FRAME-REFERENCED SAMPLE COLLECTION CARD

Abstract

The invention relates to a frame-referenced sample collection card (A) which reduces contact with the sample area by applying no pressure on the sample collection area of ​​the patient, with reference marks around the sample area (1), which can be used in many diagnostics such as dried blood cards, genetic analysis, forensic genetics, molecular diagnosis.

Description

1 TARIFF FRAME-REFERENCED SAMPLE COLLECTION CARD Technical Area 5 Our invention is generally used in the healthcare sector for sample collection to diagnose diseases. Frame-referenced sample collection that reduces contact with the sample area that can be used in the process. It relates to the card. The invention is particularly relevant for many applications such as dried blood cards, genetic analysis, forensic genetics, and molecular diagnostics. any pressure on the patient's sample collection site that can be used in diagnosis from the application to the sample area with reference markers located around the sample area. This relates to a frame-referenced sample collection card that reduces contact. State of the Art Today, blood and tissue samples are used to obtain information about a person's health status. Various samples, such as tissue samples, are taken and tested. Based on the results of these tests, the person's overall health is assessed. Information about health status is obtained. 20 In the known state of the art, the areas from which samples will be taken on dried blood cards are printed. This is shown with perfectly circular rings formed by pressure. These rings are used for sampling. It is pressed directly over the filtration zone. This design causes various problems. This is possible. One of them is the finger touching the inside of the circle. Especially; midwife, 25 The nurse or lab staff member places their fingers directly on the filter paper to create the card. This can be caused by DNA contamination, skin cell infectivity, and foreign biological agents. Material contamination can occur. These situations can affect precise results. Again, under the known state of the technique, the printing ink is applied to the filtration area at 30°C. This is applied to change the absorbance behavior and ensure homogeneous absorption. can lead to negative consequences such as affecting and complicating optical evaluation. It is possible. There are many differences in the current production methods. In the current methods, the sample area is 35 Because it is limited by the pressure, the user refers to the circle directly as the sample area. 2 It involves contact. In this case, although the purpose of the print is guidance, it carries a risk of contact. It increases. Also, in existing methods, forensic genetics, molecular diagnostics and newborn screening programs Human-induced contamination can lead to inaccurate results. 5 In patent application number 2017 / 13060 relating to the previous technique, it was stated as "Specifically for blood samples. It is referred to as a "sampling apparatus". In the invention abstract section, it states "The invention is described in Claim 1." a sampling setup, especially a sampling device for blood samples It is stated that "it is related to the mechanism." However, in this invention, 10 directly into the sample area. There is no mention of reduced contact. The patent application numbered EP0637750A2 relating to the previous technique is titled "Analysis of Sample Liquids". It is referred to as the "method". In the invention abstract, it states, "This invention uses a method that addresses highly information-intensive tasks." 15 reagent solutions used to perform and control the data analysis process This invention relates to a method for the analysis of sample liquids, applied to containers containing them. Furthermore, a method for producing reagent containers equipped with code carriers and the code itself. For analyzing sample liquids using reagent vessels equipped with carriers. It is related to a system. The method developed according to the invention is a code with high information density. Because it rationalizes the analysis procedure of reagent vessels equipped with carriers, 20 It has been stated that "preferably it can be used in clinical analysis devices." However, in this invention mentioned, There is no mention of a reduction in direct contact with the sampling area. The existence of the technical problems explained above and the solutions provided to these problems The inadequacy of the system has created the need to create a frame-referenced sample collection chart. 25 Purpose of the Invention The present invention meets the aforementioned requirements and eliminates all technical problems. It relates to the frame-referenced sample collection card, which eliminates and introduces some additional advantages. 30 The main aim of the invention is to completely replace traditional circular printing on filter paper. a frame system that references only the outer perimeter of the sampling area by removing it The aim is to minimize direct contact between the sample area and the water source. 3 Another purpose of the invention is to eliminate the need for the user to place their finger on the filter paper. The goal is to ensure the card is held securely without the user hearing it. Another aim of the invention is to reduce the risk of human DNA contamination by minimizing contact with the sample area. The goal is to ensure its reduction. Another aim of the invention is to keep the sample area clean by reducing contact with the sample area. The goal is to ensure it stays. Another aim of the invention is to improve the reliability of analysis by reducing contact with the sample area. is to ensure. Another aim of the invention is to reduce contact with the sample area, thereby preserving fingerprints and epidermal cells. The goal is to reduce contamination. 10 Another purpose of the invention is to allow the user to easily determine the correct sample area using frame reference. The goal is to ensure its determination. Another aim of the invention is to improve the standardization of sampling. Another objective of the invention is to reduce the pre-analytical error rate. Another aim of the invention is to contribute to laboratory quality management. 15 The structural and characteristic features and all the advantages of the invention are given in the figures below. Thanks to the detailed explanation written with references to the figures, it becomes clearer. This will be understood, and therefore the evaluation should also take these figures and detailed explanations into account. It must be done by taking it. Figures that will help understand the invention. The best way to utilize the advantages of the existing invention, together with its structure and additional elements. For it to be understood, it must be considered together with the figures explained below. Figure 1; Perspective of the frame-referenced sample collection card, which is the subject of the invention. It is the appearance. Figure 2; Front view of the frame-referenced sample collection card, which is the subject of the invention. It is the appearance. 30 4 Figure 3; Back view of the frame-referenced sample collection card, which is the subject of the invention. It is the appearance. System references 5 A. Sample card 1. Sample area 2. Barcode 3. Information area 10 4. Approval area 5. Card barcode 6. Patient information 7. Doctor's information 8. General information area 15 The drawings do not necessarily need to be scaled and are necessary for understanding the invention. Details that are not present may have been fabricated. Furthermore, at least to a large extent Elements that are identical or at least have substantially identical functions are numbered the same. It is shown. 20 Detailed Description of the Invention The present invention meets the aforementioned requirements while eliminating all disadvantages. It relates to the frame-referenced sample collection card, which eliminates and introduces some additional advantages. 25 This detailed explanation describes the preferred frame-referenced sample collection card, which is the subject of the invention. The structures discussed are explained solely for the purpose of facilitating a better understanding of the subject. Figure 1 shows the perspective view of the frame-referenced sample collection card, which is the subject of the invention. This is the appearance. The mentioned sample card (A) is defined by the framework created in the external environment. This sample provides a visual reference to the user while preventing contact with the sample itself. area (1), the sample of the patient in each sample section with another patient barcode (2) that prevents mixing, how the user places the sample on the sample card (A) 35 Information field (3), patient's name, surname, identity number, sample collection date, telephone patient information including number, address, whether or not they received a blood transfusion, and if so, when. information (6), doctor’s name, surname, institution and department, email address, telephone number information general information about the sample card (A) including doctor information (7), informing the patient about the sample card (A) The card, which allows access to patient information (6) and doctor information (7) by scanning the area (8). barcode (5), name, surname, date and of the patient or the patient’s guardian, doctor and witness. It consists of the approval area (4) containing their signatures. In the sample card (A) which is the subject of the invention, the sample area (1) in the sample card (A) frames that provide the user with a visual reference to the circles and contact the filtration surface. The sample is filled without being filled. Afterwards, the sample area (1) is allowed to dry at room temperature. It is expected. The dried sample area (1) is folded so that sample area (1) remains inside. It is then sent to the laboratory for analysis. Sample card (A) DNA in the laboratory It can be analyzed by different methods such as amplification or HPLC. Cut in the laboratory. With samples, a single drop can be used to perform the necessary analysis for testing 2 to 4 parameters. Analysis room This takes place inside a microplate at a certain temperature. Microplate reader ELISA 15 The reading process is carried out from the reader. 25 35

Claims

6 REQUESTS 1. The invention is a sample card (A) used in the health sector for diagnosing diseases, feature;  While providing the user with a visual reference defined by the framework created in the external environment, 5 here is the sample area which prevents contact outside the sample (1),  preventing a patient's sample from being mixed with another patient's sample in each sample collection area blocking barcode (2),  A card that allows access to patient information (6) and doctor information (7) by scanning it. barcode (5) 10 It includes.

2. Sample card (A) conforming to Claim 1, its characteristic is;  how the user should drop their sample onto the sample card (A) and then Information area (3), 15 which provides information on how to store it.  Patient's name, surname, identification number, sample collection date, telephone number, patient information including address, whether or not they received a blood transfusion, and if so, when. information (6),  Doctor's name, surname, institution and department, email address, and phone number information containing doctor information (7), 20  The name, surname, date, and signature of the patient or the patient's guardian, the doctor, and the witness. Approval area containing (4),  General information area (8) giving the patient information about the sample card (A) It includes.

3. The invention is a sample card (A) used in the health sector for diagnosing diseases, feature;  Visual reference to the user of the circles of the sample area (1) on the sample card (A). The frames provide support for filling the sample without contacting the filtration surface.  Allowing the sample area (1) to dry at room temperature, 30  The dried sample area (1) should be folded so that sample area (1) remains inside,  sending to the laboratory for analysis,  DNA amplification, HPLC, etc., in the laboratory of the sample card (A) analyzed using one of the methods,  For laboratory-cut samples, a single drop is needed to test 2 to 4 parameters. analysis to be done, 7  The analysis takes place in a microplate at room temperature,  Reading process from the microplate reader ELISA reader It includes the steps involved in the process. 10 20 30 35

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