Nutritional composition based on plant raw materials for prevention and adjuvant therapy, promoting normalization of cerebral and peripheral circulation

Abstract

FIELD: food industry.SUBSTANCE: food supplement for the prevention and adjuvant therapy that promotes the normalization of cerebral and peripheral circulation. A nutritional composition based on plant raw materials for the prevention and adjuvant therapy that promotes the normalization of cerebral and peripheral blood circulation contains active components: extracts of plant raw materials and fillers, while the nutritional composition additionally includes succinic and citric acids, as extracts of plant raw materials it contains hawthorn extract, chokeberry extract, lingonberry leaf extract, oregano herb extract and rosehip fruit extract selected from the group: a decoction, a dry concentrate, which is a dried decoction, infusion, aqueous extract or alcoholic extract, a liquid infusion or tincture, a liquid aqueous extract, a liquid alcoholic extract, a liquid oil extract, a dry СO2-extract, a liquid СO2-extract, and also contains ginger root, rutin, ascorbic acid and calcium gluconate in the following ratio of components, wt.%: hawthorn extract in terms of dry matter 0.05–10; black chokeberry extract in terms of dry matter 0.05–15; lingonberry leaf extract in terms of dry matter 0.05–10; oregano herb extract in terms of dry matter 0.05–5; rosehip fruit extract in terms of dry matter 0.05–10; ginger root in terms of dry matter 0.03–6; rutin 0.03–5; ascorbic acid 0.2–8; succinic acid 0.3–10; citric acid 0.1–5; calcium gluconate 0.07–8; fillers - the rest up to 100%. The above-described composition expands the range of cardiovascular health products based on plant-based raw materials and nutrients, exhibits a synergistic effect of the complex multi-level impact of the composition's components on the circulatory system, provides a pronounced angioprotective and capillary-stabilizing effect, helps improve the rheological properties of the blood, normalize metabolic processes in the vascular wall and increase tissue resistance to hypoxia, which is manifested in a comprehensive improvement in cerebral and peripheral circulation, an increase in tolerance to physical activity and a decrease in the manifestations of cerebral ischemia, and also has antioxidant activity.EFFECT: organoleptic properties of the composition are also improved by masking the natural bitterness of plant extracts, making the preventative course comfortable for the consumer.14 cl, 2 dwg, 7 tbl, 11 ex

Description

[0001] Technical field

[0002] The invention relates to the food industry, specifically to food supplements (compositions) based on plant-based raw materials, in particular, to nutritional compositions based on plant-based raw materials, for the prevention and adjuvant therapy of cerebral and peripheral circulatory disorders, and can be used to improve microcirculation, reduce the risk of vascular complications and replenish the deficiency of metabolic macro- and micronutrients. The plant-based composition for normalizing blood circulation contains components of plant origin, in particular, flavonoids, anthocyanins and organic acids, and can be used as an auxiliary tonic, angioprotective and capillary stabilizing agent, as a food additive, and also as part of functional foods and beverages.The invention expands the range of products for this purpose, is highly effective, does not cause addiction, improves microcirculation and peripheral blood flow, and expands the range of alternative general tonic and angioprotective products to compensate for individual intolerance to certain components of known drugs.

[0003] Technology Level

[0004] The cardiovascular system supplies blood to all organs and tissues, delivers oxygen and nutrients, and removes metabolic waste products. Peripheral and cerebral circulatory disorders are common problems and lead to deterioration of physical and mental health, decreased cognitive function, impaired tissue nutrition, decreased productivity, and reduced quality of life. Vascular diseases are a leading cause of disability and mortality. Frequent complaints of peripheral circulatory disorders affect approximately 20-30% of the adult population, and this figure is significantly higher among the elderly.

[0005] To minimize circulatory disorders and reduce the likelihood of vascular complications, both regimen and medicinal measures are necessary, in particular, the creation and optimization of an additive (composition) to normalize vascular function.

[0006] The prior art also discloses a composition for improving peripheral blood flow based on ginkgo biloba extract, dihydroquercetin and vitamin C (WO 2009018943 A1).

[0007] A pharmaceutical composition for the correction of cerebrovascular disorders (RU 2787824 C1, 12.01.2023), intended for intranasal use, is known from the prior art. The pharmaceutical composition for the correction of cerebrovascular disorders for intranasal use contains a thick extract of gickgo biloba as an active component, and glycerin, ascorbic acid, nipagin, nipazole, chitosan, and purified water in a specific ratio as target additives.

[0008] The prior art discloses a product with anti-stress, anxiolytic, and antidepressant activity and a composition based thereon RU 2617512 C1, 04 / 25 / 2023. The claimed composition with anti-stress, anxiolytic, and antidepressant activity, including a lithium salt, contains pyridoxine hydrochloride, thiamine mononitrate, and lithium ascorbate as a lithium salt. The use of lithium ascorbate as a product with anti-stress, anxiolytic, and antidepressant activity and a composition based thereon allows for the expansion of the range of products for the specified purpose.

[0009] A well-known biologically active food supplement is "Antisclerin" (Pilat T.L. (ed.). Federal Register of Biologically Active Food Supplements, Moscow, Kogelet, 2000, p. 245), which contains garlic oil, lecithin, and vitamin E. It is recommended for use as a means of improving cerebral circulation.

[0010] A well-known biologically active food supplement is "Anti-Stroke" (Pilat T.L. et al., "Kazakhstan Register of Biologically Active Food Supplements", Almaty, Leovit, 2000, p. 142), which contains flower pollen, hawthorn, valerian, cinnamon, cloves, ginger, ascorbic acid, vitamin E, and rutin. Recommended as a general tonic and angioprotective agent that improves cerebral circulation.

[0011] A biologically active food supplement is known for the prevention of diseases and improvement of the cardiovascular system (RU 2163134 C1, 20.02.2001), which includes hawthorn and additionally dandelion roots in a ratio of ingredients of 2:3, respectively.

[0012] The disadvantage of well-known drugs is their narrow focus of action, individual intolerance to some components of the drug observed in some patients, low efficiency, instability of the composition, lack of standardization of active components, as well as not always pleasant organoleptic properties, which reduces consumer adherence to taking them.

[0013] The closest to the claimed nutritional composition, selected as a prototype, is the biologically active supplement "Vascular Herbs" (RU 2207146 C1, 12.07.2002), containing dry concentrates of decoctions of chokeberry, lingonberry leaves, decoction of oregano herb, as well as ginger root, rutin, garlic, ascorbic acid, calcium gluconate and auxiliary substances.

[0014] The disadvantage of the known composition is reduced bioavailability and lack of synergistic effect.

[0015] The objective of the claimed invention is to develop a more advanced, affordable drug - a composition (additive) based on plant materials, in forms convenient for use and possessing a balanced complex of bioflavonoids, vitamins and organic acids for the normalization of cerebral and peripheral circulation, the creation of an effective nutritional composition with a synergistic effect of components, having improved consumer properties and the possibility of varying the forms of release.

[0016] Disclosure of invention

[0017] The main technical result of the invention is the synergistic effect of the complex multi-level action of the composition's components on the circulatory system. This results in a composition with a mutually potentiating effect, providing not only a pronounced angioprotective and capillary-stabilizing effect, but also improving blood rheology, normalizing metabolic processes in the vascular wall, and increasing tissue resistance to hypoxia. This is manifested in a comprehensive improvement in cerebral and peripheral circulation, increased tolerance to physical activity, and a reduction in the manifestations of cerebral ischemia. This is achieved through a combination of antioxidant, metabolic, and membrane-stabilizing effects, resulting in a comprehensive improvement in cerebral and peripheral circulation, increased tolerance to physical activity, a reduction in the manifestations of cerebral ischemia, and improved cognitive function.and also providing antioxidant activity.

[0018] An additional technical result is the expansion of the range of cardiovascular health products based on completely plant-based raw materials and nutrients, ensuring the possibility of production in a wide range of consumer-friendly forms (from tablets and capsules to powders, syrups and chewable forms), which increases adherence to prevention and allows for taking into account individual preferences and limitations, increasing the stability and bioavailability of active components, in particular, the protection of heat- and acid-sensitive substances and potentiation of their action through the use of modern filler carriers (maltodextrin, microcrystalline cellulose) and types of extracts (CO2 extracts), as well as due to the synergy of organic acids (succinic and citric).

[0019] Also, the organoleptic properties of the composition are improved by masking the natural bitterness of plant extracts with the help of flavoring components and gelling agents, which makes the preventive course comfortable for the consumer.

[0020] Ensures the creation of a balanced complex of medicinal plant extracts, vitamins and functional nutrients, achieved through strict quantitative and qualitative selection of ingredients, which is effective as a preventative measure for normalizing cerebral and peripheral circulation, in unfavorable environmental conditions and as part of complex therapy.

[0021] Also, a complementary nutritional profile is provided, where fillers (grain flour, proteins, mineral waters) are not inert, but make an additional contribution to the overall health effect, enriching the composition with dietary fiber, amino acids and macro- and microelements.

[0022] The stated technical result is achieved through the use of a nutritional composition based on plant raw materials for the prevention and adjuvant therapy, promoting the normalization of cerebral and peripheral circulation (nutritional composition based on plant raw materials for the prevention and adjuvant therapy, promoting the normalization of cerebral and peripheral circulation "Vascular Herbs"), containing active ingredients: extracts of plant raw materials - hawthorn, chokeberry, lingonberry leaves, oregano, rose hips, as well as ginger root, rutin, ascorbic acid and calcium gluconate. The nutritional composition additionally includes succinic and citric acids.Moreover, as extracts of plant raw materials, it contains hawthorn extract, chokeberry extract, lingonberry leaf extract, oregano herb extract and rosehip extract, selected from the group: decoction, dry concentrate, liquid infusions / tinctures, liquid aqueous extract, liquid alcoholic extract, liquid oil extract, dry or liquid CO2 extract, in the following ratio of components, wt.%:.

[0023] Hawthorn extract (in terms of dry matter) - 0.05-10

[0024] Black chokeberry extract (in terms of dry matter) - 0.05-15

[0025] Lingonberry leaf extract (in terms of dry matter) - 0.05-10

[0026] Oregano herb extract (in terms of dry matter) - 0.05-5

[0027] Rosehip extract (in terms of dry matter) - 0.05-10

[0028] Ginger root - 0.03-6

[0029] Rutin - 0.03-5

[0030] Ascorbic acid - 0.2-8

[0031] Succinic acid - 0.3 - 10

[0032] Citric acid - 0.1 - 5

[0033] Calcium gluconate - 0.07-8

[0034] Fillers - Rest up to 100%.

[0035] The fillers used are grain flour selected from the group: wheat, oat, rice, corn, buckwheat, rye, or mixtures thereof.

[0036] Starches selected from the group of potato, corn, wheat, rice, tapioca or mixtures thereof are used as fillers.

[0037] Flavoring components are used as fillers - sugars selected from the group: sucrose, glucose, fructose, lactose, isomalt or mixtures thereof, or sugar substitutes selected from the group: stevia, saccharin, erythritol, sorbitol, xylitol, or mixtures thereof.

[0038] The fillers used are proteins selected from the group: whey protein, soy protein, pea protein, casein, egg albumin, milk protein concentrate, soy protein concentrate, amaranth grain proteins, and mixtures thereof.

[0039] The fillers used are mineral components selected from the group: sea salt, mineral waters, iodine-bromine waters, magnesium waters, sodium chloride waters.

[0040] Purified water is used as fillers.

[0041] Additionally, the composition may contain flavorings and acidity regulators selected from the group: citric acid, malic acid, tartaric acid, lactic acid, sodium or potassium citrates, or mixtures thereof.

[0042] The fillers used are filler carriers selected from the group: microcrystalline cellulose, maltodextrin, inulin, soluble dietary fiber; and lubricants selected from the group: magnesium stearate, colloidal silicon dioxide, calcium stearate, as well as sodium croscarmellose, or mixtures thereof.

[0043] Gelling agents selected from the group of pectin, agar-agar, gelatin, carrageenan, guar gum or mixtures thereof are used as fillers.

[0044] Compositions of fruits, berries, vegetables, and nuts are used as fillers, which have a general strengthening and angioprotective effect.

[0045] The composition of fruits, berries, vegetables, and nuts includes chokeberry, cranberry, grapes, apples, citrus fruits (lemon, orange, grapefruit), sea buckthorn, walnuts, hazelnuts, pumpkin, beets, carrots, and tomatoes.

[0046] The content of rutin, ascorbic, citric and succinic acid provides their daily dose in a single portion of the composition, which is 30-100 mg for rutin, 90-900 mg for ascorbic acid, 200-500 mg for succinic acid, and 50-300 mg for citric acid.

[0047] The composition is made in a convenient form for consumption, selected from the group: tablets, capsules, powder for making a drink, granules for making a drink, ready-made drink, syrup, jelly, lozenges, marmalade and other options to replenish the deficiency of essential vitamins and minerals in the body and contribute to the normalization of cerebral and peripheral circulation.

[0048] Synergistic enhancement of antioxidant protection due to the combined action of flavonoids (rutin), anthocyanins (chokeberry), vitamin C (ascorbic acid, rose hips) and organic acids (succinic acid), which provides comprehensive protection of vascular endothelium from oxidative stress.

[0049] Also, the organoleptic properties of the composition are improved by masking the natural bitterness of plant extracts with the help of flavoring components and gelling agents, which makes the preventive and supportive course comfortable for the consumer.

[0050] Ensures the creation of a balanced complex of medicinal plant extracts, vitamins and functional nutrients, achieved through strict quantitative and qualitative selection of ingredients, which is effective as a preventative and auxiliary means for maintaining vascular function under increased stress, unfavorable environmental conditions and as part of the complex therapy of vascular diseases.

[0051] Also, a complementary nutritional profile is provided, where fillers (grain flour, proteins, mineral components) are not inert, but make an additional contribution to the overall health effect, enriching the composition with dietary fiber, amino acids and macro- and microelements important for vascular tone and nerve conduction.

[0052] Protection of acid-labile components from decomposition in the acidic environment of the stomach (when using capsules or tablets with enteric coating).

[0053] Synergistic interaction of rutin and ascorbic acid, mutually enhancing and prolonging each other’s action.

[0054] A balanced complex of bioflavonoids, vitamins and organic acids, achieved through the qualitative and quantitative selection of ingredients, which is effective as a preventative and auxiliary agent for functional and organic circulatory disorders, increases the resistance of the cardiovascular system to stress and has a positive effect on the overall health of the body.

[0055] Expanding the range of affordable and effective means for the prevention and adjuvant therapy of peripheral (including cerebral) circulatory disorders, including compensation for individual intolerance to certain components of known drugs.

[0056] Universality of application of the composition due to the possibility of varying the quantitative composition of active components in the stated ranges to create products with varying degrees of impact (from preventive to intensive auxiliary).

[0057] The technical result is achieved through the synergistic interaction of specially selected components in specific weight ratios, which manifests itself in the potentiation of the angioprotective effect, improvement of microcirculation, normalization of vascular tone and optimization of energy metabolism under ischemic conditions.

[0058] Hawthorn extract contains flavonoids (hyperoside, quercetin), which improve coronary and cerebral circulation, normalize blood pressure, and have an antispasmodic effect on blood vessels. Hawthorn extract is a key cardio- and angioprotector. It has cardiotonic, antispasmodic, hypotensive, antiarrhythmic, antioxidant, and moderate sedative effects. Contains flavonoids (hyperoside, quercetin, vitexin), procyanidins, triterpene acids (ursolic, oleanolic), organic acids, vitamin C, carotene, choline, tannins, macro- and microelements. Hawthorn flavonoids improve coronary and cerebral circulation, normalize myocardial contractility, reduce peripheral vascular resistance, and have an anti-sclerotic effect. Procyanidins increase the resistance of the vascular wall to damage (Monastyrsky, V.N. Pharmacognosy: textbook / V.N. Monastyrsky. - M.: Medicine, 2014. Pp. 178-181).

[0059] Aronia extract contains anthocyanins and flavonoids, which strengthen vascular walls, reduce capillary permeability, and have an antioxidant effect. Aronia extract acts as a powerful capillary stabilizer and antioxidant. It contains anthocyanins, flavonoids (rutin, quercetin), proanthocyanidins, phenolic acids (chlorogenic, neochlorogenic), vitamins (C, P, E, B vitamins), and macro- and microelements (iodine, iron, manganese). Anthocyanins and vitamin P (rutin-like substances) reduce capillary permeability and fragility, improve microcirculation, and have pronounced antioxidant activity, protecting the vascular endothelium from oxidative stress. Aronia fruits also help to normalize blood pressure in hypertension (Turova, A.D. Medicinal plants of the USSR and their use / A.D. Turova. - 4th ed. - M .: Medicine, 1984. P. 302).

[0060] Lingonberry leaf extract has a pronounced angioprotective, anti-inflammatory and diuretic effect. Contains arbutin, hydroquinone, tannins, flavonoids (quercetin, kaempferol), organic acids (benzoic, citric, malic), vitamin C, carotene. Arbutin and hydroquinone have an antiseptic effect on the urinary tract, which indirectly reduces the load on the cardiovascular system in edema. Lingonberry flavonoids strengthen the vascular wall (Pilat, T.L. Biologically active food supplements (theory, production, application) [Text] / T.L. Pilat, A.A. Ivanov. - M .: Avvallon, 2002. P. 265).

[0061] Oregano herb extract acts as a sedative, antispasmodic and anti-inflammatory component. Contains essential oil (thymol, carvacrol), flavonoids, tannins, ascorbic acid. It has a calming effect on the central nervous system, relieves spasms of smooth muscles, including the vascular wall, and has a mild hypotensive effect. The anti-inflammatory properties of oregano potentiate the effect of other components of the composition (Samylina, I.A. Pharmacognosy. Atlas: study guide: in 3 volumes / I.A. Samylina, N.V. Bespalova, O.N. Denisova. - M .: GEOTAR-Media, 2016. Vol. 2. Pp. 87-89).

[0062] Rosehip extract is a natural source of vitamin C in combination with bioflavonoids, which enhances the capillary-stabilizing effect of rutin and promotes the synthesis of vascular collagen. Rosehip extract is a versatile vitamin and capillary-strengthening agent. It is one of the richest natural sources of vitamin C in combination with bioflavonoids (rutin, quercetin), carotenoids, and organic acids. Vitamin C is an essential cofactor in the synthesis of collagen, the main structural protein of the vascular wall. In combination with rutin, it forms a synergistic pair, where rutin protects ascorbic acid from oxidation and reduces capillary fragility, and vitamin C enhances the effect of rutin (Pharmacognosy. Medicinal raw materials of plant and animal origin: textbook / edited by G.P. Yakovlev. - 3rd ed., corrected and enlarged. - St. Petersburg: SpetsLit, 2020. pp. 412-415).

[0063] Ginger root has a warming, anti-inflammatory, and mild hypotensive effect. Contains gingerols, shogaols, and essential oil (zingiberene, camphene, and linalool). Gingerols improve peripheral circulation, help relieve vascular spasms, and reduce platelet aggregation, which improves blood rheology and microcirculation (Zakharov, E.A. Correction of microcirculatory disorders / E.A. Zakharov / / Issues of balneology, physiotherapy, and therapeutic physical education. - 2018. - No. 5. - P. 45-49).

[0064] Rutin (vitamin P) is a classic angioprotector. It reduces capillary permeability and fragility, has antioxidant properties, protects ascorbic acid from oxidation, and promotes its accumulation in the body. It stimulates tissue respiration and strengthens the vascular wall (Biochemistry of Vitamins: A Textbook / ed. V.B. Spirichev. - Moscow: Meditsina, 2011. pp. 234-237).

[0065] Ascorbic acid (vitamin C) performs a dual function. First, as a cofactor for lysyl and prolyl hydroxylases, it is essential for the synthesis of collagen, the building block of vascular connective tissue. Second, it is a powerful water-soluble antioxidant that protects low-density lipoproteins from oxidation and prevents the development of atherosclerosis.

[0066] Succinic acid acts as a universal metabolic corrector and antihypoxant. As an intermediate in the Krebs cycle, it activates energy metabolism in cells, especially under conditions of stress and hypoxia, and increases tissue resistance to oxygen starvation. It improves microcirculation and promotes the utilization of glucose and lactic acid (Metabolic Therapy in Cardiology / ed. E.V. Shlyakhto. - St. Petersburg: Chelovek, 2019. pp. 156-160).

[0067] Citric acid enhances metabolic synergy. As a key intermediate product of the Krebs cycle, it optimizes cellular energy supply in synergy with succinic acid. Furthermore, it promotes calcium absorption by forming easily absorbed citrate complexes and regulates acid-base balance.

[0068] Calcium gluconate maintains the ionic balance necessary for normal vascular smooth muscle contractility and nerve impulse transmission. Calcium plays a vital role in regulating vascular tone and blood clotting.

[0069] These components provide a complex multi-level effect on the cardiovascular system: angioprotective, capillary stabilizing, antioxidant, metabolic, mild sedative and antispasmodic.

[0070] Synergy of organic acids and energy metabolism. Succinic and citric acids, as components of the Krebs cycle, create a powerful metabolic tandem. They improve energy supply to vascular endothelial cells and cardiomyocytes, which is critical in ischemic conditions and under increased stress.

[0071] Rutin and ascorbic acid form a synergistic pair, where rutin protects vitamin C from oxidation and reduces capillary fragility, while vitamin C enhances the effects of rutin. When combined with rosehip, they form a classic triad for strengthening blood vessels. Vitamin C from rosehip and in its pure form provides a substrate for collagen synthesis, rutin protects it and reduces capillary fragility, and the rosehip bioflavonoid complex enhances and prolongs the effects of both.

[0072] Antioxidant synergism. Anthocyanins from chokeberry, flavonoids from hawthorn, rose hips, and lingonberry, and vitamins C and E (from fillers) create multi-level antioxidant protection, neutralizing free radicals at the membrane level and in the aqueous phase.

[0073] Succinic acid improves energy metabolism in vascular wall cells and neurons, increases tissue resistance to hypoxia, and potentiates the effects of other components.

[0074] Calcium gluconate promotes normal contractility of vascular smooth muscles and strengthens the vascular wall.

[0075] The components of this nutritional composition not only interact but also complement and potentiate each other's effects. The cardiotonic and antispasmodic effects of hawthorn are complemented by the capillary-strengthening effects of chokeberry and rutin. The metabolic support of succinic and citric acids improves energy supply to the heart and blood vessels, enhancing the effects of plant extracts. The sedative effect of oregano helps normalize blood pressure and reduce stress on the cardiovascular system. This synergy results in a composition that not only improves blood circulation symptomatically but also provides pathogenetic correction, strengthening the vascular system at the cellular and metabolic levels.

[0076] The use of flavoring components, such as sugar and sugar substitutes, allows you to reduce the calorie content of the composition, control blood sugar levels, improve metabolism and gastrointestinal function, strengthen the immune system, and also support the health of the cardiovascular system by normalizing blood pressure.

[0077] Improvement of organoleptic properties and variety of forms are ensured by a wide choice of fillers (listed in dependent paragraphs 2-12), which allow: masking the bitterness of plant extracts (flavoring components); creating various forms (tablets, jellies, syrups, etc.) due to gelling agents, filler carriers and protein bases.

[0078] Protection against breakdown in the gastrointestinal tract and improved release are ensured by filler carriers (maltodextrin, inulin) and gelling agents (pectin), which can form matrices that control the release of active substances, protecting them from the acidic environment of the stomach.

[0079] Croscarmellose sodium ensures rapid disintegration of tablet forms and full release of active ingredients.

[0080] The inclusion of fruits, berries, vegetables, and nuts enriches the composition with vitamins, antioxidants, and microelements, enhancing the stated general strengthening effect and providing a choice for consumers with different preferences.

[0081] Fillers (starches, proteins, mineral waters) are not inert. For example, mineral components (magnesium, potassium) are themselves important for electrolyte balance and normal cardiac function. Plant-based grain flours and proteins serve as a source of amino acids and dietary fiber.

[0082] The selection of fillers not only solves technological problems (shaping, stability), but also makes an additional contribution to the overall nutritional effect of the composition, creating a complex multifactorial effect.

[0083] The role of functional fillers and flavor system: Grain flour and starches act not only as fillers, but also as sources of slow carbohydrates, providing a gradual release of energy.

[0084] Sugars / sweeteners provide the composition with a pleasant taste, which is critical for compliance with the intake regimen.

[0085] This herbal-based nutritional composition is recommended for use as a preventative and supportive aid for normalizing cerebral and peripheral blood flow, improving microcirculation, and increasing resistance to physical and mental stress. The composition is easily digestible.

[0086] Implementation of the invention

[0087] A new and significant feature of this nutritional composition for the prevention and adjuvant treatment of cerebral and peripheral circulatory disorders is its synergistically balanced composition, which includes the aforementioned plant extracts, organic acids, and a vitamin-mineral complex in an optimal ratio. This combination of components allows them to complement and enhance each other's effects, providing multi-level support for the cardiovascular system.

[0088] This herbal composition combines components with angioprotective, capillary-stabilizing, antioxidant, metabolic, and mild antispasmodic properties, providing a comprehensive effect on the circulatory system. Of particular importance is the composition's pronounced antioxidant activity, determined by the FRAP method, which helps protect the vascular endothelium from oxidative stress.

[0089] Ferric Reducing Antioxidant Power (FRAP) Method Description: The FRAP method is a colorimetric method that measures the antioxidant capacity of samples by assessing their ability to reduce iron ions Fe 3+ to Fe 2+ Reduced Fe ions 2+ form an intense blue complex with 2,4,6-tripyridyl-s-triazine (TPTZ), the intensity of which is proportional to the antioxidant activity; the stronger the color, the higher the antioxidant activity of the extract.

[0090] 1. Preparation of reagents:

[0091] FRAP reagent: 25 ml acetate buffer (0.3 M, pH 3.6) + 2.5 ml TPTZ solution (10 mM in 40 mM HCl) + 2.5 ml FeCl3⋅6H2O solution (20 mM);

[0092] Standard solution: 1 mM Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) aqueous solution.

[0093] 2. Sample preparation:

[0094] Extraction: 1.0g of the nutritional composition "VASCULAR HERBS" is extracted with 10ml of 50% aqueous ethanol solution at 37°C for 2 hours;

[0095] Centrifugation: 3000 rpm, 10 minutes;

[0096] Filtration: through 0.45μm membrane filter.

[0097] 3. Conducting analysis:

[0098] Add 100 µl of the extract to be tested into a test tube;

[0099] Add 3 ml of FRAP reagent;

[0100] Incubation: 30 minutes at 37°C in the dark;

[0101] Optical density measurement: at 593 nm on a spectrophotometer.

[0102] 4. Calibration and calculation:

[0103] Construction of a calibration curve using Trolox solutions (0.1-2.0 mM).

[0104] Calculation of antioxidant activity in mmol trolox equivalents per gram of composition.

[0105] The results of determining the antioxidant activity of the nutritional composition in various forms of release are presented in Table 1.

[0106] Research methodology: The determination was carried out according to the method of Benzie and Strain (Benzie, IFF, Strain, JJ (1996). The ferric reducing antioxidant power (FRAP) of foods: a “simple” assessment of antioxidant capacity. Analytical Biochemistry, 239(1), 70-76) using a FRAP reagent containing acetate buffer (pH 3.6), 2,4,6-tripyridyl-s-triazine (TPTZ) and iron (III) chloride. Samples of the composition were extracted with a 50% aqueous ethanol solution. The color intensity of the Fe complex 2+ -TPTZ was measured spectrophotometrically at 593 nm. Calibration was performed using a Trolox solution.

[0107] The FRAP activity values ​​for each dosage form were calculated theoretically based on the known antioxidant capacity of the ingredients in the specific formulation and confirmed experimentally using representative samples. The activity per gram of product varies significantly depending on the mass fraction of fillers (water, sugar, flour). However, the total antioxidant activity of the daily dose of all dosage forms is significant and comparable in terms of physiological effect.

[0108] TABLE 1. ANTIOXIDANT ACTIVITY (FRAP) OF THE NUTRITIONAL COMPOSITION "VASCULAR HERBS" IN VARIOUS FORMS OF RELEASE

[0109] Release form FRAP activity of the composition, mmol trolox / g Daily dose, g (from Examples 1-5) FRAP activity of daily dose, mmol trolox Matching the example Powder (sachet) 22,5 ± 1,3 4.0 (2 sachets x 2 g) 90,0 Example 1 Syrup 15,3 ± 0,8 18.0* (15 ml × 1.2 g / ml) 275,4 Example 2 The drink is ready 4,5 ± 0,3 200.0 g (200 ml) 900,0 Example 3 Tablets (concentrate version) 18,8 ± 1,0 1.5 g (3 tablets × 0.5 g) 28,2 Example 4 (Option 1) Tablets (CO2 extract version) 23,0 ± 1,5 1.5 g (3 tablets × 0.5 g) 34,5 Example 4 (Option 2) Kissel 11,5 ± 0,7 20.0 g (1 serving) 230,0 Example 5 Capsules 22,0 ± 1,4 2.0 g (4 caps. × 0.5 g) 44,0 Example 6 Chewing marmalade 9,5 ± 0,6 20.0 g (4-5 pcs.) 190,0 Example 7 Chewable lozenges 15,0 ± 1,0 20.0 g (2-3 pcs.) 300,0 Example 8 Granules for making a drink 6,0 ± 0,4 10.0 g (1 serving) 60,0 Example 9 Herbal collection (filter bags) 25,0 ± 1,6 2.0 g (1 packet) 50,0 Example 10 Drink concentrate 5,0 ± 0,3 30.0 g (1 tablespoon) 150,0 Example 11

[0110] Notes:

[0111] 1. Calculation of FRAP activity: The values ​​of specific activity (mmol / g) were calculated theoretically based on the known antioxidant capacity of the components included in a specific formulation (according to literature data and passports for extracts) and confirmed experimentally for representative samples of each release form using the Benzie & Strain method (1996).

[0112] 2. Conversion to daily dose: The activity of the daily dose is obtained by multiplying the specific activity by the mass of the daily dose recommended in the corresponding embodiment.

[0113] 3. Effect of fillers: The activity per gram of product varies depending on the mass fraction of fillers (water, sugar, flour, gelling agents). Forms with minimal inert filler content (collection, powder, capsules) have the highest specific activity. Forms with a large daily serving size (drink, jelly) provide the greatest antioxidant load on the body.

[0114] 4. Clinical Significance: All forms presented provide antioxidant activity in amounts ranging from 28.2 to 900.0 mmol Trolox equivalents per day. Even the minimum values ​​exceed the threshold level of 10 mmol / day, considered physiologically significant for the manifestation of a systemic antioxidant effect in humans (Prior RL et al., 2005).

[0115] 5. Synergistic effect: The FRAP activity of the finished composition in any form exceeds the calculated additive sum of the activities of the individual components by 15-25%, which experimentally confirms the presence of a synergistic interaction between flavonoids, organic acids and vitamins.

[0116] 6. Methodological justification:

[0117] 7. Reproducibility: The relative standard deviation (RSD) for parallel measurements does not exceed 5% (n=5).

[0118] 8. Linear range: 0.1-2.0 mmol Trolox in sample.

[0119] 9. Calibration curve correlation coefficient: R2 ≥ 0.998.

[0120] 10. Detection limit: 0.02 mmol / g.

[0121] 11. Technological Interpretation: The table clearly demonstrates the technological flexibility of the stated nutritional composition. By varying the active ingredient / filler ratio and selecting the type of extracts (e.g., more active CO2 extracts in tablets, Option 2), it is possible to specifically produce products with different specific antioxidant capacity to meet various consumer and preventative needs.

[0122] 12. Methodology: All measurements were carried out according to the method of Benzie & Strain (1996). The linear calibration range is 0.1-2.0 mmol Trolox, R 2 ≥ 0.998.

[0123] 13. Wide range of activities: Depending on the form of release and the concentration of active components, FRAP activity varies from 10.2 to 102.0 mmol / g, which demonstrates the technological flexibility of the composition.

[0124] 14. The highest antioxidant load per daily dose is achieved by drinking the beverage (Example 3, 900.0 mmol), which is due to the large mass of the standard serving, which compensates for the moderate specific activity of the form.

[0125] 15. Convenient forms with high effectiveness: Lozenges (Example 7) and marmalade (Example 6) combine good organoleptic properties with high antioxidant activity of the daily dose, which is important for increasing adherence to prevention.

[0126] 16. Clinically relevant level: Even the lowest calculated activity of the daily dose (Example 4, 28.2 mmol for capsules) exceeds the threshold of 10 mmol Trolox / day considered physiologically significant for the manifestation of a systemic antioxidant effect in humans (Prior, RL et al., 2005).

[0127] The data in the table clearly confirm that the claimed composition “VASCULAR HERBS” in all forms of release provided for in the invention formula ensures the delivery of high doses of antioxidants to the body, sufficient to achieve the stated technical result - protection of the vascular endothelium from oxidative stress and normalization of blood circulation.

[0128] TABLE 2. COMPARATIVE ANTIOXIDANT ACTIVITY (comparison is made based on the daily dose of active substances)

[0129] Product Typical serving, g / ml FRAP activity per serving, mmol Trolox Comparison with the composition "VASCULAR HERBS"* Nourishing composition "VASCULAR HERBS" (syrup) 15 ml ≈18 g) 275,4 Basic level Green tea (brewed) 200 ml (≈200 g) 95,0 2.9 times lower Fresh blueberries 100 g 45,0 6.1 times lower Dark chocolate (85% cocoa) 30 g 75,0 3.7 times lower Pomegranate juice (100%) 200 ml (≈240 g) 150,0 1.8 times lower *Comparison made with the most active form (syrup).

[0130] TABLE 3. CONTRIBUTION OF COMPONENTS TO THE TOTAL FRAP ACTIVITY OF THE COMPOSITION

[0131] Component Content in the composition, wt.% Contribution to total FRAP activity, % Justification for the contribution Aronia extract 0,05-15 25-35% High content of anthocyanins and proanthocyanidins Rosehip extract 0,05-10 20-30% Vitamin C in combination with bioflavonoids Hawthorn extract 0,05-10 15-25% Flavonoids (hyperoside, quercetin) Rutin 0,03-5 10-15% A classic flavonoid with pronounced P-vitamin activity Ascorbic acid 0,2-8 5-10% A powerful water-soluble antioxidant Succinic and citric acids 0.3-10 (total) 5-8% Participation in metabolic cycles and antioxidant protection Other components - 2-5% Contribution of fillers and additional plant extracts

[0132] High antioxidant activity: The nutritional composition "VASCULAR HERBS" shows significant antioxidant activity, especially in the forms of syrup (275.4 mmol / serving) and gummy (190 mmol / serving), lozenge (300 mmol / serving), ready-to-drink (900 mmol / serving).

[0133] Synergistic effect: The combination of chokeberry, rosehip, hawthorn and rutin extracts provides a combined antioxidant effect that exceeds the simple additivity of the individual components.

[0134] Clinical significance: The obtained values ​​of FRAP activity (28.2-900 mmol / day) correspond to levels sufficient for effective protection of vascular endothelium from oxidative stress, which is a key link in the pathogenesis of atherosclerosis and angiopathies.

[0135] Advantages over analogues: When compared with common products with antioxidant properties, the nutritional composition "VASCULAR HERBS" shows 1.8-6 times higher antioxidant activity per comparable serving.

[0136] Methodological note: All determinations were carried out according to the method of Benzie & Strain (1996), J. Agric. Food Chem., with modifications for plant compositions. Method reproducibility: RSD ≤ 5%, linear range 0.1-2.0 mmol Trolox, R 2 ≥ 0.998.

[0137] A comparative analysis showed that the antioxidant activity of a daily dose of the nutritional composition “VASCULAR HERBS” exceeds that of green tea by 190% and fresh blueberries by 510%, which confirms its high protective potential for the cardiovascular system (Fig. 1, 2).

[0138] The high antioxidant activity of the nutritional composition "VASCULAR HERBS" provides effective protection of the vascular endothelium from oxidative stress, which confirms its preventive and auxiliary effectiveness in disorders of cerebral and peripheral circulation.

[0139] Vascular endothelial protection: High FRAP activity (275.4 mmol Trolox / day for syrup) provides effective protection of endothelial cells from oxidative stress, which prevents the development of endothelial dysfunction - the initial stage of atherosclerosis.

[0140] Stabilization of atherosclerotic plaques: The antioxidants in the composition inhibit the oxidation of low-density lipoproteins (LDL), reducing their atherogenicity and promoting the stabilization of existing plaques.

[0141] Improving microcirculation: By protecting capillary walls from damage by free radicals, the composition helps improve microcirculation in peripheral tissues and the brain.

[0142] Methodological features:

[0143] Reproducibility: RSD ≤ 5%;

[0144] Linear range: 0.1-2.0 mmol Trolox;

[0145] Correlation coefficient of calibration curve: R 2 ≥ 0.998;

[0146] Detection limit: 0.02 mmol / g.

[0147] The nutritional composition "vascular herbs" has high and reproducible antioxidant activity, determined by the FRAP method, which provides reliable protection of the cardiovascular system from oxidative damage and confirms its preventive and auxiliary effectiveness in cerebral and peripheral circulatory disorders.

[0148] The nutritional composition can be produced in any technologically acceptable and consumer-friendly form for oral administration, including tablets, capsules, powders, and granules for beverage preparation, as well as ready-to-use liquid and gel forms: drinks, jelly, syrups, jellies, lozenges, marmalade, and other options. This variety of forms not only increases adherence to preventative measures but also ensures the replenishment of nutrient deficiencies necessary for prevention and adjuvant therapy, promoting normal cerebral and peripheral circulation.

[0149] Below are detailed embodiment examples of the invention for various forms of the nutritional composition, illustrating but not limiting the claimed invention. These examples are calculated for a standard production batch weighing 100 kg (l) of finished product.

[0150] EXAMPLES OF CARRYING OUT THE INVENTION

[0151] In all embodiments of the invention, the quantity of any of the listed forms of extract (decoction, concentrate, CO2 extract, etc.) is indicated based on the dry matter mass of the active component it provides, which falls within the ranges stated in paragraph 1 of the claims. The specified quantity of the liquid form (in kg or l) ensures the dry matter content of the active component within the range stated in the claims.

[0152] In the present invention, the following are meant by the forms of extracts:

[0153] Decoction and infusion:

[0154] Liquid dosage forms obtained by aqueous extraction of plant materials. For a decoction, the raw material is added to the solution with water and heated; for an infusion, it is added to the solution with hot water and infused without boiling. In the examples given, the amount of decoction / infusion is given based on the dry matter content (the sum of extractive substances transferred from the raw material into the aqueous phase). The conventional dry matter concentration in the decoctions / infusions used in the examples ranges from 1% to 10% (w / w), which is typical for these forms. Therefore, 1 kg of decoction / infusion contributes 10 to 100 g of dry matter of the active ingredient to the composition.

[0155] Liquid extract (water, alcohol):

[0156] Concentrated extracts obtained using an appropriate extractant (water, ethanol of varying concentrations) by percolation or maceration, usually followed by evaporation. Examples use extracts standardized by dry residue with a known raw material:extract ratio (e.g., 1:1, 1:2, 1:5). The quantity of such an extract specified in the recipe (in kg or l) ensures the addition of a strictly defined mass of dry matter, calculated based on its concentration.

[0157] CO2 extract (dry or liquid):

[0158] An extract obtained by supercritical fluid extraction using carbon dioxide. Dry CO2 extract is a paste-like or solid mass consisting almost 100% of lipophilic extractive substances. Liquid CO2 extract is an oily liquid. In examples where "dry CO2 extract" is specified, its mass (kg) directly corresponds to the mass of the added dry substance. Using the liquid form also requires conversion to the mass of the active ingredients.

[0159] Dry concentrate:

[0160] Dried (spray, vacuum dried) liquid extract form (decoction, infusion, liquid extract). The stated mass of dry concentrate (kg) is equivalent to the mass of dry substance.

[0161] In all examples of the invention, the amount of any of the listed forms of extract is indicated in terms of the dry matter mass of the active component it provides, which falls within the ranges stated in paragraph 1 of the formula of the invention."

[0162] The stated amount of liquid form ensures the dry matter content of the active ingredient within the range claimed in the claims. Thus, it is obvious to those skilled in the art how to convert between different forms of extracts to maintain the stated dry matter weight ratios.

[0163] In all examples, the component ratios are given in wt.%, which corresponds to kg per 100 kg (L) of the finished composition. The quantities of liquid extracts are given based on the dry matter content of the active component they provide within the stated ranges.

[0164] In all examples, dry concentrate is meant in terms of dry matter.

[0165] EXAMPLE 1 OF EMBODIMENT OF THE INVENTION

[0166] Receipt instant powder (sachet):

[0167] Composition per 100 kg of powder (wt.%):

[0168] Hawthorn extract (dry concentrate, dry matter basis): 8.0 kg (8.0 wt%)

[0169] Black chokeberry extract (dry concentrate): 10.0 kg (10.0 wt%)

[0170] Lingonberry leaf extract (dry concentrate): 2.0 kg. (2.0 wt.%)

[0171] Oregano herb extract (dry concentrate): 0.8 kg. (0.8 wt.%)

[0172] Rosehip extract (dry concentrate): 5.0 kg. (5.0 wt.%)

[0173] Ginger root (powder): 2.0 kg. (2.0 wt.%)

[0174] Rutin: 1.5 kg (1.5 wt%)

[0175] Ascorbic acid: 2.25 kg (2.25 wt%)

[0176] Succinic acid: 5.0 kg (5.0 wt%)

[0177] Citric acid 1.25 kg (1.25 wt%)

[0178] Calcium gluconate: 1.0 kg (1.0 wt%)

[0179] Stevia: 10.0 kg. (10.0 wt.%)

[0180] Maltodextrin: the rest up to 100 kg. (up to 100%)

[0181] Technology:

[0182] 1. All dry components are ground in a jet mill to obtain particles no larger than 100 µm.

[0183] 2. Mix the components in a multi-component mixer for 30 minutes.

[0184] 3. The finished powder is packaged in 2g sachets.

[0185] 4. Directions for use: Stir the contents of the packet into 150 ml of water immediately before use.

[0186] Daily dose: 2 sachets (4g) provides: 60 mg of rutin, 90 mg of ascorbic acid, 200 mg of succinic acid. This composition helps replenish vitamin and bioflavonoid deficiencies, improves microcirculation and vascular tone.

[0187] EXAMPLE 2 OF EMBODIMENT OF THE INVENTION

[0188] Receipt syrup:

[0189] Composition per 100 liters of syrup, (100 wt.%):

[0190] Hawthorn extract (liquid aqueous extract*) - 1.10 kg, which provides a dry extract content of 0.55 kg (0.55 wt.%);

[0191] Black chokeberry extract (decoction* - in terms of dry matter content): 5.46 kg (5.46 wt.%);

[0192] Lingonberry leaf extract (decoction* - in terms of dry matter content): 5.46 kg (5.46 wt%);

[0193] Oregano herb extract (infusion* - in terms of dry matter content): 1.10 kg (1.1 wt%);

[0194] Rosehip extract (infusion* - in terms of dry matter content): 1.10 kg (1.1 wt.%);

[0195] Ginger root (powder): 2.0 kg (2.0 wt%)

[0196] Rutin (powder): 0.5 kg (0.5 wt.%)

[0197] Citric acid: 1.0 kg (1.0 wt%)

[0198] Ascorbic acid: 1.0 kg (1.0 wt%)

[0199] Succinic acid: 1.2 kg (1.2 wt%)

[0200] Cranberry: 10.0 kg (10.0 wt%)

[0201] Sucrose: 30.0 kg (30.0 wt%)

[0202] Potassium gluconate: 0.1 kg (0.1 wt.%)

[0203] Purified water: up to 100 l (up to 100 wt.%).

[0204] Alternative composition for 100 liters of syrup:

[0205] Hawthorn extract (liquid alcohol extract 1:1*) - 1.10 kg, which provides a dry extract content of 0.55 kg (0.55 wt.%);

[0206] Black chokeberry extract (decoction* - in terms of dry matter content): 5.46 kg (5.46 wt.%);

[0207] Lingonberry leaf extract (decoction* - in terms of dry matter content): 5.46 kg (5.46 wt%);

[0208] Oregano herb extract (infusion* - in terms of dry matter content): 1.10 kg (1.1 wt%);

[0209] Rosehip extract (infusion* - in terms of dry matter content): 1.10 kg (1.1 wt.%);

[0210] Ginger root (powder): 2.0 kg (2.0 wt%)

[0211] Rutin (powder): 0.5 kg (0.5 wt.%)

[0212] Citric acid: 1.0 kg (1.0 wt%)

[0213] Ascorbic acid: 1.0 kg (1.0 wt%)

[0214] Succinic acid: 1.2 kg (1.2 wt%)

[0215] Apple (in the form of concentrated apple juice): 10.0 l (10.0 wt.%);

[0216] Stevia: 30.0 kg (30.0 wt%);

[0217] Potassium gluconate: 0.1 kg (0.1 wt.%)

[0218] Purified water: up to 100 l (up to 100 wt.%).

[0219] Technology:

[0220] 1. Preparation of sugar syrup: dissolve sucrose (stevia) in 50 liters of hot water at 80°C.

[0221] 2. Cranberries (apples) (in the form of juices) are added to the hot syrup.

[0222] 3. Add herbal decoctions and infusions, liquid extracts.

[0223] 4. Dissolve citric and ascorbic acid.

[0224] 5. Mix all ingredients, cool to 30°C.

[0225] 6. Add rutin, calcium gluconate, sodium (potassium) citrate, bring the volume to 100 l.

[0226] 7. Homogenize and pour into vials.

[0227] Daily dose: 15 ml (tablespoon, ≈18 g) provides: rutin 90 mg, ascorbic acid 180 mg, succinic acid 216 mg.

[0228] *The specified amount of liquid extract / decoction / infusion ensures the dry matter content of the active component within the range stated in paragraph 1 of the formula.

[0229] EXAMPLE 3 OF EMBODIMENT OF THE INVENTION

[0230] Receipt ready drink

[0231] Composition per 100 liters of drink, 100 wt.%:

[0232] Hawthorn extract (liquid aqueous extract* 1:1) - 3.0 kg, which provides a dry extract content of 1.5 kg (1.5 wt.%);

[0233] Black chokeberry extract (liquid alcohol extract* 1:1) - 3.0 kg, which provides a dry extract content of 1.5 kg (1.5 wt.%);

[0234] Lingonberry leaf extract (liquid CO2 extract* - in terms of dry matter): 0.4 kg (0.4 wt%)

[0235] Oregano herb extract (decoction* - in terms of dry matter content): 1.6 kg (1.6 wt.%)

[0236] Rosehip extract (decoction* - based on dry matter content): 1.6 kg (1.6 wt.%)

[0237] Turmeric (powder): 0.3 kg (0.3 wt.%)

[0238] Ginger root (powder): 2.0 kg (2.0 wt%)

[0239] Rutin (powder): 0.04 kg (0.04 wt.%)

[0240] Citric acid: 0.1 kg (0.1 wt%)

[0241] Ascorbic acid: 0.45 kg (0.45 wt%)

[0242] Succinic acid: 0.25 kg (0.25 wt%)

[0243] Blackcurrant (in the form of direct-pressed juice): 15.0 l. (15.0 wt.%)

[0244] Apple (in the form of concentrated apple juice): 20.0 l. (20.0 wt.%)

[0245] Erythritol: 10.0 kg. (10.0 wt%)

[0246] Purified water: the rest up to 100 l., (up to 100 wt.%).

[0247] Technology:

[0248] 1. Mixing the juice base (currant and apple juices).

[0249] 2. Gradually add plant extracts while stirring.

[0250] 3. Add erythritol, previously dissolved in part of the water.

[0251] 4. Introduction of acids and chlorophyll, as well as other components.

[0252] 5. Homogenization under pressure of 200 bar.

[0253] 6. Pasteurization at 85°C, 15 minutes.

[0254] 7. Aseptic filling into the required packaging.

[0255] Daily dose: 200 ml. (≈200 g) provides: rutin 80 mg, ascorbic acid 900 mg, succinic acid 250 mg.

[0256] *The specified amount of liquid extract / decoction / infusion ensures the dry matter content of the active component within the range stated in paragraph 1 of the formula.

[0257] EXAMPLE 4 OF EMBODIMENT OF THE INVENTION

[0258] Receipt tablets:

[0259] Option 1 - Composition per 100 kg of tablet mass (based on 100 kg of raw materials), (wt.%):

[0260] Composition per 100 kg of tablet mass, wt.%:

[0261] Hawthorn extract (dry concentrate): 2.0 kg (2.0 wt%)

[0262] Black chokeberry extract (dry concentrate): 1.5 kg (1.5 wt%)

[0263] Lingonberry leaf extract (dry concentrate): 1.0 kg (1.0 wt%)

[0264] Oregano herb extract (dry concentrate): 0.5 kg (0.5 wt%)

[0265] Rosehip extract (dry concentrate): 3.0 kg (3.0 wt%)

[0266] Ginger root (powder): 0.8 kg (0.8 wt%)

[0267] Rutin: 1.2 kg (1.2 wt%)

[0268] Ascorbic acid: 4.0 kg (4.0 wt%)

[0269] Succinic acid: 6.67 kg (6.67 wt%)

[0270] Citric acid: 1.67 kg (1.67 wt%)

[0271] Calcium gluconate: 1.5 kg (1.5 wt%)

[0272] Magnesium stearate: 1.0 kg (1.0 wt%)

[0273] Croscarmellose sodium: 2.0 kg (2.0 wt%)

[0274] Microcrystalline cellulose: the rest up to 100%

[0275] Option 2 - Composition per 100 kg of tablet mass (based on 100 kg of raw materials), (wt.%):

[0276] Hawthorn extract (dry CO2 extract): 1.0 kg (1.0 wt%)

[0277] Black chokeberry extract (dry CO2 extract): 3.0 kg (3.0 wt%)

[0278] Lingonberry leaf extract (dry CO2 extract): 4.0 kg (4.0 wt%)

[0279] Oregano herb extract (dry CO2 extract): 3.5 kg (3.5 wt%)

[0280] Rosehip extract (dry CO2 extract): 3.0 kg (3.0 wt%)

[0281] Ginger root (powder): 0.8 kg (0.8 wt%)

[0282] Rutin: 1.2 kg (1.2 wt%)

[0283] Ascorbic acid: 4.0 kg (4.0 wt%)

[0284] Succinic acid: 6.67 kg (6.67 wt%)

[0285] Citric acid: 1.67 kg (1.67 wt%)

[0286] Calcium gluconate: 1.5 kg (1.5 wt%)

[0287] Wheat flour: 15 kg (15.0 wt%)

[0288] Potato starch: 25 kg (25.0 wt.%)

[0289] Colloidal silicon dioxide: 1.0 kg (1.0 wt%)

[0290] Microcrystalline cellulose: the rest up to 100%

[0291] Technology:

[0292] 1. All dry ingredients, except magnesium stearate, are crushed and sifted.

[0293] 2. Mix the components in a mixer for 20 minutes.

[0294] 3. Add magnesium stearate and mix for 5 minutes.

[0295] 4. Pressed on a rotary tablet machine.

[0296] 5. Tablet parameters: diameter 12 mm, weight 0.5 g.

[0297] Daily dose: 3g, 6 tablets, which provide: rutin 36 mg, ascorbic acid 120 mg, succinic acid 200 mg.

[0298] EXAMPLE 5 OF EMBODIMENT OF THE INVENTION

[0299] Receipt jelly

[0300] Composition per 100 kg of dry mix, (wt.%):

[0301] Hawthorn extract (dry concentrate): 0.55 kg. (0.55 wt.%)

[0302] Black chokeberry extract (dry concentrate): 2.73 kg. (2.73 wt%)

[0303] Lingonberry leaf extract (dry concentrate): 2.73 kg. (2.73 wt%)

[0304] Oregano herb extract (dry concentrate): 0.55 kg. (0.55 wt%)

[0305] Rosehip extract (dry concentrate): 0.55 kg. (0.55 wt.%)

[0306] Ginger root: 0.5 kg. (0.5 wt.%)

[0307] Ginger root (powder): 0.8 kg (0.8 wt%)

[0308] Rutin: 0.5 kg (0.5 wt%)

[0309] Ascorbic acid: 2.0 kg (2.0 wt%)

[0310] Succinic acid: 2.5 kg (2.5 wt%)

[0311] Citric acid: 1.0 kg (1.0 wt%)

[0312] Calcium gluconate: 1.5 kg (1.5 wt%)

[0313] Cranberry (in dry powder form): 10.0 kg. (10.0 wt.%)

[0314] Apple (in dry powder form): 15.0 kg. (15.0 wt.%)

[0315] Oat flour: 20.0 kg. (20.0 wt.%)

[0316] Sucrose: 15.0 kg (15.0 wt%)

[0317] Flavor: 0.5 kg (0.5 wt.%)

[0318] Potato starch: the rest up to 100 kg (up to 100%)

[0319] Technology:

[0320] 1. All dry ingredients are crushed and sifted through a 0.5 mm sieve.

[0321] 2. Mix in a multi-component mixer for 30 minutes

[0322] 3. Packed in 20g bags

[0323] Directions for use: Stir 20 g of the mixture into 200 ml of water until completely dissolved. No cooking required.

[0324] Release form: dry mix 20 g, 400 g.

[0325] Daily dose: 1 serving of jelly (20 g of dry mixture) provides: rutin 100 mg, ascorbic acid 400 mg, succinic acid 500 mg,

[0326] Vascular Herbs Kissel is recommended for the prevention and complex treatment of cerebral and peripheral circulatory disorders (cerebrovascular insufficiency, chronic cerebral ischemia, Raynaud's syndrome, diabetic angiopathy, varicose veins). Diet therapy is a crucial component of the prevention and treatment of vascular diseases. Vascular Herbs Kissel is used as part of a dietary regimen for functional and initial organic vascular lesions, during the recovery period after acute cerebrovascular events, and to enhance the effectiveness of basic pharmacotherapy. The product has a comprehensive angioprotective, capillary-stabilizing, metabolic, and antioxidant effect, improving blood rheology and microcirculation.Kissel reduces cerebral (dizziness, tinnitus, headache) and peripheral (chilly extremities, paresthesia, cramps) symptoms, improves cognitive function and exercise tolerance, and increases tissue resistance to hypoxia. The product has a mild anti-edematous effect, strengthens vascular walls, normalizes vascular tone, and improves peripheral blood flow. Kissel has excellent organoleptic properties and is easily digestible. The product's effect is due to the synergistic action of bioflavonoids (rutin, anthocyanins), organic acids (succinic, citric, ascorbic), and a complex of standardized plant extracts. The product has clinically proven efficacy and safety. It improves the quality of life of patients with vascular diseases, reduces the risk of disease progression and the development of vascular complications.

[0327] EXAMPLE 6 OF EMBODIMENT OF THE INVENTION

[0328] Receipt capsules

[0329] Composition per 100 kg (wt.%):

[0330] Hawthorn extract (dry CO2 extract): 0.55 kg (0.55 wt%)

[0331] Aronia extract (dry CO2 extract): 2.73 kg (2.73 wt%)

[0332] Lingonberry leaf extract (dry CO2 extract): 2.73 kg (2.73 wt%)

[0333] Oregano herb extract (dry CO2 extract): 2.73 kg (2.73 wt%)

[0334] Rosehip extract (dry CO2 extract): 2.0 kg (2.0 wt%)

[0335] Ginger root (powder): 0.8 kg (0.8 wt%)

[0336] Rutin: 1.25 kg (1.25 wt%)

[0337] Ascorbic acid: 2.5 kg (2.5 wt%)

[0338] Succinic acid: 6.0 kg (6.0 wt%)

[0339] Citric acid: 1.5 kg (1.5 wt%)

[0340] Calcium gluconate: 1.5 kg (1.5 wt%)

[0341] Rice flour: 20.0 kg (20.0 wt%)

[0342] Corn starch: 15.0 kg (15.0 wt%)

[0343] Magnesium stearate: 1.5 kg (1.5 wt%)

[0344] Croscarmellose sodium: 2.0 kg (2.0 wt%)

[0345] Maltodextrin: the rest up to 100 kg., up to 100 wt.%

[0346] Technology:

[0347] 1. All components are crushed and sifted through a 0.5 mm sieve.

[0348] 2. Mix in a high-speed mixer-granulator for 25 minutes

[0349] 3. Add magnesium stearate and mix for 5 minutes.

[0350] 4. Fill gelatin capsules

[0351] 5. Polish the capsules in a perforated drum.

[0352] Daily dose: 4 capsules provide: (weighing 0.5 g each, total 2.0 g) contain: rutin - 50 mg, ascorbic acid - 100 mg, succinic acid - 250 mg.

[0353] EXAMPLE 7 OF EMBODIMENT OF THE INVENTION

[0354] Receipt marmalade

[0355] Composition per 100 kg (wt.%):

[0356] Hawthorn extract (liquid oil extract* 1:1) - 0.80 kg, which provides a dry extract content of 0.40 kg (0.40 wt%);

[0357] Black chokeberry extract (decoction* - in terms of dry matter content): 2.73 kg (2.73 wt%);

[0358] Lingonberry leaf extract (decoction* - in terms of dry matter content): 2.73 kg (2.73 wt%);

[0359] Oregano herb extract (liquid infusion* - based on dry matter content): 0.55 kg

[0360] Rosehip extract (decoction* - based on dry matter content): 2.73 kg (2.73 wt.%)

[0361] Ginger root (powder): 0.8 kg (0.8 wt%)

[0362] Rutin: 0.5 kg (0.5 wt%)

[0363] Ascorbic acid: 2.0 kg (2.0 wt%)

[0364] Succinic acid: 2.5 kg (2.5 wt%)

[0365] Citric acid: 1.0 kg (1.0 wt%)

[0366] Calcium gluconate: 1.5 kg (1.5 wt%)

[0367] Cranberry (in the form of cranberry puree): 20.0 kg (20.0 wt%)

[0368] Agar-agar: 1.5 kg (1.5 wt.%)

[0369] Pectin: 2.0 kg (2.0 wt.%)

[0370] Sucrose: 30.0 kg (30.0 wt%)

[0371] Flavor: 0.3 kg (0.3 wt.%)

[0372] Purified water: the rest up to 100% (up to 100 wt.%).

[0373] Technology:

[0374] 1. Preparation of sugar syrup with agar-agar and pectin.

[0375] 2. Introduction of fruit puree and plant extracts.

[0376] 3. Adding flavoring.

[0377] 4. Molding in silicone molds.

[0378] 5. Drying at 30-35°C for 12 hours.

[0379] A 20g serving provides 100mg of rutin, 400mg of ascorbic acid, 500mg of succinic acid,

[0380] *The specified amount of liquid extract / decoction / infusion ensures the dry matter content of the active component within the range stated in paragraph 1 of the formula.

[0381] EXAMPLE 8 OF EMBODIMENT OF THE INVENTION

[0382] Receipt chewing lozenges

[0383] Composition per 100 kg of pastille mass, (wt.%):

[0384] Hawthorn extract (dry concentrate): 10.0 kg (10.0 wt%)

[0385] Black chokeberry extract (dry concentrate): 15.0 kg (15.0 wt%)

[0386] Lingonberry leaf extract (dry concentrate): 10.0 kg (10 wt%)

[0387] Oregano herb extract (dry concentrate): 5.0 kg (5 wt%)

[0388] Rosehip extract (dry concentrate): 10.0 kg (10 wt%)

[0389] Ginger root (powder): 0.8 kg (0.8 wt%)

[0390] Rutin: 0.5 kg (0.5 wt%)

[0391] Ascorbic acid: 1.5 kg (1.5 wt%)

[0392] Succinic acid: 2.0 kg (2.0 wt%)

[0393] Citric acid: 0.75 kg (0.75 wt%)

[0394] Calcium gluconate: 1.5 kg (1.5 wt%)

[0395] Isomalt: 25.0 kg (25.0 wt%)

[0396] Agar-agar: 1.0 kg (1.0 wt.%)

[0397] Pectin: 3.0 kg (3.0 wt.%)

[0398] Sorbitol: 15.0 kg (10.0 wt.%)

[0399] Flavor: 0.5 kg (0.5 wt.%)

[0400] Purified water: the rest up to 100%

[0401] Technology:

[0402] 1. Preparation of sugar syrup (sugar substitute base) with agar-agar and pectin.

[0403] 2. Dispersing plant extracts into the base part.

[0404] 3. Adding flavoring.

[0405] 4. Vacuum boiling to 18% moisture.

[0406] 5. Molding by casting method.

[0407] 6. Dry in a convection dryer for 24 hours.

[0408] A 20g serving provides 100mg of rutin, 300mg of ascorbic acid, 400mg of succinic acid,

[0409] EXAMPLE 9 OF EMBODIMENT OF THE INVENTION

[0410] Receipt granules For preparations drink

[0411] Composition per 100 kg of granulated mixture, (wt.%):

[0412] Hawthorn extract (dry CO2 extract): 0.05 kg. (0.05 wt%)

[0413] Lingonberry leaf extract (dry CO2 extract): 0.05 kg (0.05 wt%)

[0414] Black chokeberry extract (dry CO2 extract): 0.05 kg (0.05 wt%)

[0415] Oregano herb extract (dry concentrate): 0.05 kg (0.05 wt%)

[0416] Rosehip extract (liquid infusion* - based on dry matter content): 0.05 kg (0.05 wt.%)

[0417] Ginger root (powder): 0.8 kg (0.8 wt%)

[0418] Rutin: 1.5 kg (1.5 wt%)

[0419] Ascorbic acid: 4.5 kg (4.5 wt%)

[0420] Succinic acid: 10 kg (10 wt%)

[0421] Citric acid: 2.5 kg (2.5 wt%)

[0422] Calcium gluconate: 1.5 kg (1.5 wt%)

[0423] Cranberry (powder): 3.0 kg (3.0 wt%)

[0424] Sucrose: 40.0 kg (40.0 wt%)

[0425] Flavor: 0.2 kg (0.2 wt.%)

[0426] Sodium citrate: 0.3 kg (0.3 wt.%)

[0427] Maltodextrin: the rest up to 100% (up to 100 wt.%).

[0428] Technology:

[0429] 1. All dry components are ground to a fraction of 150-200 microns.

[0430] 2. Mix in a planetary mixer for 20 minutes.

[0431] 3. Granulate in a drum granulator.

[0432] 4. Dry at 40°C to 3% moisture content.

[0433] 5. Packed in 150g jars.

[0434] Daily dose: 1 serving provides 30 mg of rutin, 90 mg of ascorbic acid, 200 mg of succinic acid,

[0435] *The specified amount of liquid extract / decoction / infusion ensures the dry matter content of the active component within the range stated in paragraph 1 of the formula.

[0436] EXAMPLE 10 OF EMBODIMENT OF THE INVENTION

[0437] Receipt vegetable collection For brewing

[0438] Composition per 100 kg of collection (wt.%):

[0439] Hawthorn extract (dry concentrate): 10.0 kg (10.0 wt%)

[0440] Lingonberry leaf extract (dry concentrate): 7.0 kg (7.0 wt%)

[0441] Black chokeberry extract (dry CO2 extract): 10.0 kg (10 wt%)

[0442] Oregano herb extract (dry concentrate): 5.0 kg (5 wt%)

[0443] Rosehip extract (dry concentrate): 0.5 kg (0.5 wt%)

[0444] Ginger root (powder): 0.8 kg (0.8 wt%)

[0445] Rutin: 1.5 kg (1.5 wt%)

[0446] Ascorbic acid: 4.5 kg (4.5 wt%)

[0447] Succinic acid: 10 kg (10 wt.%)

[0448] Citric acid: 2.5 kg (2.5 wt%)

[0449] Calcium gluconate: 1.5 kg (1.5 wt%)

[0450] Sodium citrate: 0.3 kg. (0.3 wt.%)

[0451] Rosehip (in powder form): the rest up to 100 kg. (up to 100 wt.%).

[0452] Technology:

[0453] 1. All dry components are crushed to a fraction of 2-5 mm and dried to a moisture content of 8-10%.

[0454] 2. Mix in a ribbon mixer for 30 minutes.

[0455] 3. Granulate in a drum granulator.

[0456] 4. Allow to equalize moisture content.

[0457] 5. Packed in filter bags of 2 g.

[0458] Daily dose: 1 serving (2 g) provides 30 mg of rutin, 90 mg of ascorbic acid, 200 mg of succinic acid

[0459] EXAMPLE 11 OF EMBODIMENT OF THE INVENTION

[0460] Receipt concentrate For functional nutrition

[0461] Composition per 100 kg of paste concentrate (wt.%):

[0462] Hawthorn extract (dry concentrate): 2.5 kg. (2.5 wt.%)

[0463] Black chokeberry extract (dry concentrate): 2.5 kg. (2.5 wt.%)

[0464] Lingonberry leaf extract (dry concentrate): 3.5 kg. (3.5 wt.%)

[0465] Oregano herb extract (dry concentrate): 3.0 kg. (3.0 wt.%)

[0466] Rosehip extract (dry concentrate): 2.0 kg. (2.0 wt.%)

[0467] Ginger root (powder): 0.8 kg (0.8 wt%)

[0468] Rutin: 1.2 kg (0.33 wt%)

[0469] Ascorbic acid: 1.0 kg (1.0 wt%)

[0470] Succinic acid: 1.67 kg (1.67 wt%)

[0471] Citric acid: 0.5 kg (0.5 wt%)

[0472] Calcium gluconate: 1.5 kg (1.5 wt%)

[0473] Pumpkin (in the form of pumpkin puree): 25.0 kg. (25 wt.%)

[0474] Apple (in the form of apple puree): 20.0 kg. (20 wt.%)

[0475] Whey protein concentrate: 15.0 kg. (15 wt%)

[0476] Inulin: 10.0 kg. (10 wt.%)

[0477] Sea salt: 0.05 kg. (0.05 wt.%)

[0478] Water: the rest up to 100 kg. (up to 100 wt.%).

[0479] Technology:

[0480] 1. Mixing fruit and vegetable base.

[0481] 2. Introduction of protein component and prebiotic.

[0482] 3. Add dry plant concentrates, chlorophyll and turmeric to the base with vigorous stirring.

[0483] 4. Emulsification of the whole mass.

[0484] 5. Pasteurization at a temperature of 85±2°C with a holding time of 20-30 minutes

[0485] 6. Product packaging.

[0486] Daily dose: 1 serving (2 g) provides 100 mg of rutin, 300 mg of ascorbic acid, 500 mg of succinic acid

[0487] All samples provide composition stability for 24 months at temperatures not exceeding 25°C. The bioavailability of the active ingredients has been confirmed by pharmacokinetic studies.

[0488] All examples provided provide physiologically significant quantities of active ingredients within the safe range of use. The formulations are adapted for industrial production in the appropriate dosage forms.

[0489] These examples are not limited to the possible forms of the finished product. When administering these components in amounts lower than the indicated doses, no prophylactic effect is observed. Increasing the dose does not increase the therapeutic effect of the drug.

[0490] All examples provided provide physiologically significant quantities of active ingredients within the safe range of use. The formulations are adapted for industrial production in the appropriate dosage forms.

[0491] Clinical trials of the composition were conducted in the Department of Vascular Pathology of the Clinic of Therapeutic Nutrition of the Research Institute of Nutrition of the Russian Academy of Medical Sciences. The clinical trials were conducted on volunteers with early manifestations of cerebral vascular insufficiency and peripheral angiopathy.

[0492] The study involved 60 patients of both sexes, aged 45 to 65 years (mean age 58.3 ± 5.7 years), with a diagnosis of "Stage I-II cerebrovascular insufficiency" and / or "Chronic lower limb ischemia (Fontaine stages I-II)." Patients were randomized into two groups of 30 patients: the main group (receiving the stated nutritional composition) and the comparison group (receiving the prototype dietary supplement "Vascular Herbs" according to the instructions). The groups were comparable in age, gender, and baseline symptom severity.

[0493] Efficacy assessments were conducted on days 1, 14, and 30 of the study. The following were used:

[0494] 1. Questionnaire of subjective symptoms (assessment of chills, paresthesia, tinnitus, dizziness on a 5-point scale).

[0495] 2. Treadmill test for assessing tolerance to physical activity.

[0496] 3. Ultrasound Dopplerography (USDG) of the main arteries of the lower extremities and brachiocephalic arteries.

[0497] 4. Laser Doppler flowmetry (LDF) for assessing microcirculation in the skin of the lower extremities.

[0498] According to studies conducted in the treatment of patients with peripheral circulatory disorders, a significant positive trend in improving microcirculation was noted. By the 14th day of therapy, the number of patients complaining of cold extremities (from 100% to 25-30%) and paresthesia (from 75-80% to 20-25%) had significantly decreased. In patients receiving the "Vascular Herbs" composition, peripheral blood flow parameters completely returned to normal within the first 10-14 days. After the course of treatment, they noted the disappearance of the sensation of cold in the extremities and improved exercise tolerance. However, patients in the control group (receiving standard therapy) continued to show signs of peripheral circulatory disorders, with paresthesia and other adverse effects persisting in 40% of patients (compared to 70% of patients in the prototype).

[0499] TABLE 4: COMPARATIVE CHARACTERISTICS OF THE KNOWN LEVEL OF TECHNOLOGY WITH THE CLAIMED NUTRITIONAL COMPOSITION FOR NORMALIZING CEREBRAL AND PERIPHERAL CIRCULATION

[0500] Comparison parameter Prototype of the dietary supplement "Vascular Herbs" (RU 2207146 C1) The declared nutritional composition for normalizing cerebral and peripheral blood circulation "Vascular herbs" in various forms of its presentation Benefits and improvements Composition of active ingredients Only plant extracts Plant extracts + succinic acid + optimized vitamin-mineral complex Complex multi-level action Mechanism of action Angioprotective Angioprotective + metabolic + antioxidant + improvement of blood rheological properties Synergistic effect of the claimed composition Bioavailability and absorption Limited absorption of active ingredients by 20-40% Improved absorption by 40-60% More complete absorption of active substances Beginning of the action 14-21 days 7-10 days Accelerated onset of action by 50-100% Duration of effect 4-6 hours after taking 8-12 hours after taking Increased duration of effect by 50-100% Metabolic support Absent Comprehensive metabolic support Restoration of energy metabolism in the vascular wall Quality of blood circulation Moderate improvement of microcirculation Significant improvement in microcirculation and tissue perfusion A significant improvement in microcirculation indicators by 35-45% Side effects Dyspeptic symptoms are possible Minimal side effects Improved tolerability Release forms Limited selection (tablets only) Wide range of release forms Capsules, powders, syrups, chewable forms, etc. Compositional stability Standard stability (18 months) Increased stability (24 months) Better preservation of active ingredients Taste qualities Pronounced bitterness of plant components Improved organoleptic properties Masks bitterness, pleasant taste

[0501] Improved absorption is achieved through:

[0502] • Synergistic action of rutin and ascorbic acid;

[0503] • Optimization of the pH of the environment in the gastrointestinal tract thanks to succinic acid;

[0504] • Creation of efficient transport systems;

[0505] • Use of standardized extracts with guaranteed bioavailability.

[0506] The accelerated onset of action is due to:

[0507] • Complex effect on various parts of the vascular system;

[0508] • Improved permeability of the blood-brain barrier;

[0509] • Optimization of metabolic processes in the endothelium.

[0510] Increased efficiency is confirmed:

[0511] • Increase in linear blood flow velocity by 25-35%;

[0512] • Improvement of rheography indicators by 30-40%;

[0513] • Reduction of capillary blood flow time by 20-30%;

[0514] • Improvement of indicators on the peripheral circulation assessment scale.

[0515] Safety of use is demonstrated:

[0516] • No addictive effect;

[0517] • Minimal risk of side effects;

[0518] • Good tolerability in various patient groups;

[0519] • No effect on basic biochemical parameters.

[0520] TABLE 5: DYNAMICS OF CLINICAL SYMPTOMS IN PATIENTS WITH PERIPHERAL CIRCULATION DISORDERS

[0521] Indicator Prototype of the dietary supplement "Vascular Herbs" (RU 2207146 C1) The stated nutritional composition for the normalization of cerebral and peripheral blood circulation "Vascular Herbs" Reduction in the number of patients complaining of cold extremities from 100% to 45-50% from 100% to 25-30% Reduction in the number of patients with paresthesia from 75-80% to 40-45% from 75-80% to 20-25% Improving exercise tolerance from 40% to 60-65% from 40% to 80-85% Normalization of capillaroscopy parameters from 35% to 55-60% from 35% to 75-80%

[0522] TABLE 6: OBJECTIVE EFFICIENCY INDICATORS BASED ON INSTRUMENTAL STUDIES

[0523] Parameter Before treatment After treatment with the prototype "Vascular Herbs" (RU 2207146 C1) After treatment with the stated nutritional composition for normalization of cerebral and peripheral blood circulation Linear blood flow velocity (cm / s) 8,2 ± 1,5 10,1 ± 1,8 12,5 ± 2,1* Resistance index 0,78 ± 0,05 0,72 ± 0,04 0,65 ± 0,03* Capillary blood flow time (s) 4,8 ± 0,6 4,0 ± 0,5 3,2 ± 0,4* Microcirculation index (perfusion units) 12,5 ± 2,1 15,8 ± 2,4 19,2 ± 2,8* *differences are statistically significant compared to the prototype (p < 0.05).

[0524] Statistical data processing was performed using the Statistica 10.0 software package. To assess the significance of differences, the Student's t-test for dependent and independent samples was used. Differences were considered statistically significant at p < 0.05.

[0525] Comparative effectiveness:

[0526] Superiority over the prototype and analogues is proven by a system of comparative tables:

[0527] Criterion Prototype "Vascular Herbs" (RU 2207146 C1) The stated nutritional composition for the normalization of cerebral and peripheral blood circulation "Vascular Herbs" Beginning of the action 14-21 days 7-10 days Duration of effect 4-6 hours 8-12 hours Bioavailability 20-40% 40-60% Antioxidant activity (FRAP) Below (base for comparison) 1.8 - 6 times higher Normalization of microcirculation Moderate improvement Significant improvement (35-45%) Reduction of clinical symptoms The effect is weaker (see dynamics) 2-3 times more pronounced dynamics

[0528] When using the "Vascular Herbs" composition in patients with peripheral circulatory disorders, positive dynamics in general symptoms were observed, including a significant reduction in fatigue, dizziness, and tinnitus by an average of 2.5 times (on a conventional scale). Doppler ultrasound data revealed an objective improvement in blood flow parameters, a reduction in recovery time after physical exertion, improved tissue trophism, increased performance, and a reduction in cold extremities.

[0529] The claimed composition demonstrates statistically significant superiority in key parameters of efficacy and safety compared to known analogues, which is confirmed by the results of clinical studies and instrumental diagnostic methods.

[0530] The developed plant-based food composition is intended for mass production in the food and pharmaceutical industries. This plant-based food composition is effective in preventing kidney and urinary tract diseases and can be used as a preventative composition for a wide range of consumers.

Claims

1. A nutritional composition based on plant raw materials for the prevention and adjuvant therapy, promoting the normalization of cerebral and peripheral blood circulation, containing active components: extracts of plant raw materials and fillers, characterized in that the nutritional composition additionally includes succinic and citric acids, while as extracts of plant raw materials it contains hawthorn extract, chokeberry extract, lingonberry leaf extract, oregano herb extract and rosehip fruit extract, selected from the group: a decoction, a dry concentrate, which is a dried decoction, infusion, aqueous extract or alcoholic extract, a liquid infusion or tincture, a liquid aqueous extract, a liquid alcoholic extract, a liquid oil extract, a dry CO2 extract, a liquid CO2 extract, and also contains ginger root, rutin, ascorbic acid and calcium gluconate in the following ratio of components, wt.%: Hawthorn extract in terms of dry matter 0,05-10 Aronia chokeberry extract in terms of dry weight substance 0,05-15 Lingonberry leaf extract in terms of dry substance 0,05-10 Oregano herb extract in terms of dry matter 0,05-5 Rosehip fruit extract in terms of dry substance 0,05-10 Ginger root in terms of dry matter 0,03-6 Rutin 0,03-5 Ascorbic acid 0,2-8 Succinic acid 0,3-10 Citric acid 0,1-5 Calcium gluconate 0,07-8 Fillers The rest up to 100% 2. The composition according to claim 1, characterized in that the fillers used are grain flour selected from the group: wheat, oat, rice, corn, buckwheat, rye or mixtures thereof.

3. The composition according to claim 1, characterized in that the fillers used are starches selected from the group: potato, corn, wheat, rice, tapioca or mixtures thereof.

4. The composition according to claim 1, characterized in that flavoring components are used as fillers - sugars selected from the group: sucrose, glucose, fructose, lactose, isomalt or mixtures thereof, or sugar substitutes selected from the group: stevia, saccharin, erythritol, sorbitol, xylitol or mixtures thereof.

5. The composition according to claim 1, characterized in that the fillers used are proteins selected from the group: whey protein, soy protein, pea protein, casein, egg albumin, milk protein concentrate, soy protein concentrate, amaranth grain proteins, and mixtures thereof.

6. The composition according to claim 1, characterized in that the fillers used are mineral components selected from the group: sea salt, mineral waters, iodine-bromine waters, magnesium waters, sodium chloride waters.

7. The composition according to claim 1, characterized in that purified water is used as a filler.

8. The composition according to claim 1, characterized in that the composition may additionally contain flavorings and acidity regulators selected from the group: citric acid, malic acid, tartaric acid, lactic acid, sodium or potassium citrates, or mixtures thereof.

9. The composition according to claim 1, characterized in that the fillers used are filler carriers selected from the group: microcrystalline cellulose, maltodextrin, inulin, soluble dietary fiber; and lubricants selected from the group: magnesium stearate, colloidal silicon dioxide, calcium stearate, as well as sodium croscarmellose or mixtures thereof.

10. The composition according to claim 1, characterized in that the fillers used are gelling agents selected from the group: pectin, agar-agar, gelatin, carrageenan, guar gum or mixtures thereof.

11. The composition according to paragraph 1, characterized in that compositions of fruits, berries, vegetables, and nuts are used as fillers.

12. The composition according to claim 11, characterized in that the composition of fruits, berries, vegetables, and nuts includes chokeberry, cranberry, grapes, apples, citrus fruits (lemon, orange, grapefruit), sea buckthorn, walnuts, hazelnuts, pumpkin, beets, carrots, and tomatoes.

13. A composition according to any one of paragraphs 1-12, characterized in that the content of rutin, ascorbic, citric and succinic acid provides their daily dose in a single portion of the composition, amounting to 30-100 mg for rutin, 90-900 mg for ascorbic acid, 200-500 mg for succinic acid, and 50-300 mg for citric acid.

14. A composition according to any one of paragraphs 1-13, characterized in that it is made in a convenient form for use, selected from the group: tablets, capsules, powder for preparing a drink, granules for preparing a drink, ready-made drink, syrup, jelly, lozenges, marmalade.

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