A hydrogel mixture of sericin and polyvinyl alcohol containing fluoroquinolone antibiotics.

Abstract

Page 1 of 3 pages. Details of the invention? A name that reflects the invention? A hydrogel mixture of sericin and polyethylene alcohol containing a fluoroquinolone antibiotic. Branches of science related to invention. Five branches of chemistry related to hydrogels containing sericin and polyvinyl alcohol that encapsulate antibiotics. Fluoroquinolone group Background in the relevant art or science? Osteomyelitis is an inflammation of the bone marrow or muscle. The surrounding environment is contaminated with infections, most of which are caused by bacteria. The most common types of bacteria are: 10Staphylococcusaureus,Staphylococcusepidermidis,Escherichiacoli and Pseudomonas In cases of acute infection, such as aeruginosa, doctors will treat with intravenous antibiotics. Medically, in cases of chronic infection, pus-filled cavities in the bone are commonly detected, requiring surgery. The bone is cut to drain pus or remove dead bone tissue caused by the infection, and treated concurrently with antibiotics. Topical application to maintain high and sustained drug concentrations in infected areas for prolonged periods in bone disease treatment. 15. Chronic infectious inflammation treated with topical antibiotics involves implanting bone cement pellets mixed with antibiotics in the creases of the affected area. After surgery, however, bone cement cannot be broken down in the body, which is a limitation. This is important because repeat surgery is necessary to remove the bone cement fragments after treatment is complete, thus ensuring the patient receives... This causes further pain, increases treatment costs, and hinders bone healing. The aging process is due to the embedding of bone cement granules, and also because antibiotics are mixed with bone cement granules during the manufacturing process. 20 must be in powder form and able to withstand high temperatures (Inzana, Schwarzetal.2016). Due to these limitations, A biodegradable topical antibiotic delivery system has been developed to promote bone healing. And it can be used with many forms of antibiotics to increase the options for choosing medication. Currently, the use of drug delivery systems... Specifically, when combined with tissue engineering technology, it plays a crucial role in disease treatment and serves as a framework for assistance. In cell growth, hydrogel is a very popular form of cell culture scaffold. 25. Because it has a flexible texture and a structure similar to tissue (Sahoo, Vanden Bergetal. 2018, Cheng, (Aminetal.2019) In addition, due to the physical properties of hydrogels, they are able to release drugs. Continuously and maintaining the drug concentration in the active area for a long period of time (Narayanaswamy and Torchilin 2019). Therefore, it is suitable for topical drug delivery, and numerous studies have developed hydrogels from biomaterials such as polymers. Ceramics, metals, and composite materials. 30. Sericin is a natural polymer extracted from silkworm cocoons in textile factories. Sericin is a waste product. While sericin is used to remove silk threads by rinsing with water, it possesses a variety of biological effects, such as preventing cell death. (Liu,Wangetal.2016) has antioxidant activity (Takechi,Wadaetal.2014) and anticoagulant properties. (Sano, Tamadaetal.2009) and promotes cell proliferation (Liu, Wangetal.2016). There are also... Sericin has high biocompatibility and biodegradability. These properties make sericin... 35. Significant benefits for medical applications, both in drug delivery and tissue engineering. (Page 2 of 3) In addition, synthetic polymers such as polyvinyl alcohol are polymers that are compatible with the body and... Biodegradable and approved by the U.S. Food and Drug Administration for applications. In the field of biomedical medicine, polyvinyl alcohol possesses mechanical and biological properties that make it suitable for various applications. Drug delivery and tissue engineering. 5. Patents and research related to the invention of a hydrogel composed of silkworm cocoon-derived substances or sericin. And polyvinyl alcohol? Thai patent application number 0701006725 is for the invention of a hydrogel wound dressing material consisting of... Silkworm cocoons and polyvinyl alcohol? But it is fibroron from silkworm cocoons that is used as a raw material in the textile industry, while... Sericin is a waste material that the researchers and their team see as having the potential to be used beneficially. 10. According to research by GangTao et al. (2019), a hydrogel composed of sericin and Polyvinyl alcohol? And antibiotic contamination for use in wound dressing, but it's actually a hydrogel invention. A mixture of sericin and polyvinyl alcohol is prepared first, then dried and immersed in the antibiotic gentamicin. According to the study by Biman et al. (2011), it is a sericin / polyvinyl alcohol invention. Hydrogel films are used in tissue engineering, but this research uses glutaraldehyde crosslinking agents. 15(Glutaraldehyde) is used to help form a hydrogel and to prevent mixing with antibiotics. According to a study by Pornanong et al. (2013), a hydrogel composed of sericin was invented. And polyvinyl alcohol? For use in helping to heal wounds, but this research used the crosslinking agent genipine. (Genipin) To help form the hydrogel, glycerin is used as a plasticizer and it is not mixed with medication. Patience Twenty inventors and their team therefore conceived the idea of ​​developing a hydrogel mixed with sericin and polyvinyl alcohol in order to... It is used as a topical delivery system for fluoroquinolone antibiotics and as an aid in bone healing for treatment. Chronic infectious osteomyelitis Characteristics and purpose of the invention. A hydrogel mixture of sericin and polyvinyl alcohol containing a fluoroquinolone antibiotic. The 25 components are as follows: sericin, polyvinyl alcohol, and fluoroquinolone antibiotics. The purpose of this invention is to develop a hydrogel mixture of sericin and polyvinyl alcohol. The inclusion of fluoroquinolone antibiotics represents a new dimension in the treatment of chronic infectious osteomyelitis, potentially replacing bone marrow implants. The traditional formulation, with its biodegradable properties, high body compatibility, flexibility, and ability to release medication, Antibiotics can be delivered in a constant dose and for an extended period, and their structure also facilitates the delivery of antibiotics. 30 bone cells? Bone adhesion to promote bone cell growth. In addition, the hydrogel synthesis process is... Synthetic products that are environmentally friendly, free from harmful chemical contaminants, and made from recycled materials. Let's use nature to its fullest potential. Complete disclosure of the invention. A hydrogel mixture of sericin and polyvinyl alcohol containing a fluoroquinolone antibiotic. 35. The components are as follows (page 3 of 3). A 40-70 percent by weight sericin solution. A 20-50% by weight polyvinyl alcohol solution. Fluoroquinolone antibiotics 5-15 percent by weight. The sericin solution can be prepared by boiling silkworm cocoons in water and then filtering out the fibrous portion, which is fibroin. 5. And the waste water is sericin, which, according to this invention, is dried to obtain... Sericin powder is prepared as a 1-5% by mass / volume sericin solution by dissolving the sericin powder. Sericin is heated with hot water at 80-100 degrees Celsius to be used as a component of a hydrogel mixture of sericin and polyvinyl. The invention of this fluoroquinolone-containing alcoholic antibiotic uses a good concentration of sericin solution. The highest percentage is 2 percent by mass to volume. 10. A polyvinyl alcohol solution with a concentration of 5-10 percent by mass / volume can be prepared by taking... Polyvinyl alcohol powder is boiled in hot water (80-100 degrees Celsius) to be used as a component of the hydrogel mixture. Between sericin and polyvinyl alcohol, the fluoroquinolone antibiotic according to this invention is used. The optimal polyvinyl alcohol solution concentration is 10 percent by mass per volume. Fluoroquinolone antibiotics such as ciprofloxacin and levofloxacin at concentrations of 0.3–1. 15 percent by mass / volume to be used as a component of a hydrogel mixture of sericin and polyvinyl. Alcohol containing the fluoroquinolone antibiotic according to this invention; the concentration of the fluoroquinolone antibiotic... The best vnoiloxin concentration is 0.5 percent by mass per volume. Testing the inhibitory effect of a hydrogel mixture on bacterial growth in solid media. Ricin and polyvinyl alcohol demonstrate efficacy in releasing ciprofloxacin to inhibit bacteria. 20. Staphylococcus aureus and Escherichia coli formed a ring. The clear area surrounding the hydrogel, with its large size indicating its effectiveness in inhibiting bacterial growth, is evident. A hydrogel mixture of sericin and polyvinyl alcohol containing the antibiotic ciprofloxacin provides an inhibitory site. The growth of microorganisms was very good in the hydrogel mixture of sericin and polyvinyl alcohol that did not contain antibiotics. Does ciprofloxacin create an inhibitory site for the growth of either of these two types of bacteria? 25. Testing the adhesion of bone cells (MC3T3-E1 cells) to a hydrogel mixture of sericin and polyvinyl chloride. Niacin alcohol containing the antibiotic ciprofloxacin was used to culture cells on a hydrogel for 3 days. The results... Scanning electron microscopy revealed bone cells capable of adhering to and spreading on hydrothermal sclera. A gel demonstrating a hydrogel mixture of sericin and polyvinyl alcohol containing the antibiotic ciprofloxacin. Suitable for use as a cell culture scaffold. 30 of the best ways to invent things. As described in the section on complete disclosure of the invention;

Claims

OCR09WP21 / 04 / 25681. A hydrogel mixture of sericin and polyvinyl alcohol containing fluoroquinolone antibiotics with the following composition: 40-70% by weight of sericin solution, 20-50% by weight of polyvinyl alcohol solution, and 5-15% by weight of fluoroquinolone antibiotics.

2. A hydrogel mixture of sericin and polyvinyl alcohol containing fluoroquinolone antibiotics as per claim 1, which uses fluoroquinolone antibiotics such as ciprofloxacin, levofloxacin, etc.

3. A hydrogel mixture of sericin and polyvinyl alcohol containing fluoroquinolone antibiotics according to claim 1, where the sericin solution can be prepared by boiling silkworm cocoons in water and filtering out the fibrous portion (fibroin) and the waste water (sericin). According to this invention, the waste water (sericin) is dried to obtain sericin powder. 4.A hydrogel mixture of sericin and polyvinyl alcohol containing fluoroquinolone antibiotics as per Patent 1 or 2, where sericin powder is prepared as a sericin solution of concentration 1-5% by mass / volume by dissolving the sericin powder in hot water of 80-100°C, with the optimal concentration of the sericin solution being 2% by mass / volume; and a hydrogel mixture of sericin and polyvinyl alcohol containing fluoroquinolone antibiotics as per Patent 1, where a polyvinyl alcohol solution of concentration 5-10% by mass / volume can be prepared by boiling the polyvinyl alcohol powder in hot water of 80-100°C, with the optimal concentration of the polyvinyl alcohol solution being 10% by mass / volume.