SELECTIVE ENZYMATIC DELAMINATION OF THREE-DIMENSIONAL CELLULAR STRUCTURES DErivED FROM PLURIPOTENT STEM CELLS AND A BIOREACTOR SYSTEM AND A PROCEDURE FOR EX VIVO PERFUSION CULTURE
TR202613299A2Pending Publication Date: 2026-09-21T C ISTANBUL MEDIPOL UNIVERSITESI
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Patent Information
- Application Number
- TR202613299
- Authority / Receiving Office
- TR · TR
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2026-08-06
- Publication Date
- 2026-09-21
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Abstract
The invention involves the creation of three-dimensional cellular structures derived from pluripotent stem cells to target tissue or while preserving the endodermal layer, the mesodermal layer, or both, which are essential for the organ regions with neural lineage orientation or potential for neural structure formation, neural tube removing it by selective enzymatic delamination before its formation and ex vivo It is related to a bioreactor system (100) and method that sustains perfusion culture.
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