CONTEXT-DEPENDENT DRUG SUITABILITY VALUE-BASED PHYSICAL DRUG DISTRIBUTION CONTROL SYSTEM AND METHOD

Abstract

The invention relates to a physical drug dispensing control system (1) and method for controlling a physical drug dispensing mechanism (70) that dispenses medication to a patient, using data relating to the drug, prescription and patient. The system (1) comprises a drug identification device (20), a patient identification interface (30), a processor (10), a memory (11), a drug suitability calculation engine (12), a database (40), a controller (60) and a physical drug dispensing mechanism (70). Parameters determined from the drug, prescription and patient data are weighted according to the patient's clinical context and a drug suitability value is calculated. Based on the calculated drug suitability value, the physical drug dispensing mechanism (70) is activated, paused or locked. The system (1) can receive feedback data on the dispensing result via a feedback interface (80) and use it in subsequent suitability assessments.

Description

1 TARIFF CONTEXT-DEPENDENT DRUG ELIGIBILITY-BASED PHYSICAL DRUG DISTRIBUTION CONTROL SYSTEM AND METHOD Technological Field: The invention relates to health technologies, medical automation, drug management, and physical drug delivery. these systems relate to the technical field, particularly regarding a drug to be delivered to a patient. suitability based on patient data, prescription data, drug interaction information and usage 10 a system that allows evaluation based on multiple parameters, such as history It relates to the system. The invention also allows the resulting drug conformity value to be presented only to the user. not to be used as a decision support output, but as part of the physical drug delivery mechanism 15 a control command to start, pause or lock transformation and real-time control of the mechanism in question It encompasses a technical structure that enables this. State of the Art: 20 In healthcare facilities, care centers and individual use settings storage, preparation, timely delivery of medicines and prevention of unauthorized access Different physical drug delivery systems are used to prevent this. The scope includes automated medicine dispensers, smart medicine cabinets, and robotic dispensing. units, time-controlled pill boxes, and medication that operates according to prescription information. Vending machines are known. These systems generally involve patients or prescriptions. gathering information, determining the drug to be distributed, and a predefined time or based on the principle of carrying out the physical distribution process according to the usage plan It is based on. 30 2 In current physical drug dispensing systems, prescription number, patient ID, and drug... data such as barcode or predefined distribution time It can be used if the prescription record of the drug to be dispensed matches the record. The mechanism can be activated. However, prescriptions are required in such structures. Matching is mostly done in the form of binary verification and 5 the medication listed in the prescription, at the time of dispensing, in the patient's current clinical condition. Whether it is suitable given the circumstances is not being further evaluated. In other words, the presence of the drug in the prescription is considered sufficient for physical distribution. This includes dose deviation, timing of use deviation, drug interaction, and organ deviation. Functional values, chronic disease profile, and past usage compliance, among others. a physical inspection decision based on the combined evaluation of multiple parameters It is not being created. The known technique can also include the patient's health information, medication history, or By evaluating physiological data, drug recommendations, risk scores, or warning outputs are generated. 15 There are decision support systems that are formed. The results obtained in these systems... The results are usually displayed to the user, physician, or caregiver via the screen. This is information or a suggestion offered. However, the calculated value... a physical drug delivery mechanism that directly alters the operating state Used as a control signal; according to the evaluation result of the mechanism, 20 operation, temporary suspension or locking; also the aforementioned transactions within a predefined maximum delay time The implementation is not adequately met in existing structures. The patent numbered TR 2025 / 010377 was encountered in the literature search. In the application, patients' health information and feedback regarding medication use are included. Analyzing notifications using an artificial intelligence model, potential drug Predicting interactions and side effects and recommending medication accordingly. The creation of this system is described. The system in question involves patient data and medication. In terms of evaluating their interactions, the technical field of the present invention is 30 Although close, the calculated result is related to the physical drug delivery mechanism. The conversion of a transmitted control command into a control command is not explained. Furthermore, the relevant 3 The document describes how the physical mechanism is operated according to a drug suitability rating. Temporarily stopping or locking; depending on the patient's context. Dynamically changing the weights of the evaluation parameters; if the predefined maximum delay time is exceeded the mechanism being put into a safe state and the usage incidents that occurred 5 a closed-loop control structure where the subsequent physical control behavior is modified It is not available. The patent numbered TR 2025 / 020209 was encountered in the literature search. in the application, prescription number or patient ID 10 at hospital emergency departments By making a query via the number, the medicine is obtained from a physical vending machine. It is described how to obtain it through [the relevant authority]. The prescription is included in the document. While there is a technical link between data and physical drug delivery, The system's operation is primarily based on verifying patient and prescription records. It is based on. In addition to prescription matching, the relevant document also includes dose and time 15 deviation, drug interactions, organ function, chronic disease profile, and history by evaluating different data sets together, such as drug usage data The generation of a drug suitability rating; the consideration of that rating in different physical operations transforming the patient's situations and evaluation parameters The weighting according to context is not explained. 20 The patent numbered TR 2026 / 001829 was encountered in the literature search. in the application, a calibrated probability value is generated for the risk of diabetes. The healthcare decision support structure is detailed in patent application number TR 2025 / 023008. Describe a decision support system used for the early diagnosis of breast cancer. 25 These applications are being processed based on health data to determine quantitative risk. or generally relevant in terms of generating evaluation output together, the control of the physical drug delivery mechanism, calculated the value is used as a physical control signal or for drug delivery a 30 for switching the operation between different mechanical operating states It does not contain any structure. 4 The literature review also included document number TR 2021 / 008550 and “Meal The patent document is titled "A Drug Preparation Machine Capable of Grouping Drugs". This has been reached. The document in question contains prescriptions for medications in tablet form. a machine recipe for preparing meals according to its specifications The machine in question includes a recognition module that identifies the type of drug tablet, 5 a drug container, a detonating module for separating the tablet from its packaging, capsule material that combines medications to be used in the same meal It includes an assembly module and a packaging module that packages the capsules. The specifications also state that the processor provides the user with online access to meal dosage information. The platform can be accessed via e-Nabız or prescription reading method, and the other 10 machines It can direct its components according to prescription and dosage information. It is explained. However, the main purpose of document number TR 2021 / 008550 is to provide information on the prescription. Separating the specified medications from their blister packs, grouping them according to meal portions, 15 encapsulation and packaging. The document in question contains the information found in the prescription. a drug is modified according to the patient's condition at the time of dispensing or preparation evaluation includes prescription, dosage, timing, drug interactions, organ functions, and A context-dependent analysis of multiple parameters relating to historical usage consistency. Establishing a drug suitability value; this value is transmitted to the physical mechanism 20 converting it into a real-time control signal or the mechanism Based on the evaluation results, operation, pause, and lockup states. The exchange between them is not explained. The relevant document is the prescription instruction. although it is intended to be physically fulfilled, the prescription whether its implementation is appropriate in terms of current patient conditions 25 a separate and context-dependent physical control layer that evaluates It does not offer. US9014847B2 was encountered in the international literature search. Patent document number [number] describes a device that dispenses medication at predefined times to patient 30. test results that can verify identity, such as breath alcohol level or cognitive test results. a drug control that can block distribution if certain criteria are not met The system is described. However, the document also includes prescription matching, dosage, and factors such as timing, drug interactions, organ function, and usage history. a composite drug weighted according to patient context from different data sets creating a suitability value and determining whether this value is for operation, pause or It is not explained how to convert it to one of the locking commands. 5 The patent numbered US7359765B2 was encountered during the literature search. The document states that the medications are distributed to authorized users at predetermined times. An electronic pill dispenser for dispensing pills is described. The system is geared towards the physical execution of the time schedule, and the patient's 10 A multiparameter drug suitability assessment based on the current clinical context. the creation of dynamic evaluation parameters weighting or conditional suspension of the distribution mechanism It does not explain. The patent numbered US7844361B2 was encountered in the literature search. the document describes usage such as opening or moving the medicine container. detection of events and transmission to the remote healthcare provider a system for monitoring adherence to prescribed medication use However, the document's fundamental approach is that drug use should be 20 It involves monitoring and reporting, and is context-dependent based on clinical and prescription data. the creation of a suitability value and the physical distribution mechanism of this value It is not explained how this is converted into a control command. During the literature search, the numbered US20080077440A1 was encountered (25). in the patent document, one or more physiological parameters from the user The choice of medication is made based on an evaluation of the available information. Describe an automated drug dispenser in which the dosage or administration time can be determined. However, the document also addresses prescription suitability, drug interactions, 30 different data categories such as organ function and past usage compliance a compound drug by dynamically weighting it according to patient context 6 creating a suitability value and determining whether this value is for operation, pause or It is not explained how it is converted into one of the locking commands. The patent numbered US10255412B2 was encountered in the literature search. in the document, 5 obtained from an inhaler or similar drug delivery device. Analysis of usage events including information such as time, location, and type of usage. a treatment and usage compliance management system based on its description This document is obtained from a specific drug delivery device. This involves the analysis of usage data, across multiple clinical and prescription perspectives. to create a general drug eligibility value from the data and general purpose 10 It does not explain how the physical medicine dispenser is controlled according to this value. The patent numbered US11090434B2 was encountered in the literature search. in the document, specifically according to physiological data obtained from the glucose sensor Determining the insulin dose and administering it to the patient via a pump is 15. An automated drug dispensing system is described. However, the relevant structure... It is aimed at a specific therapeutic application and involves different drugs, prescription data, drug interactions, organ function, and usage history all together. a context-dependent general drug suitability assessment by evaluating 20 creation and operation, pause or locking of the physical dispenser It does not explain how to change between the situations. The patent numbered US11743424B1 was encountered in the literature search. The document states that the medications, contained in a locked container, are administered to the user in a controlled manner. 25 A dispenser for verification purposes is described in the document. relevant in terms of restricting physical access and verifying usage. However, the decision to lock down or deploy is a multi-parameter and context-based one. It does not generate a dependent drug eligibility account. The patent numbered EP2485704A1 was encountered during the literature search. The document states that medicine pouches are mechanically presented to the user, and the pouches 7 barcode information on it can be read and medication compliance can be checked. A drug dispenser that can be monitored is described. However, the document states... Establishing a multiparameter and context-dependent clinical relevance value and activating, pausing or restarting the physical distribution mechanism of this value Converting it into a control signal that switches between interlocking states 5 It is not explained. The literature review revealed US8100829B2 and its continuation. In the patent application documents numbered US8403847B2, 10 by transforming and combining different health data related to the patient The description describes the creation of a health score representing the patient's overall health status. This is done according to the relevant documents, depending on the patient's clinical condition. Changing the influence or weight of health factors on the calculation This is explained in detail. However, these documents are intended to be distributed. The suitability of the drug depends on the prescription, dosage, timing of use, drug interactions, and usage. 15 evaluation of the compatibility parameters; the physical value of the calculated value operation, pause or lockout of the drug delivery mechanism conversion to command or physical drug delivery mechanism It does not include a structure for direct control. The patent numbered US10902946B2 was encountered in the literature search. The document includes an adherence score for medication use, based on past usage. It is described that the update should be made taking into account the events in question. The document includes the compliance score, the current usage event, and the previous compliance score. Calculation via a weighted correlation that takes both into account 25 This is explained. However, the relevant document describes it as a context-dependent drug. calculation of the suitability value or the physical drug of that value activation, deactivation or locking of the distribution mechanism It does not contain a structure for converting it into a control command. The patent numbered WO2024138127A1 was encountered in the literature search. The document states that different drug regimens can be administered through a physical drug dispenser. 8 implementation, taking patient health measurements and related to those measurements Treatment efficacy by determining reliability weights The evaluation is described. The results obtained indicate that the current drug regimen is... It is used to maintain the current treatment or to switch to a different drug regimen. However, the document in question includes an image of the specific drug to be distributed. Identification via barcode and / or RFID data; drug-related conformity. Creating a context-dependent drug suitability value from its parameters and this Physical drug delivery by comparing the value with a lower and an upper decision threshold. 10 of the start, pause or lock commands for the mechanism The conversion to one is not explained. Therefore, the relevant document provides treatment. While moving towards the evaluation and selection of the regime, the current invention will be distributed. direct physical dispensing control of the suitability assessment of a specific drug. It transforms. When current techniques are considered together, the known solutions generally consist of two. It appears that they are grouped into main categories. The first group includes prescription, time, patient identity, drug identification or working according to a limited number of predefined conditions The first group includes physical drug delivery and preparation systems. By evaluating patient and drug data, recommendations, risk scores, treatment management, or 20 Decision support and automated drug delivery systems that generate dose adjustment output. It is located there. Some physical drug delivery systems have a time schedule, user based on identity, alcohol level, cognitive test result, or specific physiological data 25 Depending on the situation, it is possible to prevent or modify the distribution. Together, these systems ensure prescription matching, dosage and timing accuracy, and drug safety. different factors such as interactions, patient history, organ function, and usage compliance data categories with varying weights depending on patient context A general and composite drug suitability rating based on evaluation 30 It is not being created. 9 Similarly, healthcare decision support and automated drug delivery systems for patients While it is possible to generate risk, recommendation, or dosage outputs based on the data, the outputs operate a general-purpose physical drug delivery mechanism, temporary Integrated features for switching between pause or lock states. its use within a control layer; the control process is pre-prepared 5 to be completed within the defined maximum delay time and the subsequent physical control behavior will change the usage events that occurred In existing structures, this closed-loop system is not sufficient. It is not being met. Therefore, prescription matching, dosage and timing appropriateness, drug interactions, patient different data such as history, organ function and usage compliance together by evaluating and establishing a context-dependent drug suitability value; activation, temporary pause whose value is transmitted to the physical drug delivery mechanism or converts the control operation to a locking command; a predefined 15 usage completed and realized within the maximum latency period using feedback about the incident in subsequent physical control behavior The need for an integrated technical system continues. Brief Description of the Invention: 20 The invention enables a drug to be dispensed to a patient solely based on the information provided in the prescription. no, the suitability of the drug for the relevant patient at the time of distribution evaluation and the resulting assessment of physical drug delivery It relates to a system that enables its use in controlling the mechanism. 25 The invention includes the patient, the prescription, the drug, and past usage behavior. Context-dependent drug suitability is determined by evaluating multiple data points together. a value is created. This value is presented only to the user. This is not intended as information or advice, but rather as a matter of principle regarding the physical drug delivery mechanism. 30 a control signal for starting, pausing or locking It is being transformed. Thanks to this structure, the patient's current clinical condition, along with what is included in the prescription, is displayed. drug interactions, dose or timing deviations, or past usage behavior uncontrolled distribution of a drug that is unsuitable for medical care This can be prevented. Furthermore, the control process must be completed within the specified time frame. If the process cannot be completed, the system will enter a safe operating state. It can be passed through. The primary purpose of the invention is to convert the calculation result regarding drug suitability into a physical drug. a control that directly changes the operating status of the distribution mechanism 10 It is to convert it into a signal. Another purpose of the invention is to address prescription, dosage, timing of use, drug interactions, and patient information. different data such as history, organ function and usage compliance together By evaluating the patient's current condition, a drug suitability value of 15 is determined. to create. Another aim of the invention is to adapt the physical drug delivery mechanism to different risk factors. depending on the circumstances, they can operate, temporarily suspend or lock it, and the decision is made accordingly. If it cannot be produced within the specified time, uncontrolled distribution will occur. 20 To prevent. Another purpose of the invention is to provide feedback regarding the physical distribution or use event. By using notification data in subsequent drug suitability assessments, past closed loop 25 where the results of the process affect the future physical control behavior It is about creating a structure. Explaining the Figures: The invention will be described by reference to the attached figures, so that the invention is defined in 30 Its features will be understood more clearly. However, the purpose of this invention is not this specific one. It is not about limiting it with regulations. On the contrary, the invention's accompanying claims 11 all alternatives and modifications that can be included within the area defined by it and the inclusion of their equivalencies is also intended. The details shown are only It is shown for the purpose of describing the preferred arrangements of the present invention and both the shaping of methods and the rules and concepts of invention To provide the most useful and easily understandable description of its features, 5 It should be understood that they are presented in these drawings; Figure 1 shows the general architecture of the physical drug delivery control system that is the subject of this invention. Schematic view showing the diagram. Figure 2 - Control and feedback of the physical drug delivery mechanism subject to the invention. Schematic view showing the notification structure. Explanation of References: 1. Physical drug dispensing control system 10. Processor 11. Memory 12. Drug suitability calculation engine 20. Drug identification system 20 21. Sensor Camera 22 23. Barcode reader 24. RFID reader 30. Patient identification interface 25 31. User terminal 32. Authorized personnel interface 40. Database 50. Communication interface 51. External health information system 30 60. Controller 70. Physical drug delivery mechanism 12 71. Actuator 72. Medicine container 73. Drug selection and transfer mechanism 74. Locking mechanism 80. Feedback interface 5 81. Feedback source Timer 90. 100. Notification interface Description of the Invention: 10 This detailed description explains the context-dependent drug suitability value of the invention. Physical drug delivery control system based on (1), only better for the subject for the purpose of understanding and without creating any limiting effect. This is explained as follows. 15 As shown in Figure-1, the physical drug delivery control system (1) delivers to the patient. identification of the drug to be provided, data relating to the relevant patient and prescription. obtaining the data and calculating the drug's suitability rating using that data. and depending on the calculated value, the physical drug delivery mechanism (70) 20 It is based on the principle of checking drug suitability. The system (1) the calculation result is presented to the user only as information or a suggestion. not producing; the result in question is due to the physical drug delivery mechanism (70) It converts the operating state into a control signal that directly changes it. The system (1); at least one processor (10), at least one memory (11) associated with the processor (10), drug suitability calculation engine (12), drug identification mechanism (20), patient identification interface (30), database (40), communication interface (50), at least one controller (60), physical drug delivery mechanism (70), feedback interface (80), It includes a timer (90) and a notification interface (100). The system (1) also includes 30 user terminal (31), authorized personnel interface (32) and external health information system It can work in relation to (51). 13 The processor (10) obtains the drug, patient, prescription and usage information within the scope of the system (1). processing the data, running the drug suitability calculation engine (12) and the obtained the control signal to be transmitted to the controller (60) depending on the calculation result It refers to the data processing structure that constitutes the processor (10); a central server, 5 local computer, embedded processing unit, edge computing device, or a combination of these. It can be found on the communicating combination. Memory (11) stores the program instructions executed by the processor (10), computation parameters, decision thresholds, weighting coefficients, patient and drug data, and 10 Memory (11) can store the intermediate data generated during the process. memory, permanent memory, local data storage, remotely accessible data storage It can be implemented in the form of a single area or a combination of these. The drug suitability calculation engine (12) is stored in memory (11) and processor (10) 15 program instructions, rule-based algorithm, statistical computational model, machine learning model, artificial neural network model or It may include a combination of these. In some applications, drug suitability The calculation engine (12) performs entirely deterministic calculations. While it can work, in some applications all or a 20 calculation operations section through an AI-powered inference model It can be accomplished. Drug identification device (20), through physical drug delivery mechanism (70) It generates descriptive data regarding the drug to be distributed or administered to the patient. 25 The drug identification device (20) may include at least one sensor (21), Depending on the mentioned sensor (21) application, the camera (22), barcode in the form of a reader (23), RFID reader (24) or a combination thereof It is applicable. Camera (22) captures the medicine, the medicine packaging, the blister structure, the label, the shape, obtain an image of its color or identifying markings. 14 It can do so. Barcode reader (23), drug packaging or drug carrier It can read one-dimensional or two-dimensional codes on the surface. RFID reader (24) RFID associated with the drug, drug packaging, drug container or dispensing unit. It can retrieve identifying data from the tag. The sensor (21) helps to identify the drug depending on the application. including the quantity, weight, location, or physical characteristics of the drug or drug carrier weight sensors, optical sensors, proximity sensors that can generate data regarding their characteristics, It may also include a position sensor or a dose amount sensor. (mentioned) It is not necessary for all sensors to be in the same application, 10 of these depending on the structure of the physical drug delivery mechanism (70) to be implemented One or more of them can be used. Detection of the drug by the drug identification device (20) means the system detects the drug. The event that initiates the conformity assessment can be used as a trigger. When the drug detection event occurs, the processor (10), the relevant patient, prescription and drug 15 to start the process cycle for retrieving the data and set the timer (90) puts into operation. Patient identification interface (30), where the physical drug dispensing process will be carried out. It enables the identification of the patient. Patient identification interface (30); ID 20 card reader, health card reader, biometric reader, username and password input area, mobile device authentication structure, near field communication interface or similar authentication structure It may include. The user terminal (31) enables the patient to authenticate, to view instructions and warnings generated by the system and necessary It allows data to be entered into the system in these situations. User terminal (31); touchscreen terminal, computer, tablet, mobile device or physical medicine 30 in the form of user interface on the distribution mechanism (70) It is applicable. Authorized personnel interface (32), physician, pharmacist, nurse, care staff or It allows authorized users, such as system administrators, to access the system. Authorized personnel interface (32) to approve a paused distribution process can be given, intervention in the locked physical drug delivery mechanism (70) This can be done, decision thresholds or system settings depending on the authorization level 5 It can be modified and past transaction records can be reviewed. Database (40); patient identification data, demographic data, chronic diseases information, active prescription records, dosage and usage time information, kidney and liver function values, drug interaction records, contraindications 10 information, past medication usage records, usage compliance data, calculated drug suitability values ​​and generated physical control commands It can store it. External health information system (51); hospital information management system, electronic health 15 registration system, electronic prescription system, pharmacy information system, laboratory information It refers to the system or similar external data source. Processor (10), Communication interface (50) to the database (40) and external health information system (51) It can be accessed via [link / website]. Communication interface (50); processor (10), database (40), external health information system (51), controller (60), user terminal (31), authorized personnel interface (32) and data and control messages between physical drug delivery mechanisms (70) It enables transmission. Communication interface (50), wired or wireless. It can use at least one of the communication technologies. The system components are the same 25 They can be located within a physical device, or they can be located far apart and on a network. It can also be positioned on different devices that communicate with each other. The drug suitability calculation engine (12) is obtained from the drug identification system (20). drug identifier data obtained from patient identification interface (30) patient identification information and database (40) or external health information system (51) 30 It evaluates the relevant records together. In this evaluation... At least one or more of the following parameters can be used: 16 • Matching status of the identified drug with the active prescription, • The detected or administered dose corresponds to the dose stated in the prescription. • Compliance of the dispensing time with the usage time specified in the prescription, • Interaction between the identified drug and other medications the patient is taking situation, 5 • patient's chronic illnesses and past medical records, • kidney or liver function values, • Information on contraindications for the drug, • Patient's past medication adherence. The mentioned parameters are common to the drug suitability calculation engine (12). It can be converted into a calculation range. In this context, the parameter... linear or nonlinear normalization process of the values It is applicable; in some applications, the sigmoid transformation function is used. It can be used. A parameter expressing the magnitude of risk or deviation, 15 a higher normalized value will represent higher fit Included in the calculation by reversing the process or converting it to a fitness value. It is possible. The drug suitability calculation engine (12) represents the patient's current conditions with 20 the impact of each parameter on the calculation according to clinical context data It can change. Clinical context data; patient's chronic disease profile, organ functional values, age information, active medications, current prescription records, and usage. It can include at least one of the compatibility values. The weighting coefficients of the parameters are determined based on the clinical context data for each. It can be redefined in the evaluation cycle. For example, kidney If the function value falls outside a predefined range, the dose The weighting of suitability and drug interaction parameters can be increased. Similarly liver dysfunction, certain chronic diseases, or low 30 usage compatibility, the impact of relevant parameters on the calculation It can be changed. 17 In some applications, the weighting coefficients depend on the clinical context vector Γ. It is expressed in the form wi(Γ) and is linearized using a sigmoid transformation. It is calculated in a way that is not the case. The determined weighting coefficients add up to one. It can be normalized so that they are equal. Thus, the same drug and the same prescription 5 For data, the clinical conditions of patients may differ, or the health of the same patient may differ. Different drug suitability values ​​if the condition changes over time. It can be produced. Drug suitability calculation engine (12), drug suitability in a sample application Its value can be calculated according to the following relationship: 10 DSS=w₁(Γ)×σ(Rx_match)+w₂(Γ)×σ(Dose_deviation)+w₃(Γ)×σ(Time_deviation)+ w₄(Γ)×σ(Drug_interaction)+w₅(Γ)×σ(Patient_history)+w₆(Γ)×CS Here, DSS represents the drug suitability value; Rx_match represents the active prescription 15 with the detected drug. The value relating to the match between; Dose_deviation, prescribed dose and the deviation between the doses offered or the dose appropriateness derived from this deviation The parameter relating to its value; Time_deviation, with the prescribed usage time. the deviation between the current distribution time or the time derived from it The parameter relating to the suitability value; Drug_interaction, 20 related to drug interaction. The evaluation value is based on Patient_history, the patient's past health history and medication use. CS represents the evaluation value related to the records; it also refers to the patient's past medication use. It expresses the value of a history of harmony, representing its integration. σ is the normalization or transformation function applied to the relevant parameter; 25 w₁(Γ) and w₆(Γ) are weighting coefficients determined according to the patient's clinical context. This demonstrates the correlation in question, which is illustrative and relates to drug suitability assessment. different parameters, transformation functions, weighting methods Alternatively, it can be obtained through the use of computational models. The calculated drug eligibility value ranges from zero to one in some applications. It is produced as a normalized real number. High drug availability. 18 the value indicates that the drug is more suitable for distribution to the relevant patient; low drug The suitability value indicates a higher risk in terms of distribution. It can demonstrate this. The processor (10) calculates the drug suitability value based on at least one predefined decision. It compares with the threshold. In a preferred practice, the lower decision threshold and the upper 5 A decision threshold is used, and the drug suitability value is determined from three different decision ranges. It is classified into one of the following categories. The drug suitability value must be equal to or higher than the upper decision threshold. The distribution authorization status is determined accordingly. The lower limit of the drug suitability value is decision 10. Conditional distribution occurs when the situation is between the threshold and the upper decision threshold. It is determined that the drug suitability value is lower than the lower decision threshold. In this case, the distribution blocking status is determined. Distribution permission is conditional. The deployment and deployment blocking states are respectively operation, pause, and This corresponds to locking commands. 15 These situations are classified as RS-0, RS-1, and RS-2 risks in some applications, respectively. They can be expressed as classes. Decision thresholds can be fixed values. such as patient group, drug type, clinical risk level, or administration setting Configurable values ​​are also possible. 20 The processor (10) controls the specified risk class or decision status. It transmits the signal to the controller (60). The controller (60) is the microcontroller, Programmable logic controller, embedded control board, motor control board or it can be implemented in the form of a similar physical control structure. 25 The controller (60) controls the physical drug depending on the control signal it receives from the processor (10). to operate, pause or lock the dispensing mechanism (70) It switches to one of the situations. The drug suitability value is only displayed on the screen. Instead of being shown, the status of the physical mechanism is transmitted to the controller (60) 30 changing the system from a decision support structure to a physical control system. The locking mechanism (74) provides the actuator (71) in some applications. 19 mechanically and / or electronically inhibiting its movement and / or the drug the outlet, flap, slide, or release opening through which the medication is delivered to the patient It can be configured to shut down. As shown in Figure-2, the physical drug delivery mechanism (70) requires at least one 5 It includes an actuator (71). The actuator (71) receives the control from the controller (60). Selection, transportation, and release of the drug depending on the command, at least one of the following processes: providing or making physically accessible It is carrying out. Physical drug delivery mechanism (70), drug reservoir depending on the application. (72), drug selection and transfer mechanism (73) and locking mechanism (74) The mechanism (70) may include a motor, electromagnet, valve, cover, slide, turntable, conveyor belt, screw conveyor, robotic gripper, dosing device or one or more of the physical components such as the drug delivery duct 15 It may include. Physical drug delivery mechanism (70); automatic drug dispenser, smart medicine cabinet, robotic medicine dispensing unit, medicine vending machine or It can be implemented in the form of a similar physical drug delivery device. If the operating command is generated, the controller (60) activates the actuator (71) 20 by running the drug selection and transfer from the drug dispenser (72) directing the patient to the physical exit via the device (73) and to the patient It ensures that it is presented. If a pause command is generated, the controller (60) temporarily suspends the distribution operation. It stops or prevents the start of the process. Pause In the case of physical drug delivery mechanism (70), the same process cycle in a waiting state which can be resumed after authorized approval It can be kept. Appropriate approval via the authorized personnel interface (32). If received, the start command can be transmitted to the controller (60). 30 If the locking command is generated, the controller (60) locks the locking mechanism (74) to activate or operate the actuator (71) electronically or mechanically It prevents this. The lock status is not just a screen warning, authorized intervention, re-authentication, or predefined security The operation of the physical drug delivery mechanism (70) without performing the procedure 5 It is a physical exercise condition that prevents it. Timer (90), physical control from the time the drug identification event takes place the command to the controller (60) or physical drug delivery mechanism (70) It monitors the time until transmission. Timer (90) is a separate 10 It can be an electronic timer, processor (10) or controller (60) It can also be implemented in the form of a software-based timer. Predefined drug suitability assessment and control command transmission. The project is expected to be completed within the maximum delay time, T_max. Exceeding the T_max time, inability to receive the necessary data, communication 15 If the connection is interrupted or a reliable decision cannot be made, the system (1) switches to safe mode. In safe mode, the controller (60), default pause of the physical drug delivery mechanism (70) It takes this situation into account and prevents uncontrolled drug distribution. Some high In risky applications, the safe state command can also be used as a lockout command. It can be configured. Notification interface (100), calculated drug eligibility value, determined risk class, Reasons for pause or lockup include missing data, T_max exceeding, or unauthorized access. Notification regarding the need for intervention must be given to the user, authorized personnel, and physician. 25 or ensures that it is transmitted to an external health information system (51). Notification; user terminal (31), authorized personnel interface (32), mobile device, electronic mail, text message, hospital information system notification or audible and / or visual alarm It can be presented through. Feedback interface (80), physical delivery process or drug use event feedback data on the result from at least one feedback source (81) 21 is received. The source of feedback (81); in the physical drug delivery mechanism (70) at least one sensor, controller (60), physical drug delivery mechanism (70), user terminal (31), authorized personnel interface (32), mobile device, connected medical It can be a device or an external health information system (51). Feedback data includes whether the drug was physically distributed, and the distribution process. whether it has been completed, user or patient information regarding whether the patient has taken the medication personnel verification, physical mechanism operational status, authorized approval, This may include information such as transaction cancellation or subsequent health records. Thus, it may include a return. The notification varies depending on the specific sensor type, and is subject to different technical or user preferences. It can be obtained from various sources. 10 The system (1) represents the feedback data of the patient’s past medication adherence. It can be used to update the CS value. In some applications... The CS value is updated according to the following relationship: CS_new = α × Compatibility_event + (1 − α) × CS_current Here, CS_new sets the updated compatibility value; CS_current, The compatibility value of the usage before the update; Compatibility_event, relevant usage If the event is completed properly, the score is 1; if not completed, the score is 0.20. The event value that can be taken as; α is the forget-meaning value chosen between zero and one. It refers to the factor. The compatibility event is seen as a multi-level or continuous value instead of a binary value. It is also possible to determine this. For example, delayed usage, partial verification, 25 Use completed with authorized intervention or use rejected are different events. It can be represented by its values. The updated CS value is stored in memory (11) or in the database (40) and In the next drug suitability assessment, add 30 to the drug suitability calculation engine. (12) is given as input. Thus, the feedback obtained from a use case is notification, clinical context used in subsequent evaluation, parameters 22 their weights and consequently to be transmitted to the physical drug delivery mechanism (70) It can modify the control command. This structure allows for the review of past operation results. Adaptive closed-loop control, which feeds back into subsequent physical control behavior. It forms its architecture. In an example application, a patient user with chronic kidney failure It performs identity verification via terminal (31). Drug identification device (20), the medicine prepared for distribution barcode reader (23) It identifies and starts the processing cycle through the processor (10), the patient's active prescription, kidney function tests, other medications used, and 10 usage history from the database (40) or from an external health information system (51) It is receiving. Drug suitability calculation engine (12), depending on kidney function value increasing the weights of dose appropriateness and drug interaction parameters; finding 15 deviation of the administered dose from the dose specified in the prescription and differences between the active ingredients It evaluates the interaction data along with other parameters. The calculated If the drug suitability value falls between the lower and upper decision thresholds, the processor (10) determines the conditional state and sends the (60) pause command to the controller. It transmits. 20 Controller (60) in the waiting state of the physical drug delivery mechanism (70) holding and actuating the actuator without obtaining approval from the authorized personnel interface (32) (71) does not operate. If approval is given, the distribution process will be run. It can be continued with the command; rejection of approval or higher risk 25 If detected, the mechanism can be put into a locking position. All The evaluation and verification process is carried out within the T_max time frame. In some applications, the physical drug delivery mechanism (70) delivers different drugs Multiple medicine containers for storing medicines separately (72) 30 It may include. The drug selection and transfer mechanism (73) received from the controller (60). one of the mentioned medicine containers (72) is selected depending on the control command 23 It accesses and directs the relevant medication to the dispensing outlet. Physical drug delivery. mechanism (70) of the selection, transport and / or distribution of the drug from the reservoir It may include at least one sensor to detect when it has been released from its exit. The mentioned sensor is located in the drug reservoir (72), drug selection and transfer mechanism (73) It can be positioned on and / or at the drug dispensing outlet. 5 In conclusion, the subject of the invention is the physical drug dispensing control system (1); to be dispensed Identifying the drug and the related patient, prescription, dosage, timing, drug interactions, patient. at least some of the data on history, organ function and usage compliance together with the patient, drug suitability depends on the clinical context. 10 to produce value and to use physical medicine through controller (60) operation, pause or locking of the distribution mechanism (70) a physical control signal that enables it to switch to one of its states It transforms. The system (1) also if the decision cannot be produced within the specified period transitioning to a secure state and feedback regarding the physical distribution or usage event. It uses the notification data in the subsequent control behavior. Thus, the drug Compliance data is a decision support output that is only displayed or reported. by moving away from physical drug delivery, the process is now real-time and closed-loop. an active technical control parameter that affects in a cyclical manner It is being transformed.

Claims

24 REQUESTS 1. The suitability of a drug to be physically administered to a patient. based on the evaluation and the aforementioned evaluation result, the patient 5 of a physical drug delivery mechanism that delivers drugs (70) It is a method for monitoring, and its characteristic feature is; • an image, barcode and / or RFID data relating to the mentioned drug obtaining the mentioned data through the identification mechanism (20) and the mentioned data Identifying the drug by matching it with drug records, • A patient identification interface (30) 10 for the patient to whom the mentioned drug will be administered determined through, • Descriptive data, prescription data, and patient data relating to the mentioned drug. Prescription matching by processing the data by a processor (10), Dosage appropriateness, timing of use, drug interactions, patient history and determining at least two of the usage compatibility parameters, 15 • The mentioned parameters are normalized by the mentioned processor (10) converting into numerical values, • patient's chronic disease profile, organ function values, age, activity Clinical context including at least one of the following: drug and usage compliance data. Depending on the data, the weighting coefficients for the mentioned parameters are 20. by the mentioned processor (10) in each evaluation cycle redefinition, • the aforementioned converted into normalized numerical values parameters, along with their redefined weighting coefficients by evaluating the physical drug delivery mechanism (70) 25 a drug suitability value that determines the working status mentioned Calculation by processor (10), • the aforementioned drug suitability value by the aforementioned processor (10) with a predefined lower decision threshold and an upper decision threshold According to the comparison results, the physical drug delivery mechanism (70) 30 one of the related start, pause or lock commands creation, • and the generated control command is physically transmitted through a controller (60) including the steps of implementation of the drug delivery mechanism (70) It is the characterization of the situation.

2. It is a method according to Claim 1, and its characteristic is that the mentioned weighting coefficients are 5 patient-related clinical context data is linearly processed by a processor (10). each by processing it using a non-existent transformation function It is a redefinition within the evaluation cycle.

3. It is a method according to claim 2, and its characteristic is; the aforementioned nonlinear 10 the transformation function being a sigmoid transformation function and the mentioned The sum of the weight coefficients by the processor (10) will be equal to one. It is the normalization of the situation.

4. It is a method according to claim 1, and its characteristic is; 15 DSS represents drug suitability value, Γ represents clinical context data, and σ represents normalization. function, Rx_match prescription matching parameter, Dose_deviation dose deviation parameter, Time_deviation usage time deviation parameter, Drug_interaction parameter, Patient_history patient history parameter, CS usage compliance value and w₁(Γ), w₂(Γ), 20 w₃(Γ), w₄(Γ), w₅(Γ) and w₆(Γ) are weighting coefficients based on clinical context data. to express, • drug suitability value by the processor (10); DSS=w₁(Γ)×σ(Rx_match)+w₂(Γ)×σ(Dose_deviation)+w₃(Γ)×σ(Time_d eviation)+w₄(Γ)×σ(Drug_interaction)+w₅(Γ)×σ(Patient_history)+w₆(Γ)×25 It is calculated according to the CS relation.

5. It is a method according to claim 1, and its characteristic is; • the aforementioned drug suitability value was determined in advance by the processor (10). Comparison with a defined lower decision threshold and an upper decision threshold, 30 • drug suitability value equal to or higher than the upper decision threshold If so, the execution command is executed by the processor (10), 26 • drug suitability value equal to or higher than the lower decision threshold and if it is lower than the upper decision threshold, by the processor (10) the pause command, • if the drug suitability value is lower than the lower decision threshold The creation of the lock command by the processor (10) and 5 The generated command is transmitted to the controller (60).

6. It is a method according to Claim 1, and its characteristic is that it involves identifying the drug's identity. the control command generated to the physical drug delivery mechanism (70) The time until its implementation is 10 via a timer (90) monitoring and a predefined maximum delay for the aforementioned processes It must be completed within the given timeframe.

7. This is a method according to Claim 6, and its characteristic is the aforementioned maximum delay. Exceeding the time limit is necessary for calculating the drug eligibility value. inability to receive data, interruption of communication link and / or reliable 15 If a control command cannot be generated, the controller (60) pause or lockout of the physical drug delivery mechanism (70) It is the transition to that state.

8. It is a method according to claim 1, and its characteristic is; 20 • the outcome of the physical drug delivery process and / or drug use event feedback data related to a feedback interface (80) taking, • the patient's compliance value, according to the aforementioned feedback data Update by processor (10), 25 • updated usage compatibility value a memory (11) and / or stored in the database (40) and • the mentioned updated usage compatibility value processor (10) in the subsequent drug eligibility assessment performed by It is the use of. 30 9. It is a method according to claim 8, and its characteristic is; 27 CS_new updated usage compatibility value, CS_current update The previous usage compatibility value, Compatibility_event, to the relevant usage event. the related event value and the forgetting factor α, which is defined between zero and one. to express, • usage compatibility value by processor (10); CS_new = α × 5 The compatibility event is updated according to the relation + (1 − α) × CS_current.

10. This is a method according to claim 5, and its characteristic is that the locking command is sent to the controller. (60) If transmitted, a locking device (74) by the controller (60) activation and / or physical drug delivery mechanism (70) 10 the electronic or mechanical operation of the actuator (71) It is to prevent.

11. This is a method according to Claim 1, and its characteristic feature is that the patient's identity card, health card, biometric data, user identification information, mobile device and / or close relative 15 Identity data obtained via field communication with patient records through the patient identification interface (30) by matching It is the determination of.

12. It is a method according to Claim 1, and its characteristic is that it relates to the patient's kidney and / or 20 liver function test outside a predefined range If the processor (10) determines that the dose is appropriate and / or the weight coefficient of the drug interaction parameter processor (10) It is increased by.

13. The physical drug delivery mechanism that delivers medication to a patient. (70), using data relating to the mentioned patient and the drug to be distributed is a physical drug dispensing control system (1) for monitoring, feature; • Obtain image, barcode and / or RFID data relating to the medicine to be distributed 30 to determine the drug's suitability by matching the mentioned data with drug records. 28 a drug identification mechanism to enable the identification of the drug (20), • to obtain the identity data of the patient to whom the mentioned drug will be distributed and by matching the aforementioned identity data with patient records a patient identification interface to enable patient identification 5 (30), • data relating to the patient, the medication, and the patient's prescription. at least one database for storage (40), • mentioned drug identification system (20), patient identification interface (30) and at least one processor (10) associated with the database (40), 10 • Program instructions executed by the mentioned processor (10), evaluation parameters, weighting coefficients, and decision thresholds at least one memory for storage (11), • Descriptive data, prescription data, and patient data relating to the mentioned drug. Data includes prescription matching, dosage appropriateness, and timing of use appropriateness, 15 At least the following parameters: drug interaction, patient history, and usage compliance. to determine the two; the mentioned parameters are normalized numerically converting into values; patient's chronic disease profile, organ function at least one of the following data points: values, age, active medications, and usage compliance. 20 parameters mentioned, depending on the clinical context data included. re-determining the weighting coefficients in each evaluation cycle; and converted into normalized numerical values parameters with redefined weighting coefficients by evaluating the study of the physical drug delivery mechanism (70) 25 a drug suitability calculation engine associated with the mentioned processor (10) (12), • The aforementioned drug suitability value is defined by a predefined lower decision threshold and a comparison with the upper decision threshold and according to the comparison result 30 to create one of the start, pause or lock commands. The mentioned processor (10), 29 • to receive the control command generated by the mentioned processor (10) and physical drug delivery depending on the aforementioned control command from operating, pausing or locking the mechanism (70) to pass on to someone; in the case of a locking command, a locking mechanism (74) 5 related to activation and / or physical drug delivery mechanism (70) to prevent the actuator (71) from working electronically or mechanically at least one controller (60), • and depending on the control command it receives from the mentioned controller (60) at least one actuator for delivering medicine to the patient (71) 10 characterized by containing a physical drug delivery mechanism (70) It is done.

14. According to claim 13, a physical drug dispensing control system (1) is characterized by: • physical drug delivery mechanism (70) to preserve drugs at least one medicine container for (72), 15 • to select and carry a medicine from the mentioned medicine container (72) and / or a drug selection and transfer mechanism for discontinuation (73), • to activate the aforementioned drug selection and transfer mechanism (73) It must contain at least one actuator (71).

15. A physical drug dispensing control system (1) in accordance with claim 13 or 14, Its feature is that the physical drug delivery mechanism (70) is dependent on the locking command. the most effective way to physically prevent a drug from being delivered to a patient It contains a minimal locking mechanism (74).

16. According to claim 15, a physical drug dispensing control system (1) is characterized by; mechanically and / or electronically prevent the movement of the actuator (71) It includes a locking mechanism (74) structured in this way.

17. A physical drug dispensing control system (1) in accordance with claim 15 or 16, 30 its feature is that the drug outlet channel, flap, slide and / or release opening has at least a locking mechanism configured to close one (74) It includes.

18. According to claim 14, a physical drug dispensing control system (1) is characterized by; drug By operating the selection and transfer mechanism (73), the selected drug is drug 5 to be removed from the container (72) and directed to the drug dispensing outlet It includes an actuator (71) to provide power.

19. According to claim 14, a physical drug dispensing control system (1) is characterized by; a The medicine is selected from the medicine container (72), transported and / or dispensed. It must contain at least one sensor to detect when it has been released from its exit.

20. According to Claim 19, a physical drug dispensing control system (1) is characterized by; drug in the reservoir (72), on the drug selection and transfer device (73) and / or the drug It must include at least one sensor located at the distribution outlet. 15 21. According to claim 14, a physical drug dispensing control system (1) is characterized by; • multiple devices for storing different medications separately medicine container (72), • Depending on the control command received from the controller (60), the mentioned drug 20 By accessing one of the selected containers (72), the relevant medicine is delivered to the medicine dispensing outlet. a drug selection and transfer mechanism for guidance (73) It includes.

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