Temperature-Sensitive Adaptive Dermal Barrier System

Abstract

The present invention relates to a temperature-sensitive adaptive dermal barrier system for topical application. The system contains a composition acceptable as a cosmetic or pharmaceutical, which is structured to form a reversible barrier phase on the skin surface when applied to the skin. The barrier phase reversibly modulates at least one measurable physical parameter in response to ambient temperature, skin surface temperature, or a temperature gradient between them. This parameter may include permeability, diffusion behavior, elastic modulus, viscoelasticity, packing density, vapor permeability, transepidermal water loss resistance, surface friction, adhesion level, gloss, or a combination thereof. Under low temperature conditions, the barrier phase may exhibit increased compactness and decreased permeability. Under high temperature conditions, the barrier phase may exhibit increased flexibility and controlled vapor permeability while maintaining barrier integrity.

Description

Temperature-Sensitive Adaptive Dermal Barrier System 1. TECHNICAL FIELD The present invention applies to cosmetics, dermocosmetics, topical skin care, and dermatological aids. products, personal protective skin compositions, barrier support systems and temperature This relates to formulations applied to sensitive surfaces. More specifically, the invention creates a reversible barrier on the skin's surface when applied to the skin. the phase that forms the barrier phase and the ambient temperature, skin surface temperature or at least one measurable physical response to the temperature gradient between them a topically applicable adaptive dermal barrier that modulates the parameter It relates to the system. The invention also relates to permeability, diffusion behavior, barrier compactness, and elastic modulus. viscoelasticity, vapor permeability, transepidermal water loss resistance, free volume, film continuity, microstructural organization, tactile characteristics, or any of these dermal combinations that are controlled and adjusted according to changing thermal conditions It relates to systems. The invention relates to creams, lotions, emulsions, gels, serums, balms, sticks, sprays, foams, masks, and patches. in film, hybrid systems or other topically acceptable dosage forms applicable. 1. 2. STATE OF KNOWLEDGE OF THE ART Human skin is exposed to cold air, hot air, wind, indoor heating, air conditioning, and sweating conditions. Exercise-related warm-up, sunlight exposure, repetitive indoor-outdoor use Dynamic environmental and physiological temperature, including transitions and transient thermal stress. It is constantly exposed to changes. Traditional topical barrier products generally provide the following static protection: It is based on the following mechanisms: • Petrolatum films • Hydrocarbon occlusive layers • Stationary lipid replacement systems • Silicone protective coatings • Wax-based barrier systems • Lamellar emulsions • Moisturizing moisturizers • Non-adaptive polymeric films While such products may provide temporary benefits, they are generally optimized for limited conditions. And it may perform poorly when thermal conditions change. Examples: Feels heavy or greasy in hot conditions, Inadequate barrier in cold conditions. Support, rigid films that crack or become brittle, extreme high temperatures Stickiness, aesthetic deterioration after repeated temperature cycles, water loss. inability to dynamically regulate Some temperature-sensitive materials are known in various technical fields; however, these Systems are mostly based on: Single-threshold crossing behavior, Narrow crossing. Intervals, Irreversible transitions, Non-cosmetic substrates, Daily dermal Materials impractical for use, non-repeatable mechanisms, barriers. Inflation mechanisms that do not provide optimization Therefore, while maintaining comfort, repeatability, and barrier performance, the changing a commercially viable dermal that can adaptively respond to temperature variations The need for a barrier system continues. 2. 3. TECHNICAL PROBLEM The technical problem that the present invention aims to solve requires a device that satisfies the following characteristics: Our goal is to offer a dermal barrier system. 1. Increasing barrier compactness at low temperatures. 2. To provide improved flexibility and controlled breathability at high temperatures. 3. To make reversible transitions between at least two functional states. 4. Remaining structurally stable after repeated heating / cooling cycles. 5. To reduce user discomfort associated with abrupt environmental changes. 6. To provide a measurable and repeatable thermal response. 7. It can be produced using traditional cosmetic production equipment. 8. Activation systems powered by external electronics, sensors, or energy. not requiring 9. To remain consistent with traditional cosmetic ingredients and optional active ingredients. 3.4. SUMMARY OF THE DISCOVERY The present invention describes the response of at least one measurable physical parameter to temperature variation. reversibly modulating, reversible barrier phase on the skin an adaptive dermal barrier system containing a topically applicable composition It offers. Measurable physical parameters can be selected from: Transmittance coefficient (P), Diffusion coefficient (D), Elastic modulus (E), Viscoelastic response, Packing density, Free volume, Film continuity, Vapor permeability rate, Water activity (aw), Transepidermal Water resistance, Optical scattering, Surface friction, Adhesion level, Brightness, Degree of microstructural organization, Phase-to-volume ratio, Combinations of these. In preferential applications: Low Temperature Condition: Tighter packing, Lower permeability, Reduced TEWL, Increased cohesion. Medium Temperature Condition: Balanced protection, balanced flexibility, enhanced sensory comfort. High Temperature Condition: Increased flexibility, decreased tackiness, controlled vapor. Transmission, preserved structural continuity. Transition between states; continuous, gradual, nonlinear, sigmoidal, buffered, It may be hysteretic, delayed, multi-stage, or a combination of these. 4 5. DEFINITIONS • Barrier phase: A continuous or intermediate phase that can affect the exchange between the skin and the environment. A physical structure left as a discontinuous, topically applied treatment. • Reversible: When the thermal condition is reversed or removed, it returns to its previous state. Return to a fully or partially functional state. • Low temperature condition: Generally below 20°C, preferably 0–15°C. • Moderate temperature condition: Typically 20–32°C. • High temperature condition: Generally above 32°C, preferably 32–45°C. • Wide temperature range: 0–45°C; preferred extended range −10 to +50°C; Engineering description range: −20 to +70°C. • Hysteresis: The functional pathway differs during warming up from the pathway during cooling down. being. • Controlled permeability: Measurable permeability while maintaining barrier integrity. change. 5 6. DETAILED EXPLANATION 6.1 System Forms Adaptive dermal barrier systems can have the following structures: • Regular movies • Discontinuous micro-region networks • Lamellar structures • Semi-occlusive matrices • Gel-lipid hybrids • Phases left behind with balm • Particle-reinforced networks • Polymer-lipid composites • Multilayered accumulations • Combinations of these 6.2 Functional Mechanisms Adaptive behavior can be achieved through one or more of the following reversible mechanisms: • Lipid phase transition • Wax crystal rearrangement • Polymer mobility shift • Proximity effect to glass penetration • Free volume modulation • Supramolecular packing change • Interval change due to hydration • Unified network reorganization • Particle-network redistribution • Hybrid phase reorganization 6 6.3 Content Classifications Lipid Components: Ceramides, cholesterol, fatty acids, esters, triglycerides, hydrocarbons, silicones, natural oils, synthetic emollients, waxes Polymeric Components: Acrylate polymers, polyurethane dispersions, cellulose derivatives, polysaccharides, coupling polymers, thermosensitive polymers, film-forming polymers copolymers Humectants: Glycerin, propanediol, butylene glycol, sorbitol, betaine, sodium PCA Optional ingredients: Soothing agents, antioxidants, anti-aging actives, UV Filters, preservatives, perfumes, pigments, sensory modifiers. 7. PREFERRED PARAMETER RANGES In preferential applications: ₂ ₁ • P / P permeability ratio: 1.05 – 5.00 • Preferably: 1.10 – 3.00 • Preferably: 1.20 – 2.50 • Change in elastic modulus: at least 5%, preferably at least 10% • TEWL reduction in low temperature mode: at least 5%, preferably 10% – 60% • Post-thermal cycling preserved functional response: at least 70% preferably at least 80% that's preferably at least 90% 7 8. HYSTERESİS AS A TECHNICAL ADVANTAGE In preferential applications, the system exhibits hysteresis during heating and cooling. This hysteresis can provide the following benefits: • Delayed barrier collapse during warm-up • Temporary maintenance of protective compactness after exposure to cold. • Smoother adaptation during environmental transitions • Reducing sudden tactile changes • Continuity of functional barrier behavior Accordingly, hysteresis is not a random artifact; it is a purposeful functional buffering mechanism. It is the effect. 9. SAMPLE FORMULATIONS The following examples are given to illustrate the invention; they do not limit the claims. Example 1 – Adaptive Protective Cream Phase Component % A / A A. Purified Water is topped up to 100. Glycerin 4.00 A Propanediol 3.00 A Disodium EDTA 0.10 B Caprylic / Capric Triglyceride 6.00 B Cetearyl Alcohol 3.50 B Glyceryl Stearate Citrate 2.00 B Shea Butter 2.00 B Ceramide NP 0.30 B Cholesterol 0.20 C VP / Eicosene Copolymer 1.20 C Hydroxyethylcellulose 0.25 D Phenoxyethanol and Ethylhexylglycerin 0.90 D-Tocopherol 0.20 Citric acid and / or sodium hydroxide pH 5.4–5.8 It formed a continuous adaptive barrier phase on the skin surface when applied topically. Example 2 – Adaptive Gel Serum Phase Component % A / A 100 A Purified Water completed A Propanediol 4.00 A Glycerin 2.00 A Disodium EDTA 0.05 B Hydroxyethylcellulose 0.30 B Xanthan Gum (transparent quality) 0.05 C VP / Eicosene Copolymer 0.80 C Caprylic / Capric Triglyceride 1.50 Polyglyceryl-6 Caprylate / Caprate or suitable solvent C 1.20 emulsifier D-Panthenol 1.50 D Ectoin 0.30 D Ceramide NP dispersion or liposomal ceramide complex 0.20 E Phenoxyethanol and Ethylhexylglycerin 0.90 Citric acid and / or sodium hydroxide pH 5.3–5.8 It has formed a thin polymer-lipid hybrid barrier phase. Example 3 – Adaptive Balm Stick Phase Component % A / A A Caprylic / Capric Triglyceride 24.00 A Hydrogenated Polyisobutene or C13-15 Alkane 15.00 A Shea Butter 10.00 A Candelilla Wax 8.00 A. Beeswax or Synthetic Wax 7.00 Cetearyl Alcohol 6.00 A Hydrogenated Castor Oil 4.00 B VP / Eicosene Copolymer 3.00 B Ceramide NP 0.20 B Cholesterol 0.20 Beta-tocopherol 0.50 C Silica Dimethyl Silylate or suitable oil-gel compound 1.00 C Bisabolol 0.30 A. The remaining emollient oil is topped up to 100%. In practice, it formed a semi-occlusive adaptive lipid-polymer barrier phase. 9 10. COMPARATIVE PERFORMANCE DATA Representative test results: • Sample 1 reduced TEWL compared to the light cream comparator at 10°C. • Example 1, lower viscosity at 35°C compared to petrolatum control. has shown. • Example 2, better barrier than static comparator in repeated 5°C / 45°C cycles. It has demonstrated continuity. • Example 3: Maintaining flexibility at high temperatures while providing low-temperature protection. has continued. These results represent an improvement compared to static barrier systems. 10 11. APPLICABILITY TO INDUSTRY The invention can be produced using the following standard industrial equipment: • Mixers • Homogenizers • Vacuum emulsifiers • Heating boilers • Cooling tanks • Filling lines • Patch coating systems • Stick filling systems Areas of application: • Facial care • Body care • Hand care • Lip care • Scalp care • Post-procedure care • Climate defense products • Sports skincare • Premium dermocosmetic products • Protective dermatological aids 11 12. CONCLUSION The invention describes measurable barrier properties in reversible environments with varying temperatures. It offers an adaptive dermal barrier system that can be modulated in this way. Unlike traditional static systems, it adapts dynamically to thermal conditions. It ensures comfort, repeatability, and barrier support. Thus, it is commercially viable. It offers a viable next-generation dermal barrier platform. Composition: cream, lotion, emulsion, gel, serum, balm, stick, spray, foam, mask, It can be in patch, film, ointment, or hybrid dosage form. 12

Claims

1. It is an adaptive dermal barrier system for topical application, suitable for cosmetics or It must contain a pharmaceutically acceptable composition. The composition forms a reversible barrier phase on the skin's surface when applied to the skin. It must be structured in such a way that the composition contains at least one lipid component and at least It contains a small amount of polymeric structuring component and optionally at least one It contains moisturizers and / or sensory regulators, and the barrier phase adapts to environmental temperature and skin conditions. at least one in response to surface temperature or temperature gradient between them its ability to reversibly modulate a measurable physical parameter, measurable physical parameters: permeability coefficient (P), diffusion coefficient (D), elastic modulus (E), viscoelastic response, packing density, free volume, film continuity, vapor permeability rate, water activity (aw), transepidermal water loss resistance, optical scattering, surface friction, adhesion level, gloss, degree of microstructural organization, characterized by the phase-volume ratio and the selection of combinations thereof. Adaptive dermal barrier system.

2. Adaptive dermal barrier system according to claim 1, with a barrier phase at low temperature. at least the first functional state under the given conditions and the second under higher temperature conditions. An adaptive dermal barrier system characterized by its functional status.

3. According to claim 2, it is an adaptive dermal barrier system, and the first functional state is... higher packing density and lower compared to the second functional state. An adaptive dermal barrier system characterized by its permeability.

4. According to claim 2, it is an adaptive dermal barrier system, and the second functional state is... Higher flexibility and more controlled steam compared to the first functional state. An adaptive dermal barrier system characterized by its permeability.

5. According to Claim 1, it is an adaptive dermal barrier system, and there is at least one measurable continuous or stepwise modulation of the physical parameter throughout the temperature range. stepped, nonlinear, sigmoidal, multi-stage, threshold-supported, buffered, occurring with hysteresis, asymmetrically, or a combination of these. The characterized adaptive dermal barrier system. 13 6. Adaptive dermal barrier system according to claim 1, where the barrier phase is subjected to repeated heating. and reversible transitions between functional states during cooling cycles an adaptive dermal barrier system characterized by its construction.

7. According to claim 1, it is an adaptive dermal barrier system, and the barrier phase is during heating. the functional pathway will be different from the functional pathway during cooling An adaptive dermal barrier system characterized by exhibiting hysteresis.

8. According to claim 7, the adaptive dermal barrier system is involved, and the hysteresis in question is related to the previous delaying the loss of barrier compactness during warming after cold exposure an adaptive dermal barrier system characterized by...

9. According to claim 7, the adaptive dermal barrier system is involved, and the hysteresis in question is internal and external. by providing smoother adaptation during repeated transitions between environments The characterized adaptive dermal barrier system.

10. Adaptive dermal barrier system according to Claim 1, with at least two full heating / cooling cycles. at least 70% of the initial functional response of the barrier phase after the cycle An adaptive dermal barrier system characterized by its protective properties.

11. Adaptive dermal barrier system according to claim 10, with at least 80% preserved response. an adaptive dermal barrier system characterized by its presence.

12. Adaptive dermal barrier system according to claim 10, with at least 90% preserved response. an adaptive dermal barrier system characterized by its presence.

13. Adaptive dermal barrier system according to Claim 1, at higher reference temperature the measured permeability (P₂) is lower than the permeability (P₁) measured at a lower reference temperature. Adaptive dermal barrier characterized by a ratio between 1.05 and 5.

00. system.

14. According to claim 13, it is an adaptive dermal barrier system, and the ratio in question is between 1.10 and 3.

00. an adaptive dermal barrier system characterized by its presence between these two elements.

15. According to claim 13, it is an adaptive dermal barrier system, and the ratio in question is between 1.20 and 2.

50. an adaptive dermal barrier system characterized by its presence between these two elements. 14 16. It is an adaptive dermal barrier system according to claim 1, with elastic modulus in two thermal states. an adaptive dermal barrier characterized by a variation of at least 5% between the two. system.

17. Adaptive dermal barrier system according to claim 16, with an elastic modulus of at least 10%. An adaptive dermal barrier system characterized by a change in its rate.

18. Adaptive dermal barrier system according to Claim 1, with a barrier phase at low temperature. by reducing transepidermal water loss compared to untreated skin under these conditions The characterized adaptive dermal barrier system.

19. According to claim 18, the adaptive dermal barrier system is involved, and the reduction in question is at least... An adaptive dermal barrier system characterized by a 10% concentration.

20. Adaptive dermal barrier system according to Claim 1, where the barrier phase is at high temperature. lower viscosity compared to a petrolatum-based comparator under these conditions An adaptive dermal barrier system characterized by its ability to provide 21. It is an adaptive dermal barrier system according to claim 1, with a mild barrier phase. Higher barrier support at lower temperatures according to the humidifier comparator. An adaptive dermal barrier system characterized by its ability to provide 22. According to claim 1, it is an adaptive dermal barrier system, and the barrier phase is a lipid phase transition, wax crystal rearrangement, polymer mobility shift, glass transition proximity effect, free volume modulation, supramolecular packing change, hydration-induced spacing change, associative network rearrangement, particle-network from redistribution, microzone reorganization or hybrid phase reorganization characterized by its creation through one or more selected reversible mechanisms. the developed adaptive dermal barrier system.

23. Adaptive dermal barrier system according to claim 1, whose composition includes ceramides, cholesterol, fatty acids, esters, triglycerides, hydrocarbons, silicones, natural oils, at least one of the following selected from synthetic emollients, waxes or combinations thereof An adaptive dermal barrier system characterized by the presence of lipid components.

24. It is an adaptive dermal barrier system according to Claim 1, and the composition is acrylate. polymers, polyurethane dispersions, cellulose derivatives, polysaccharides, compounding polymers, thermosensitive polymers, film-forming copolymers, or their derivatives characterized by containing at least one polymeric component selected from its combinations Adaptive dermal barrier system.

25. According to claim 24, it is an adaptive dermal barrier system, and the polymeric component in question... acrylates / C10-30 alkyl acrylate crosspolymer, polyacrylate crosspolymer-6, sodium polyacrylate, polyurethane-35, hydroxyethylcellulose, hydroxypropyl methylcellulose, VP / eicosene copolymer, VP / hexadecene copolymer, xanthan gum, sclerotium gum, carbomer, acrylate copolymer or at least one of these combinations an adaptive dermal barrier system characterized by its inclusion.

26. According to claim 1, it is an adaptive dermal barrier system, and its composition includes glycerin, propanediol, butylene glycol, sorbitol, betaine, sodium PCA or any of these characterized by containing at least one moisturizer selected from its combinations Adaptive dermal barrier system.

27. According to claim 1, it is an adaptive dermal barrier system, and the composition also has a soothing effect. agents, antioxidants, anti-aging agents, UV filters, barrier supports agents, preservatives, perfumes, pigments, sensory regulators or their derivatives by including one or more optional components selected from combinations The characterized adaptive dermal barrier system.

28. According to Claim 1, it is an adaptive dermal barrier system in which the barrier phase is a continuous film. an adaptive dermal barrier system characterized by its inclusion.

29. According to claim 1, it is an adaptive dermal barrier system with a discontinuous barrier phase. An adaptive dermal barrier system characterized by the presence of a microregion network.

30. It is an adaptive dermal barrier system according to claim 1, and the barrier phase has a lamellar structure. an adaptive dermal barrier system characterized by its inclusion.

31. Adaptive dermal barrier system according to Claim 1, with a polymer-lipid hybrid barrier phase. An adaptive dermal barrier system characterized by its structural integrity. 16 32. According to Claim 1, it is an adaptive dermal barrier system, and the composition is a cream, lotion, emulsion, gel, serum, balm, stick, spray, foam, mask, patch, film, ointment or hybrid An adaptive dermal barrier system characterized by its presentation in dosage form.

33. Adaptive dermal barrier system according to Claim 1, the composition of which is external electronic sensors, batteries, powered controllers or user-operated thermal An adaptive dermal barrier system characterized by the absence of activation devices.

34. According to Claim 1, it is an adaptive dermal barrier system in which modulation occurs depending on the environment and / or Adaptive dermal response is characterized by the skin's passive response to thermal conditions. barrier system.

35. It is an adaptive dermal barrier system according to Claim 1, and the barrier phase must also include at least one Characterized by modulating the release kinetics of the active ingredient according to temperature conditions. the developed adaptive dermal barrier system.

36. According to claim 1, it is an adaptive dermal barrier system, the same as that achieved by heating. the measurable physical difference between the temperature reached by cooling and the same temperature reached by cooling. Adaptive dermal barrier is characterized by giving different values ​​in the parameter. system.

37. According to Claim 1, it is an adaptive dermal barrier system, and the barrier phase is at ambient temperature. after stabilizing, it will return completely or partially to the previous reference state. An adaptive dermal barrier system characterized by its rotation.

38. According to claim 1, it is an adaptive dermal barrier system, and the barrier phase is daily. after repeated transitions between cold and hot environments encountered during use An adaptive dermal barrier system characterized by its ability to maintain functional integrity.

39. A method for supporting skin barrier performance under varying temperature conditions. and, unlike any of the previous claims, the adaptive dermal barrier system on the skin its topical application and thus the barrier phase responds to temperature changes reversibly modulating at least one measurable physical parameter a method characterized by its inclusion. 17 40. Cosmetic, adaptive dermal barrier system according to previous requests 1 to 38, dermocosmetics, pharmaceutical excipients, medical device excipients or preservatives Use characterized by its application in personal care products.

41. It is an adaptive dermal barrier system according to Claim 1, and the polymeric structuring component The composition is characterized by being present in amounts ranging from 0.1% to 10% of the total weight. the developed adaptive dermal barrier system.

42. Adaptive dermal barrier system according to claim 41, with polymeric structuring agent. the component being present in a range of 0.3% to 5% of the total weight of the composition. The characterized adaptive dermal barrier system.

43. Adaptive dermal barrier system according to Claim 1, with lipid component composition Adaptive, characterized by being present in between 1% and 30% of total weight. Dermal barrier system.

44. Adaptive dermal barrier system according to claim 43, with lipid component composition. Adaptive, characterized by being present in between 3% and 20% of total weight. Dermal barrier system.

45. According to claim 1, it is an adaptive dermal barrier system, and the composition is VP / eicosene. copolymer, VP / hexadecene copolymer, acrylates copolymer, polyurethane dispersion, At least one of the polyurethane film-forming polymers and combinations thereof that have been selected. An adaptive dermal barrier system characterized by the presence of a film-forming polymer.

46. ​​According to claim 45, it is an adaptive dermal barrier system, and the film-forming polymer... The composition is characterized by being present in amounts ranging from 0.1% to 8% of the total weight. the developed adaptive dermal barrier system. 18