Wound dressings containing silver nanoparticles as an antimicrobial agent, and the manufacturing process of such products.

Abstract

OCR 10KL (31 / 07 / 2569) This invention relates to a wound dressing product containing silver nanoparticles that act as an antimicrobial agent. The manufacturing process for this product involves polyvinyl alcohol, hydroxypropyl methylcellulose, and silica. Vernitrate, eucalyptus leaf extract, absorption enhancer, plasticizer, distilled water or dehydrated water. Ionization is achieved by preparing polyvinyl alcohol (PVA) dissolved in deionized water. (Deionized water) is centrifuged until the polyvinyl alcohol is completely dissolved. Hydroxypropyl is then added. Hydroxypropyl methylcellulose (HPMC) is mixed into a polyvinyl alcohol solution. Mix until the hydroxypropyl methylcellulose is completely dissolved in the polyvinyl alcohol solution. Silver nanoparticles were synthesized using aqueous extract of eucalyptus leaves as a reducing agent and silver nitrate as a precursor. The precursor for silver nanoparticle formation is deionized water, in order to reduce silver ions. Silver atoms (Ag0) are then added, and the resulting silver nanoparticle solution is centrifuged to collect the silver particle precipitate. The resulting substance is used as an active antimicrobial agent and then added to the prepared polymer solution. Add permeation enhancers and plasticizers to increase absorption. Mix the flexible material until it forms a homogeneous paste, then pour it onto a mold. Leave it until the wound dressing material sets, resulting in a sheet of the material. Wound dressing containing nanoparticles.

Claims

OCR 09WP 11 / 06 / 2569 1. Wound dressings containing silver nanoparticles with antimicrobial properties. - Polyvinyl alcohol, 2.5-7.5% by weight. - Hydroxypropyl methylcellulose, 0.25-1.0% by weight. - Silver nitrate, 1-10% by weight. - Eucalyptus leaf extract, 0.5-10% by weight. - Absorption enhancer, at a concentration of 0.1-0.33% by weight. - Plasticizers: 0.1-0.33% by weight. Distilled water or deionized water is used to achieve 100% by weight.

2. Wound dressing product containing silver nanoparticles with antimicrobial properties, as per claim 1, where the additive... Absorption can be achieved through select options such as eucalyptus oil or clove essential oil. Clove oil, lecithin, or menthol, either individually or in combination. go 3. Wound dressing product containing silver nanoparticles that are antimicrobial agents, as per claim 1, where the substance... Stiffeners can be selected from glycerol, sorbitol, or polyethylene glycol 400. (poly(ethylene glycol) 400) either one or two of them combined.

4. Wound dressings containing silver nanoparticles that are antimicrobial agents, as per claim 1, where polyvinyl... Alcohol options include Carbopol c-974P and polyvinyl alcohol. Alcohol), polyvinylpyrrolidone, or hydroxypropyl methylcellulose. (Hydroxy Propyl Methyl Cellulose) one or more of these together.

5. A process for manufacturing wound dressings containing silver nanoparticles with antimicrobial properties, as per claim 1. Where the steps are as follows: a. Dissolve 5% by weight polyvinyl alcohol (PVA) in... Deionized water is centrifuged until polyvinyl alcohol dissolves. At this stage, a homogeneous polyvinyl alcohol solution is obtained. B. Add hydroxypropyl methylcellulose (HPMC) to the mixture. The polyvinyl alcohol solution obtained from step A is mixed until hydroxypropyl methylcellulose is formed. It dissolves homogeneously with the polyvinyl alcohol solution. At this stage, a polymer solution is obtained. C. Synthesize silver nanoparticles using aqueous extract of eucalyptus leaves as a reducing agent and sil... Vernitrate is a precursor for the formation of silver nanoparticles, by dissolving it in a reducing agent with a concentration of 50. Milligrams per milliliter with deionized water. Then add both substances into the container. Deionized water is left at room temperature to allow the reduction of silver ions to become silver. The atom (Ag0), which is the nucleus, gives off silver particles, forming a solution of silver nanoparticles. The resulting silver nanoparticle solution is then centrifuged to collect the resulting silver particle precipitate. For use as an active ingredient in antimicrobial agents, this step yields a silver particle precipitate. d. Add the silver particle precipitate obtained from step c to the polymer solution prepared in step b. Mix thoroughly, then add the permeation enhancer and plasticizer. Plasticizers are added to increase flexibility and to create a homogeneous mixture. e. Spread the wound dressing preparation material obtained from step d onto the Teflon mold, ensuring it is evenly distributed. The mold is left in place until the wound dressing material sets. The ideal temperature is 25-28 degrees Celsius. After 72 hours, a wound dressing material containing nanoparticles will be obtained.

6. A process for manufacturing wound dressings containing silver nanoparticles with antimicrobial properties, as per claim 5. In step A, the optimal temperature is 100 degrees Celsius.

7. A manufacturing process for wound dressings containing silver nanoparticles with antimicrobial properties, as per claim 5. In step C, the optimal concentration of silver nitrate is 0.1-1 millimolar.

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