FUNGICIDE AND BACTERICIDE PREPARATION AND ITS METHOD OF USE

Abstract

The invention relates to agriculture, particularly plant cultivation, and involves the use of copper with thiourea or a fungicidal and bactericidal preparation based on its derivatives, as well as the spring and winter applications of this preparation cereals and legumes, open and greenhouse vegetables, woody and shrub-like plants, fruit trees, strawberries and other fruits, essential oil plants, garden plants, ornamental plants, gourds such as melons and watermelons, interrow crops, industrial and It relates to its use in the cultivation of forage crops. Fungicide or bactericide preparation, copper (I) with thiourea or methylthiourea, or N,N'-dimethylthiourea, or ethylthiourea, or N,N'-diethylthiourea, or ethylenethiourea, or N,N'-bis(dimethylamino-methyl)thiourea complex compound and also silver with thiourea or methylthiourea, or N,N'- dimethylthiourea, or ethylthiourea, or N,N'-diethylthiourea, or ethylenethiourea, or N,N'- It contains the bis(dimethylamino-methyl)thiourea complex compound. It is a fungicidal or bactericidal preparation. Also copper (I) and silver thiourea or methylthiourea, or N,N'-dimethylthiourea, or ethylthiourea, or N,N'-diethylthiourea, or ethylenethiourea, or N,N'-bis(dimethylaminomethyl) It contains a complex compound formed with thiourea. 3 independent, 5 dependent receptors.

Description

FUNGICIDE AND BACTERICIDE PREPARATION AND ITS METHOD OF USE TECHNICAL FIELD The invention relates to agriculture, particularly plant production, and involves copper, silver, and a fungicidal and bactericidal preparation based on thiocarbamide or its derivatives and also the word The subject of this preparation is summer and winter cereals and legumes, in open and protected areas. cultivated vegetables, tree and shrub species, fruit, fruit-like, and essential oil plants, garden, ornamental, melon-watermelon group, interrow cultivated, industrial and fodder crops It relates to its use in seed cultivation. The invention concerns the pre-planting treatment of seeds and also in greenhouses, home gardens, parks and farms, and agriculture. in complexes, forest nurseries, forestry enterprises, botanical gardens and in landscaping efforts, during plant cultivation, post-emergence It can be used for application to plants. PREVIOUS TECHNIQUE The intensive use of pesticides and their mixtures in agriculture is causing problems for crops. This leads to a certain slowdown in the growth and development rate of plants, It not only negatively affects the development of agricultural plants, but also, especially, water scarcity. and in conditions of climate warming, it also has negative effects on the quality of agricultural products. This can be the reason. In this context, during the cultivation of crops, seeds and planted crops... A need has arisen to reduce the pesticide load in the cultivation of these areas. It is emerging. From the current state of the art, fungicides based on dithiocarbamic acid derivatives, For example, mancozebin, which is a type of mixed salt, appears to be well known. 2 S NC S X S NC S , Here, X is Zn and Mn; substituted benzimidazole derivative-based fungicides, for example Benomil, thiabendazole, fuberidazole and carbendazim; triazole derivative-based fungicides, for example triadimefon, triadimenol, diclobutrazol, flutrimazole, flutriafen, etaconazole, Propiconazole and butrazole; imidazole derivative-based fungicides, such as imazalil and Prochlorase; fungicides based on esters and amides of phosphoric and thiophosphoric acids; amines, Fungicides based on amidines and guanidines, for example, those based on polyhexamethyleneganidine salts. Fungicides are included in the known state of the art. In addition, other classes exist. Fungicides based on chemical compounds are also widely used. As an alternative to organic synthetic substances, copper (II) compounds based in agriculture Pesticides are also widely used. These types of substances are relatively inexpensive and... They stand out for their ease of production, and also for the fact that they cause plant diseases. not only fungal in origin, but also a wide range of bacterial agents. It has the ability to suppress its development. A water-insoluble copper compound widely used in agriculture worldwide. The first truly antimicrobial agricultural preparation consisted of a mixture of copper sulfate and lime milk. Bordeaux mixture was formed. This was followed by copper hydroxide, copper carbonate and copper oxychloride. Other copper compounds have also begun to be used. Copper compounds have high... Their effectiveness is due to the low probability of resistance development in phytopathogens and their interaction with plant cells. They are characterized by having low toxicity to mammals. Preparations with higher fungicidal effect are based on complex compounds of copper. These are the examples. For instance, in RF Patent No: 2536404, the fight against plant fungal diseases is described. for the purpose of [N,N′-bis(dimethylaminomethyl)thiocarbamide-oxalate] copper sulfate pentahydrate Its usage has been explained. Once it enters the soil, copper does not remain in dissolved form; it mixes with clay minerals and It readily binds with humus components. However, copper from the soil... removal by washing, transport by rainwater, or uptake by plants 3 Because it is present in limited amounts, it accumulates especially in the top 15 cm layer of soil, affecting the surrounding area. This can lead to accumulation and biodegradation. Indeed, for over a century... continuous application of high concentrations of copper compounds throughout, Copper accumulation in cultivated agricultural soils is 40–50 times higher compared to uncultivated soils. This has led to copper reaching even higher levels. Therefore, copper in agriculture... The use of its compounds is restricted. In this context, the relatively low value of the metal New copper that retains its antimicrobial and fungicidal efficacy even at high concentrations. The development of preparation forms has gained importance. One of the strategies to maximize the effectiveness of copper compounds is to use efficient The reduction in the particle size of the material has been achieved; because smaller particles, coating, This ensures a more homogeneous distribution and adhesion, and prevents the preparation from flowing. It increases its resistance. Additionally, it has a higher specific surface area and surface-to-volume ratio. These types of particles enable the faster release of active Cu²⁺ ions. However, the feasibility of this approach, in terms of aggregation, is questionable. obtaining stable particles with a diameter smaller than 1 µm with sufficient economic efficiency. It is limited due to technological constraints that prevent it from being implemented. Another approach to increasing the effectiveness of copper-based pesticides is... more active chemical forms of the metal in question, for example copper (I) compounds This is the subject of research. Indeed, monovalent copper in the form of Cu₂O oxide is found in Nordox, a Norwegian company. NORDOX 75 WG fungicide, produced by [company name] and commercially available. It constitutes the main active ingredient (860 g / kg). However, this preparation The disadvantage is the large size of the copper oxide particles, which affects the preparation. It reduces its effectiveness. From the prior art, RF Patent No: 2022126588 dated 12.10.2022 as described in patent application number [number], at least one thiocarbamide, methylthiocarbamide, N,N′-dimethylthiocarbamide, ethylthiocarbamide, N,N′-diethylthiocarbamide, ethylenethiocarbamide or formed by N,N′-bis(dimethylaminomethyl)thiocarbamide with copper (I) ions A fungicidal and bactericidal preparation containing a complex compound is known. In this preparation, copper is present in solution form, which is different from similar products. It significantly increases the biological activity of the preparation. However, this preparation... The effectiveness of fungicide or bactericide application carried out with these methods is insufficient in some cases. It can remain. 4 In this context, more effective copper-based fungicide and bactericide preparations Its development presents a technical problem. The stated technical result is a fungicidal and bactericidal one, which is explained in detail below. This is achieved through the preparation and the application of the method of use. 5 DETAILED DESCRIPTION OF THE INVENTION Various complex compounds formed with thiocarbamide and its derivatives During the experimental investigation of its biological activity, it was found to contain Cu⁺ and Ag⁺ ions. These types of complexes exhibit high fungicidal and bactericidal activity, and are also suitable for agricultural use. It has acceptable chemical stability and low phytotoxicity for applications. It has been determined that, within this scope, the combined use of silver and copper complexes, This provides a higher level of effectiveness compared to applying them separately. This situation makes it possible for these preparations to be used as fungicides during plant cultivation in agriculture. to reach a conclusion regarding the possibility of using them as bactericidal preparations It makes it possible. The invention for which the application has been filed is a fungicide or a substance that can be applied in plant cultivation. This relates to bactericidal preparations; summer and winter cereals and legumes, both open and protected. vegetables, tree and shrub species, fruits, berry plants, and essential oil plants grown in the area. including garden, ornamental, melon-watermelon group, interrow cultivated, industrial and fodder crops. It is suitable for use in the cultivation of various crops. The invention application describes at least one form of thiocarbamide, methylthiocarbamide, N,N′- dimethylthiocarbamide, ethylthiocarbamide, N,N′-diethylthiocarbamide, ethylenethiocarbamide or At least one of the following is formed by N,N′-bis(dimethylaminomethyl)thiocarbamide and copper (I) ions complex compound and also at least one thiocarbamide, methylthiocarbamide, N,N′- dimethylthiocarbamide, ethylthiocarbamide, N,N′-diethylthiocarbamide, ethylenethiocarbamide or At least one of the following is formed by N,N′-bis(dimethylaminomethyl)thiocarbamide and silver ions containing complex compounds or, alternatively, from the aforementioned thiocarbamide derivatives at least one mixture formed by copper (I) and silver ions together with any of them. This relates to a fungicidal or bactericidal preparation containing a complex compound. The invention application concerns a system where the mass ratio of copper to silver is between 50:1 and 1:10. This relates to a fungicide or bactericide preparation, among others. The invention for which the application is made is in a complex compound of copper (I) or silver, or copper (I) and the counterion, succinate, which is part of the complex compound formed by silver, malate, citrate, lactate, formate, acetate, salicylate, phosphate, phosphite, rhodanide, methosulfate, 8 to 18 Monocarboxylic acids containing saturated or unsaturated alkyl radicals with carbon atoms, iodide, alkylphosphonates, borate, glycinate, glutamate, ethylenediaminetetraacetate or This relates to a fungicide or bactericide preparation selected from the orthoethylidene diphosphonate group. 6 The invention for which the application has been submitted is also a fungicide or bactericide in plant cultivation. This relates to the method of use of the preparation; summer and winter cereals and legumes, open and vegetables, tree and shrub species, fruit, berry fruits, essential oils grown in protected areas plants, garden, ornamental, melon-watermelon group, interrow cultivated, industrial and fodder crops It is applicable in the cultivation of various crops, including [list of crops]. The applied-for invention is a fungicide or bactericide for plant cultivation. This relates to the method of use of the preparation; in this method, plant seeds or Vegetative plants are treated with a solution containing the preparation. The invention is described below with examples of alternative applications. Example 1 As a fungicidal and bactericidal preparation, complexed with ethylene thiomove-environment (ETU). silver that has formed a complex with copper (I) compound and ethylene thiomone. A mixture of the compound was used. This mixture contained bis-formate anion. imidazolidine-2-thionyl copper (I) complex [CuETU₂]⁺HCOO⁻ with bis- containing nitrate anion The imidazolidine-2-thionyl silver complex consists of the compounds [AgETU₂]⁺NO₃⁻, The mixture is prepared with a copper and silver ratio of 10:1 by mass. The preparation was obtained in the following manner. The calculated amount of ground copper carbonate, along with a stirrer and thermometer... It was placed in an equipped balloon along with the required amount of room temperature distilled water. The resulting mixture was stirred for 10 minutes to create an aqueous suspension. During mixing, the complexing agent ethylenethiomine was added sequentially via a dropper funnel, Solutions containing ascorbic acid and formic acid as reducing agents in calculated amounts. It was added to the suspension. Then the reaction mixture was heated to 60 °C and left for 2 hours. It was stirred continuously. A large release of carbon dioxide gas was observed during the reaction. 2 hours Eventually the suspension was almost completely dissolved and the reaction mixture, bis-imidazolidine- + - 2-thionyl-copper (I) formate [CuETU] HCOO became a clear solution. From this 2 Then the reaction mixture was cooled to room temperature, stirred for another 30 minutes, and It floated down. The calculated amount of silver nitrate is placed in a container equipped with a stirrer and thermometer. The balloon was filled with the required amount of room temperature distilled water. The resulting... Add the calculated amount of complex 7 to the solution through a dropper funnel during mixing. A solution containing the ethylenethiomire catalyst was added. Then the reaction mixture was heated to 60 °C. It was heated and stirred until the reaction mixture was bis-imidazolidin-2-thionyl-silver (I) nitrate. + - [AgETU] formed a clear solution of NO. After that, the reaction mixture was left in the room. 2 3 It was cooled to room temperature, stirred for another 30 minutes, and then strained. The mixture of the obtained filtrates was used as bactericidal and fungicidal preparation P-1. The bactericidal and fungicidal activity of the obtained P-1 preparation was determined under in vitro conditions. Phytopathogenic microorganisms: Erwinia atroseptica, Sclerotinia sclerotiorum, and UgLaTF7 It was examined against Fusarium equiseti. These microorganisms cause bacterial blight in plants. They are the causative agents of diseases such as sclerotinosis and root and stem rot. Furthermore, the obtained... The microbiological activity of the preparation was compared with two commercially available analogs. Compared: «Kocide 2000» (copper hydroxide based, USA) and «Zerox» (colloidal silver (essentially, Russia). Bactericidal effect against Erwinia atroseptica is due to the reduction of colony-forming units (CPUs). The bacteria were identified by enumeration method. For this, bacteria were incubated on LB agar at 28 °C for 24 hours. It was grown in a medium; then washed with sterile water and diluted 1:1. The suspension was prepared. The resulting suspension was transferred to test tubes and the calculated amount was added. The preparation was added until the final concentration was reached and left to stand for 30 minutes. Control Equal volumes of water were added to the tubes. After incubation, 50 µl of suspension was taken. It was removed, resuspended, and placed on the surface of the agar medium using a sterile spatula. It spread. After 72 hours of incubation at +28 °C, the colony count was calculated. The preparations were examined at different dilutions, P1–P4; in these dilutions The concentration of the active ingredient is 2, 20, 200 and 600 depending on the total copper and silver content. ppm (ppm – parts per million, 10⁻⁶) or for comparison samples 0.2; 2; 20; 60 for silver. The concentrations were determined as ppm for the inventor and 2; 20; 200; 600 ppm for copper. Obtained within the scope of the invention. The P1–P4 dilutions of the preparation contained the following compositions: P1 – 0.18 Ag and 1.8 Cu, P2 – 1.8 In the comparison examples: Ag and 18 Cu, P3 – 18.2 Ag and 182 Cu, P4 – 54.5 Ag and 545 Cu The dilutions were as follows: P1 – 0.2 Ag or 2 Cu, P2 – 2 Ag or 20 Cu, P3 – 20 Ag or 200 Cu, P4 – 60 Ag or 600 Cu. Fungicidal effect of Sclerotinia sclerotiorum and UgLaTF7 against Fusarium equiseti, In Petri dishes, phytopathogenic mycelium is prepared by adding the preparation to pea agar medium. the ratio of its radial growth to its growth in fungicide-free control medium (evaluated as a percentage). When this rate is 100, there is no fungicidal effect; 0.8 When this occurs, the growth of the phytopathogen is considered to be completely suppressed. A diameter of 5 mm... The agar block containing mycelium was placed in the center of a Petri dish and incubated at +23–25 °C. They were incubated under lighting conditions. Measurement of the examined fungal colonies was performed using a control method. In this example, radial growth was performed when the colony diameter reached 50–75% of the Petri dish diameter. The evaluation is based on total copper and silver content at 2, 20, 60 and 200 ppm. concentrations of silver at 0.2; 2; 6; 20 ppm for comparison sample. The tests were performed at their respective concentrations, in two repetitions. The results of the laboratory tests (Tables 1, 2) show that the P-1 preparation The [CuETU₂]+HCOO⁻+[AgETU₂]+NO₃⁻ compound inhibited the growth of the three phytopathogens studied. It has been shown to be able to suppress more effectively than analog versions it was compared with. The data obtained indicate that the prepared preparation is effective at low concentrations of the active substance. even exhibits significant antimicrobial activity against both bacterial and fungal phytopathogens. It shows that he possesses it. Table 1. KOE of P-1 preparation and its analogs against Erwinia atroseptica. Comparison of bactericidal activity based on colony-forming unit. Reproductive Preparation Control, water P1 P2 P3 P4 P-1 >10000 2 0 0 0 + - [CuETU ] HCOO >10000 6 0 0 0 2 «Zerox» >10000 2500 200 170 29 Copper hydroxide «Kocide 2000» >10000 >10000 >10000 >10000 >10000 Table 2. Comparison of fungicidal activity – in medium with preparation addition and Percentage of colony diameters (%) in control – Sclerotinia sclerotiorum and UgLaTF7 Fusarium P-1 preparation and its analogues against equiseti 9 Reproductive Preparation Control, water Sclerotinia sclerotiorum Fusarium equiseti Р1 Р2 Р3 Р4 Р1 Р2 Р3 Р4 P-1 100 0 0 0 0 89 0 0 0 + - [CuETU ] HCOO 100 70 0 0 0 100 59 5 0 2 «Zerox» 100 100 95 0 0 100 100 100 89 Copper hydroxide «Kocide 2000» 100 100 100 100 100 100 98 93 93 Example 2 As a fungicide and bactericide preparation, a mixture of ethylene thiomoresis with copper (I) and silver. A complex compound was used. The preparation was obtained as follows: The calculated amount of ground copper (I) oxide (Cu₂O) and silver nitrate, molar ratio 1:1 – mass ratio 1:1.7 for copper and silver. so that – containing the required amount of room temperature distilled water, a mixer and The mixture was placed in a balloon equipped with a thermometer. The resulting mixture was an aqueous suspension. It was mixed for 10 minutes to form the mixture. Mixing was done on the suspension. During this process, the calculated amounts of complexing agent are administered sequentially via a dropper funnel. Ethylene thiomine and citric acid solutions were added. The reaction mixture was then heated to 60 °C and stirred for 2 hours. A significant release of carbon dioxide was observed during the reaction. After 2 hours, the suspension... It was almost completely dissolved, and the reaction mixture became a clear solution of the complex compound. It became... Then the reaction mixture was cooled to room temperature, for another 30 minutes. It was mixed and filtered. The resulting filtrate was labeled as bactericidal and fungicidal preparation P-2. It was used. The bactericidal and fungicidal activity of the resulting P-2 preparation was determined using the method in Example 1. The preparation was examined similarly. The preparation was tested at different dilutions, P1–P4; this In dilutions, the concentration of the active substance is 2, 20, depending on the total copper and silver content. 200 and 600 ppm, and in comparison samples only silver or copper. It was determined. The P1–P4 dilutions of the preparation obtained within the scope of the invention have the following compositions. It contained: P1 – 1.25 Ag and 0.75 Cu, P2 – 12.5 Ag and 7.5 Cu, P3 – 125 Ag and 75 Cu, P4 – For comparison samples, the dilutions were as follows: P1 – 2 Ag (375 Ag and 225 Cu). or 2 Cu, P2 – 20 Ag or 20 Cu, P3 – 200 Ag or 200 Cu, P4 – 600 Ag or 600 Cu. 10 The results of the laboratory tests (Tables 3, 4) show that the P-2 preparation was examined in three stages. It can suppress the growth of phytopathogens more effectively than compared analogs. has shown. The data obtained indicate that the prepared preparation is effective at low concentrations of the active substance. even exhibits significant antimicrobial activity against both bacterial and fungal phytopathogens. It shows that he possesses it. Table 3. KOE of P-2 preparation and its analogs against Erwinia atroseptica. Comparison of bactericidal activity based on colony-forming unit. Reproductive Preparation Control, water P1 P2 P3 P4 P-2 >10000 0 0 0 0 + - [CuETU ] HCOO >10000 6 0 0 0 2 "Zerox" >10000 200 170 0 0 Copper hydroxide «Kocide 2000» >10000 >10000 >10000 >10000 >10000 Table 4. Comparison of fungicidal activity – in medium with preparation addition and Percentage of colony diameters (%) in control – Sclerotinia sclerotiorum and UgLaTF7 Fusarium P-2 preparation and its analogues against equiseti Reproductive Preparation Control, water Sclerotinia sclerotiorum Fusarium equiseti Р1 Р2 Р3 Р4 Р1 Р2 Р3 Р4 P-2 100 0 0 0 0 0 0 0 0 + - [CuETU ] HCOO 100 70 0 0 0 100 59 5 0 2 «Zerox» 100 95 0 0 0 100 100 0 0 Copper hydroxide «Kocide 2000» 100 100 100 100 100 100 98 93 93 Examples Group 1 In Samples Group 1, copper (I) and silver were used as fungicide or bactericide preparations. thiourea, methylthiourea, N,N'-dimethylthiourea, ethylthiourea, N,N'-diethylthiourea, ethylenethiourea or mixtures of complex compounds formed with N,N'-bis(dimethylamino-methyl)thiourea These mixtures were used with a mass ratio of 50:1 to 1:10 for copper and silver. It is prepared in this way. The counterions used are succinate, malate, citrate, lactate, formate, and acetate. salicylate, phosphate, phosphite, rhodanide, methosulfate, iodide, borate, glycinate, glutamate, Ethylenediaminetetraacetate and orthoethylidenediphosphonate were used. The preparations are as shown in Sample 1. It was obtained and tested in a similar way using the method. For comparison purposes. [Cu(ETU)₂]HCOO⁻, «Zerox» and copper hydroxide «Kocide 2000» preparations were used. (Tables 5–7). In all cases, the effectiveness of the resulting preparations against the tested strains is comparable to that of the analogous preparation. The effectiveness of the preparations was found to be higher than that of the stated technical result. This shows that it has been obtained. Table 5. Preparations declared within the scope of invention – copper (I) and silver complex Mixtures of compounds – and the codes of analogs; KCu and KAg – copper (I) and respectively Complexing agent for silver; PCu and PAg – in the complex compound copper (I) and respectively Counterion for silver; Cu:Ag – mass ratio of copper and silver. Example Code K, PK, P Cu:Ag Cu Cu Ag Ag P-3 Thiourea, formiate Thiourea, nitrate 50:1 P-4 Methylthiourea acetate Methylthiourea acetate 25:1 P-5 N,N'-dimethylthiourea, phosphite Thiourea, acetate 10:1 P-6 Ethylthiourea, succinate Ethylthiourea, nitrate 5:1 P-7 N,N'-diethylthiourea, citrate Ethylthiourea, acetate 1:1 P-8 Ethylenethiomourea, lactate Ethylenethiomourea, nitrate 1:5 P-9 N,N'-bis(dimethylamino-methyl)thiourea, N,N'-bis(dimethylamino- 1:10 salicylate methylthiourea, acetate Table 6. Copper (I) and silver complex compounds against Erwinia atroseptica. Preparations obtained from mixtures and analogues are classified as Colony Forming Units (CCU). Comparison of bactericidal activity based on 12 Reproductive Preparation Control, water P1 P2 P3 P4 P-2 >10000 5 0 0 0 P-3 >10000 3 0 0 0 P-4 >10000 1 0 0 0 P-5 >10000 0 0 0 0 P-6 >10000 0 0 0 0 P-7 >10000 0 0 0 0 P-8 >10000 0 0 0 0 P-9 >10000 0 0 0 0 + - [CuETU ] HCOO >10000 6 0 0 0 2 «Zerox» >10000 2500 200 170 29 Copper hydroxide «Kocide 2000» >10000 >10000 >10000 >10000 >10000 Table 7. Comparison of fungicidal activity against Sclerotinia sclerotiorum. Ratio of colony diameters (%) in medium with preparation addition and in control – copper (I) and Preparations obtained from mixtures of silver complex compounds and their analogues Reproductive Preparation Control, water P1 P2 P3 P4 P-2 100 0 0 0 0 P-3 100 0 0 0 0 P-4 100 0 0 0 0 P-5 100 0 0 0 0 P-6 100 0 0 0 0 P-7 100 0 0 0 0 P-8 100 0 0 0 0 P-9 100 0 0 0 0 + - [CuETU ] HCOO 100 70 0 0 0 2 "Zerox" 100 100 95 0 0 Copper hydroxide «Kocide 2000» 100 100 100 100 100 Examples Group 2 13 In Samples Group 2, copper (I) and silver were used as fungicide or bactericide preparations. thiourea, methylthiourea, N,N'-dimethylthiourea, ethylthiourea, N,N'-diethylthiourea, ethylenethiourea or complex compounds formed with N,N'-bis(dimethylamino-methyl)thiourea Succinate, malate, citrate, lactate, formate, acetate, and salicylate have been used as counterions. phosphate, phosphite, rhodanide, methosulfate, iodide, borate, glycinate, glutamate, ethylenediaminetetraacetate and orthoethylidene diphosphonate was preferred. The preparations had a copper:silver molar ratio of 3:1, 1:1 and They were prepared in a 1:3 ratio. The preparations were obtained in a similar way to the method in Example 2. It has been processed and tested. For comparison purposes, [Cu(ETU)₂]HCOO⁻, «Zerox» and copper Hydroxide preparations «Kocide 2000» were used (Tables 8–10). In all cases, the effectiveness of the resulting preparations against the tested strains is comparable to that of the analogous preparation. The effectiveness of the preparations was found to be higher than that of the stated technical result. This shows that it has been obtained. Table 8. Preparations declared within the scope of invention – mixture of copper (I) and silver. The codes for complex compounds – and their analogs; Cu:Ag – the molar ratio of copper and silver. Example Code Complex Former, Counterion Cu:Ag P-10 Thiourea, nitrate 3:1 P-11 Methylthiourea, acetate 1:1 P-12 N,N'-dimethylthiourea, phosphite 1:3 P-13 Ethylthiourea, succinate 3:1 P-14 N,N'-diethylthiourea, citrate 1:1 P-15 Ethylenethiomere, lactate 1:3 P-16 N,N'-bis(dimethylamino-methyl)thiourea, salicylate 1:1 Table 9. Comparison of bactericidal activity against Erwinia atroseptica (KOE – Colony Forming Unit) – obtained from complex compounds of copper (I) and silver. preparations and analogues 14 Reproductive Preparation Control, water P1 P2 P3 P4 P-10 >10000 0 0 0 0 P-11 >10000 0 0 0 0 P-12 >10000 0 0 0 0 P-13 >10000 0 0 0 0 P-14 >10000 0 0 0 0 P-15 >10000 0 0 0 0 P-16 >10000 0 0 0 0 + - [CuETU ] HCOO >10000 6 0 0 0 2 «Zerox» >10000 2500 200 170 29 Copper hydroxide «Kocide 2000» >10000 >10000 >10000 >10000 >10000 Table 10. Comparison of fungicidal activity against Sclerotinia sclerotiorum. Ratio of colony diameters (%) in medium with preparation addition and in control – copper (I) and preparations and analogues obtained from complex compounds of silver Reproductive Preparation Control, water P1 P2 P3 P4 P-10 100 0 0 0 0 P-11 100 0 0 0 0 P-12 100 0 0 0 0 P-13 100 0 0 0 0 P-14 100 0 0 0 0 P-15 100 0 0 0 0 P-16 100 0 0 0 0 + - [CuETU ] HCOO 100 70 0 0 0 2 "Zerox" 100 100 95 0 0 Copper hydroxide «Kocide 2000» 100 100 100 100 100

Claims

1. Thiomocarbamide with at least one copper (I) ion or methylthiomocarbamide, N,N′-dimethylthiomocarbamide, ethylthiomocarbamide, N,N′- diethylthiomocarbamide, ethylenethiomocarbamide, or N,N′- Fungicide or bactericide containing bis(dimethylaminomethyl)thiomocarbamide complex compound. the preparation, the preparation in question also contains at least one silver ion and thiomocarbamide or methylthiomocarbamide, N,N′-dimethylthiomocarbamide, ethylthiomocarbamide, N,N′- diethylthiomocarbamide, ethylenethiomocarbamide, or N,N′- It is characterized by containing the complex compound bis(dimethylaminomethyl)thiomocarbamide.

2. According to claim 1, the preparation is a fungicide or bactericide and contains copper and It is characterized by having a silver content by mass between 50:1 and 1:

10.

3. Fungicide or bactericide preparation according to Claim 1, containing copper (I) or silver. The counterion present in the complex compound is: succinate, malate, citrate, lactate, formate, acetate, salicylate, phosphate, phosphite, rhodanide, methosulfate, saturated or containing 8 to 18 carbon atoms. Monocarboxylic acids containing unsaturated alkyl radicals, iodide, alkylphosphonates, borate, from the glycinate, glutamate, ethylenediaminetetraacetate and orthoethylidenediphosphonate groups It is characterized by its selection.

4. A fungicide or bactericide preparation according to Claim 1, used in plant cultivation. It is characterized by its usability; the preparation in question is suitable for summer and winter cereals. legumes, vegetables grown in open and protected areas, tree and shrub species, fruit, Fruity, essential oil plants, garden, ornamental, melon-watermelon group, interrow cultivated, in the cultivation of various crops, including industrial and forage crops It is characterized by its practicality.

5. A complex compound containing at least one copper (I) and silver ion. with thiomocarbamide or methylthiomocarbamide, N,N′-dimethylthiomocarbamide, ethylthiomocarbamide, N,N′-diethylthiomocarbamide, ethylenethiomocarbamide or N,N′- Fungicide or bactericide preparations containing bis(dimethylaminomethyl)thiomocarbamide are characterized It is done.

6. According to claim 5, it is a fungicide or bactericide preparation used in plant cultivation. It is characterized by its usability; the preparation in question is suitable for summer and winter cereals. legumes, vegetables grown in open and protected areas, tree and shrub species, fruit, 17 Fruity, essential oil plants, garden, ornamental, melon-watermelon group, interrow cultivated, in the cultivation of various crops, including industrial and forage crops It is feasible.

7. Fungicide or bactericide preparation according to claim 5, containing copper (I) and silver. The counterion present in the complex compound is: succinate, malate, citrate, lactate, formate, acetate, salicylate, phosphate, phosphite, rhodanide, methosulfate, saturated containing 8 to 18 carbon atoms. or monocarboxylic acids with unsaturated alkyl radicals, iodide, alkylphosphonates, from the groups borate, glycinate, glutamate, ethylenediaminetetraacetate and orthoethylidenediphosphonate It is characterized by its selection.

8. Application of fungicide or bactericide preparation to the plant according to any of the requirements 1–7. method of use in cultivation, in which case plant seeds or vegetation are used Treating the plants in this state with a solution containing the relevant fungicide or bactericide preparation. It is characterized by its performance.