Dermocosmetic formulation containing Gypsophila Nabelekii root extract.

TR202612879A2Pending Publication Date: 2026-08-21KARADENIZ TEKNIK UNIVERSITESI TEKNOLOJI TRANSFERI UYGULAMA & ARASTIRMA MERKEZI MUDURLUGU
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Patent Information

Application Number
TR202612879
Authority / Receiving Office
TR · TR
Patent Type
Applications
Current Assignee / Owner
Filing Date
2026-07-30
Publication Date
2026-08-21
Patent Text Reader

Abstract

The invention relates to a dermocosmetic formulation in gel form that performs both facial cleansing and skin care functions, containing an ethanol extract obtained from the roots of Gypsophila nabelekii by microwave-assisted extraction.
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Description

Dermocosmetics containing Gypsophila Nabelekii root extract. FORMULATION TECHNICAL FIELD The invention describes microwave-assisted extraction of Gypsophila nabelekii roots. Containing ethanol extract obtained by this method, it performs facial cleansing and skin care functions. It involves a dermocosmetic formulation in gel form that performs a combined function. PREVIOUS TECHNIQUE Most products developed for facial cleansing purposes remove impurities from the skin's surface. synthetic surfactants for removing dirt and residues It includes moisturizing products alongside cleansing products. There are also products containing Gypsophila paniculata root extract. However, Most current facial cleansing products focus solely on the cleansing function. and its additional effects on skin care are limited. Using only products that have cleaning properties will not improve the cleaning process. followed by moisturizing, anti-aging care, or improving skin appearance. This makes it necessary to resort to different products for this purpose. Multiple products Using them separately increases the time consumers allocate for daily care, as well as the product This also leads to an increase in costs. These limitations of current products based on synthetic surfactants, on the surface Naturally derived active ingredients that can contribute to skin care as well as cleansing. This highlights the need for versatile formulations, especially those containing... For cleansing, moisturizing, antioxidant support and improving skin appearance. Existing products have the advantage of combining functions within a single product. It appears to be insufficient. THE PURPOSE OF THE INVENTION The primary aim of the invention is to produce ethanol from the roots of Gypsophila nabelekii. Containing the extract as an active ingredient, and intended for facial cleansing and skin care. a gel that combines biological effects within the same formulation The goal is to produce dermocosmetic products. 1 With this formulation developed for this purpose, the skin surface is effectively cleaned. supporting the skin's antioxidant defense capacity during cleansing The goal is to target the powerful antioxidant properties of Gypsophila nabelekii root extract. In addition to its capacity, it exhibits inhibitory effects on collagenase and tyrosinase enzymes. Thanks to this, the formulation helps prevent skin sagging and wrinkles, It is intended to have anti-aging effects and offer skin whitening effects. Another aim of the invention is to identify the different secondary components found within the extract. By taking advantage of the synergistic effect of metabolites, both facial features can be achieved with the use of a single product. It provides both cleansing and multiple biological effects for skin care. Thus, the need to use different care products after cleaning to reduce and provide the user with advantages in terms of time and cost. is the goal. The invention also involves Gypsophila nabelekii, which grows naturally in the flora of Türkiye. the utilization of this type of plant in cosmetic and dermocosmetic products, local plant-based transforming raw materials into a high value-added product and national cosmetics and a naturally derived, sustainable and versatile product for the dermocosmetic sector. It aims to achieve this. DETAILED DESCRIPTION OF THE INVENTION The invention concerns dermocosmetics containing Gypsophila nabelekii root extract. The formulation combines facial cleansing and skincare functions in a single product. It is prepared in gel form to carry out the process. The active ingredient of the formulation is... Obtained from Gypsophila nabelekii roots using microwave-assisted extraction method. This results in an ethanol extract. This extract has strong antioxidant capacity. It demonstrates and produces an inhibitory effect on collagenase and tyrosinase enzymes. It brings. The formulation contains ethanol extract of Gypsophila nabelekii roots by weight. It is used at a concentration of 0.5-5%. The formulation also contains 82.6-97.64% by weight. Pure water, 0.1-2% carbomer, 1-5% glycerin and / or D-panthenol, 0.05%- 0.2% ethylenediaminetetraacetic acid, 0.05-1% acetic acid, 0.05-1% hyaluronic acid at a certain percentage, stable preservative at a rate of 0.6-1.2%, 0.1-1% triethanolamine and / or sodium hydroxide with 0.01-1% ylang-ylang, rose or It contains one or a combination of lavender essential oils. 2 The invention describes an example of an optimum product that provides optimum performance. Formulation: 2.00% by weight ethanol extract of Gypsophila nabelekii roots. 1.00% carbomer, 1.00% glycerin and 1.00% D-panthenol, 0.10% ethylenediaminetetraacetic acid, 0.50% acetic acid, 0.90% hyaluronic acid, 1.00% stable preservative, 0.20% triethanolamine and 0.20% sodium hydroxide, 0.20% ylang-ylang and 0.10% rose essential oil and contains 91.80% pure water. Ethanol extract of Gypsophila nabelekii roots is the active ingredient in the formulation. The extract is weighed for use as a raw material. The weighed extract is then stored at a temperature of 20-25°C. It is dissolved in pure water under conditions of 40-60% relative humidity. Dissolution The process is preferably carried out using a magnetic stirrer operating at a speed of 300-700 rpm. This process is carried out and a homogeneous extract solution is obtained at the end. The polymer solution that forms the gel structure is prepared in a separate container. Carbomer can be used as a gelling agent, as can hydroxyethyl cellulose, methyl cellulose, At least one of chitosan and ethyl cellulose can be used. Polymer or polymer mixture, Added to pure water at a concentration of 0.1-3% by weight, according to the total formulation. Polymers are added to pure water and allowed to swell, then... A homogeneous polymer solution is obtained by mixing, preferably at a speed of 800-1200 rpm, for at least 2-5 hours. It is being prepared. The prepared extract solution and the polymer solution are combined and magnetically Mix on a blender, preferably at a speed of 300-600 rpm, for approximately 20-30 minutes. It is mixed. As a result of this process, the gel structure of the plant extract is homogenized. A mixture is obtained in which the ingredients are distributed in this manner. The resulting homogeneous mixture is then called... to enhance the moisturizing properties of the formulation and its effect on supporting the skin barrier for the purpose of containing at least 1-5% by weight of glycerin and / or D-panthenol. It is added to contribute to the stability of the components in the formulation. For this purpose, ethylenediaminetetraacetic acid is used as a chelating agent at a concentration of 0.05-0.2% by weight. Acid is used. Enhancing skin moisturizing properties while the mixing process continues. For this purpose, 0.05-1% by weight of hyaluronic acid is added. To adjust the pH value of the formulation and ensure its stability. Acetic acid is used at a concentration of 0.05-1% by weight. Completion of gel formation, stabilization of the gel structure and appropriate A pH regulating agent is added to achieve the desired viscosity. For this purpose... triethanolamine and / or sodium hydroxide in controlled amounts of 0.1–1% by weight. 3 is added to the mixture. The pH value of the prepared formulation should be compatible with the skin. It is kept between 4.5 and 6.5. Antimicrobial preservative system to extend the shelf life of the formulation. It is used. The protective system contains a stable protective product at a concentration of 0.6-1.2% by weight. It may contain phenoxyethanol and ethylhexylglycerin as antimicrobial preservatives. Sodium benzoate and potassium sorbate, at least one of which can be chosen. To increase the oxidative stability of the formulation, 0.05-1% by weight is added. ascorbic acid at a certain percentage, vitamin E or tocopherol at a rate of 0.01-1%, 0.005-0.5% butyl hydroxytoluene at a rate of 0.01-5% or plant-derived antioxidants Green tea extract and grape extract can be used as plant-based antioxidants. seed extract, rosemary extract or combinations thereof in the formulation It can be added. In the final stage of the preparation process, the product is given aroma and sensory properties. To achieve this, a mixture of essential oils and / or perfumes at a concentration of 0.01-1% by weight. is added. The essential oils used are ylang-ylang essential oil and rose essential oil. At least one lavender essential oil is selected. After adding all the components, the formulation is left at room temperature. On a magnetic stirrer, preferably at a speed of 400-600 rpm, for 10-15 minutes. They are mixed. At the end of the mixing process, a gel is formed in which the components are homogeneously distributed. A product in this form is obtained. The prepared gel is filled into suitable packaging. It is being made ready for use. Different secondary metabolites found in Gypsophila nabelekii root extract Thanks to the combined effect they create, the formulation, in addition to its facial cleansing function, It exhibits antioxidant, collagenase inhibitory, and tyrosinase inhibitory effects. In this respect, the formulation helps to support the skin's antioxidant defense capacity, to prevent skin sagging and wrinkles, to provide anti-aging care, and It contributes to creating a skin whitening effect. Cleaning and care functions are combined in the same gel formulation. the introduction allows the user to use multiple products separately for different purposes. This reduces the need for it. Thus, Gypsophila nabelekii root extract is a naturally sourced ingredient. And while benefiting from its multifaceted biological effects, facial cleansing and skin care are combined in one package. This is ensured through the product. 4

Claims

1. A gel-form product for use in facial cleansing and skin care. It is a dermocosmetic formulation, characterized by its extract from the roots of Gypsophila nabelekii. It is characterized by containing ethanol extract.

2. Dermocosmetic formulation according to Claim 1, characterized by its content of 0.5-5% by weight. ethanol extract of Gypsophila nabelekii roots, pure water, gelling agent at least one polymer, glycerin and / or D-panthenol, ethylenediaminetetraacetic acid, acetic acid, hyaluronic acid, antimicrobial preservative system, pH regulating agent It is characterized by containing a mixture of essential oils and / or perfume.

3. Dermocosmetic formulation according to claim 1 or 2, characterized by its weight. 0.5-5% ethanol extract of Gypsophila nabelekii roots, 82.6-97.64% pure water at a rate of 0.1-3%, at least one gel-forming polymer, 1-5% glycerin and / or D-panthenol, 0.05-0.2% ethylenediaminetetraacetic acid, 0.05-1% acetic acid, 0.05-1% hyaluronic acid, 0.6-1.2% antimicrobial preservative system, 0.1-1% pH regulating agent at a ratio of 0.01-1%, and essential oil and / or perfume at a ratio of 0.01-1%. It is characterized by containing a mixture.

4. Is it a dermocosmetic formulation according to any of the above requirements, Its characteristic feature is that it contains 0.1-2% carbomer by weight as a gel-forming polymer. It is characterized by its inclusion.

5. Is it a dermocosmetic formulation according to any of the above requirements, Its characteristic feature is that it consists of carbomer, hydroxyethyl cellulose, methyl cellulose, chitosan, and ethyl cellulose. It is characterized by containing at least one gel-forming polymer.

6. Is it a dermocosmetic formulation according to any of the above requirements, Its feature is that it acts as a moisturizing and skin barrier supporting agent by 1-5% by weight. It is characterized by containing at least one of the following: glycerin and D-panthenol, in a given ratio.

7. Is it a dermocosmetic formulation according to any of the above requirements, Its characteristic feature is that it is at least as effective as a pH regulating agent as triethanolamine and sodium hydroxide. It is characterized by the fact that it includes one of them.

8. Is it a dermocosmetic formulation according to any of the above requirements, Its defining characteristic is that its pH value ranges from 4.5 to 6.

5.

9. Is it a dermocosmetic formulation according to any of the above requirements, Its feature is that the antimicrobial preservative system contains phenoxyethanol and ethylhexylglycerin. It is characterized by containing at least one of the following: sodium benzoate and potassium sorbate.

10. Is it a dermocosmetic formulation according to any of the above requirements, Its characteristic feature is that it contains 0.05-1% by weight to increase oxidative stability. It is characterized by its ascorbic acid content.

11. Is it a dermocosmetic formulation according to any of the above requirements, Its characteristic feature is the presence of 0.01-1% by weight of E to increase oxidative stability. It is characterized by containing vitamin A and / or tocopherol.

12. Is it a dermocosmetic formulation according to any of the above requirements, Its characteristic feature is that it contains 0.005-0.5% by weight to increase oxidative stability. It is characterized by containing butyl hydroxytoluene.

13. Is it a dermocosmetic formulation according to any of the above requirements, Its properties include plant-derived antioxidants such as green tea extract and grape seed extract. It is characterized by containing at least one of the following: extract and rosemary extract.

14. Is it a dermocosmetic formulation according to any of the above requirements, Its features include ylang-ylang essential oil, rose essential oil, and lavender essential oils. It is characterized by containing at least one essential oil. 6