A DEVICE AND METHOD FOR INDIVIDUALIZED MEDICINE AND PERSONALIZED PHARMACY.

Abstract

The invention relates to a device and method for individualized medicine and personalized pharmacy that functions to manage polypharmacy, improve patient adherence, and transform healthcare by combining dosages and drug combinations tailored to individual patient needs into a single dosage form.

Description

1 TARIFF A FOR INDIVIDUALIZED MEDICINE AND PERSONALIZED PHARMACY. DEVICE AND METHOD Technical Area The invention provides a device and method for individualized medicine and personalized pharmacy. It is related. The invention is particularly useful for managing polypharmacy and improving patient compliance. and dosage tailored to individual patient needs to transform healthcare services. It performs the function of combining drug combinations into a single dosage form. It relates to a device and method for individualized medicine and personalized pharmacy. The Invention's Infrastructure Cardiovascular diseases, heart disease, HIV, and tuberculosis-like diseases Patients generally take four or more medications, administered at different times and on different occasions. Taking them in tablet form makes patients feel unwell and reduces adherence to medication. It reduces their rates. Today, the use of multiple drugs (polypharmacy) is common, especially in elderly and chronically ill patients. This poses a serious problem. In patients using multiple medications, the medication... Non-compliance increases health risks and also raises treatment costs. 25 Studies show that poor medication adherence costs the healthcare system billions of dollars annually. This indicates that it imposes a burden. The rate of drug non-compliance in cardiovascular patients. That's approximately 50%. In the US, the healthcare cost of medication non-compliance is $289 billion annually. It is found. 30 Licensing problems and pharmaceutical company resistance in the combined production of drugs. This is the case. Fixed-dose combination multiple drugs (polypill) are used to treat patients. It can improve compliance and prevent cardiovascular events. 2 Polypill containing 4-5 drugs is currently produced in limited quantities only at large pharmaceutical factories. It can be produced but has limited commercial access. These fixed-dose combination drugs (Polypil) are inexpensive, suitable for production, and low-income. It should be suitable for widespread use in countries. Secondary 5 in low-income countries. The biggest obstacles to prevention are medication adherence and access to treatment. A joint study prepared by WHO (World Health Organization) and Wellcome in 2008 The report mentions that Polipil is being tested for secondary prevention of cardiovascular disease. Instead of long-term studies, they considered bioequivalence sufficient. Because individual drugs have a long-term impact on reducing morbidity and mortality. Periodical studies have already been completed. Currently, organizations like WHO and Wellcome focus on cardiovascular diseases. Although he suggested the production of polypill for diseases such as HIV and tuberculosis, these drugs are only available after 15 years. It can be produced by large pharmaceutical companies, but due to licensing problems... It is not becoming widespread. Polypiles are not in widespread use. They are only used in specialized, pioneering research projects. They can be prepared and given to the patients in the study group. 20 The current polypill dosage range and the fact that it does not allow for patient-specific dose adjustment. Another limiting factor in its use is... Due to side effects from any of the standard doses in current polypill systems, 25 The patient may also discontinue 3-4 other beneficial medications. However, when using the medications individually... If a side effect occurs with any of the medications, the others can be continued and the medication causing the side effect can be avoided. It can be changed. The drugs considered for polypill are generally older, post-patented, and generic, numbering around 30. This is considered true when considering the original content, but the original company... or generic companies may pursue secondary patenting of these drugs through coformulation. The trend continues. Evidence suggests that companies are developing new co-formulations close to patent expiration dates. 3 This shows that, in addition to other factors, it tends to develop and maintain a monopoly in the market. Therefore, the routine production and use of polypiles remain limited. Policapr devices are dispensed by pharmacists according to a doctor's prescription, tailored to the specific patient. It can prepare medications in specific doses. Users can save time with this system. and while saving effort, treatment processes are made easier and safer. They can continue to do so. Policapr combines practicality and patient comfort in modern healthcare solutions. It is a new generation approach that brings them together. Compounding pharmacy is especially important for children and elderly patients. It is a critical solution. However, this process carries some serious risks: incorrect dosage and Content errors, risk of contamination, medication due to incorrect concentration. The effects of Policapr minimize these risks that arise in the production of compound drugs. It offers an innovative system. With precise dosage control, it eliminates the risk of incorrect dosage; The closed system and UV disinfection prevent the risk of contamination; Error 15 It includes automated formulation technology that reduces the dosage; personalized and safe medicine. It minimizes the risk of errors by ensuring efficient production. Polymer sandwiches used in polypile technology hold different active pharmaceutical ingredients (APIs). It enables controlled and targeted delivery through release mechanisms and drug 20 It increases the effectiveness of treatment while minimizing the risk of side effects. Immediate Release. (Immediate Release): Polymer sandwiches dissolve rapidly, releasing their active ingredients. It releases immediately. Controlled Release: Delayed Release (Delayed-release): The active ingredient is released for a specific period thanks to enteric-coated polymers. then it is released. Sustained-release: Active ingredient for 25 minutes It is released gradually, providing a long-lasting effect. Targeted Release Release: The active ingredient is released to specific target areas, such as the intestine. They are released via engineered polymer systems. Compound drug preparation becomes scalable and automated with Policapr 30 (compounding pharmacy) reliably for chronic and rare diseases Personalized medicine design; polypill for drugs whose production has been discontinued by commercial manufacturers. Production; production of special dosages and formulations for the elderly and children; commercial 4 The production of medicines that are not readily available through conventional methods, using special formulas tailored to individual needs. It enables the production of adjustable pain management medications. Medications prescribed by a doctor (e.g., antihypertensive drugs, diabetes medications, cholesterol medications) (drug reducers) Policapr 5 drug pellets stored in a polymer sandwich prepared with these pellets. The device combines the substances into a single-dose form, and then transforms them into the final product. It is called a polypyle. In the literature, the subject is discussed in the Chinese utility model application numbered CN202027926U. "A utility model is defined as a model relating to medical and healthcare assistive devices, consisting of a base and a base of 10..." Consisting of an attached shredding device, a material collection device and a dust scavenger, It presents a portable production device for capsules used in traditional Chinese medicine; here The material collection device and dust sweeper are threaded to the shredding device. It is connected. A motor is fixed inside the base, and the shredding device is attached at one end. a shredder with an opening in the shredding cavity and a rotating shaft 15 It consists of a cutting unit. The shredding blade is fixed to the shredding cutter, The rotating shaft extends out of the shredding cavity to the output shaft of a dispensing machine. It is connected. The portable production device for traditional Chinese medicine capsules, traditional The fact that Chinese medicine is easy to grind into powder saves time and effort. Thanks to its ability to provide a good taste and the fact that the powder can be packaged directly into capsules, it is both delicious and easy to prepare. It also has advantages such as being easy to use for patients.” is provided. The application in question describes a portable production device for capsules used in traditional Chinese medicine. It is described. 25 Furthermore, the literature mentions Chinese patent application number CN106667774 regarding this matter. The invention is essentially the crushing of existing Cordyceps sinensis and Chinese herbal medicine. and an integrated crushing and tableting process aimed at converting it into a tablet. It describes the device. The crushing and tableting integrated device, primary crushing component, 30 grinding and crushing component, tablet forming and shaping component, control component and external It consists of a shell; the primary crushing component operates in an oxygen-isolating environment, tableting. and to increase the powder flow of the shaping component, a high point is placed on the wall of a storage hopper. It adds a compressed air valve, so no dust remains on the device body. Crushing and The pharmaceutical powder, which is crushed into tablets by the tablet-making integrated device, is finely ground. When used as a buccal tablet, it binds to the oral mucosa, leading to oral-gastrointestinal tract infections. Through absorption, the active components of the drug rapidly enter the body. Also available in crushed and tablet form. Thanks to its integrated device, the raw material can be processed in a single machine. Time and energy are saved, the device is suitable for family and small shop use. "It is being made suitable." The application in question incorporates an integrated device for crushing and tablet processing. Furthermore, in the literature, PCT application number WO2019059857 mentions 10 issues related to this topic. “The invention allows patients to easily administer multiple medications in fixed-dose combinations.” Mobile multi-drug tablet combiner that allows users to take the tablets by combining them into a single tablet. It is related to the device.” The aforementioned PCT application concerns the disclosure of a mobile multi-drug tablet combining device. is being done. Due to the disadvantages mentioned above, individualized medicine and personalized medicine are crucial. There was a need to develop a device and method for pharmacy. Disclosure of the Invention Based on this position in the art, the aim of the invention is to eliminate the existing disadvantages. A device and method for individualized medicine and personalized pharmacy that eliminates the need for personalized medicine. to reveal. 25 Another aim of the invention is to provide dosages and medications tailored to individual patient needs. by offering the ability to combine these products into a single dosage form, pharmacy The goal is to create a structure that aims to revolutionize practice. Another aim of the invention is to increase patient adherence to treatment by reducing drug burden. and to create a structure that ensures patient compliance. 6 Another aim of the invention is to create a structure that reduces healthcare costs. to place. Another aim of the invention is to treat complications arising from polypharmacy by preventing them. The goal is to create a structure that reduces costs. 5 Another purpose of the invention is that, thanks to its compact structure, it can be used in hospitals, pharmacies and families. They can be easily integrated into medical practices and have an industrial and user-friendly design. It is about creating a structure. Another aim of the invention is to offer modern medicine personalized dosage and combination for each patient. The goal is to create a structure that allows for adaptable, personalized treatment. Another aim of the invention is to produce faster, more reliable and more precise products than traditional methods. The goal is to create a structure that performs the function of combining drugs. 15 Another aim of the invention is to use Polypilin for UV-resistant drugs. Improves stability, enabling long-term use, and is suitable for UV bonding. For non-drug applications, drug pellets are combined with polymer spray or polymer film. The aim is to create a structure that prevents chemical change and interaction. 20 Another purpose of the invention is both device manufacturing and personalized medicine production. The goal is to create a structure that provides an advantage in terms of costs. Another aim of the invention is to create a small and portable structure for every pharmacy, hospital or family home. The goal is to create a structure that enables its use in medicine. Another aim of the invention is to provide a critical solution, especially for child and elderly patients. to place. Another purpose of the invention is to prevent dosage and content errors, contamination risks, and incorrect usage. Effects that arise in the production of compound drugs, such as drug effects caused by concentration The goal is to create a structure that minimizes risks. 7 Another aim of the invention is to eliminate the risk of incorrect dosage through precise dosage control. It is about creating a structure. Another aim of the invention is to prevent contamination through a closed system and UV disinfection. Preventing risk; including automated formulation technology that reduces error rates; providing 5 benefits to the individual. A structure that minimizes the risk of error by ensuring the production of specialized and safe medicines. to place. Another aim of the invention is to use it as a filler material in existing tablet drug systems. By eliminating the additives used, many patients experience additive-related allergies. The goal is to create a structure that prevents this. Another objective of the invention is to combine the pharmaceutical active ingredient (API) with the polymer sandwiches used. drugs that are delivered in a controlled and targeted manner through different release mechanisms A structure has emerged that increases the effectiveness of treatment while minimizing the risk of side effects. to place. Another aim of the invention is that the polymer sandwiches dissolve rapidly, releasing the active ingredient they contain. immediate release of the agent thanks to enteric-coated polymers. The substance is released after a certain period of time, resulting in controlled and delayed release, active ingredient 20. The substance is released gradually over time to provide a long-lasting effect. With extended release, the active ingredient will be released in specific target areas such as the intestine. Targeted release by being released with polymer systems designed in this way The goal is to create a structure that provides opportunities. Another aim of the invention is to enable scalable and automated preparation of compound drugs. with reliable, personalized medicines for chronic and rare diseases. to its design; to the production of drugs that commercial manufacturers have stopped producing using polypill; to the elderly and the production of special dosages and formulations for children; commercially 30 a system has been created that makes it possible to produce adjustable pain management medications. to place. 8 Another objective of the invention is to create sandwich bonding methods for three different polymers in various sizes and shapes. A structure that allows for polyp design, thereby improving swallowing and drug compliance. to place. Explaining the Figures 5 Figure 1 - Individualized medicine and personalized pharmaceutical device, which are the subject of the invention. a representative view Figure 2 - Individualized medicine and personalized pharmacy, the subject of the invention. The device contains 10 drug molecules within a polymer sandwich layer suitable for different release requirements. appearance of pellets Figure 3 - Individualized medicine and personalized pharmacy, the subject of the invention. Appearance of cartridges containing drug pellets in the device Figure 4 - A representative view of multiple pellet collection with a pharmaceutical pellet plunger. Figure – 5 Individualized medicine and personalized pharmacy device that is the subject of the invention 15 Detailed view of the drug pellet combining unit inside. Figure 6 - Combining drug pellet discs with polymer tape and forming a polypile. a representative view of the process Figure 7 shows how to combine pharmaceutical pellet discs by polymer spraying to produce a single polypile. a representative view 20 Figure 8 - Representation of how to produce a single polypile by combining drug pellet discs with UV light. an appearance Reference Numbers 1. Prescription Entry Unit 2. Drug Preparation Unit 3. Assembly Unit 4. Quality Control Box 5. Pre-filled Medicine Dispenser 30 6. Pharmaceutical Pellets 6.1 Active Pharmaceutical Ingredients Layer 6.2 Polymer Sandwich Layer Suitable for Different Oscillation Requirements 7. Pharmaceutical Pellet Cartridges 9 8. Polymer Foiling Unit 8.1 Rotary Rail 8.2 Polymer Tape 8.3 Upper Piston 8.4 Lower Piston 5 9. UV binding unit 9.1 UV Source 9.2 UV Top Piston 9.3 UV Lower Piston 10. Polymer Spraying Unit 10 10.1 Polymer Spray Holes 10.2 Polymer Compression Top Piston 10.3 Polymer Compression Lower Piston 11. Cartridge Drilling Upper Piston 12. Cartridge Drilling Lower Piston 15 Detailed Description of the Invention This detailed explanation aims to provide a better understanding of the innovation in the invention. This is explained with examples that will not create any limiting effect. 20 The invention aims to manage polypharmacy, improve patient adherence, and enhance healthcare. to transform services by tailoring dosages and medications to individual patient needs. It performs the function of combining their components into a single dosage form. It is a device for individualized medicine and personalized pharmacy; its feature is that the doctor 25 the prescription is either integrated into the device's software or manually entered by the pharmacist. The prescription input unit (1) into which the prescription is entered, polymer sandwich layer suitable for different oscillation needs (6.2) Layer of active pharmaceutical ingredients prepared in different doses Drug pellets for the production of personalized single-dose polypill containing (6.1) (6), the aforementioned drug Drug pellet cartridges (7) in the form of discs or flat rods containing pellets (6), mentioned 30 from inside the pellet cartridges (7) containing the drug pellets (6), cartridge patient-specific cartridge that ejects via upper piston (11) and lower piston (12) of the cartridge. Drug preparation unit (2) which automatically selects the dosage and drug combinations, drug Combining unit (3) which combines the drug pellets (6) coming from the preparation unit (2) and pre-filled medicine container in which combined medicine pellets (6) are stored as single dose individual. (5) is characterized by containing. Figure 1 shows the individualized medicine and personalized pharmacy that are the subject of the invention. A representative view of the device is depicted. 5 Figure 2 shows the individualized medicine and personalized pharmacy that are the subject of the invention. The drug is placed in a polymer sandwich layer (6.2) suitable for different release needs in the device. The appearance of the pellets (6) is depicted. Figure 3 shows the individualized medicine and personalized pharmacy that are the subject of the invention. Appearance of drug pellet cartridges (7) containing drug pellets (6) in the device It is depicted. Figure 4 shows the cartridge drilling upper piston (11), cartridge drilling lower piston (12) and multi-drug 15 A representative view of collecting pellets (6) is depicted. Figure 5 shows the individualized medicine and personalized pharmacy device that are the subject of the invention. The image shows a detailed view of the drug pellets (6) combining unit (3). Figure 6 shows how to combine the drug pellet (6) discs with the polymer band (8.2) and form them into a polypil. A representative view of the delivery process is depicted. In Figure 7, the drug pellet (6) discs are combined with the polymer spraying unit (10) into a single disc. A representative view of polyply production is depicted. 25 Figure 8 shows how to combine drug pellet (6) discs with UV light to produce a single polypile. A representative view is depicted. The invention, which is the subject of the individualized medicine and personalized pharmacy device, is for doctors 30 the prescription is either integrated into the device's software or manually entered by the pharmacist. The prescription input unit (1) into which the prescription is entered, polymer sandwich layer suitable for different oscillation needs (6.2) Layer of active pharmaceutical ingredients prepared in different doses Drug pellets for the production of personalized single-dose polypill containing (6.1) (6), the aforementioned drug 11 Drug pellet cartridges (7) in the form of discs or flat rods containing pellets (6), mentioned from inside the pellet cartridges (7) containing the drug pellets (6), cartridge patient-specific cartridge that ejects via upper piston (11) and lower piston (12) of the cartridge. Drug preparation unit (2) which automatically selects the dosage and drug combinations, drug Combining unit (3) which combines the drug pellets (6) coming from the preparation unit (2), 5 Dosage accuracy and reliability of the combined drug pellets Quality control box (4), which is automatically tested in terms of quality control pre-filled medicine container in which combined medicine pellets (6) are stored as single dose individual. (5), drug pellets (6) formed as a coupling unit (3) are uniform and stable 10 which ensures the sorting and compression of the materials in some way via a polymer belt (8.2) polymer foiling unit (8), polymer tape (8.2) wraps the drug pellets (6) By facilitating the process, the rotary rail (8.1) provides precision during the process of drug pellets (6) The upper piston (8.3) compresses with a slight force in the coupling unit (3), coupling by supporting the (3) drug pellets (6) in the unit with a light force, polymer band (8.2) 15 to keep the drug pellets (6) together in order to prepare them for winding lower piston (8.4) which provides a coupling unit (3) to the drug pellets (6) UV rays UV bonding unit (9) which combines with UV rays to produce a single polyply Using a UV source (9.1) that enables the bonding of drug pellets (6) to each other, the drug taking the medicine pellets (6) from the pellet cartridges (7) and stacking the process UV upper piston (9.2) which performs the assembly, UV lower piston 20 which acts as support during assembly. piston (9.3), polymer spray injection process as a coupling unit (3) polymer spraying performs the process of combining drug pellets (6) by applying unit (10) causes the drug pellets (6) to stick together by means of polymer spray spraying. polymer located on the wall of the coupling unit (3) which forms a stable structure by providing spray holes (10.1), polymer compression of drug pellets (6) with bottom piston (10.3) 25 Polymer compression top piston (10.2) main which enables stacking by being compressed between them. It consists of parts. The aforementioned personalized medicine and personalized pharmacy device represent a modern pharmacy. It is a drug preparation and delivery device developed for applications. This device has 30 to prepare personalized drug dosages for patients quickly, accurately and hygienically. Policapr is being developed, particularly for individualized drug therapy. Pharmacies that want to optimize their pharmaceutical production processes (medicine), Policapr is an innovative solution for hospitals and pharmaceutical companies. It is available in micrograms. 12 By measuring the dosage, it ensures that medications are prepared in patient-specific doses. With its automated system, it minimizes human error and shortens preparation time. User A user-friendly display allows pharmacists to easily manage the device. Closed Thanks to its system structure, it eliminates the risk of contamination. Wide range of drugs With its storage space, it is possible to store different formulations in an organized manner. 5 It makes it possible. The device that is the subject of the invention utilizes innovative polymer technology and, where necessary, polymers. spraying unit (10), polymer foiling unit (8) or UV bonding unit (9) by allowing its use, it enables the production of individualized drug formulations. 10 This device provides benefits for both patients and healthcare providers. It offers a solution tailored to their needs. Polymer sandwiches suitable for different release requirements are used in polypile technology. layers (6.2), controlled release of the drug active ingredient (API) through different release mechanisms 15 and ensures targeted delivery, increasing effectiveness in drug therapy while minimizing side effects. It minimizes the risks. Immediate Release: Polymer sandwich system suitable for different release requirements. The layers (6.2) dissolve rapidly, immediately releasing the active ingredient they contain. 20 Controlled Release: Delayed Release: Enteric Thanks to the coated polymers, the active ingredient is released after a certain period of time. Extended Sustained-release: The active ingredient is released gradually over time, over a long period. Provides a sustained effect. Targeted Release: The active ingredient enters the intestine free polymer systems designed to be released in specific target regions, such as those mentioned above. It is left behind. Polymers stored in cartridges for polypile production, suitable for different release requirements. Drug pellets (6) inside sandwich layer (6.2) polymer foiling unit (8); spray Polymer spraying unit (10) via biocompatible polymers for coating, required 30 In this case, UV-sensitive and stable polymer via UV coupling unit (9) They are brought together using matrices. 13 The contents of a Polypill prepared for a cardiovascular patient might be as follows: (e.g. Amlodipine 5 mg), Statin (e.g., Atorvastatin 10 mg), Anticoagulant (e.g., Aspirin 100 mg). Drug pellets (6) are basically composed of a layer of active pharmaceutical ingredients (6.1) Polymer sandwich layer suitable for different oscillation needs in position (6.2) It consists of 5 polymers suitable for different oscillation needs, providing different oscillation characteristics. sandwich layers (6.2) are non-mixing and different in appearance within a single polypyle It provides multiple dosing options with varying kinetics in a single polypill. Polymer sandwich layer suitable for different release requirements (6.2); substrate, hydrophilic polymer film, top layer, UV-curing polymer coating or different 10 Polymer sandwiches can be created by using polymers in combination. Pellets are placed inside a polymer sandwich layer (6.2) suitable for different release requirements. to adjust its physical stability and bioavailability, different fillers or Binders can be used. Drug pellets in a polymer sandwich layer (6.2) suitable for different release requirements (6) can be brought together in 3 different ways: Drug pellets (6) that do not interact at all with the drug pellets. Coating with polymer tape (8.2), UV bonding via UV source (9.1) or polymer Connecting with the spraying unit (10). Compliance with regulations in these three different combinations of fastening methods. facilitating, offering an option based on interaction with the drug or polymer, the patient It facilitates drug administration, prevents drugs from mixing, and reduces drug-specific release. It ensures the supply of medication and prevents interactions between different drugs within the polypill. Three different Polymer sandwich bonding method allows for polypile design in different sizes and shapes. 25 This improves swallowing and medication compliance. In the invention, individualized medicine and personalized pharmacy device The drug pellets used (6) contain the active pharmaceutical ingredients layer (6.1) in the correct doses. 30 small, delicate and stabilized tablets that allow for preparation in an individualized form. They are processed pharmaceutical units. 14 Drug pellets (6) contain the active pharmaceutical ingredients (AFB) layer (6.1) and the auxiliary in an individualized dosage form where the substances are combined in a controlled manner These are small, round, or custom-shaped units used. These drug pellets (6) are selected according to patient-specific prescriptions and used in Polypil production. Polymer sandwich layer suitable for different release needs (6.2) is used. Ingredients: Fillers, binders, lubricants, controlled-release agents, Disintegrants, coatings, film coatings, and protective coatings may be present, and the drug release agent may be affected. and determined according to pharmaceutical properties or all these properties are appropriate externally depending on the drug. This is provided by the polymer layer. 10 For the production of sandwich pharmaceutical pellets (6), the active ingredients and auxiliary materials are homogenized. The mixture is stirred to form a homogeneous pellet. The medicine... pellets (6), release profile and stability with suitable polymer coating material They are coated according to their requirements. Drug pellets (6) are released into the body quickly, slowly or 15 It can be adapted for controlled release. Drug pellets (6), mentioned in different combinations in individualized medicine and personalized pharmacy devices They can be combined. Example Polyply Drug Formulation: Metformin pellet for diabetes + Amlodipine pellets for hypertension + Atorvastatin pellets for hyperlipidemia + Blood For example, Acetylsalicylic acid 75 mg pellets as a diluent. 20 for all different release needs. Suitable polymer sandwich layers (6.2) with different release properties in a single polypyle They can exist within it without chemically mixing with each other. The aforementioned personalized medicine and personalized pharmacy device is based on the prescription. Selecting the necessary drug pellets (6). Selected drug pellets (6) polymer spraying 25 spray via unit (10), polymer foiling unit (8) or UV bonding unit (9) Polymer integrated into a single Polypile with UV bonding or polymer tape film (8.2). This ensures a reliable and stable dosage tailored to individual patient needs. The form is obtained. These innovative drug pellets (6) are used in individualized treatment approaches. It is designed to redefine standards. 30 Patient-specific prescription information is integrated into the device's software or provided by the pharmacist. This information can be entered manually. Based on this information, individualized medication is provided. Combinations are being prepared. The necessary medications are located in the device's reservoir. The drug pellet cartridges (7) containing pellets (6) are automatically selected. Drug pellets placed inside the polymer (6) are prepared in the drug preparation unit (2) as required In doses, the medicine is delivered by means of the cartridge drilling upper piston (11), cartridge drilling lower piston (12) The pellets are separated from their cartridges (7) and come to the assembly unit (3). Multidrug The pellets (6) are combined into single tablets (Polypiles) using different combination methods. 5 Drug pellets (6) are bonded in the bonding unit (3); with polymer tape film (8.2) by UV bonding. or can be safely combined by polymer spraying and delivered in a single dose. It forms a polyp. Drug pellet (6) combinations are also treated with UV rays which are included in the appropriate drugs. It can be prepared in a stable and reliable form by being fixed. The resulting polypyle hand Without touching, the medicine is placed into the ready medicine container (5) and given to the patient. UVC inside the device The system produces medicine intermittently when there is no drug production via the UV source (9.1). It is operated for disinfection. The device in question is used for the dosage of the manufactured medicines. It automatically tests its sensitivity and reliability. Personalized polypill. The medicines are collected in the ready medicine container (5) to be given to the patients and delivered to the patient. is being done. Within the polymer sandwich layer (6.2) suitable for the different release requirements mentioned, 20 Positioned drug pellets (6) personalized medicine in modern pharmaceutical applications It serves the concept of treatment. Polymer sandwich suitable for different release needs. layer (6.2) and drug pellet (6) structure, accurate dosing, controlled release and stability It aims to meet basic requirements such as these. The Policapr device utilizes this technology. By optimizing, it offers a fast, effective, and patient-centered solution. 25 The polymer sandwich layer (6.2) suitable for the different release requirements mentioned above, for the drug It consists of two separate layers surrounding the outer part of the pellets (6). This coating, It is designed to ensure the protection and controlled release of drug pellets (6). The coating minimizes the interaction of drug components with the external environment and ensures effective release. 30 presents the profile. Polymer sandwich layer (6.2) suitable for the different release requirements mentioned. The active pharmaceutical ingredients layer (6.1) is the drug content that provides the therapeutic effect. 16 These components will be released at the targeted dose and timing. It is being organized. Figure 2 shows four drug pellets (6) stacked on top of each other inside a polymer sandwich. This sequence is seen. This sequence delivers a personalized dose of 5 by the Policapr device. They are combined and made ready for polypile production. Suitable for different oscillation requirements. Drug pellets (6) located inside the polymer sandwich layer (6.2) in the Policapr device After being combined, it becomes a multi-dose Polypill drug individualized for the patient. It is being transformed. The linear cartridge (7) of the drug pellet cartridges used in the Policapr device, different drug contained within a polymer sandwich layer (6.2) suitable for release requirements It consists of pellets (6). These drug pellet cartridges (7) are used for automatic drug dosages. for the purpose of being selected by the device and combined in personalized doses. It is designed. Drug pellets (6) are isolated from each other, for correct dosage and 15 It has been designed to ensure reliability. Drug pellets from cartridges (7) used in a different module of the Policapr device disc The cartridge in the form of a circular arrangement contains drug pellets (6). The aforementioned drug The compartments inside the pellet cartridges (7) hold the medicine pellets (6) in an orderly fashion. It ensures safe storage and increases the ease of use of the device. Circular The design offers the advantage of faster access and dosage selection within the device. Drug pellets (6), polymer sandwich layer suitable for different release requirements (6.2) Thanks to this, it guarantees controlled oscillation and stability. The Policapr device, these 25 It uses cartridges to dose and combine medications according to individual needs. Linear and disc drug pellet cartridges (7) are placed in high numbers in different sections of the device. It offers flexible usage options due to its production process and the fact that it requires less modification. These drug pellet cartridges (7) improve efficiency in Policapr’s innovative drug preparation process. These are critical components that increase performance. 30 Multiple drug pellet cartridges (7) used in the Policapr device, drug pellets (6) These drug pellet cartridges (7) contain drugs in the prescribed dosage. 17 It is pre-loaded for preparation. Each drug pellet cartridge (7) contains different active ingredients. It contains drug pellets (6) with components and release properties. Cartridge punching top piston (11) to eject drug pellets (6) selected according to the prescription. and cartridges (7) for storing medicine pellets on the lower piston (12) of the cartridge drilling It performs a drilling operation. During this operation, unnecessary drug pellet cartridges are removed. (7) obstruction because the drug pellet was not advanced or (6) empty due to previous preparation. It does not constitute, thus unnecessary drug pellets (6) are eliminated and only The necessary items are collected. The cartridge is punched with the upper piston (11) and the medicine pellets are inserted. Drug pellets (6) collected from cartridges (7) are placed on the cartridge drilling lower piston (12) 10 It is accumulating. The cartridge drilling lower piston (12) is driven by the cartridge drilling upper piston (11). stacking and combining the collected drug pellets (6). This stacking ensures that different drug pellets (6) are prepared in the correct combinations. The stacked drug pellets (6) are loaded into the drug preparation unit of the Policapr device 15 (2) are transferred. Stick or Disc drug pellet cartridges (7) contain different drug pellets. (6) offers a modular system for transporting. Drug pellet cartridges (7) are an important feature that increases the functionality and ease of use of the device. These are the components. Automatic piston mechanism, fast and error-free production process 20 It offers. Stick or disc medicine pellet cartridges (7), different types of medicine It supports various combinations. This system is an innovative solution in modern pharmaceutical production. By offering this, it ensures the effective implementation of individualized treatment. Drug pellets (6) are protected by being surrounded by polymer layers. This structure, 25 It ensures the controlled release and stability of the drug pellets (6). In the first stage, this Drug pellets (6) are placed into drug pellet cartridges (7). Each drug pellet cartridge (7) can carry different drug components and needs The doses detected are selected by the device. 30 The coupling unit (3) is the mechanism that combines the drug pellets (6) according to needs. is created by polymer tape (8.2), using polymer spray and UV rays. With binding options, drug pellets (6) are formed into a single polypyle. UV rays 18 In addition to polymer bonding when necessary, it also disinfects the internal environment of the device and It enables the safe preparation of drug pellets (6). After the joining process is complete, the polypiles are finalized. Ready The polypiles are transferred to a special compartment in the Policapr device and made available for use. 5 These polypill tablets are ready-to-use multi-drug devices formulated according to individualized dosages. combinations. The coupling unit (3) sterilizes the device with UV rays while also being suitable and If preferred, UV-bondable polymers combine into drug pellets (6). 10 This method ensures the correct joining of polyps and eliminates the risk of infection. UV rays and polymer coating ensure the device's hygienic properties. It ensures flawless and fast operation. Thanks to its fully automatic mechanism, it works without errors. It presents the production process. It compresses the drug pellets (6) with a slight force in the coupling unit (3). Compressed drug pellets (6) are ready to be wrapped in polymer tape (8.2). This process ensures that the drug pellets (6) are arranged neatly and consistently. This ensures that the compression process does not damage the polymer and the active ingredients within it remain intact. The upper piston (8.3) gently pushes the drug pellets (6) in the coupling unit (3) with a slight force. By supporting it, it prepares the lower piston (8.4) for winding the polymer tape (8.2). The support ensures that the drug pellets (6) remain stable together. Polymer tape (8.2) is used to wrap drug pellets (6) to form a single polypile. It is used. The rotary rail (8.1) wraps the polymer belt (8.2) around the drug pellets (6). It facilitates and ensures precision during the process. This winding, the medicine This makes it possible to combine the pellets (6) and form a stable polypyle. Drug pellets (6) discs are wrapped with polymer tape (8.2) to form an individualized dose. Polypiles are being formed. This process both preserves the drugs and makes them easily portable. 30 and provides a consumable form. Polymer band (8.2), pharmaceutical pellets (6) It offers a stable product by protecting it from external factors. Fully automatic assembly. The process yields fast and reliable results. 19 Drug pellets (6) are taken from the drug pellet cartridges (7) and removed through the holes and The polymer compression is stacked on the lower piston (10.3). The polymer compression top The piston (10.2) ensures the placement of the drug pellets (6) in the correct order and production It initiates the process. Polymer compression lower piston (10.3) and polymer compression upper piston stacked drug pellets (6) between piston (10.2), on the wall of the coupling unit (3) 5 polymer spraying process through polymer spray holes (10.1) It is applied. Spraying causes the drug pellets (6) to stick together and It forms a stable structure. The polymer provides both protection for the drug pellets (6) and It is specifically designed to facilitate bonding. Polymer spray, polymer By spraying the drug pellets (6) discs through the spray holes (10.1), all 10 It coats their surfaces. The drug pellets (6) bond between the discs. Once completed, a single polypyle is formed. For proper stacking and holding of the aforementioned drug pellets (6) A polymer compression lower piston (10.3) is used. During the spraying process, the drug is 15 It prevents the pellets (6) from moving and provides stability. After the spraying and bonding process is completed, the drug pellets (6) discs It becomes a single polypile. This polypile is in a portable and consumable form, the same It is designed for personalized treatment over time. 20 Drug pellet (6) discs suitable for UV bonding can be bonded together with UV light to form a single polyply. It is possible to produce them. Drug pellet (6) discs, rod or disc drug pellets They are taken from cartridges (7). Drug pellets (6) are placed under UV light in accordance with the prescription. The pillars are stacked on the piston (9.3). The stacked pillars in the combining unit are 25. Polymer suitable for UV bonding by giving UV rays from the side of the pellets (6) Polypiles are produced by combining pellet discs containing these pellets. UV top piston (9.2), cartridge or disc open pellets on the drug pellets (7) (6) takes and completes the stacking process. Drug pellets (6), UV bonding 30 It is arranged stably before being conveyed to the unit (3). UV lower piston (9.3), drug It provides support during stacking of pellet (6) discs and assembly. He sees. UV Lower and upper pistons (9.2,9.3), during UV irradiation of the drug pellets (6) It guarantees that it remains in a fixed position. The coupling unit (3) can be assembled as desired and If suitable polymer pellets are available, one of the 3 existing joining methods (polymer band (8.2), polymer spray, UV bonding) one of which is using UV rays to drug pellet (6) It ensures that the discs are bonded together. UV rays are used during the bonding process. increasing sterilization and combining drug pellets (6) in a clean environment It provides. Under the effect of UV rays, the drug pellet (6) discs are fixed to each other and It becomes a single polypill. The produced polypill has individualized dosage characteristics. It is ready for use. The ready-to-use polyp is removed from the device and given to the patient. It enables personalized treatment. 10 A polyp is formed by combining discs of drug pellets (6) stacked on top of each other. discs, UV bonding, polymer spraying or polymer tape (8.2) are available and polymer by using one of three appropriate merging methods to create a single unit This process ensures that the drug pellets (6) are held together and form a stable structure. 15 It enables the creation of polypills by combining different drug components. It provides personalized dosage. Drug pellet (6) discs have different release kinetics. It can have this feature, which offers controlled and regular drug release. Drug pellets (6), 20 in combinations customized to the needs of each patient. It is manufactured. The Policapr device combines the pellets according to the patient's needs. It is selected accordingly. It will not cause any chemical or mechanical degradation. In this way, it applies the most appropriate method. This process is part of personalized medicine therapy. It offers an effective and reliable solution. Polypil is the ultimate product of personalized treatment. It combines different drug components within a single structure. It is easy for the patient to carry. It offers an easy-to-use and effective treatment tool.

Claims

21 REQUESTS 1. The invention aims to manage polypharmacy (the use of multiple drugs) and improve patient compliance. and to transform healthcare services to meet individual patient needs. It performs the function of combining dosages and drug combinations into a single dosage form. 5 It is a device that brings about individualized medicine and personalized pharmacy. The feature is that the doctor's prescription is integrated into the device's software or the pharmacist's prescription is processed by the pharmacist. The prescription input unit (1), which is entered manually by the different oscillation requirements different doses prepared into a suitable polymer sandwich layer (6.2) Personalized single 10 containing a layer of prepared active pharmaceutical ingredients (6.1) Drug pellets for the production of dose polypiles (6), disc containing the aforementioned drug pellets (6) or drug pellet cartridges in the form of flat rods (7), the aforementioned drug pellets (6) from inside the pellet cartridges (7) containing the drug pellets (6), cartridge drilling top patient-specific piston (11) and cartridge drilling lower piston (12) that extracts the cartridge. Drug preparation unit (2) which automatically selects dosage and drug combinations, 15 a combiner that combines the drug pellets (6) coming from the drug preparation unit (2) unit (3) and combined drug pellets (6) single dose individually It is characterized by containing a ready-made medicine container (5) in which it is stored.

2. For individualized medicine and personalized pharmacy in accordance with Claim 1, a 20 The device is characterized by being a combination unit (3) for drug pellets. (6) a polymer tape to arrange and compress in a neat and stable manner. (8.2) contains the polymer foiling unit (8).

3. An individualized medication that meets any of the above requirements and 25 It is a device for personalized pharmacy and its feature is that the polymer band (8.2) of the medicine by making it easier to wrap the pellets (6), providing precision during the process. It includes a rotating rail (8.1).

4. An individualized medication that meets any of the above requirements and 30 It is a device for personalized pharmacy and its feature is; drug pellets (6) The coupling unit (3) contains an upper piston (8.3) that compresses with a slight force. 22 5. An individualized medication that meets any of the above requirements. It is a device for personalized pharmacy and its feature is; in the combination unit (3) By supporting the drug pellets (6) with a light force, the polymer tape (8.2) is wound around them. to keep the drug pellets (6) together in order to make them ready It contains the lower piston (8.4). 5 6. An individualized medication that meets any of the above requirements. It is a device for personalized pharmacy and its feature is a combination unit (3) combining drug pellets (6) with UV light to produce a single polypile It contains a UV binding unit (9) which provides 10 7. An individualized medication that meets any of the above requirements. It is a device for personalized pharmacy; its feature is that it uses UV rays to deliver medication. It contains a UV source (9.1) which enables the pellets (6) to bond together.

8. An individualized medication that meets any of the above requirements. It is a device for personalized pharmacy and its feature is drug pellet cartridges (7) UV top by taking the drug pellets (6) on it and performing the stacking operation It contains a piston (9.2).

9. An individualized medication that meets any of the above requirements. It is a device for personalized pharmacy and its feature is support during assembly. It contains a UV lower piston (9.3) which serves as the function.

10. An individualized medication that meets any of the above requirements and 25 It is a device for personalized pharmacy and its feature is a combination unit (3) By applying a polymer spray process, we combine drug pellets (6) It includes a polymer spraying unit (10) that performs the process.

11. An individualized medication that meets any of the above requirements and 30 It is a device for personalized pharmacy; its feature is polymer spray dispensing. By ensuring the drug pellets (6) stick together, a stable structure is created. polymer spray holes located on the wall of the coupling unit (3) (10.1) includes. 23 12. An individualized medication that meets any of the above requirements and It is a device for personalized pharmacy and its feature is; polymer of drug pellets (6) enabling stacking by being compressed between the lower piston (10.3) It contains a polymer compression top piston (10.2).

13. An individualized medication that meets any of the above requirements. It is a device for personalized pharmacy; its feature is its integration. In terms of dosage accuracy and reliability of the manufactured drug pellets. It includes a quality control box (4) where it is automatically tested.

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