Novel process for purifying heparan-n-sulfatase.
TN2025000054A1Undetermined Publication Date: 2026-10-01GC BIOPHARMA CORP +1
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Patent Information
- Application Number
- TN2025000054P0
- Authority / Receiving Office
- TN · TN
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2025-02-21
- Publication Date
- 2026-10-01
Abstract
The present invention relates to a pharmaceutical composition of a high concentration of heparan N-sulfatase (H NS) with enhanced stability for CNS delivery and a pharmaceutical formulation comprising the same. The pharmaceutical composition and pharmaceutical formulation comprising the same according to the present invention have excellent formulation stability, such as a reduction in turbidity and a significant improvement in purity, which may be useful in enzyme replacement therapy (ERT) for the treatment of mucopolysaccharidosis type III.
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