Toothpaste ingredients

Abstract

DEPCT66 The purpose of this invention is to provide a toothpaste component that can demonstrate its effect. The highly specific stain removal is this invention providing a toothpaste composition consisting of (A). Concentrated phosphate and (B) smectite clay mineral as well as the cleaning agent component (A) The desired type is one or more species selected from a group consisting of pyrophosphate, tripoleate, or polyphosphate. Phosphate and metaphosphate and the desirable component (B) is bentonite, the amount of which is included. The desired content of components (A) and (B) is 0.05 to 7% by mass and 0.0001 to 10%. The desired masses (B) / (A) are 0.0001 to 12. -----------------------------------------------------------

Description

Dentifrice composition

[0001] The present invention relates to dentifrice compositions.

[0002] Chemical and physical removal methods are known for removing stains, which are discolored stains on teeth. Water-soluble polyphosphates are known as components used in chemical removal methods. Patent Document 1 describes an oral composition containing a water-soluble polyphosphate and a carboxylic acid isopropyl ester, while Patent Document 2 describes a whitening toothpaste composition containing a water-soluble polyphosphate, an alkyl sulfate, and polyoxyethylene hydrogenated castor oil in a specific ratio. However, in neither case is the water-soluble polyphosphate alone sufficient to achieve the desired effect. While physical removal methods using abrasives involve increasing the abrasive power of the abrasive, this approach is limited by concerns about damaging the tooth surface. Patent Document 3 also discloses that bentonite of a specific composition containing specific amounts of calcium, iron, potassium, and magnesium mined in a specific location has tooth cleaning properties, but bentonite generally has low stain removal effectiveness.

[0003] JP 2000-239135 A JP 2004-175766 A JP 2009-40756 A

[0004] An object of the present invention is to provide a dentifrice composition that can exhibit a high stain removal effect.

[0005] The present inventors provide the following [1] to

[11] . [1] A dentifrice composition containing (A) a condensed phosphate, and (B) a smectite clay mineral. [2] The dentifrice composition according to [1], wherein the component (A) is one or more selected from the group consisting of pyrophosphates, tripolyphosphates, and metaphosphates. [3] The dentifrice composition according to [1] or [2], wherein the component (B) is bentonite. [4] The dentifrice composition according to any one of [1] to [3], wherein the content of the component (A) is 0.05 to 7% by mass. [5] The dentifrice composition according to any one of [1] to [4], wherein the content of the component (B) is 0.0001 to 10% by mass. [6] The dentifrice composition according to any one of [1] to [5], wherein the ratio of the content of component (B) to the content of component (A) ((B) / (A)) is 0.0001 to 12. [7] The dentifrice composition according to any one of [1] to [6], further containing one or more surfactants selected from the group consisting of (C) a nonionic surfactant, and (D) an amphoteric surfactant. [8] The dentifrice composition according to any one of [1] to [7], further containing (E) an anionic surfactant. [9] The dentifrice composition according to any one of [1] to [8], which is used for stain removal.

[10] The dentifrice composition according to any one of [1] to [9], which is a toothpaste.

[11] A stain remover comprising (A) a condensed phosphate, and (B) a smectite clay mineral.

[0006] The present invention provides a dentifrice composition that can sufficiently remove stains. It also provides a dentifrice composition that can provide a good feeling when used in addition to the stain removal effect, and a dentifrice composition that foams well.

[0007] The present invention will be described in detail below with reference to preferred embodiments thereof. In this specification, the content of each component is based on the amount of each component charged when producing a composition.

[0008] [1. Dentifrice Composition] [Composition] The dentifrice composition of the present invention contains components (A) and (B), and preferably further contains component (C) and / or (D). It may also further contain component (E).

[0009] [(A): Condensed phosphate] Component (A) is a condensed phosphate. By including component (A), it is possible to obtain a tooth stain removal effect when used in combination with component (B).

[0010] -Examples of Condensed Phosphates- Examples of condensed phosphates include linear polyphosphates (e.g., pyrophosphate, tripolyphosphate, and polyphosphates with a high degree of polymerization) and cyclic metaphosphates (e.g., trimetaphosphate, tetrametaphosphate, and hexametaphosphate). Of these, pyrophosphate, tripolyphosphate, and metaphosphate are preferred, and pyrophosphate is more preferred. Examples of salts include alkali metal salts such as sodium salt and potassium salt.

[0011] The component (A) may be a single condensed phosphate, or a combination of two or more condensed phosphates.

[0012] -Content of Component (A)- The content of component (A) is typically 0.05% by mass or more, preferably 0.1% by mass or more, more preferably 0.3% by mass or more, even more preferably 0.5% by mass or more, and particularly preferably 0.6% by mass or more, relative to the total amount of the composition. This allows for sufficient stain removal. The upper limit is preferably 7% by mass or less, more preferably 5% by mass or less, even more preferably 4% by mass or less, and even more preferably 2% by mass or less. This allows for efficient suppression of oral mucosal irritation and is more suitable for maintaining a good feel during use. The content of component (A) is typically 0.05 to 7% by mass, preferably 0.1 to 5% by mass, 0.1 to 4% by mass, or 0.1 to 2% by mass, more preferably 0.3 to 1.5% by mass, and even more preferably 0.5 to 1.5% by mass, relative to the total amount of the composition.

[0013] [(B) Smectite Clay Mineral] Component (B) is a smectite clay mineral. By including component (B), the tooth stain removing effect of component (A) can be improved.

[0014] Examples of smectite clay minerals include bentonite, montmorillonite, beidellite, nontronite, saponite, hectorite, sauconite, and stevensite, with montmorillonite and bentonite being preferred. Sodium types are more preferred, and specific examples include sodium-type montmorillonite, sodium-type bentonite, and activated bentonite.

[0015] The component (B) may be one type of smectite clay mineral alone or a combination of two or more types.

[0016] -Content of Component (B)- The content of component (B) is typically 0.0001% by mass or more or 0.0005% by mass or more, preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 0.5% by mass or more, relative to the total amount of the composition. This enhances the tooth stain removal effect and provides a good whitening effect. The upper limit is preferably 10% by mass or less, more preferably 5% by mass or less, and even more preferably 3% by mass or less. This reduces discomfort and bitterness in the oral cavity. The content of component (B) is preferably 0.0001 to 10% by mass, more preferably 0.0005 to 10, 0.001 to 10, or 0.01 to 5% by mass, and even more preferably 0.5 to 3% by mass, relative to the total amount of the composition.

[0017] -(B) / (A)- The ratio ((B) / (A)) of the content of the component (B) to the content of the component (A) is preferably 0.0001 to 12, more preferably 0.0003 to 10, and particularly preferably 0.0005 to 5. This allows for efficient stain removal effects.

[0018] [(C) Nonionic Surfactant] Component (C) is a nonionic surfactant. By including component (C), irritation to the oral mucosa caused by component (A) can be suppressed, and the bitterness and unpleasant taste caused by component (B) can be alleviated, resulting in improved usability. -Nonionic Surfactant- Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerin fatty acid esters, sucrose fatty acid esters (e.g., maltose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), fatty acid diethanolamides (e.g., lauric acid mono- or diethanolamide), polyoxyethylene polyoxypropylene copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. The number of carbon atoms in the alkyl chain of the polyoxyethylene alkyl ether is usually 14 to 18, and the average number of moles of ethylene oxide added is usually 15 to 30 moles. The average number of moles of ethylene oxide added in polyoxyethylene hydrogenated castor oil is usually 5 to 100 moles, preferably 20 to 60 moles. The number of carbon atoms in the fatty acid of the sorbitan fatty acid ester is usually 12 to 18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is usually 12 to 18, and the average number of moles of ethylene oxide added is usually 10 to 40 moles. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14. As the nonionic surfactant, polyoxyethylene hydrogenated castor oil is preferred.

[0019] The component (C) may be a nonionic surfactant, either alone or in combination of two or more.

[0020] -Content of Component (C)- The content of component (C) is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, and even more preferably 0.1% by mass or more, relative to the total amount of the composition. This suppresses irritation to the oral mucosa caused by component (A), improves the bitterness and unpleasant taste caused by component (B), and particularly improves the feel when used. The upper limit is preferably 6% by mass or less, more preferably 5% by mass or less, and even more preferably 3% by mass or less. This allows for a sufficient improvement in foaming. The content of component (C) is preferably 0.01 to 6% by mass, more preferably 0.05 to 5% by mass, and even more preferably 0.1 to 3% by mass, relative to the total amount of the composition.

[0021] [(D) Amphoteric Surfactant] Component (D) is an amphoteric surfactant. By including component (D), irritation to the oral mucosa caused by component (A) can be suppressed, and the bitterness and unpleasant taste caused by component (B) can be reduced, thereby improving usability.

[0022] Examples of amphoteric surfactants include betaine-type amphoteric surfactants such as alkyl dimethylamino acetic acid betaine (e.g., lauryl dimethylamino acetic acid betaine) and fatty acid amidopropyl dimethylamino acetic acid betaine (e.g., cocamidopropyl betaine); N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts (e.g., N-coconut fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine); and imidazoline-type amphoteric surfactants such as coconut oil fatty acid imidazolinium betaine and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine. The alkyl group and acyl group preferably have 8 to 18 carbon atoms. Of these, betaine-type amphoteric surfactants are preferred, fatty acid amidopropyl betaine is more preferred, and cocamidopropyl betaine and lauric acid amidopropyl betaine are more preferred.

[0023] The component (D) may be a single amphoteric surfactant or a combination of two or more amphoteric surfactants.

[0024] -Content of Component (D)- The content of component (D) is preferably 0.01% by mass or more, more preferably 0.04% by mass or more, and even more preferably 0.1% by mass or more, relative to the total amount of the composition. This suppresses irritation to the oral mucosa caused by component (A), improves the bitterness and unpleasant taste caused by component (B), and particularly improves the feel when used. The upper limit is preferably 6% by mass or less, more preferably 5% by mass or less, and even more preferably 3% by mass or less. This suppresses the bitterness of component (D) itself, and particularly improves the feel when used. The content of component (D) is preferably 0.01 to 6% by mass, more preferably 0.04 to 5% by mass, and even more preferably 0.1 to 3% by mass, relative to the total amount of the composition.

[0025] -(C) / (D), (C)+(D)- The ratio of the content of component (C) to the content of component (D) ((C) / (D)) is usually 0.05 to 20, and 0.1 to 15. The total content of components (C) and (D) is preferably 0.02 to 12 mass%, more preferably 0.05 to 10 mass%, and even more preferably 0.1 to 6 mass%. By satisfying any one of these conditions, the effects of the present invention can be sufficiently obtained.

[0026] [(E) Anionic Surfactant] The component (E) is an anionic surfactant. By including the component (E), it is possible to obtain an effect of improving foaming.

[0027] Examples of anionic surfactants include alkyl sulfates, acylamino acid salts, acyltaurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and lauryl sulfoacetates. When an alkyl group is present (e.g., an alkyl subsulfate), the alkyl group may be linear or branched, saturated or unsaturated, and typically contains 12 to 14 carbon atoms. When an acyl group is present, the acyl group may be linear or branched, saturated or unsaturated, and typically contains 10 to 20 carbon atoms. The salt may be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and amino acid salts such as arginine salts, lysine salts, and histidine salts. Among these, inorganic base salts are preferred, alkali metal salts (for example, sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0028] Examples of alkyl sulfates include lauryl sulfate and myristoyl sulfate. Examples of acylamino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; lauroyl glutamate; acyl glutamates such as myristoyl glutamate and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methyl glycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt and N-methyl-N-acylalanine salt; and acyl aspartates such as lauroyl aspartate. Examples of acyltaurine salts include lauroyl methyl taurine salt, N-methyl-N-acyltaurine salt, and N-cocoyl methyl taurine salt. Examples of α-olefin sulfonates include α-olefin sulfonates having 12 to 14 carbon atoms, such as tetradecene sulfonate. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride sodium monosulfate and sodium lauryl sulfoacetate.

[0029] The component (E) may be a single anionic surfactant or a combination of two or more different anionic surfactants.

[0030] -Content of Component (E)- The content of component (E) is preferably 0.1% by mass or more, and more preferably 0.3% by mass or more, relative to the total amount of the composition. This allows for a sufficient improvement in foaming. The upper limit is preferably 4% by mass or less, more preferably 3% by mass or less, and even more preferably 2% by mass or less. This allows for the suppression of irritation caused by component (E) itself, and a sufficient improvement in the feel during use. The content of component (E) is preferably 0.1 to 4% by mass, more preferably 0.3 to 3% by mass, and even more preferably 0.3 to 2% by mass, relative to the total amount of the composition.

[0031] -(E) / (C), (E) / (D)- The ratio of the content of the component (E) to the content of the component (C) ((E) / (C)) is usually 0.1 to 7, preferably 0.5 to 5, and more preferably 2 to 4. The ratio of the content of the component (E) to the content of the component (D) ((E) / (D)) is usually 0.1 to 10, preferably 0.5 to 8, and more preferably 2 to 7. The effects of the present invention can be sufficiently obtained by keeping the ratio within each range.

[0032] The total amount of components (C) to (E) is usually 0.12 to 16% by mass, preferably 0.2 to 10% by mass, and more preferably 0.3 to 8% by mass. This allows the effects of the present invention to be fully achieved.

[0033] [Optional Components] The dentifrice composition may contain other components in addition to components (A) to (E) as long as the effects of the present invention are not impaired. Examples of other components include, but are not limited to, components that can be incorporated into dentifrice compositions, such as abrasives, binders, humectants, sweeteners, flavorings, pH adjusters, preservatives, medicinal ingredients, colorants (pigments), and solvents.

[0034] - Abrasives - The incorporation of an abrasive can exhibit a stain-removing effect. Examples of abrasives include calcium phosphate compounds such as dibasic calcium phosphate dihydrate or anhydrous calcium phosphate, monobasic calcium phosphate, tribasic calcium phosphate, calcium pyrophosphate, insoluble calcium metaphosphate, tribasic calcium phosphate, tetrabasic calcium phosphate, and octabasic calcium phosphate; silica abrasives such as anhydrous silicic acid, zeolite, precipitated silica, aluminosilicate, zirconosilicate, titanium-bonded silica, and silica gel; calcium carbonate-based abrasives such as calcium carbonate (light and heavy); aluminum-based abrasives such as aluminum hydroxide and alumina; magnesium-based abrasives such as magnesium carbonate and tribasic magnesium phosphate; apatite-based abrasives such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite; calcium hydroxide; calcium sulfate; titanium dioxide; crystalline zirconium silicate; polymethyl methacrylate; and synthetic resin-based abrasives. Among these, silica-based abrasives and calcium carbonate abrasives are preferred, and anhydrous silicic acid and calcium carbonate are more preferred. It is preferable to use an abrasive having an RDA (Radioactive Dentin Abrasion) in the range of 50 to 250. RDA can be measured according to the Hefferren method (Hefferren (1976) Journal of Dental Research, July-August, 563-573), and the values ​​shown in the examples are also measured by this method.

[0035] The content of the abrasive is usually 1 to 70% by mass, preferably 2 to 60% by mass, based on the total amount of the composition.

[0036] - Binder - Examples of binders include organic binders such as cellulose-based binders (e.g., sodium carboxymethylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethylcellulose, methylcellulose, and cationized cellulose), carrageenan, xanthan gum, guar gum, tragacanth gum, karaya gum, gum arabic, locust bean gum, sodium alginate, sodium polyacrylate, polyvinylpyrrolidone, polyvinyl alcohol, carboxyvinyl polymer (trade name: Carbopol), and propylene glycol alginate; and inorganic binders such as silicic anhydride and aluminum silicate. The content of the binder is preferably 0.1 to 10% by mass, and more preferably 1.4 to 8% by mass, of the total composition.

[0037] -Humectant- The inclusion of a humectant in the composition can further improve the feel upon use. As the thickener, a polyhydric alcohol is preferred, and examples thereof include sugar alcohols such as sorbitol, erythritol, maltitol, lactitol, and xylitol; glycerin; glycols such as propylene glycol, ethylene glycol, and polyethylene glycol (e.g., molecular weight 200 to 6000); and reduced starch saccharification products. The content of the humectant is usually 5 to 50% by mass, preferably 20 to 45% by mass.

[0038] -Fragrance- The composition can improve the sensation of use by containing a fragrance. Examples of fragrances include natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, orange oil, nutmeg oil, lavender oil, paracles oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, and wintergreen oil; menthol, 1-carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spilanthol, n-decyl alcohol, citronellol, These include fragrance components contained in the above-mentioned natural essential oils, such as α-terpineol, citronellyl acetate, cineole, ethyl linalool, and vanillin; fragrance components such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, and ethylene glycol-1-menthyl carbonate; and various blended flavors, such as mint, fruit, and herb flavors, which are obtained by combining several fragrance components and natural essential oils. The fragrances may be used alone or in combination of two or more. The content of the fragrance is typically 0.00001 to 3% by mass based on the total amount of the composition.

[0039] Sweeteners—The composition can further improve the feel when used by including a sweetener, such as xylitol, maltitol, saccharin, saccharin sodium, stevioside, aspartame, sucralose, erythritol, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, glycyrrhizin, thaumatin, and aspartylphenylalanine methyl ester.

[0040] - pH Adjuster (Other Than Component (A)) - The inclusion of a pH adjuster in the composition ensures the pH stability of the formulation. Examples of pH adjusters other than component (A) include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, or salts thereof; inorganic acids such as phosphoric acid (orthophosphoric acid) or salts thereof; and hydroxides such as sodium hydroxide. The content of the pH adjuster is typically an amount that results in a pH of the composition after addition of the pH adjuster of 5 to 9, preferably 6 to 8.5. In this specification, the pH value is typically the value measured at 25°C and 3 minutes after the start of measurement, and can be measured using a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

[0041] - Preservatives - The preservative properties of the formulation can be ensured by including a preservative in the composition. Examples of preservatives include parahydroxybenzoic acid esters (e.g., methyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate), sodium benzoate, etc. The preservatives may be used alone or in combination of two or more.

[0042] -Medicinal Ingredients- Examples of medicinal ingredients include bactericidal or antibacterial agents such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, zinc gluconate, zinc citrate, triclosan, thymol, hinokitiol, and lysozyme chloride; enzymes such as dextranase, mutanase, amylase, protease, and Liteque Enzyme; fluorides such as sodium fluoride, sodium monofluorophosphate, and stannous fluoride; anti-inflammatory agents such as ε-aminocaproic acid, allantoin, tranexamic acid, glycyrrhizinates (for example, dipotassium glycyrrhizinate), glycyrrhetinic acid, stearyl glycyrrhetinate, aluminum chlorohydroxy allantoinate, azulene, and dihydrocholesterol; Examples of suitable medicinal ingredients include metal salts such as zinc, copper salts, and tin salts; anti-tartar agents such as condensed phosphates and ethanehydroxydiphosphonate; blood flow promoters such as vitamin E (e.g., tocopherol acetate); dentin hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; astringents such as vitamins (e.g., vitamin C), lysozyme chloride, and sodium chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; anti-tartar agents such as zeolites; amino acids such as alanine, glycine, and proline; plant extracts such as thyme, Scutellaria Root, clove, and witch hazel; callopeptides, polyvinylpyrrolidone, anti-tartar agents, and anti-plaque agents. The medicinal ingredients may be used alone or in combination of two or more. The content of the other active ingredients can be appropriately determined to be an effective amount.

[0043] -Solvent- Examples of the solvent include water, a lower monohydric alcohol (e.g., ethanol), and a mixed solvent thereof. The amount of the solvent is usually 40% by mass or more, preferably 45 to 99.5% by mass, based on the total amount of the composition. In the case of a mixed solvent, the amount of the lower monohydric alcohol added is usually 1 to 30% by mass, preferably 1 to 20% by mass, based on the total amount of the composition.

[0044] Other Optional Components Examples of optional components other than those described above include pigments such as titanium mica and titanium oxide; charcoal powder; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetanol and stearyl alcohol; polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these components can be appropriately set within a range that does not interfere with the effects of the present invention.

[0045] [Form and Use of Composition] The composition of the present invention can be used as a dentifrice such as a toothpaste, a liquid dentifrice, a lubricant dentifrice, a powder dentifrice, or a gel dentifrice, and is preferably a toothpaste or a gel dentifrice. The composition can exhibit a stain-removing effect and can therefore be used as a stain-removing dentifrice.

[0046] The dosage form of the dentifrice composition is not particularly limited and can be appropriately selected depending on the mode of use, and examples of dosage forms include gel and paste.

[0047] [Method of Manufacturing Composition] The method of manufacturing the dentifrice composition is not particularly limited, and it can be prepared by any conventional method depending on the dosage form. For example, when used as a toothpaste, a method can be used in which the water-soluble components are prepared, and then the other components are mixed, and degassing (e.g., reduced pressure, etc.) is performed as needed. The obtained toothpaste can be placed in a container to make a product. The shape and material of the container are not particularly limited, and containers used for conventional toothpaste compositions can be used, such as plastic containers made of polyethylene, polypropylene, polyethylene terephthalate, nylon, etc.

[0048] [2. Stain Remover] The stain remover of the present invention contains components (A) and (B), and preferably further contains components (C) and / or (D), or component (E), and more preferably further contains components (C) and / or (D) and component (E). Examples, contents, and content ratios of each component are the same as those described above. The stain remover can be applied to teeth to remove colored stains (stains) that have adhered to and deposited on the teeth. The stain remover can efficiently exert the above-mentioned effects by being added to an oral composition, preferably a dentifrice composition.

[0049] The present invention will be described in more detail below with reference to examples. The following examples are provided to suitably explain the present invention, but are not intended to limit the present invention. Note that "%" means "% by mass" unless otherwise specified.

[0050] Examples 1 to 24 and Comparative Examples 1 to 2 Dentifrice compositions were prepared according to the formulations shown in Tables 1 to 3 (units of each component in the tables: mass %) using the following preparation method. The raw materials used are shown below.

[0051] [Raw Materials] -Component (A)- Sodium pyrophosphate: anhydrous sodium pyrophosphate, manufactured by Taihei Chemical Industry Co., Ltd.

[0052] -Component (B)- Bentonite: Kunipia G, manufactured by Kunimine Industries Co., Ltd., sodium bentonite

[0053] -Component (C)- Polyoxyethylene (20) hydrogenated castor oil: NIKKOL HCO-20, manufactured by Nikko Chemicals Co., Ltd.

[0054] -Component (D)- Cocamidopropyl betaine: TEGO Betaine CK, manufactured by EVONIK

[0055] -Component (E)- Sodium lauryl sulfate: Sodium Lauryl Sulfate (K12), manufactured by Dongming Jujin Chemical Industry Co., Ltd.

[0056] - Optional Components - Silica anhydrous (thickening silica): manufactured by EVONIK Corporation Silica anhydrous (abrasive silica): manufactured by EVONIK Corporation Sorbitol (70% by mass aqueous solution): manufactured by ROQUETTE Corporation Polyethylene glycol 400: manufactured by Lion Chemical Co., Ltd. Carboxymethyl cellulose: manufactured by Daicel FineChem Co., Ltd. Sodium alginate: manufactured by Kimika Co., Ltd. Sodium saccharin: manufactured by Shanghai Fortune Chemical Co., Ltd. Sodium fluoride: manufactured by Jinan Chemical Works Branch Co., Ltd.

[0057] [Method of Preparing Dentifrice Compositions] Dentifrice compositions (toothpastes) having the compositions shown in Tables 1 to 3 were prepared by a conventional method.

[0058] [Evaluation Method] The resulting dentifrice compositions were evaluated as follows.

[0059] [Method for Evaluating Stain Removal] Hydroxyapatite plate 1 (HOYA Corporation, diameter 7.0 mm x 3.5 mm; hereinafter, hydroxyapatite plate will be abbreviated as HAP plate) whose surface had been previously polished by sandblasting was immersed in a 40°C thermostatic bath for 30 minutes each in a 0.5% aqueous albumin solution, a tannin solution (50 g of Japanese tea (brand: Oimatsu) and five black tea tea bags (manufactured by Lipton, Brisk tea bags) extracted with hot water, cooled, and then mixed with 12 g of powdered coffee (manufactured by Nescafé) and adjusted to 1,200 mL with purified water), and a 0.56% aqueous ammonium iron(III) citrate solution. This procedure was repeated 8 to 9 times a day until the stains were sufficiently adhered to the HAP plate (120 cycles), yielding a stained HAP plate 2.

[0060] Next, HAP plate 2 was immersed in a dentifrice solution diluted 3 times with artificial saliva (50 mM KCl, 1 mM CaCl, 0.1 mM MgCl, 1 mM KHPO, pH 7.0) at 37°C for 2.5 minutes, and then brushed in the test solution using a flat grinder (brush used: Lion Corporation's Systema toothbrush with a 4-row head). Brushing was performed 200 times. After brushing, the plate was rinsed with water to obtain cleaned HAP plate 3.

[0061] The stain removal effect was evaluated using the L of HAP boards 1, 2, and 3.* The values ​​were measured, and * 1. L * 2. L * The stain removal rate was calculated using the following formula and evaluated according to the following criteria.

[0062] L * The value was measured using a spectrophotometer (Nippon Denshoku Co., Ltd., SE-2000). Calculation formula: Stain removal rate (%) = {(L * 2-L * 1)-(L * 3-L * 1) / (L * 2-L * 1)

[0063] - Evaluation criteria for stain removal effect - ++: Stain removal rate is 50% or more +: Stain removal rate is 45% or more but less than 50% ±: Stain removal rate is 30% or more but less than 45% -: Stain removal rate is less than 30%

[0064] [Method for evaluating the feel of use (absence of irritation to the oral mucosa, absence of bitterness or unpleasant taste)] Ten monitors applied the dentifrice composition to a toothbrush and cleaned the oral cavity, and evaluated the irritation to the oral mucosa and the taste according to the following rating scale. The average of the scores of the ten monitors was calculated and evaluated according to the following rating scale.

[0065] - Rating criteria for non-irritation to oral mucosa - 4 points: No irritation felt in the oral cavity. 3 points: Almost no irritation felt in the oral cavity. 2 points: Irritation felt in the oral cavity. 1 point: Extremely irritating felt in the oral cavity.

[0066] - Evaluation criteria for lack of irritation to oral mucosa - ++: Average score of 3.0 points or more and 4.0 points or less +: Average score of 2.5 points or more and less than 3.0 points ±: Average score of 1.5 points or more and less than 2.5 points -: Average score less than 1.5 points

[0067] - Rating criteria for the absence of bitterness and unpleasant taste - 4 points: No strange taste felt in the mouth. 3 points: A slight strange taste felt in the mouth. 2 points: A strange taste felt in the mouth. 1 point: A very strange taste felt in the mouth.

[0068] - Evaluation criteria for bitterness / absence of unpleasant taste - ++: Average score of 3.5 to 4.0 points +: Average score of 3.0 to less than 3.5 points ±: Average score of 2.0 to less than 3.0 points -: Average score less than 2.0 points

[0069] [Method for evaluating foaming] Approximately 1 g of the dentifrice composition was placed on the bristles of a regular toothbrush, and the foaming after brushing for 3 minutes was evaluated on the following 4-point scale.

[0070] - Rating criteria - 4 points: Good foaming 3 points: Foaming 2 points: Poor foaming 1 point: No foaming at all

[0071] The evaluation scores of the 10 panelists were averaged and the foaming was evaluated on the following four-point scale: ++ and + were judged to be dentifrice compositions with good foaming properties.

[0072] -Evaluation criteria- ++: 3.5 points or more and 4.0 points or less +: 3.0 points or more and less than 3.5 points ±: 2.0 points or more and less than 3.0 points -: Less than 2.0 points

[0073]

[0074]

[0075]

[0076] Compared with Comparative Example 1, which contained sodium pyrophosphate but no bentonite, and Comparative Example 2, which contained bentonite but no sodium pyrophosphate, Examples 1 to 24, which contained both bentonite and sodium pyrophosphate, exhibited a high stain removal effect (Tables 1 to 3). These results demonstrate that the present invention can provide a dentifrice composition with a good stain removal effect, and can also provide a dentifrice composition that can achieve both a stain removal effect and a good usability.

Claims

DEPCT661. Toothpaste composition consisting of: (A) concentrated phosphate; and (B) smectite clay.

2. Toothpaste composition under Reputation 1 where component (A) is one or more types selected from a group consisting of pyrophosphate, tripolyphosphate and metaphosphate.

3. Toothpaste composition under Reputation 1 or 2 where component (B) is bentonite.

4. Toothpaste composition under any of Reputation 1 through 3 where the amount of component (A) is 0.05 to 7% by mass.

5. Toothpaste composition under any of Reputation 1 through 3 where the amount of component (A) is 0.05 to 7% by mass.

6. Any toothpaste ingredient under any of the claims 1 to 4 in which the amount of component (B) is 0.0001 to 10% by mass.

7. Any toothpaste ingredient under any of the claims 1 to 6 in which the ratio ((B) / (A)) of the amount of component (B) to the amount of component (A) is 0.0001 to 12.

8. Any toothpaste ingredient under any of the claims 1 to 6 in which one or two or more additional components are included, selected from a group consisting of: (C) nonionic surfactants; and (D) cationic surfactants. 9.

9. Any toothpaste component under claims 1 to 7 that is further combined with (E) anionic surfactants; 10. Any toothpaste component under claims 1 to 8 that functions as a stain-removing toothpaste; 11. Any toothpaste component under claims 1 to 9 that functions as a dental cleaning paste; 12. A stain-removing agent that is combined with: (A) concentrated phosphate; and (B) smectite clay.