin through Fmoc deprotection and addition reactions:

[0098] (1) Attachment of the first protected amino acid of the main chain

[0099] 0.03 mol of the first protected amino acid and 0.03 mol of HOBt were dissolved in an appropriate amount of DMF. Separately, 0.03 mol of DIC was slowly added to the protected amino acid in DMF solution with stirring. The reaction was carried out at room temperature with stirring for 30 min to obtain an activated protected amino acid solution, which was set aside for further use.

[00100] 0.01 mol of the carrier resin (the degree of substitution was approximately 0.4 mmol / g) was deprotected by treatment with 20% PIP / DMF solution for 25 min. The resin was washed and filtered to obtain an Fmoc-free resin.

[00101] The activated first protected amino acid solution was added to the Fmoc-free resin, and the coupling reaction was carried out for 60-300 min. After filtration and washing, a resin containing one protected amino acid was obtained.

[00102] (2) Addition of other protected amino acids.

[00103] Using the same method as for coupling the first amino acid of the main chain, other corresponding protected amino acids of the sequence were sequentially coupled to obtain a resin containing peptides.

[00104] 2. Preparation of crude product

[00105] The peptide-resin obtained as described above was treated with a cleaving reagent (10 ml of reagent per gram of resin) in a volume ratio of TFA:water:EDT=95:5:5. The mixture was uniformly stirred and left to react at room temperature for 3 h. The reaction mixture was filtered through a sintered glass funnel and the filtrate was collected. The resin was washed three times with a small amount of TFA. The filtrates were combined and concentrated under reduced pressure. Anhydrous diethyl ether was added to precipitate the peptide. The precipitate was then washed three times with anhydrous diethyl ether and then dried in vacuo to give an off-white powder.

[00106] 3.Preparation of pure product

[00107] The crude product concentrate obtained above was purified by filtration through a mixed microporous filter membrane with a pore size of 0.45 μm and set aside for further use.

[00108] Purification was performed using high-performance liquid chromatography. The chromatographic cleaning medium was a reversed-phase C18 material with a pore size of 10 μm, and the mobile phase system consisted of 0.1% TFA / water and 0.1% TFA / acetonitrile. For a chromatographic column of 30 mm x 250 mm, the flow rate was 20 mL / min. Gradient elution and batch purification were used. The crude product solution was loaded onto the column, and elution of the mobile phase was initiated. The main peak was collected, and after removal of acetonitrile by evaporation, a purified intermediate concentrate was obtained.

[00109] The purified intermediate concentrate was filtered through a 0.45 μm membrane and set aside for further use. Salt exchange was performed by high-performance liquid chromatography. 1% acetic acid / water-acetonitrile served as the mobile phase system, and reversed-phase C18 material with a pore size of 10 μm served as the chromatographic cleaning medium. For a chromatographic column of 30 mm × 250 mm, the flow rate was 20 mL / min (the flow rate can be adjusted according to different characteristics of the chromatographic column). Gradient elution and cyclic loading were used. The sample was loaded onto the column, the elution of the mobile phase was initiated, and chromatograms were obtained. Absorbance changes were observed, and the main peak after salt exchange was collected. The purity was checked by analytical liquid chromatography.Fractions containing the main peak after salt exchange were pooled, concentrated under reduced pressure to obtain the purified product in an aqueous acetic acid solution, and then lyophilized to obtain the pure product.

[00110] Using the above method, the following compounds were synthesized.

[00111] Example 2: Determination of κ-receptor agonist activity

[00112] 1. Determination method

[00113] Human Gi-coupled κ-opioid receptor (OPRK1) can inhibit the intracellular adenylate cyclase pathway and reduce the level of cAMP when stimulated by specific opioid receptor agonists. Forskolin can stimulate the release of cAMP in cell lines with high expression of opioid receptors. By stimulating cell lines stably transfected with opioid receptors, the inhibitory effect of the test compound on forskolin-stimulated cAMP release can be measured to determine the activity of the compound. Relative light units (RLU) of cells after stimulation with different doses were determined using the homogeneous time-resolved fluorescence (HTRF) method, after which the EC value was calculated 50agonist. This method for determining activity is currently widely used to determine the activity of opioid receptor agonists at home and abroad.

[00114] The CHO-K1 cell line, which stably expresses opioid receptors, was used. Stably transfected cells were stimulated with different concentrations of agonists (with stimulation by forskolin at a certain concentration). The number of relative light units of the cells after stimulation with different doses was measured, and the EC50 value of the agonist was then calculated from this.

[00115] 2. Determination Results

[00116] The determination results are presented in the table below.

[00117] The results of the above experiments show that the compounds described in the present specification have an activity significantly higher than that of diphelikephalin. Compounds 1-142 presented in the examples have an activity 3-15 times higher than that of diphelikephalin.

[00118] Finally, it should be noted that the above embodiments are given to illustrate the technical solutions of the present specification and are not limiting. Although the present specification has been described in detail with reference to the above embodiments, one skilled in the art should understand that modifications or equivalent replacements of some or all of the technical characteristics can nevertheless be made to the described technical solutions. However, such changes or replacements do not take the essence of the corresponding technical solutions beyond the scope of the technical solutions set forth in the embodiments of the present specification. --->0" encoding="UTF-8"?><!DOCTYPE ST26SequenceListing PUBLIC "- / / WIPO / / DTD Sequence Listing1.3 / / EN" "ST26SequenceListing_V1_3.dtd">. <st26sequencelisting dtdversion="V1_3" filename="OP2524-RU-0334.Sequence Listing.xml" softwarename="WIPOSequence" softwareversion="2.3.0" productiondate="2026-06-04"> <applicationidentification> <ipofficecode>RU < / ipofficecode> <applicationnumbertext> 2025130595 / 04(071811)< / applicationnumbertext> <filingdate> 2024-04-03< / filingdate> < / applicationidentification> <applicantfilereference> OP2524-RU-0334 < / applicantfilereference> <earliestpriorityapplicationidentification> <ipofficecode> CN < / ipofficecode> <applicationnumbertext> 202310371594.6< / applicationnumbertext> <filingdate> 2023-04-10< / filingdate> < / earliestpriorityapplicationidentification> <applicantname languagecode="en"> CHENGDU AODA BIOTECHNOLOGY CO.,LTD < / applicantname> <inventiontitle languagecode="en"> κ OPIOID RECEPTOR AGONIST AND USETHEREOF < / inventiontitle> <sequencetotalquantity> 143< / sequencetotalquantity> <sequencedata sequenceidnumber="1"> <insdseq><INSDSeq_length>4< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..4< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q1"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q2"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q3"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q4"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q5"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q6"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal substituent attached toresidue 4: 1-(4-aminopiperidine-4-carboxylicacid)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FFLK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="2"> <insdseq><INSDSeq_length>4< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..4< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value>< / insdqualifier> <insdqualifier id="q7"><INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q8"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q9"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q10"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q11"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q12"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q13"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal substituent attached toresidue 4: 1-(4-aminopiperidine-4-carboxamide)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="3"> <insdseq><INSDSeq_length>4< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..4< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q14"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q15"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q16"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q17"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q18"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q19"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q20"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal substituent attached toresidue 4: 1-(4-aminopiperidine-4-carboxylicacid)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="4"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q21"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q22"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q23"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q24"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q25"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q26"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q27"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q28"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="5"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q29"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q30"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q31"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q32"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q33"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q34"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q35"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q36"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="6"> <insdseq><INSDSeq_length>6< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..6< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q37"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q38"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q39"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q40"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q41"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q42"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q43"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q44"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="7"> <insdseq><INSDSeq_length>6< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..6< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q45"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q46"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q47"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q48"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q49"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q50"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q51"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q52"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="8"> <insdseq><INSDSeq_length>7< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..7< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q53"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q54"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q55"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q56"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q57"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q58"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q59"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q60"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="9"> <insdseq><INSDSeq_length>7< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..7< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q61"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q62"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q63"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q64"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q65"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q66"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q67"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q68"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="10"> <insdseq><INSDSeq_length>8< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..8< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q69"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q70"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q71"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q72"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q73"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q74"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q75"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q76"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="11"> <insdseq><INSDSeq_length>8< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..8< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q77"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q78"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q79"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q80"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q81"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q82"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q83"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>WEBSITE< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q84"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="12"> <insdseq><INSDSeq_length>9< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..9< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q85"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q86"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q87"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q88"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q89"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q90"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q91"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q92"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="13"> <insdseq><INSDSeq_length>9< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..9< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q93"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q94"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q95"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q96"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q97"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q98"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q99"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q100"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="14"> <insdseq><INSDSeq_length>10< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..10< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q101"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q102"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q103"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q104"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q105"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q106"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q107"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 10< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q108"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="15"> <insdseq><INSDSeq_length>10< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..10< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q109"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q110"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q111"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q112"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q113"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q114"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q115"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>10< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q116"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="16"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q117"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q118"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q119"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q120"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q121"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q122"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q123"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q124"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q125"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="17"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q126"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q127"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q128"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q129"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q130"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q131"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q132"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q133"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q134"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="18"> <insdseq><INSDSeq_length>6< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..6< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value>< / insdqualifier> <insdqualifier id="q135"><INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q136"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q137"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q138"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q139"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q140"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q141"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q142"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q143"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKK< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q144"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="19"> <insdseq><INSDSeq_length>6< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..6< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q145"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q146"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q147"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q148"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q149"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q150"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q151"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q152"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q153"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q154"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="20"> <insdseq><INSDSeq_length>7< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..7< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q155"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q156"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q157"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q158"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q159"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q160"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q161"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q162"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q163"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q164"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q165"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="21"> <insdseq><INSDSeq_length>7< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..7< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q166"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q167"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q168"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q169"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q170"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q171"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q172"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q173"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q174"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q175"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q176"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="22"> <insdseq><INSDSeq_length>8< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..8< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value>< / insdqualifier> <insdqualifier id="q177"><INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q178"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q179"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q180"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q181"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q182"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q183"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q184"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q185"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>WEBSITE< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q186"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q187"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q188"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="23"> <insdseq><INSDSeq_length>8< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..8< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q189"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q190"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q191"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q192"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q193"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q194"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q195"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q196"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q197"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>WEBSITE< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q198"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q199"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>WEBSITE< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q200"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="24"> <insdseq><INSDSeq_length>9< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..9< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q201"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q202"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q203"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q204"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q205"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q206"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q207"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q208"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q209"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>WEBSITE< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q210"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q211"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q212"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q213"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="25"> <insdseq><INSDSeq_length>9< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..9< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q214"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q215"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q216"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q217"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q218"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q219"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q220"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q221"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q222"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>WEBSITE< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q223"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q224"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q225"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q226"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="26"> <insdseq><INSDSeq_length>10< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..10< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q227"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q228"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q229"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q230"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q231"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q232"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q233"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q234"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q235"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>WEBSITE< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q236"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q237"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>10< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q238"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q239"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 10< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q240"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="27"> <insdseq><INSDSeq_length>10< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..10< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q241"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q242"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q243"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q244"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q245"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q246"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q247"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q248"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q249"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>WEBSITE< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q250"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q251"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>10< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q252"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q253"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKKKKKKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>10< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q254"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKKKKKKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="28"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier><INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q255"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q256"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q257"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q258"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q259"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q260"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q261"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG1CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q262"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="29"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier><INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q263"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q264"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q265"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q266"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q267"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q268"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q269"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG1CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q270"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="30"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier><INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q271"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q272"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q273"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q274"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q275"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q276"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q277"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q278"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG1CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q279"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="31"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q280"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q281"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q282"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q283"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q284"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q285"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q286"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q287"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG1CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q288"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="32"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q289"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q290"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q291"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q292"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q293"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q294"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q295"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG2CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q296"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="33"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q297"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q298"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q299"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q300"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q301"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q302"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q303"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG2CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q304"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="34"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q305"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q306"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q307"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q308"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q309"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q310"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q311"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q312"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG2CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q313"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="35"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q314"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q315"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q316"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q317"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q318"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q319"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q320"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q321"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG2CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q322"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="36"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q323"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q324"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q325"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q326"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q327"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q328"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q329"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG3CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q330"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="37"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q331"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q332"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q333"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q334"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q335"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q336"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q337"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG3CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q338"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="38"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q339"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q340"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q341"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q342"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q343"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q344"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q345"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q346"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG3CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q347"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="39"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q348"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q349"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q350"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q351"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q352"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q353"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q354"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q355"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG3CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q356"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="40"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q357"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q358"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q359"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q360"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q361"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q362"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q363"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG4CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q364"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="41"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q365"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q366"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q367"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q368"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q369"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q370"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q371"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG4CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q372"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="42"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q373"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q374"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q375"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q376"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q377"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q378"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q379"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q380"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG4CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q381"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="43"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q382"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q383"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q384"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q385"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q386"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q387"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q388"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q389"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG4CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q390"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="44"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value>< / insdqualifier> <insdqualifier id="q391"><INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q392"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q393"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q394"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q395"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q396"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q397"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG5CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q398"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="45"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value>< / insdqualifier> <insdqualifier id="q399"><INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q400"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q401"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q402"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q403"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q404"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q405"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG5CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q406"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="46"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value>< / insdqualifier> <insdqualifier id="q407"><INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q408"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q409"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q410"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q411"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q412"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q413"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q414"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG5CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q415"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="47"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier><INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q416"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q417"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q418"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q419"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q420"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q421"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q422"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q423"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl)-PEG5CH2CO to residue 5 of thesequence FYLKK< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>5< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q424"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence> FYLKK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="48"> <insdseq><INSDSeq_length>6< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..6< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q425"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q426"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q427"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q428"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q429"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q430"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q431"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGK< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q432"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="49"> <insdseq><INSDSeq_length>6< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..6< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q433"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q434"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q435"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q436"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q437"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q438"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q439"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGK< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q440"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="50"> <insdseq><INSDSeq_length>6< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..6< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q441"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q442"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q443"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q444"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q445"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q446"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q447"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q448"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q449"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="51"> <insdseq><INSDSeq_length>6< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..6< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q450"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q451"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q452"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q453"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q454"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q455"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q456"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q457"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 6< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q458"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="52"> <insdseq><INSDSeq_length>7< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..7< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q459"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q460"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q461"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q462"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q463"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q464"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q465"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q466"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="53"> <insdseq><INSDSeq_length>7< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..7< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q467"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q468"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q469"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q470"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q471"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q472"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q473"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q474"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="54"> <insdseq><INSDSeq_length>7< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..7< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q475"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q476"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q477"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q478"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q479"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q480"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q481"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q482"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q483"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="55"> <insdseq><INSDSeq_length>7< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..7< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q484"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q485"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q486"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q487"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q488"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q489"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q490"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q491"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>7< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q492"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="56"> <insdseq><INSDSeq_length>8< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..8< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q493"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q494"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q495"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q496"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q497"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q498"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q499"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q500"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="57"> <insdseq><INSDSeq_length>8< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..8< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q501"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q502"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q503"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q504"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q505"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q506"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q507"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>WEBSITE< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q508"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="58"> <insdseq><INSDSeq_length>8< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..8< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q509"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q510"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q511"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q512"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q513"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q514"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>WEBSITE< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q515"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q516"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q517"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="59"> <insdseq><INSDSeq_length>8< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..8< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q518"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q519"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q520"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q521"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q522"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q523"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>WEBSITE< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q524"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q525"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>WEBSITE< / INSDFeature_key><INSDFeature_location> 8< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q526"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="60"> <insdseq><INSDSeq_length>9< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..9< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q527"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q528"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q529"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q530"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q531"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q532"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q533"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q534"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="61"> <insdseq><INSDSeq_length>9< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..9< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q535"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q536"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q537"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q538"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q539"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q540"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q541"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q542"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="62"> <insdseq><INSDSeq_length>9< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..9< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q543"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q544"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q545"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q546"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q547"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q548"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q549"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q550"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q551"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="63"> <insdseq><INSDSeq_length>9< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..9< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value>< / insdqualifier> <insdqualifier id="q552"><INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q553"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q554"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q555"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q556"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q557"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q558"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q559"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 9< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q560"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="64"> <insdseq><INSDSeq_length>10< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..10< / INSDFeature_location><INSDFeature_quals> <insdqualifier><INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q561"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q562"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q563"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q564"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q565"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q566"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q567"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGGGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 10< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q568"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGGGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="65"> <insdseq><INSDSeq_length>10< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..10< / INSDFeature_location><INSDFeature_quals> <insdqualifier><INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q569"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q570"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q571"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q572"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q573"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q574"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q575"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGGGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>10< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q576"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGGGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="66"> <insdseq><INSDSeq_length>10< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..10< / INSDFeature_location><INSDFeature_quals> <insdqualifier><INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q577"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q578"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q579"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q580"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q581"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q582"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>10< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q583"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q584"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGGGGK< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 10< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q585"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminalamidation< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGGGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="67"> <insdseq><INSDSeq_length>10< / INSDSeq_length><INSDSeq_moltype>AA< / INSDSeq_moltype><INSDSeq_division>PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..10< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q586"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q587"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenylalanine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q588"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Tyrosine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>MOD_RES< / INSDFeature_key><INSDFeature_location> 2< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q589"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Tyr(Et)< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 3< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q590"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Leucine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q591"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>10< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q592"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Lysine< / INSDQualifier_value>< / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 4< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q593"><INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>Residue 4 is linked via1-(4-aminopiperidine-4-carbonyl) to residue 5 of the sequenceFYLKGGGGGK< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location>10< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q594"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>C-terminal OH< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> < / INSDSeq_feature-table><INSDSeq_sequence>FYLKGGGGGK< / INSDSeq_sequence>< / insdseq> < / sequencedata> <sequencedata sequenceidnumber="68"> <insdseq> <INSDSeq_length / ><INSDSeq_moltype / ><INSDSeq_division / ><INSDSeq_sequence>000< / INSDSeq_sequence> < / insdseq> < / sequencedata> <sequencedata sequenceidnumber="69"> <insdseq> <INSDSeq_length / ><INSDSeq_moltype / ><INSDSeq_division / ><INSDSeq_sequence>000< / INSDSeq_sequence> < / insdseq> < / sequencedata> <sequencedata sequenceidnumber="70"> <insdseq><INSDSeq_length>5< / INSDSeq_length><INSDSeq_moltype> AA< / INSDSeq_moltype><INSDSeq_division> PAT< / INSDSeq_division><INSDSeq_feature-table> <insdfeature><INSDFeature_key>source< / INSDFeature_key><INSDFeature_location>1..5< / INSDFeature_location><INSDFeature_quals> <insdqualifier> <INSDQualifier_name>mol_type< / INSDQualifier_name><INSDQualifier_value>protein< / INSDQualifier_value> < / insdqualifier> <insdqualifier id="q609"> <INSDQualifier_name>organism< / INSDQualifier_name><INSDQualifier_value>synthetic construct< / INSDQualifier_value> < / insdqualifier> < / INSDFeature_quals>< / insdfeature> <insdfeature><INSDFeature_key>SITE< / INSDFeature_key><INSDFeature_location> 1< / INSDFeature_location><INSDFeature_quals> <insdqualifier id="q610"> <INSDQualifier_name>note< / INSDQualifier_name><INSDQualifier_value>D-Phenyla...

Claims

1. A κ-opioid receptor agonist according to formula I, or a pharmaceutically acceptable salt thereof: D-Phe-AA1-AA2-D-Lys-1-(4-aminopiperidine-4-carbonyl)-AA3-AA4-AA5 (formula I) where AA1 is a modified D-Phe or a modified D-Tyr; the modified D-Phe is selected from the group consisting of D-Phe(2-F), D-Phe(4-F), D-Phe(2-Cl), D-Phe(4-Cl), D-Phe(2-Br), D-Phe(4-Br), D-Phe(2-I), D-Phe(4-I), D-Phe(4-Me), D-Phe(4-Et), D-Phe(4-Ipr), D-Phe(4-NH2), D-Phe(4-NHCH3), D-Phe(4-NHCH2CH3), D-Phe(4-NHCH(CH3)2), D-Phe(4-N(CH3)2) and D-Phe(4-N(CH3)CH2CH3); and the modified D-Tyr is selected from the group consisting of D-Tyr(Me), D-Tyr(Et), D-Tyr(CH2CF3) and D-Tyr(Ipr); AA2 is D-Leu or D-cyclopropylalanine; AA3 is - (PEG m1 (СН2)m2CO) m3 -, or (AA6) m4 , or absent, where: m1 is an integer in the range from 1 to 10; m2 is an integer in the range 1 to 5; m3 is an integer in the range 1 to 5; m4 is an integer in the range 1 to 5; AA6 is AEEA or Gly or D-Ala or L-Ala or D-Leu or L-Leu or D-Phe or L-Phe or D-Ser or L-Ser or D-Thr or L-Thr or D-Tyr or L-Tyr or D-Asp or L-Asp or D-Glu or L-Glu or D-Gln or L-Gln or D-Lys or L-Lys or D-Arg or L-Arg or D-His or L-His; AA4 is (AA7) n or absent, where: n is an integer in the range 1 to 10; AA7 is D-Lys or L-Lys or D-Dap or L-Dap or D-Dab or L-Dab or D-Orn or L-Orn or D-Dah or L-Dah or D-Dao or L-Dao; AA5 represents OH or NH2.

2. A κ-opioid receptor agonist or a pharmaceutically acceptable salt thereof according to claim 1, wherein the κ-opioid receptor agonist has a structure corresponding to formula II: D-Phe-AA1-AA2-D-Lys-1-(4-aminopiperidine-4-carbonyl)-R-(AA8) P -NH2(OH) (formula II) where AA1 is modified D-Phe or modified D-Tyr; AA2 is D-Leu or D-cyclopropylalanine; R is present or absent and, when R is present, R is selected from the group consisting of -PEG m1 CH2CO-, -AEEA n1 - and -Cly n2 -; Where: m1 is an integer in the range from 1 to 5, and in particular is selected from the group consisting of 1, 2, 3, 4 and 5; n1 is an integer in the range from 1 to 5, and in particular is selected from the group consisting of 1, 2, 3, 4 and 5; n2 is an integer in the range from 1 to 5, and in particular is selected from the group consisting of 1, 2, 3, 4 and 5; AA8 is Lys or D-Lys; p is an integer ranging from 0 to 6, and in particular is selected from the group consisting of 0, 1, 2, 3, 4, 5 and 6; when p is 0, AA8 is absent.

3. A κ-opioid receptor agonist or a pharmaceutically acceptable salt thereof according to claim 2, wherein the κ-opioid receptor agonist has a structure corresponding to formula III: D-Phe-D-Tyr(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-R1-(AA8) p1 -NH2(OH) (formula III) where D-tyr(X) is a modified D-Tyr; the modified D-Tyr is selected from the group consisting of D-Tyr(Me), D-Tyr(Et), D-Tyr(CH2CF3) and D-Tyr(Ipr); R1 is present or absent; when R1 is present, R1 is selected from the group consisting of -PEG k1 CH2CO- and -Gly n2 -; Where: k1 is an integer in the range from 1 to 5, and in particular is selected from the group consisting of 1, 2, 3, 4 and 5; n2 is an integer in the range from 1 to 5, and in particular is selected from the group consisting of 1, 2, 3, 4 and 5; AA8 is Lys or D-Lys; p1 is an integer ranging from 0 to 6, and in particular is selected from the group consisting of 0, 1, 2, 3, 4, 5, and 6; when pi is 0, AA8 is absent.

4. A κ-opioid receptor agonist or a pharmaceutically acceptable salt thereof according to claim 2, wherein the κ-opioid receptor agonist has a structure corresponding to formula IV: D-Phe-D-Tyr(X)-D-cyclopropylalanine-D-Lys-1-(4-aminopiperidine-4-carbonyl)-R2-(AA8) P2 -NH2(OH) (formula IV) where D-tyr(X) is a modified D-Tyr; the modified D-Tyr is selected from the group consisting of D-Tyr(Me), D-Tyr(Et) and D-Tyr(Ipr); R2 is present or absent; when R2 is present, R2 is -PEG k2 CH2CO-; where: k2 is an integer in the range from 1 to 5, and in particular is selected from the group consisting of 1, 2, 3, 4 and 5; AA8 is Lys or D-Lys; p2 is an integer in the range from 0 to 6, and in particular is selected from the group consisting of 0, 1, 2, 3, 4, 5 and 6; when p2 is 0, AA8 is absent.

5. A κ-opioid receptor agonist or a pharmaceutically acceptable salt thereof according to claim 2, wherein the κ-opioid receptor agonist has a structure corresponding to formula V: D-Phe-D-Phe(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-(AA8) p3 -NH2(OH) (formula V) where D-Phe(X) is a modified D-Phe; the modified D-Phe is selected from the group consisting of D-Phe(2-F), D-Phe(4-F), D-Phe(2-Cl), D-Phe(4-Cl), D-Phe(2-Br), D-Phe(4-Br), D-Phe(2-I), D-Phe(4-I), D-Phe(4-Me), D-Phe(4-Et), D-Phe(4-Ipr), D-Phe(4-NH2); AA8 is Lys or D-Lys; p3 is an integer ranging from 0 to 6, and in particular is selected from the group consisting of 0, 1, 2, 3, 4, 5, and 6; when p3 is 0, AA8 is absent.

6. A κ-opioid receptor agonist or a pharmaceutically acceptable salt thereof according to any one of claims 1 to 5, wherein the κ-opioid receptor agonist has one or more structural formulas selected from the group consisting of 1) to 10): 1) D-Phe-D-Tyr(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-NH2 2) D-Phe-D-Tyr(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-OH 3) D-Phe-D-Tyr(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-(AA8) q -NH2(OH) 4) D-Phe-D-Tyr(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-PEG k1 CH2CO-AA8-NH2(OH) 5) D-Phe-D-Tyr(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-Gly n2 -AA8-NH2(OH) 6) D-Phe-D-Tyr(X)-D-cyclopropylalanine-D-Lys-1-(4-aminopiperidine-4-carbonyl)-NH2(OH) 7) D-Phe-D-Tyr(X)-D-cyclopropylalanine-D-Lуs-1-(4-aminopiperidine-4-carbonyl)-AA8-NH2(OH) 8) D-Phe-D-Tyr(X)-D-cyclopropylalanine-D-Lуs-1-(4-aminopiperidine-4-carbonyl)-PEG k2 CH2CO-AA8-NH2(OH) 9) D-Phe-D-Phe(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-NH2(OH) 10) D-Phe-D-Phe(X)-D-Leu-D-Lys-1-(4-aminopiperidine-4-carbonyl)-AA8-NH2(OH), In the above structural formulas, AA8 represents Lys or D-Lys; where: in formula 1) D-Tyr(X) represents D-Tyr(Et); in formulas 2)-3) D-Tyr(X) is D-Tyr(Me), or D-Tyr(Et), or D-Tyr(CH2CF3), or D-Tyr(Ipr), and q is 1, or 2, or 3, or 4, or 5, or 6; in formulas 4)-8), D-Tyr(X) represents D-Tyr(Et), k1 is 1, or 2, or 3, or 4, or 5; n2 is 1, or 2, or 3, or 4, or 5; k2 is 1, or 2, or 3; in formula 9) D-Phe(X) is D-Phe(4-F), or D-Phe(4-Cl), or D-Phe(4-Br), or D-Phe(4-I); in formula 10) D-Phe(X) is D-Phe(4-F), or D-Phe(4-Cl), or D-Phe(4-Br), or D-Phe(4-I), or D-Phe(4-Me), or D-Phe(4-Et), or D-Phe(4-Ipr), or D-Phe(4-NH2).

7. A pharmaceutical composition for preventing and / or relieving itching and / or pain, containing a κ-opioid receptor agonist or a pharmaceutically acceptable salt thereof according to any one of claims 1-6 and a pharmaceutically acceptable carrier.

8. The use of a κ-opioid receptor agonist, or a pharmaceutically acceptable salt thereof, according to any one of claims 1-6, and / or a pharmaceutical composition according to claim 7 for the manufacture of a medicinal product for the prevention and / or relief of itching and / or pain relief.

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