A method for converting mitragynine from kratom leaves into 7-hydroxymitragynine using liquid-phase plasma technique.

Abstract

OCR 10KL (08 / 07 / 2569) This invention concerns a process for converting mitragynine into 7-hydroxymitragynine. Genine from kratom leaves was extracted using liquid-phase plasma technology with an advanced oxidation process. Including by-product chemical substances from drug reactions and other processes. This occurs during plasma formation, where it reacts with the mitragynine structure to form 7-. 7-hydroxymitragynine exhibits beneficial pharmacological effects. It has been improved, becoming a more effective painkiller with a lower risk of addiction than morphine, due to the processing methods. The conversion of mitragynine to 7-hydroxymitragynine from kratom leaves was performed using plasma technology. This liquid phase has a simple process, is environmentally friendly, and can be easily operated. It does not require expert intervention, and is beneficial in medical and pharmaceutical fields. It can also be applied in the functional food industry, as well as other related fields.

Claims

OCR 10KL (08 / 07 / 2569) 1. A process for converting mitragynine into 7-hydroxymitragynine from kratom leaves using [technique name missing]. Liquid-phase plasma consists of the following steps: A. Prepare a solution mixed with kratom leaves. B. Prepare the cooling system. C. Prepare the reactor for liquid-phase plasma generation; the reactor has a housing. The main body is a vertical cylinder, with a narrow section in the middle of the reactor and a lower section. From the narrow section, which has a smaller diameter than the upper part, inside the reactor there is a tube that... Connecting the upper and lower parts of the reactor, the lower part of the reactor has a channel for... Allow gas to enter through the bottom of the reactor. There is a side opening above where the solution can flow in. The gas inlet port is located in the upper part of the reactor above the constriction, and there is an opening for the solution to flow. Go to the side. d. Position the two pointed electrodes on the sides of the reactor at the constricted point. The reactor is narrowed in a way that the pointed ends face each other in a left-right symmetrical manner. J. Inject gas into the gas inlet port at the bottom of the reactor. f. The kratom solution mixture is conveyed by pouring the solution into the reactor and... Connect the silicone tubing, which is fitted with a syringe pump, to the outlet port for the solution to flow out. Attach the hose to the side of the reactor housing and connect the other end to the opening. The solution flows into the side of the reactor housing, with the remaining part of the tubing attached to it. Cooling system B. Initiate the process of converting mitragynine into 7-hydroxymitragynine from... Kratom leaves are processed using liquid-phase plasma technology by applying high voltage. Connect the current-limiting resistor in series with one end of the pointed conductor. The other end of the pointed electrical conductor is connected to the system's electrical ground.

2. Process for converting mitragynine into 7-hydroxymitragynine from kratom leaves using [technique name missing]. Liquid phase plasma, as per claim 1, where kratom leaves are derived from the kratom plant and have an age of... The product is aged for years or more and then dried at 60 degrees Celsius for 24 hours before being finely ground. The particle size must be less than 125 micrometers using a 120-mesh sieve for sorting.

3. Process for converting mitragynine into 7-hydroxymitragynine from kratom leaves using [technique name missing]. Liquid phase plasma, as per claim 1, where a kratom leaf solution is provided for the mixing of powder. 1 to 10 grams of kratom with 100 to 500 milliliters of distilled water.

4. Process for converting mitragynine into 7-hydroxymitragynine from kratom leaves using [technique name missing]. Liquid phase plasma, according to claim 1, where the cooling system maintains the temperature in the range of 0 to 10°C. Celsius degrees, where the average temperature of the solution in the reactor during plasma generation is kept in the range of 20. Up to 50 degrees Celsius 5. Process for converting mitragynine into 7-hydroxymitragynine from kratom leaves using [technique name missing]. Liquid phase plasma, according to claim 1, where the distance between the electrode tips is provided. They are spaced between 0.5 and 9 millimeters apart.

6. Method for converting mitragynine into 7-hydroxymitragynine from kratom leaves using [technique name missing]. Liquid phase plasma under claim 1, where the gas of choice is air, argon, or helium. Or oxygen, with the gas flow rate specified to be in the range of 0.1 to 5 liters per minute.

7. Method for converting mitragynine into 7-hydroxymitragynine from kratom leaves using [technique name missing]. Liquid phase plasma, according to claim 1, where a peristaltic pump provides a pump speed range in 1 to 100 milliliters per minute 8. Method for converting mitragynine into 7-hydroxymitragynine from kratom leaves using [technique name missing]. Liquid phase plasma, as per claim 1, where a high voltage source is provided. DC pulse voltage of 1 to 50 kV for DC pulse voltage sources. Positive pulsed DC or -50 to -1 kilovolt (kV) for pulsed voltage sources. Negative pulsed DC (DC) with pulse frequencies ranging from 50 Hertz (Hz) to 500. Kilohertz, duty cycle value in the range of 1 to 50 percent, where the current-limiting resistor is set. The size should be between 50 ohms and 10 megaohms.

9. Method for converting mitragynine into 7-hydroxymitragynine from kratom leaves using [technique name missing]. Liquid phase plasma, as per claim 1, where mitragynine is transformed. The plasma is in the liquid phase for 5 to 30 minutes.