The Use of Tea Tree Oil and Herbal Extract-Based Formulations in the Treatment of Dermatophytosis Infections

Abstract

The invention relates to the use of tea tree oil (Melaleuca Alternifolia) and herbal extract-based topical cosmetic formulations for the treatment of dermatophyte-induced infections affecting the keratin tissue of the skin, hair, and nails, with the aim of reducing infection and promoting healing.

Description

Tea Tree Oil and Herbal Extract in the Treatment of Dermatophytosis Infections Use of Base Formulations TECHNICAL FIELD The invention relates to dermatophyte-derived bacteria that infect keratin tissue in the skin, hair, and nails. Tea tree oil is used to treat infections by reducing infection and promoting healing. (Melaleuca alternifolia) and herbal extract-based topical cosmetic formulations It is related to its usage. PREVIOUS TECHNIQUE Dermatophytosis is a superficial skin disease caused by types of fungi called dermatophytes. Dermatophytes are a general name given to infections of keratinized tissues (skin, hair, and...). They settle in the nails and cause infection. Dermatophytosis infections can occur in various parts of the body. It is seen in these areas; between the toes and on the soles of the feet, all over the body. in the form of usually round red lesions, on the scalp and hair follicles It causes infection. It leads to fungal infections in the groin area and nails. The symptoms and effects of dermatophytosis vary depending on the area where the infection is located. Dermatophytosis typically causes severe itching. Redness may also appear in the infected area. Scaling and skin peeling are common. Blisters and skin cracks are especially common on the feet. This occurs in nail fungus infections, resulting in thickening and discoloration of the nails. And fragility occurs. If there is an infection in the scalp, hair loss and baldness can occur. These areas are formed. Treatment of dermatophytosis usually involves topical antifungal creams, Lotions and shampoos are used. In severe cases, oral antifungal medications are prescribed. Natural products like tea tree oil help in the treatment of dermatophytosis. To prevent this, personal hygiene should be maintained, caution should be exercised in shared areas, and It is important to avoid humid environments. Tea tree oil (Melaleuca alternifolia) is an effective natural remedy for dermatophytosis. It is an antifungal agent. Tea tree oil is effective against dermatophytes such as Trichophyton and Microsporum. Tea tree oil exhibits antifungal and antimicrobial properties against fungi. In clinical studies investigating its effects on dermatophytosis, some commercial versions of this oil have been shown to be effective. 1 It has been found to be as effective as antifungal preparations. For example, topical butenafine and Compared to clotrimazole, using a cream containing tea tree oil offers better results. It has been found to yield results. Tea tree oil (Melaleuca alternifolia), in particular. Thanks to the high antifungal and antibacterial properties of the compound called terpinen-4-ol Tea tree oil is commonly used in the treatment of fungal infections of the nails. by killing the fungi that cause the fungus and preventing the spread of infection It has an effect. Chamomile extract for dermatophytosis (fungal infections) Research on its effects is limited. However, chamomile has a wide range of uses. It is known as a plant that offers a range of health benefits, and especially chamazulene and It contains components such as bisabolol, which are anti-inflammatory and anti-inflammatory agents that reduce inflammation. It has antimicrobial and antioxidant properties. These properties prevent skin irritation and It is beneficial in the treatment of infections. Flavonoids such as apigenin and luteolin, It enhances the antioxidant effects of chamomile extract, which protect skin health. Chamomile Specific studies on the direct use of the extract in the treatment of dermatophytosis. Although limited, it is generally used in the treatment of fungal infections and skin irritations. It is thought that it can be used for infections such as nail fungus. It relieves inflammation and reduces itching on the palms of the fingers. Rosemary leaf oil (Rosmarinus officinalis) has antifungal properties and is used in the treatment of dermatophytosis. It has antibacterial and antioxidant properties. These properties are particularly evident in Trichophyton. It has been determined that this oil has an antifungal effect against dermatophyte fungi such as various types. by disrupting the membrane structure of fungal cells, thus preventing their growth and reproduction. It prevents infection. In addition, rosemary oil helps keep the skin healthy and prevents infection. It helps prevent the spread. Rosemary oil also has wound-healing effects. It is found here. The use of this oil promotes the renewal of skin cells. contributes to faster healing of skin damage caused by dermatophytosis It is located. Chrysanthemum indicum has antifungal and antibacterial properties. It contains various components. Thanks to the polysaccharides it contains, chrysanthemum plant extract, By supporting the immune system, it helps the body fight infections. It strengthens the skin's mechanisms. Additionally, chrysanthemum extract has a soothing effect on the skin. By creating [a specific method], it alleviates discomfort. 2 Witch hazel (Hamamelis virginiana) extract has anti-inflammatory, antioxidant and astringent properties. It is an ingredient known for its effects and commonly used in skincare products. Witch hazel Hazelnuts contain tannins, flavonoids, and other polyphenols, which give them anti-inflammatory and These compounds contribute to its antimicrobial properties. These compounds help reduce inflammation and protect the skin. It helps to have a calming effect on the skin. Sage leaf extract (Salvia officinalis) contains ursolic acid, an antioxidant compound. It is a triterpenoid compound with inflammatory and antifungal effects. Sage leaf The rosmarinic acid contained in its extract also has a potent effect on dermatophytosis. It provides antioxidant and anti-inflammatory effects. Thanks to the effects of its active ingredients. a potential alternative or complementary treatment in the development of dermatophytosis It makes it an option. In in vitro studies, sage extract inhibited the growth of these fungi and some It has been found to have an effect similar to traditional antifungal treatments. Furthermore, The antibacterial properties of sage can help with secondary fungal infections that may accompany them. It provides an additional benefit in preventing bacterial infections. Roman chamomile (Anthemis nobilis) is traditionally used in the treatment of skin diseases. It is a plant extract used and has anti-inflammatory, antimicrobial and antifungal properties. It has the following properties: Chamomile extract reduces inflammation in the skin and therefore helps with eczema and dermatitis. It is used in the treatment of inflammatory skin diseases such as those mentioned. Additionally, chamomile extract... It has wound-healing properties and is therefore used in the treatment of skin injuries. Anthemis nobilis flower extract contains the active ingredients bisabolol, apigenin, and chamazulene. It contains apigenin, a compound belonging to the flavonoid class, which has antifungal and antibacterial effects. It exists. It prevents the growth of dermatophytes by disrupting their cell walls and membranes. Bisabolol is a key component of chamomile oil and is known for its antifungal properties. by disrupting the integrity of the cell membrane and inhibiting cell metabolism It stops the growth of dermatophytes. Bisabolol reduces inflammation. It relieves the symptoms of infection. This includes reducing redness, swelling, and pain in the skin. provides. Melissa (Melissa officinalis), commonly known as lemon balm, is known for its antifungal properties. fungi, especially Trichophyton species, in terms of their effects on dermatophytosis Melissa extract has antifungal activity against these infections caused by This activity demonstrates that it disrupts fungal cell membranes and inhibits hyphae growth. 3 This occurs through various mechanisms, such as blocking. Containing phenolic compounds. melissa extract inhibits the proliferation of fungal cells and spore germination. It stops the spread of infection. Due to its tannin content, it inhibits fungal cells. It binds to proteins, disrupting the cell structure. It inhibits the growth of fungal cells. and disrupts the integrity of the cell wall, leading to the death of the fungi. Thyme (Thymus vulgaris) extract contains thymol, which may be effective in the treatment of dermatophytosis. It contains active ingredients such as carvacrol. It has antifungal, antibacterial, and anti-inflammatory properties. Due to its properties, this plant is used against dermatophyte fungal infections. Thymol, found in thyme... It is one of the main active ingredients and has strong antifungal properties. Dermatofit by disrupting the cell membranes and cell walls of fungi, causing the death of fungal cells. Thymol also has antibacterial properties and helps eliminate secondary bacterial growth on the skin. It helps prevent infections. Carvacrol is potent, similar to thymol. It has antifungal and antibacterial properties. It has similar active mechanisms. The agents target the fungal cell membranes, forcing the contents of the fungal cells to come out. It is effective in eliminating microorganisms by allowing them to seep through. At the same time, Carvacrol reduces inflammation, thus reducing redness and swelling caused by dermatophytosis. It alleviates the symptoms. Horsetail (Equisetum arvense) can be used in various treatments for dermatophytosis. It contains bioactive components. This plant has antifungal, anti-inflammatory and healing properties. It is known for its properties. Horsetail is known for its high silica content. Silica is a fungus. It weakens the structure of cells, leading to cell death. This property of silica... It inhibits the growth of dermatophytes. Silica supports skin health, which... It helps heal skin tissue damaged by dermatophytosis. Horsetail This herb is rich in flavonoids. It helps with fungal infections. It reduces inflammation and accelerates the skin's healing process. Flavonoids release free radicals. It reduces oxidative stress in the skin by neutralizing radicals, which contributes to the healing process. It is found. Marshmallow flower extract (Althaea officinalis) is used in traditional medicine for various skin conditions. It has been used in treatment. It is effective against fungal infections such as dermatophytosis. It contains several bioactive components that may be present. Marshmallow flower especially contains mucilage polysaccharides. It contains and is an important component, having soothing and moisturizing effects on the skin. It reduces irritation caused by fungal infections and helps the skin heal. Mucilage forms a protective barrier on the skin, which prevents fungi from getting onto the skin more easily. 4 It prevents further damage and helps the skin repair itself. At the same time... Marshmallow flower is rich in flavonoids. These compounds reduce inflammation and kill various microorganisms, including fungi. It has an antimicrobial effect. Flavonoids also have antioxidant properties. It has properties that protect skin cells from free radical damage and support the healing process. The soothing effect of mucilage calms skin irritated by dermatophytosis and It moisturizes. It also forms a protective barrier, preventing fungi from forming on the skin. It reduces its effect. The flavonoids and other components found in marshmallow flower protect skin cells. It protects against oxidative stress caused by free radicals and helps keep the skin healthy. provides. Yarrow extract (Achillea millefolium) is used for fungal infections such as dermatophytosis. It contains various bioactive components that may be effective against various ailments. It has antifungal, anti-inflammatory, and... It is known for its healing properties. The sesquiterpene lactones and volatile compounds found in yarrow. Oils have antifungal effects by targeting the fungal cell membrane and disrupting its integrity. It demonstrates the inhibition of enzymes in fungal cell walls. By doing so, it also prevents them from reproducing. These compounds inhibit the growth of dermatophytes. and prevents its reproduction. Yarrow is rich in flavonoids. These compounds, It reduces inflammation and protects against various microorganisms, including fungi. It exhibits antimicrobial effects. The tannins found in yarrow are bioactive components and They possess antimicrobial properties. These compounds inhibit the growth of dermatophyte fungi. It inhibits and prevents the spread of infection caused by dermatophytosis. It helps relieve symptoms by reducing inflammation and redness. Tannins and Flavonoids inhibit the growth of fungi as well as other pathogens. It helps control the infection. Coltsfoot extract (Tussilago farfara), due to its pyrrolizidine alkaloid content, helps with coughs. These are bioactive components found in the plant and possess antimicrobial properties. These compounds, It inhibits the growth of dermatophyte fungi and prevents the spread of infection. Pyrrolizidine alkaloids and tannins target the cell walls of dermatophyte fungi. By doing so, it prevents the growth and multiplication of fungal cells. This prevents the infection. It contributes to the healing process by preventing the spread of the disease. The tannins in cough grass... It helps to tighten the skin thanks to its astringent effect. Under known techniques, formulations containing tea tree oil are used to treat dermatophyte-derived substances. It has been shown to be effective in reducing symptoms in infections. However, the synergistic effects of different plant extracts have not yet been fully investigated. and are combined formulations containing multiple plant extracts, dermatophytes There are a limited number of studies examining its effectiveness against infections. In this context, tea tree oil is used in the treatment of dermatophyte infections. to present a formulation that targets the synergistic effects of different plant extracts Research and development work is required on existing inventions. In conclusion, all the problems mentioned above necessitate innovation in the relevant field. It has brought it to this state. THE PURPOSE OF THE INVENTION The present invention aims to eliminate the aforementioned problems and provide technical solutions in the relevant field. It aims to create an innovation. The main purpose of the invention is to treat keratinized skin, hair, and nails caused by dermatophytes. In the treatment of infections that infect tissues, it promotes recovery by reducing infection. Topical cosmetics containing tea tree oil and various herbal extracts to provide this. The goal is to reveal the structure of the formulations. Another aim of the invention is to alleviate the symptoms of dermatophytosis infections. Another aim of the invention is to prevent the spread of fungal infections on the skin and to treat fungal infections. to prevent its growth. One aim of the invention is to support the skin's natural defense mechanisms. The goal is to create a stronger barrier against infections. Another aim of the invention is to provide anti-inflammatory, antifungal and The goal is to offer antimicrobial effects while avoiding the side effects of chemical antifungal agents. A BRIEF DESCRIPTION OF THE INVENTION All the purposes mentioned above and those that will emerge from the detailed explanation below. The present invention aims to achieve infection of the keratin tissue in the skin, hair, and nails. to relieve symptoms and promote healing of dermatophyte-related infections 6 to provide formulation production containing tea tree oil and herbal extracts This is the method. Accordingly, to create the spray form... a) To form the oil phase, tea tree oil, rosemary oil and chrysanthemum oil Polysorbate 80 as a surfactant and Polyglycerol-2 as an emulsifier. Dipolyhydroxystearate is added and the mixture is placed in a reservoir at a temperature of 25-30°C. mixing b) In a separate reservoir, the active phase is formed by sequentially immersing the components in the solvent. Witch hazel, sage leaves, chamomile flowers, lemongrass, thyme, horsetail, By dissolving extracts of marshmallow flower, yarrow, and coltsfoot. mixing, c) Water is added to the oil phase obtained in step A and left for 30-40 minutes. mixing, d) The mixture obtained in step C is added to the mixture obtained in step B. addition of the active phase, e) The mixture obtained in step D is kept at a temperature of 25-30°C for 60-100 minutes. mixing in the homogenizer device for a specified period of time, f) The mixture obtained in step E is left to rest in the tank for 20-24 hours. waiting, g) The final mixture obtained in step F is transferred to containers using the filling machine. transfer, It includes the steps involved in the process. A preferred configuration of the invention is to create the spray form without an oil phase. Therefore, by removing steps a and b from the method, step c is introduced first. To form the xth active phase, tea tree extract and rosemary extract were added in that order. hydrosol, witch hazel, sage leaf, chamomile flower, lemongrass, thyme, horsetail, marshmallow flower, yarrow, and coltsfoot extracts at 25-30°C Dissolving and mixing with water at a temperature of 60-100 minutes, The mixture obtained in step y.x is left to stand for 30-40 minutes. to obtain a homogeneous form inside the homogenizer device It is mixed with citric acid as a stabilizer. 7 Another preferred configuration of the invention involves eliminating method steps a and b and using method c. before the step x. Tea tree oil and surfactant to form the oil active phase. mixing and homogenization in a homogenizer device at room temperature Polyglycerol-2-dipolyhydroxystearate and polysorbate to provide a mixture and the addition of polysorbate 80 as a surfactant at a temperature of 25-30°C, y. Rosemary hydrosol, chrysanthemum, witch hazel to form the water active phase. hazelnuts, sage leaves, chamomile, thyme, horsetail, marshmallow flower The process involves dissolving and mixing the extracts in water. A preferred configuration of the invention is to form a spray form using a, b, c, d and e. method steps are removed by sequentially prioritizing method step f. x. To form the oil active phase, tea tree oil and rosemary oil are added in that order. oil, chrysanthemum oil, chamomile oil, thyme oil as carrier oil Homogenizer device in caprylic / capric triglyceride at 25-30°C mixing inside for 30-40 minutes, Dicaprylyl is added as a softener to the oil phase obtained in step y.a of the process. Homogenizer used to obtain a homogeneous form by adding carbonate. The mixture should be stirred inside the device at a temperature of 25-30°C for 30-40 minutes. Another preferred configuration of the invention is to form the solution using a, b, c and by removing method d steps and before method e step x. Capric triglyceride to form the oil phase and glyceryl as an emulsifier. Mixing behenate at a temperature of 65-70°C, y. To form the active phase, tea tree oil and clove oil are added in that order. bud oil, lavender flower oil, sweet almond oil and propolis extract It is mixed by dissolving it in undecyclic acid. A preferred configuration of the invention is to create cream and ointment forms; before process step a x1. Carbomer is used as a thickener to form the A phase of emulsion, Mixing triethanolamine and water as an emulsifier at a temperature of 75-80°C, 8 Propylene glycol is used as a solvent in the mixture obtained in step x2.x1. by adding and mixing at a temperature of 75-80°C, x3. In a second chamber, the surfactant is used to form the emulsion B phase. polyoxyethylene (25) cetyl / stearyl ether as a substance, stearic acid as an emulsifier and cetyl stearyl alcohol as an emulsion stabilizer at a temperature of 75-80°C mixing, Implementation of method step a and methods b, c and d after method step a by removing the steps and prioritizing method e before method f  The mixtures obtained in steps x2, x3 and a are homogenized in the homogenizer device. for 30-40 minutes until a homogeneous form is obtained inside. mixing,  Preservative is added to the resulting mixture at a temperature of 30-40°C and left for 60-100 minutes. It is the mixing of substances over time. Another preferred configuration of the invention is to create the oil phase in process step a. by weight  Tea Tree Oil (Melaleuca Alternifolia) in a concentration of 5-20%  Rosemary oil (Rosmarinus Officinalis) in a concentration of 0.5-2%  Chrysanthemum oil at a concentration of 0.3-1% In step b, by weight, to form the active phase  Witch Hazel Extract (Hamamelis Virginiana) in a concentration of 1.5-5%  Sage Leaf Extract (Salvia Officinalis) in a concentration of 0.3-1%  Chamomile Flower Extract (Anthemis Nobilis) at a concentration of 0.3-1%  0.3-1% concentration of Melissa Extract (Melissa Officinalis)  Thyme Extract (Thymus Vulgaris) in a concentration of 0.3-1%  Horsetail Extract (Equisetum Arvense) in the range of 0.3-1%  Marshmallow Flower Extract (Althaea Officinalis Root) at a concentration of 0.3-1%  Yarrow Extract (Achillea Millefolium) at a concentration of 0.3-1%  Coltsfoot Leaf Extract (Tussilago Farfara) at a concentration of 0.3-1% It includes. 9 A preferred configuration of the invention is to form the active phase at process step x. by weight  5-10% Tea Tree Extract (Melaleuca Alternifolia)  0.5-2% Rosemary Hydrosol (Rosmarinus Officinalis)  0.3-1% Chrysanthemum Extract  1.5-5% Witch Hazel Extract (Hamamelis Virginiana)  0.3-1% Sage Leaf Extract (Salvia Officinalis)  0.3-1% Chamomile Extract (Anthemis Nobilis)  0.1-2% Thyme Extract (Thymus Vulgaris)  0.3-1% Horsetail Extract (Equisetum Arvense) It includes. Another preferred configuration of the invention is the oil active phase at process step x. to form by weight  5-10% Tea Tree Oil Extract (Melaleuca Alternifolia) In step y of the process, water is used to form the active phase by weight.  0.5-2% Rosemary Hydrosol (Rosmarinus Officinalis)  0.3-1% Chrysanthemum Extract  1.5-5% Witch Hazel Extract (Hamamelis Virginiana)  0.3-1% Sage Leaf Extract (Salvia Officinalis)  0.3-1% Chamomile Extract (Anthemis Nobilis)  0.1-2% Thyme Extract (Thymus Vulgaris)  0.3-1% Horsetail Extract (Equisetum Arvense)  0.3-1% Marshmallow Flower Extract (Althaea Officinalis Root) It includes. A preferred configuration of the invention is to form the oil active phase at process step x. by weight  5-10% Tea Tree Oil (Melaleuca Alternifolia)  0.5-2% Rosemary Oil (Rosmarinus Officinalis)  0.3-1% Chrysanthemum Oil  0.3-1% Chamomile Extract (Anthemis Nobilis)  0.1-2% Thyme Oil (Thymus Vulgaris) It includes. Another preferred configuration of the invention is to create the oil phase at process step x. by weight  Capric triglycerides in the range of 69.40-80%  Glyceryl behenate as an emulsifier in the range of 3-5% In step y of the process, the active phase is formed by weight.  1-5% Clove Bud Oil (Eugenia Caryophyllus)  0.3-1% Lavender Flower Oil (Lavendula Angustofolia)  5-10% Sweet Almond Oil (Prunus Amygdalus Dulcis)  0.2-1% Undecyclic Acid  69.40-80% Capric Triglycerides It includes. Another preferred configuration of the invention is to create the oil phase in process step d. by weight  5-10% Tea Tree Oil (Melaleuca Alternifolia)  0.1-3% Rosemary Oil (Rosmarinus Officinalis)  0.3-1% Chrysanthemum Oil  0.3-1% Chamomile Extract It includes. DETAILED DESCRIPTION OF THE INVENTION This detailed explanation concerns the invention of tea in the treatment of dermatophytosis infections. The use of tree oil and plant extract-based formulations is solely related to the subject matter. with examples that will not create any limiting effects so that it can be understood better It is explained. 11 The invention aims to improve dermatophyte-related infections by reducing infection. formulations for topical application of tea tree oil It is concerned with the formulation of combinations with different plant extracts. Traditional antifungal treatments often contain chemical components and are long-term. Their use leads to side effects, resistance development, and skin irritation. In this context, The invention offers a natural and effective solution against dermatophyte infections: tea tree oil. It contains the synergistic effects of (Melaleuca Alternifolia) and other herbal extracts. This The components offer a faster and safer approach to eliminating infection while remaining on the skin. compared to traditional methods in reducing irritation and supporting the healing process. It provides significant advantages. The preferred configuration of the invention is to create a spray form. a) To form the oil phase, tea tree oil, rosemary oil and chrysanthemum oil Polysorbate 80 is added as a surfactant and C12-13 Pareth-9 as an emulsifier. and mixed in a container at a temperature of 25-30°C, b) To form the active phase in a separate container, sequentially in ethyl alcohol... Witch hazel, sage leaves, chamomile flowers, lemongrass, thyme, horsetail, By dissolving extracts of marshmallow flower, yarrow, and coltsfoot. mixing, c) Water is added to the oil phase obtained in step A and left for 30-40 minutes. mixing, d) The mixture obtained in step C is added to the mixture obtained in step B. addition of the active phase, e) The mixture obtained in step D is kept at a temperature of 25-30°C for 60-100 minutes. mixing in the homogenizer device for a specified period of time, f) The mixture obtained in step E is left to rest in the tank for 20-24 hours. waiting, g) The final mixture obtained in step F is transferred to containers using the filling machine. transfer, It includes the steps involved in the process. 12 Content by Weight Percentage Tea Tree Oil (Melaleuca alternifolia) 5-20% Rosemary Oil (Rosmarinus officinalis) 0.5-2% Chrysanthemum Oil (0.3-1%) boreale) Witch Hazel Extract (Hamamelis 1.5-5%) (Virginia) Sage Leaf Extract (Salvia 0.3-1%) officinalis) Chamomile Flower Extract (Anthemis 0.3-1%) nobilis) Melissa Extract (Melissa officinalis) 0.3-1% Thyme Extract (Thymus vulgaris) 0.3-1% Horsetail Extract (Equisetum 0.3-1%) arvense) Marshmallow Flower Extract (Althaea officinalis 0.3-1%) root) Yarrow Extract (Achillea 0.3-1%) millefolium) Coltsfoot Leaf Extract (Tussilago 0.3-1%) braggart) C12-13 Pareth-9 4.5-10% Polysorbate 80 5-10% Ethyl alcohol 1-5% Fragrance 3-5% Table 1: Spray form content as the preferred alternative formulation of the invention. This formulation uses tea tree oil to combat dermatophyte-related skin infections. (Melaleuca alternifolia), rosemary oil (Rosmarinus officinalis), chrysanthemum oil (Chrysanthemum boreale), witch hazel (Hamamelis virginiana), sage (Salvia officinalis), chamomile (Anthemis nobilis), lemon balm (Melissa officinalis, thyme (Thymus) vulgaris), horsetail (Equisetum arvense), hollyhock (Althaea officinalis root), extracts of yarrow (Achillea millefolium) and coltsfoot (Tussilago farfara) Their synergistic effects are utilized. Tea tree (Melaleuca alternifolia), rosemary 13 (Rosmarinus officinalis), thyme (Thymus vulgaris) and lemon balm (Melissa officinalis), for example. The components target fungal cells with their strong antifungal properties, while chamomile (Anthemis nobilis), witch hazel (Hamamelis virginiana), marshmallow flower (Althaea officinalis) Soothing herbs such as coltsfoot (root) and cough grass (Tussilago farfara) relieve skin irritation and It relieves inflammation. Horsetail extract (Equisetum arvense) has a high silica content. While supporting skin health, yarrow (Achillea millefolium) has anti-inflammatory effects. It contributes to the healing process of the infection. Emulsifier and surfactant, oil and water. It creates a stable formulation by ensuring homogeneous mixing of the phases; the solvent is... It contributes to the dissolution of the components. The pleasant fragrance enhances the user experience. It improves and completes the formulation. C12-13 Pareth-9 is a nonionic alcohol obtained from lauryl and myristyl (C12-13) fatty alcohols. It is a surfactant and an ethoxylated alcohol. The preferred alternative formulation of the invention is to create a spray form. a) To form the active phase, tea tree extract, rosemary hydrosol, in that order, Witch hazel, sage leaves, chamomile flowers, lemongrass, thyme, horsetail, Marshmallow flower, yarrow, and coltsfoot extracts are heated to 25-30°C for 60 minutes. Dissolving and stirring with water for 100 minutes, b) The mixture obtained in step a is homogenized for 30-40 minutes. Citric acid is used as a stabilizer to obtain a homogeneous form inside the device. mixing with acid, c) Adding a preservative to the mixture obtained in step b and mixing it, d) The mixture obtained in step c is left to rest in a tank for 20-24 hours. waiting, e) The final mixture obtained in step d is transferred to containers using the filling machine. transfer, It includes the steps involved in the process. Content by Weight Percentage Tea Tree Extract (Melaleuca 5-10%) alternifolia) Rosemary Hydrosol (Rosmarinus 0.5-2%) officinalis) 14 Chrysanthemum Extract (0.3-1%) boreale) Witch Hazel Extract (Hamamelis 1.5-5%) (Virginia) Sage Extract (Salvia officinalis) 0.3-1% Chamomile Extract (Anthemis nobilis) 0.3-1% Thyme Extract (Thymus vulgaris) 0.1-2% Horsetail Extract (Equisetum 0.3-1%) arvense) Citric Acid 0.01-0.2% Preservative 1-3% Water 73.80-90.69% Table 2: Spray form content as the preferred alternative formulation of the invention. This formulation contains tea tree extract (Melaleuca), which is effective against dermatophyte infections. rosemary hydrosol (Rosmarinus officinalis), chrysanthemum (Chrysanthemum alternifolia), witch hazel (Hamamelis virginiana), sage (Salvia officinalis), chamomile (Anthemis nobilis), thyme (Thymus vulgaris) and horsetail (Equisetum arvense). Herbal ingredients were used. Tea tree (Melaleuca alternifolia) and thyme extracts. (Thymus vulgaris) targets fungal cells with its strong antifungal properties, while witch hazel extracts of hazelnut (Hamamelis virginiana) and chamomile (Anthemis nobilis) have anti- It soothes skin irritation with its anti-inflammatory effects. Rosemary hydrosol (Rosmarinus officinalis) and horsetail (Equisetum arvense), promotes skin health and healing of infected areas. It speeds up the process. Chrysanthemum (Chrysanthemum boreale) contributes to alleviating the infection. While providing these benefits, sage (Salvia officinalis) has antioxidant and antimicrobial effects on the skin. It forms a protective barrier. The stabilizer maintains the homogeneity of the formulation, Preservatives increase the product's shelf life and ensure its reliability. To create a spray form in a preferred alternative configuration of the invention. a) Tea tree oil and surfactant to form the oil active phase. mixing in a homogenizer device at room temperature and obtaining a homogeneous mixture. C12-13 Pareth-9 and polysorbate 20 were used to provide the mixture, and as a surfactant... Addition of polysorbate 80 at a temperature of 25-30°C, b) To form the aqueous active phase, rosemary hydrosol, chrysanthemum, witch hazel extracts of hazelnut, sage leaf, chamomile, thyme, horsetail, and marshmallow flower by dissolving and mixing it in water, c) the oil phase obtained in process step a and the water obtained in process step b The phase is homogenized until a homogeneous form is obtained in the homogenizer device. 30- Mixing for 40 minutes, d) As a stabilizer, the mixture obtained in step d is added at a temperature of 25-30°C. Citric acid is added and the mixture is homogenized in a homogenizer for 60-100 minutes. mixing, e) The mixture obtained in step e is left to rest in a resting tank for 20-24 hours. waiting, f) The final mixture obtained in step f is transferred to containers by the filling machine. transfer, It includes the steps involved in the process. Content by Weight Percentage Tea Tree Oil (Melaleuca Alternifolia) 5-10% Rosemary Hydrosol (Rosmarinus 0.5-2%) Officinalis) Chrysanthemum Extract 0.3-1% Witch Hazel Extract (Hamamelis 1.5-5%) Virginiana) Sage Extract (Salvia Officinalis) 0.3-1% Chamomile Extract (Anthemis Nobilis) 0.3-1% Thyme Extract (Thymus Vulgaris) 0.1-2% Horsetail Extract (Equisetum 0.3-1%) Arvense) Marshmallow Flower Extract (Althaea 0.3-1%) (Officinalis Root) Citric acid 0.01-0.2% Preservative 1-3% Ethyl alcohol 7-10% C12-13 Pareth-9 4.5-6.5% 16 Polysorbate 20 2.0-5.0% Polysorbate 80% 5-10 Water 21.3-71.89% Table 3: Spray form content as the preferred alternative formulation of the invention. This formulation contains tea tree oil (Melaleuca alternifolia), which has antiseptic and antibacterial properties. Its properties make it widely used in skincare products. Rosemary hydrosol. (Rosmarinus officinalis) revitalizes the skin with its antioxidant effect, while improving blood circulation. It supports chrysanthemum boreale extract, which has anti-inflammatory properties. It soothes skin irritations. Witch hazel extract (Hamamelis virginiana) protects the skin. While known for its firming effect, sage extract (Salvia officinalis) balances the oil levels in the skin. It provides. Chamomile extract (Anthemis nobilis) soothes and relaxes the skin with its calming effect. It is used in the care of plants. Thyme extract (Thymus vulgaris) has antibacterial and antifungal properties. It has the following properties. Horsetail extract (Equisetum arvense) increases skin elasticity, Marshmallow flower extract (Althaea oficinalis root) moisturizes and protects the skin. These components... In addition, stabilizers, preservatives, solvents, and emulsifiers enhance the effectiveness of the formula. By increasing its effectiveness, it extends the product's shelf life and makes it compatible with the skin. To create a spray form in a preferred alternative configuration of the invention. a) To form the oil active phase, tea tree oil, rosemary oil, in that order: chrysanthemum oil, chamomile oil, thyme oil are used as carrier oils with caprylic / capric acid. Triglycerides are mixed in a homogenizer at a temperature of 25-30°C for 30-40 minutes. stirring for a period of minutes, b) Dicaprylyl carbonate as a softener in the oil phase obtained in process step a. and by adding caprylyl glycol as a preservative to obtain a homogeneous form. inside the homogenizer device at a temperature of 25-30°C for 30-40 minutes. mixing, c) The mixture obtained in step b is left to rest in the tank for 20-24 hours. waiting, d) The final mixture obtained in step c is transferred to containers using the filling machine. transfer, It includes the steps involved in the process. 17 Content by Weight Percentage Tea Tree Oil (Melaleuca alternifolia) 5-10% Rosemary Oil (Rosmarinus officinalis) 0.5-2% Chrysanthemum Oil (0.3-1%) boreale) Chamomile Oil (Anthemis Nobilis) 0.3-1% Thyme Oil (Thymus Vulgaris) 0.1-2% Caprylic / capric triglycerides 10-20% Caprylyl glycol 1-3% Dicaprylyl carbonate 61-82.60% Table 4: Spray form content as the preferred alternative formulation of the invention. This formulation contains tea tree oil (Melaleuca alternifolia), a powerful antiseptic and With its antibacterial properties, rosemary helps treat skin infections. oil (Rosmarinus officinalis) revitalizes the skin while providing antioxidant effects against aging. It reduces the symptoms. Chrysanthemum boreale oil is relaxing and soothing. It has properties that relieve skin irritations. Chamomile oil (Anthemis nobilis) soothes the skin. It reduces inflammation and redness on the skin and is known for its calming effect. Thyme oil Thymus vulgaris, with its antibacterial and antifungal properties, cleanses the skin of microbes. Carrier oils allow essential oils to interact better with the skin, moisturizing it while doing so. They nourish. Preservatives extend the shelf life of products, maintaining their effectiveness, while emollients moisturize the skin. It softens and smooths the texture. In the preferred alternative configuration of the invention, to form the solution. a) Capric triglyceride to form the fat phase and glyceryl as an emulsifier. Mixing behenate at a temperature of 65-70°C, b) To form the active phase, tea tree oil and clove bud oil, in that order. oil, lavender flower oil, sweet almond oil and propolis extract Dissolving and mixing in undecyclic acid, c) Water is added to the oil phase obtained in step a) and homogenized. The mixture should be left in the device for 30-40 minutes until a homogeneous form is obtained. mixing, d) The active ingredient obtained in step b is added to the mixture obtained in step c. mixing of the phase and adding vitamin E as a preservative, 18 e) Allow the mixture obtained in step d to rest for 20-24 hours. being kept in the tank, f) The final mixture obtained in step e is transferred to containers by the filling machine. transfer, It includes the steps involved in the process. Content by Weight Percentage Caprylic / capric triglycerides 69.40-80% Glyceryl Behenate 3-5% Undecyclic Acid 0.2-1% Tea Tree Oil (Melaleuca alternifolia) 20-50% Clove Bud Oil (Eugenia 1-5%) caryophyllus) Lavender Flower Oil (Lavendula 0.3-1%) angustofolia) Sweet Almond Oil (Prunus amygdalus 5-10%) dulcis) Propolis extract 0.1-2% Vitamin E 1-3% Table 5: Solution form content as the preferred alternative configuration of the invention. In this formulation, Capric Triglyceride is easily absorbed by the skin and has moisturizing properties. It is a carrier oil that provides a characteristic effect. Emulsifiers mix water and oil-based components. It ensures the formula is homogeneous. Undecyclic Acid regulates the skin's pH balance and has anti- It offers anti-inflammatory effects. Tea Tree Oil (Melaleuca Alternifolia) is antibacterial and... With its antifungal properties, clove helps treat skin infections. Eugenia caryophyllus bud oil has antimicrobial properties that kill microbes on the skin. While cleansing, Lavender Flower Oil (Lavendula Angustofolia) has a calming and relaxing effect. It provides beneficial effects. Sweet almond oil (Prunus Amygdalus Dulcis) nourishes, moisturizes, and It softens the skin. Propolis extract protects the skin with its antioxidant and antibacterial properties. Preservatives, on the other hand, extend the shelf life of the formula, ensuring the effectiveness and safety of the product. The combination of these components provides a healing effect. The preferred alternative formulation of the invention involves creating a cream and ointment form. on 19 a) Carbomer as a thickener to form the A phase of the emulsion, Mixing triethanolamine and water as an emulsifier at a temperature of 75-80°C, b) By adding propylene glycol as a solvent to the mixture obtained in step a) Mixing at a temperature of 75-80°C, c) surfactant to form emulsion phase B in a second reservoir polyoxyethylene (25) cetyl / stearyl ether as a substance, stearic acid as an emulsifier and cetyl stearyl alcohol as an emulsion stabilizer at a temperature of 75-80°C mixing, d) rosemary oil to form the oil phase in a third chamber, chrysanthemum oil, chamomile extract and tea tree oil, surfactant and mixing the fabric softener at a temperature of 30-40°C, e) The mixtures obtained in steps b, c and d are placed in the homogenizer device. for 30-40 minutes until a homogeneous form is obtained inside. mixing, f) A preservative is added to the mixture obtained in step e at a temperature of 30-40°C. Mixing for 60-100 minutes, g) The mixture obtained in step f is left to rest in the tank for 20-24 hours. waiting, h) The final mixture obtained in step g is transferred to containers by the filling machine. transfer, It includes the steps involved in the process. Content by Weight Percentage Tea Tree Oil (Melaleuca alternifolia) 5-10% Rosemary Oil (Rosmarinus officinalis) 0.1-3% Chrysanthemum Oil (0.3-1%) boreale) Chamomile extract 0.3-1% Glycerin 1-5% Water 75-85% Carbomer 0.3-1% Triethanolamine (TEA) 0.2-1% Propylene Glycol 3-10% Glyceryl Stearate (and) PEG-100 Stearate 1-5% Stearic acid 1-5% Polyoxyethylene (25) cetyl / stearyl ether 5-10% Cetyl Stearyl Alcohol 2-10% Glycerin 1-5% Citric Acid 0.05-0.1% Table 6: Cream and ointment form as the preferred alternative formulation of the invention. content This formulation contains tea tree oil (Melaleuca alternifolia), a powerful antiseptic and While possessing antibacterial properties, rosemary oil (Rosmarinus officinalis) revitalizes the skin. It offers antioxidant effects. Chrysanthemum oil (Chrysanthemum boreale) soothes skin irritations. While soothing, chamomile extract exhibits calming properties and It reduces inflammation. Glycerin moisturizes the skin and prevents water loss, while water is the key component of the formula. It is a carrier substance. Triethanolamine and stearic acid mix with oil and water-based components. It ensures the formation of a stable emulsion. Solvents enable the components to function effectively. It helps in dissolution. The emulsion stabilizer maintains the homogeneity of the formula. Emollients smooth and soften the skin, while preservatives extend the product's shelf life. It ensures its effectiveness by extending its lifespan. The scope of protection of the invention is specified in the claims attached hereto, and these details are strictly adhered to. The explanation cannot be limited to those given for illustrative purposes. Because a technically skilled person... the person, without deviating from the main theme of the invention, in light of what has been described above, similar It is clear that these structures can emerge. 21

Claims

1. The invention relates to a disease caused by dermatophytes that infect the keratinized tissue of the skin, hair, and nails. Tea tree oil to alleviate symptoms of infections and promote healing. The formulation production method involves oils and plant extracts; its characteristic feature is that it is produced in a spray. to create the form a) To form the oil phase, tea tree oil, rosemary oil and chrysanthemum oil Polysorbate 80 as a surfactant and Polyglycerol-2 as an emulsifier. Dipolyhydroxystearate is added and the mixture is placed in a reservoir at a temperature of 25-30°C. mixing b) In a separate reservoir, the active phase is formed by sequentially immersing the components in the solvent. Witch hazel, sage leaves, chamomile flowers, lemongrass, thyme, horsetail, By dissolving extracts of marshmallow flower, yarrow, and coltsfoot. mixing, c) Water is added to the oil phase obtained in step A and left for 30-40 minutes. mixing, d) The mixture obtained in step C is added to the mixture obtained in step B. addition of the active phase, e) The mixture obtained in step D is kept at a temperature of 25-30°C for 60-100 minutes. mixing in the homogenizer device for a specified period of time, f) The mixture obtained in step E is left to rest in the tank for 20-24 hours. waiting, g) The final mixture obtained in step F is transferred to containers using the filling machine. transfer, It is characterized by including the process steps.

2. This method conforms to Claim 1 and its characteristic feature is that it creates a spray form without an oil phase. Therefore, by removing steps a and b from the method, step c is introduced first. To form the xth active phase, tea tree extract and rosemary extract were added in that order. hydrosol, witch hazel, sage leaf, chamomile flower, lemongrass, thyme, horsetail, marshmallow flower, yarrow, and coltsfoot extracts at 25-30°C Dissolving and mixing with water at a temperature of 60-100 minutes, 22 The mixture obtained in step y.x is left to stand for 30-40 minutes. to obtain a homogeneous form inside the homogenizer device mixing with citric acid as a stabilizer, It is characterized by including the process steps.

3. This is a method that conforms to Claim 1, and its characteristic is that steps a and b are removed, resulting in method c. before the method step x. Tea tree oil and surfactant to form the oil active phase. mixing and homogenization in a homogenizer device at room temperature Polyglycerol-2-dipolyhydroxystearate and polysorbate to provide a mixture and the addition of polysorbate 80 as a surfactant at a temperature of 25-30°C, y. Rosemary hydrosol, chrysanthemum, witch hazel to form the water active phase. hazelnuts, sage leaves, chamomile, thyme, horsetail, marshmallow flower The extracts are dissolved and mixed in water. It is characterized by including the process steps.

4. The method conforming to Claim 1, characterized by the use of a, b, c, d to form a spray. and method steps e are removed and prioritized before method step f, respectively. x. To form the oil active phase, tea tree oil and rosemary oil are added in that order. oil, chrysanthemum oil, chamomile oil, thyme oil as carrier oil Homogenizer device in caprylic / capric triglyceride at 25-30°C mixing inside for 30-40 minutes, Dicaprylyl is added as a softener to the oil phase obtained in step y.a of the process. Homogenizer used to obtain a homogeneous form by adding carbonate. Mixing inside the device at a temperature of 25-30°C for 30-40 minutes. It is characterized by including the process steps.

5. The method conforming to Claim 1, characterized by the use of a, b, c to form the solution. and by removing method d steps and before method e step x. Capric triglyceride to form the oil phase and glyceryl as an emulsifier. Mixing behenate at a temperature of 65-70°C, y. To form the active phase, tea tree oil and clove oil are added in that order. bud oil, lavender flower oil, sweet almond oil and propolis extract Dissolving and mixing in undecyclic acid, 23 It is characterized by including the process steps.

6. The invention relates to a dermatophyte-derived substance that infects the keratin tissue of the skin, hair, and nails. Tea tree oil to alleviate symptoms of infections and promote healing. The formulation production method involves oils and plant extracts; its characteristic feature is that it is a cream. and to form the ointment; before process step a x1. Carbomer is used as a thickener to form the A phase of emulsion, Mixing triethanolamine and water as an emulsifier at a temperature of 75-80°C, Propylene glycol is used as a solvent in the mixture obtained in step x2.x1. by adding and mixing at a temperature of 75-80°C, x3. In a second chamber, the surfactant is used to form the emulsion B phase. polyoxyethylene (25) cetyl / stearyl ether as a substance, stearic acid as an emulsifier and cetyl stearyl alcohol as an emulsion stabilizer at a temperature of 75-80°C mixing, Implementation of method step a and methods b, c and d after method step a by removing the steps and prioritizing method e before method f  The mixtures obtained in steps x2, x3 and a are homogenized in the homogenizer device. for 30-40 minutes until a homogeneous form is obtained inside. mixing,  Preservative is added to the resulting mixture at a temperature of 30-40°C and left for 60-100 minutes. mixing for a period of time, It is characterized by including the process steps.

7. This method conforms to Claim 1 and its characteristic is that it forms the oil phase in process step a. by weight  Tea Tree Oil (Melaleuca Alternifolia) in a concentration of 5-20%  Rosemary oil (Rosmarinus Officinalis) in a concentration of 0.5-2%  Chrysanthemum oil at a concentration of 0.3-1% In step b, by weight, to form the active phase 24  Witch Hazel Extract (Hamamelis Virginiana) in a concentration of 1.5-5%  Sage Leaf Extract (Salvia Officinalis) in a concentration of 0.3-1%  Chamomile Flower Extract (Anthemis Nobilis) at a concentration of 0.3-1%  0.3-1% concentration of Melissa Extract (Melissa Officinalis)  Thyme Extract (Thymus Vulgaris) in a concentration of 0.3-1%  Horsetail Extract (Equisetum Arvense) in the range of 0.3-1%  Marshmallow Flower Extract (Althaea Officinalis Root) at a concentration of 0.3-1%  Yarrow Extract (Achillea Millefolium) at a concentration of 0.3-1%  Coltsfoot Leaf Extract (Tussilago Farfara) at a concentration of 0.3-1% It includes.

8. This method complies with claim 2 and its characteristic is to form the active phase at process step x. by weight  5-10% Tea Tree Extract (Melaleuca Alternifolia)  0.5-2% Rosemary Hydrosol (Rosmarinus Officinalis)  0.3-1% Chrysanthemum Extract  1.5-5% Witch Hazel Extract (Hamamelis Virginiana)  0.3-1% Sage Leaf Extract (Salvia Officinalis)  0.3-1% Chamomile Extract (Anthemis Nobilis)  0.1-2% Thyme Extract (Thymus Vulgaris)  0.3-1% Horsetail Extract (Equisetum Arvense) It includes.

9. This method complies with claim 3 and its characteristic is that it removes the oil active phase at process step x. to form by weight  5-10% Tea Tree Oil Extract (Melaleuca Alternifolia) In step y of the process, water is used to form the active phase by weight.  0.5-2% Rosemary Hydrosol (Rosmarinus Officinalis)  0.3-1% Chrysanthemum Extract  1.5-5% Witch Hazel Extract (Hamamelis Virginiana)  0.3-1% Sage Leaf Extract (Salvia Officinalis)  0.3-1% Chamomile Extract (Anthemis Nobilis)  0.1-2% Thyme Extract (Thymus Vulgaris)  0.3-1% Horsetail Extract (Equisetum Arvense)  0.3-1% Marshmallow Flower Extract (Althaea Officinalis Root) It includes.

10. This method complies with claim 4 and its characteristic is that the oil active phase is removed at process step x. to form by weight  5-10% Tea Tree Oil (Melaleuca Alternifolia)  0.5-2% Rosemary Oil (Rosmarinus Officinalis)  0.3-1% Chrysanthemum Oil  0.3-1% Chamomile Extract (Anthemis Nobilis)  0.1-2% Thyme Oil (Thymus Vulgaris) It includes.

11. This method complies with claim 5 and its characteristic is to form the oil phase at process step x. by weight  Capric triglycerides in the range of 69.40-80%  Glyceryl behenate as an emulsifier in the range of 3-5% In step y of the process, the active phase is formed by weight.  1-5% Clove Bud Oil (Eugenia Caryophyllus)  0.3-1% Lavender Flower Oil (Lavendula Angustofolia)  5-10% Sweet Almond Oil (Prunus Amygdalus Dulcis)  0.2-1% Undecyclic Acid  69.40-80% Capric Triglycerides It includes.

12. This method complies with Claim 6 and its characteristic is that it forms the oil phase in process step d. by weight  5-10% Tea Tree Oil (Melaleuca Alternifolia)  0.1-3% Rosemary Oil (Rosmarinus Officinalis)  0.3-1% Chrysanthemum Oil  0.3-1% Chamomile Extract It includes. 26