A process for manufacturing cross-linked chitosan beads using radiation treatment for development as a filler and controlled-release material for essential oils.

Abstract

OCR 09WP 05 / 02 / 2568 A process for manufacturing cross-linked chitosan beads using radiation treatment for development. Packaging and controlled release of essential oils consisting of (1) preparation of chitosan beads with Methods for neutralization to form chitosan into spherical beads and (2) enhancement of elasticity and Strength refers to the ability to retain or contain essential oils, inducing the development of... Chitosan chains are cross-linked using a radioactive process combined with the use of cross-linking agents from the derivative group. Poly(ethylene glycol)

Claims

OCR 10KL (22 / 04 / 2569) 1. A process for manufacturing cross-linked chitosan beads using radiation treatment for development into... The packaging and release control system for essential oils consists of the following steps: a. Dissolve chitosan in organic acid to obtain a chitosan solution at a concentration in the percentage range. 0.5 - 4.0 by weight per volume B. Add the solution obtained from step A to an inorganic base solution with a concentration in the range of 1.0 - 2.5 molar. Then, soak it for 12–48 hours to obtain chitosan granules that have formed into spherical shapes. After that, wash away the substances that have formed. Rinse with distilled water 3-5 times. C. Dissolving the crosslinking agent (a polyethylene glycol derivative) in an organic solvent yields: Solutions of crosslinking agent with concentrations ranging from 0.25% to 2.0% by weight per volume. D. Add 3-10 chitosan beads to the solution prepared in step C, allowing the beads to settle. Distribute the sample thoroughly in the solution and soak for 12–24 hours. D. Irradiate the substance prepared in step D to induce cross-linking through a radiological process using radiation. Ionizing type radiation with absorbed doses in the range of 5 - 30 kilograys (kGy). f. Wash the irradiated sample with an organic solvent capable of dissolving the formed polymer. The crosslinking agent used in step C is polymerized 3-5 times, followed by washing in distilled water. 3-5 times B. Allow the substance obtained from step F to stand at room temperature.

2. A process for manufacturing cross-linked chitosan beads using radiation treatment for development into... Encapsulator and controlled-release agent for essential oils, pursuant to claim 1, where selectable organic acids are available. Acetic acid, lactic acid, or propanic acid, either individually or in combination.

3. A process for manufacturing cross-linked chitosan beads using radiation treatment for development into... A container and controlled release agent for essential oils, pursuant to claim 1, which is an inorganic base solution. You can choose either sodium hydroxide or potassium hydroxide, or a mixture of both.

4. A process for manufacturing cross-linked chitosan beads using radiation treatment for development into... Encapsulator and controlled release agent for essential oils, pursuant to claim 1, whereby the crosslinking agent is Polyethylene glycol derivatives can be selected from poly(ethylene glycol)diacrylate and poly(ethylene glycol)diacrylate. Methyl ether and polyethylene glycol) dimethacrylate, either individually or in combination.

5. A process for manufacturing cross-linked chitosan beads using radiation treatment for development into... Fillers and controlled-release agents for essential oils, as per claim 1, whereby organic solvents for... Dissolve the crosslinking agent, which is a poly(ethylene glycol) derivative, using ethanol, methanol, or isophosphate. One or a mixture of both.

6. A process for manufacturing cross-linked chitosan beads using radiation treatment for development into... Essential oil filler and release control device, pursuant to claim 1, which concerns the type of ionizing radiation. One or more options are available: gamma rays, X-rays, electron beams, or ionizing beams, or a combination of both.

7. A process for manufacturing cross-linked chitosan beads using radiation treatment for development into... A container and controlled release device for essential oils, pursuant to claim 1, under irradiation conditions. You can choose between a vacuum, or the presence of air, nitrogen gas, or nitrous oxide gas. One, or a combination of both.

8. A process for manufacturing cross-linked chitosan beads using radiation treatment for development into... Fillers and controlled-release agents for essential oils, as per claim 1, whereby organic solvents for... Dissolve the polymer formed by crosslinking with a solvent such as ethanol or methanol. Or isopropanol, either individually or in combination.

9. Radio-cross-linked chitosan beads for use as fillers and control agents. The release of essential oils obtained through any of the processes described in claims 1-8.

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