A multi-phase pharmaceutical composition targeting menstrual pain, digestive disorders, and nervous tension.

Abstract

This invention relates to a pharmaceutical composition consisting of a combination of herbal extracts and vitamins optimized in specific dosage ranges, developed for the relief of menstrual pain, spasms, and inflammation, as well as symptoms of digestive and nervous system origin. The composition includes ginger extract (1–2000 mg), fennel extract (1–2000 mg), chamomile extract (1–2000 mg), cinnamon extract (1–1000 mg), peppermint extract (1–1000 mg), curcumin extract (1–1000 mg), vitamin B6 (1–500 mg), and vitamin B1 (1–500 mg). The combined use of these components produces a simultaneous and synergistic effect on multiple biological pathways, including COX / LOX inhibition, smooth muscle antispasmodic effect, neurological modulation, and digestive system regulation. The technical contribution of the composition lies in the complementary pharmacodynamic interaction between mint and ginger, which provide a rapid onset of action, and curcumin and cinnamon, which exhibit long-lasting anti-inflammatory properties.The composition can be produced in various pharmaceutical dosage forms, including capsules, tablets, gels, syrups, suspensions, or suppositories. Thanks to multi-system targeting, optimized dose intervals, and a synergistic mechanism, the invention offers enhanced therapeutic support compared to existing technology.

Description

A multi-faceted treatment targeting menstrual pain, digestive disorders, and nervous tension. Pharmaceutical Composition 1. Technical Scope of the Invention This discovery helps treat menstrual pain (dysmenorrhea), particularly in women aged 18–45. Menstrual spasms, inflammation, digestive system disorders, and nervous system problems. herbal extracts and vitamins developed to reduce tension naturally. The invention relates to a pharmaceutical composition consisting of a combination of the following: gastric symptoms such as spasms, nausea, functional dyspepsia, stress, mild anxiety, and weakened immunity. A supportive pharmaceutical composition for the relief of multisystem symptoms. provides 2. State of the Art (Prior Art) There are various herbal products on the market used for menstrual cramps or digestive problems. They exist; however, these products mostly contain a single or limited number of active ingredients and multiple The mechanism does not offer a synergistic combination that targets the intended action. While current products typically use single herbs such as ginger or fennel;  Targeting inflammation pathways (COX / LOX),  Supports the antispasmodic effect on smooth muscles,  It regulates the neurological pain threshold,  Relaxes the digestive system,  Provides immune modulation A complex herbal-vitamin combination that offers a multi-layered effect simultaneously. There is no example in the literature. Furthermore, although dosage ranges in known mixtures vary commercially, they are optimized as in this invention. A dose adjustment based on synergy has been made (range 350–750 mg – for ginger and fennel). It is not available. Therefore, the composition offered by the invention represents a significant innovation and technical advancement compared to existing technology. It involves progress. 3. The Technical Problem That the Invention Aims to Solve Common problems with existing herbal products include: 35 1. They are focused on a single mechanism → they target only pain or only spasm. 2. Slow onset or short duration of effects → low user satisfaction. 1 3. They do not offer cross-system benefits → nausea and gas that accompany menstrual pain, Common symptoms such as stress and insomnia remain unresolved. 4. Low bioavailability → when some plant components are taken alone 40 cannot show its effect. 5. Lack of dose optimization → either too wide a range or low efficacy. There are products. This invention was developed to solve all the aforementioned technical problems. 4. Purpose of the Invention 45 The main objective of this invention is to create a highly efficient and synergistic system that provides the following technical characteristics: The goal is to develop pharmaceutical compositions: • Rapid and long-lasting reduction of menstrual cramps, spasms, and inflammation.  It can affect the digestive, nervous, and immune systems simultaneously.  Combining plant-based active ingredients in optimized dosages 50  Raising the neurological pain threshold with vitamins B6 and B1  Establishment of a dual-phase (fast + long-term) pharmacodynamic profile  Creating a stable formulation applicable to different pharmaceutical forms This specially formulated combination differs from existing techniques, offering multifaceted therapeutic support. provides. 55 5. Technical Summary of the Invention The invention describes a pharmaceutical product containing the following active substances at specified dosage ranges. It is a composition:  Ginger extract: 1–2000 mg  Fennel extract: 1–2000 mg 60  Chamomile extract: 1–1500 mg  Cinnamon extract: 1–1000 mg  Peppermint extract: 1–1000 mg  Curcumin extract: 1–1000 mg  Vitamin B6: 25–500 mg 65  Vitamin B1: 1–500mg When used together, these components provide the following technical advantages: 2  Inflammation is suppressed through COX / LOX inhibition.  Smooth muscle antispasmodic effect relieves uterine and gastrointestinal contractions.  Neurological modulation raises the pain threshold and reduces stress. 70  It regulates digestion and relieves gas, nausea, and bloating.  Immune modulation strengthens antioxidant defenses. This multi-path effect constitutes the fundamental technical contribution of the invention. 6. Detailed Descriptions of the Components 6.1 Ginger Extract (350–750 mg) It inhibits COX / LOX enzymes thanks to the compounds gingerol and shogaol. It has a rapid onset of action. It provides relief from nausea and gastrointestinal spasms. 6.2 Fennel Extract (350–750 mg) Fit relaxes the uterine muscles with its estrogenic and antispasmodic effects. Gas and bloating reliever It has an activity. 80 6.3 Chamomile Extract (300–1000 mg) Thanks to its matrix and apigenin content, it is a powerful smooth muscle relaxant and sedative. 6.4 Cinnamon Extract (300–1000 mg) As a COX inhibitor, it reduces inflammation. By promoting blood circulation, it improves pain perception. 6.5 Peppermint Extract (300–1000 mg) 85% menthol has an immediate antispasmodic effect. It relieves symptoms of nausea and heartburn. It relieves the pain. 6.6 Curcumin Extract (300–1000 mg) It exhibits strong anti-inflammatory and antioxidant properties. It provides long-lasting effects. 6.7 Vitamin B6 (25–75 mg) 90. By contributing to the synthesis of serotonin and dopamine, it affects mood, pain threshold, and hormonal balance. It has an effect on it. 6.8 Vitamin B1 (50–150 mg) It strengthens neuronal transmission, reduces muscle tension, and supports overall energy metabolism. 7. Synergistic Effect Mechanism 95. The technical effect provided by the invention is greater than the sum of the effects of its individual components. It creates synergy: 3 1. Ginger + Curcumin + Cinnamon → powerful anti-inflammatory synergy 2. Chamomile + Fennel + Mint → fast and effective antispasmodic synergy 3. Vitamins B6 + B1 → reducing pain perception via the nervous system 100 4. Herbal extracts + vitamins → intersystemic cross-reaction Thanks to this combination:  The effect starts quickly (mint + ginger)  And it lasts a long time (cinnamon + curcumin) This technically creates a dual-phase pharmacodynamic profile. 105 8. Pharmaceutical Forms The invention is applicable in the following dosage forms:  Capsule  Tablet  Chewable tablet 110  Softgel  Syrup / solution  Suspension  Gel formulation  Vaginal suppositories 115  Powder / granule form In all formulations, the stability of the active ingredients is maintained by excipients. 9. Production Method (Process) – Example Applications Example 1 – Capsule Form Production 1. Herbal extracts are supplied in dried and standardized form. 120 2. Weighed within the specified mg ranges. 3. Vitamins B1 and B6 are added. 4. A homogeneous mixture is obtained in the mixer. 5. If necessary, magnesium stearate is added to improve fluidity. 6. The mixture is filled into hard or soft capsules. 4 125 Example 2 – Tablet Form 1. After weighing, the extracts and vitamins are granulated with a binder. 2. Drying is done. 3. The granules are compressed to form tablets. Example 3 – Syrup Form 130 1. A soluble extract is prepared in water or a water-ethanol mixture. 2. The vitamins are dissolved and added to the mixture. 3. Appropriate pH adjustment and preservatives are used to maintain stability. 10. Stability and Shelf Life Because the extracts used in the composition are sensitive to oxidation: 135  Antioxidant preservatives,  Moisture-preventing agents,  Light-resistant packaging It provides stability for at least 24 months with continued use. 11. Areas of Application 140. The invention may be applied in the following cases: Women's Health • Menstrual cramps  Menstrual cramps  PMS symptoms 145  Stress and tension related to the hormone cycle Digestive system  Nausea  Gas, bloating  Abdominal / sporadic cramps 150  Indigestion Nervous system  Stress, tension  Sleep disorders  Mild anxiety symptoms 155 Immune System  Antioxidant support  Strengthening the immune system during seasonal changes 12. Conclusion This invention contains a multi-biological blend of plant extracts and B vitamins in optimized doses. It offers a fast-acting and long-lasting pharmaceutical compound that targets 160 pathways simultaneously. Technically... as a new, industrially viable formulation with an inventive step It deviates from the current technique. 6

Claims

Claim 1 The invention relates to pain, spasms, inflammation, and associated digestive and nervous system disorders of the menstrual period. It is a pharmaceutical compound used to relieve symptoms; its characteristic feature is that the compound... It contains the following active ingredients synergistically together in specific dosage ranges:  Ginger extract: 1–2000 mg  Fennel extract: 1–2000 mg  Chamomile extract: 1–1500 mg  Cinnamon extract: 1–1000 mg  Peppermint extract: 1–1000 mg  Curcumin extract: 1–1000 mg  Vitamin B6: 1–500 mg  Vitamin B1: 1–500 mg And the compound in question in any pharmaceutically accepted dosage form (tablet, The advantage is that it can be prepared in various forms (capsules, soft gelatin capsules, syrup, suspension, gel, suppositories, coated tablets, etc.). Claim 2 The composition is according to Claim 1; ginger, curcumin and cinnamon extracts are used to inhibit COX / LOX enzymes. It provides analgesic and anti-inflammatory effects through inhibition; chamomile, fennel and mint. The extracts showed antispasmodic effects on smooth muscles; vitamins B6 and B1 have neurological effects. It raises the pain threshold through its modulator effect, and this combination involves multiple biological pathways. It is characterized by creating a synergistic technical effect. Claim 3 The composition according to Claim 1; a combination of the rapid onset effect of mint and ginger, and curcumin and cinnamon. Its long-term anti-inflammatory effect creates a dual-phase pharmaceutical profile in a single dose. It is characterized by... Claim 4 This is a combination according to claim 1; for primary dysmenorrhea, menstrual cramps, PMS, premenstrual tension and It is used to reduce pain related to hormonal cycles. Claim 5 According to claim 1, it is a combination of symptoms including nausea, gas, bloating, spasms, indigestion, and functional disorders.

35. It is used to relieve the symptoms of dyspepsia. 7 Claim 6 According to Claim 1, it is a combination of conditions such as stress, nervous tension, sleep disturbance, and anxiety. Its purpose is to provide calming support in these situations. Claim 7 Compound according to Claim 1, 40; the body through antioxidant and immune modulation. It is used to increase resistance to infections. Claim 8 According to Claim 1, this is the method for preparing the composition; (a) Standardized dried ginger, chamomile, fennel, cinnamon, mint and turmeric herbs Obtaining 45 extracts, (b) weighing the obtained extracts within the specified dosage ranges and homogenizing them. mixing, (c) supplementation of vitamin B6 and vitamin B1, (d) Granulation, capsule filling, dissolution in solution, gel of the mixture according to the selected pharmaceutical form. 50 production or conversion into dosage form by wick casting methods It is a method that includes the following steps. Claim 9 The composition is according to Claim 1; all active ingredients are stable against oxidation and moisture effects. pharmaceutical adjuvants that act as carriers, binders, sliders, or protective agents to ensure retention. It is characterized by the addition of 55 articles. 8