Detection device and use thereof
Patent Information
- Authority / Receiving Office
- TW · TW
- Patent Type
- Applications
- Current Assignee / Owner
- BOMDIC
- Filing Date
- 2025-01-09
- Publication Date
- 2026-07-16
AI Technical Summary
Current blood glucose monitoring devices require invasive needle pricks, causing pain and infection risk.
A non-invasive detection device using metainterfaces on opposite sides of an analyte to resonate with a signal, calculating glucose concentration based on the peak value of the resulting signal.
The device enhances detection sensitivity by increasing the frequency of the detected signal with increasing glucose concentration, allowing accurate non-invasive glucose measurement.
Smart Images
Figure TWG2TA001067948_001 
Figure TWG2TA001067948_002 
Figure TWG2TA001067948_003
Abstract
Description
Technical Field
[0001] The present invention relates to a detection device and its use, and in particular to a detection device capable of detecting glucose in a non-invasive manner and its use. Prior Art
[0002] Currently, most blood glucose monitoring devices require an invasive needle prick to collect blood, which is then analyzed. However, invasive needle pricks are not only painful for the user, but also pose a risk of infection due to skin damage caused by the needle prick. Summary of the Invention
[0003] The present invention provides a detection device and use thereof, which can detect glucose in a non-invasive manner.
[0004] The detection device of the present invention is used to detect the glucose concentration in an object to be detected. The detection device includes a signal source, a first metainterface, a second metainterface, and a detector. The signal source is used to provide a first signal. The first metainterface is arranged on the first side of the object to be detected and includes a first substrate and a plurality of first patterns arranged on the first substrate. The second metainterface is arranged on the second side of the object to be detected and includes a second substrate and a plurality of second patterns arranged on the second substrate. The detector is used to receive a second signal. The second signal is a signal resulting from the interaction between the first signal and glucose. The direction of travel of the first signal is toward the first metainterface and the second metainterface, and the first signal resonates with the first metainterface and the second metainterface, respectively. Detecting the glucose concentration in the object to be detected includes the following steps: calculating the glucose concentration in the object to be detected based on the peak value of the second signal.
[0005] In one embodiment of the present invention, the above-mentioned calculation of the glucose concentration in the analyte based on the peak value of the second signal includes the following steps: providing a relationship diagram between the resonance frequency and the known glucose concentration; comparing the resonance frequency corresponding to the peak value of the second signal with the relationship diagram; and calculating the glucose concentration corresponding to the resonance frequency corresponding to the peak value based on the relationship diagram.
[0006] In one embodiment of the present invention, the frequencies of the first signal and the second signal are 0.1 GHz to 10 GHz.
[0007] In one embodiment of the present invention, the traveling direction of the first signal is perpendicular to the first metainterface and the second metainterface.
[0008] In one embodiment of the present invention, the sizes of the plurality of first patterns and the plurality of second patterns are 0.5 cm to 10 cm.
[0009] In one embodiment of the present invention, the plurality of first patterns and the plurality of second patterns have the same size and shape.
[0010] In one embodiment of the present invention, the plurality of first patterns and the plurality of second patterns are in the shape of a ring structure with a gap.
[0011] In one embodiment of the present invention, there is a first spacing between two adjacent first patterns in the plurality of first patterns, there is a second spacing between two adjacent second patterns in the plurality of second patterns, and the first spacing is substantially the same as the second spacing.
[0012] In one embodiment of the present invention, the first spacing and the second spacing are 1 mm.
[0013] In one embodiment of the present invention, the material of the plurality of first patterns and the plurality of second patterns is metal.
[0014] The detection device of the present invention is used as a wearable device to detect blood sugar in a non-invasive manner.
[0015] Based on the foregoing, in a detection device according to one embodiment of the present invention, by disposing the first and second metainterfaces on opposite sides of the analyte, the frequency of the detected second signal can be increased as the glucose concentration increases. This allows the detection device according to this embodiment to non-invasively detect the frequency of the second signal and thereby determine the glucose concentration in the analyte.
[0016] To make the above features and advantages of the present invention more clearly understood, embodiments are given below and described in detail with reference to the accompanying drawings. Simple diagram description
[0017] FIG1 is a schematic perspective view of a detection device according to an embodiment of the present invention. FIG. 2 is a schematic three-dimensional diagram of the metainterface in FIG. 1 . FIG. 3 is a schematic plan view of a pattern in the metainterface of FIG. 2 . 4 to 6 are schematic plan views of patterns in a metainterface according to various embodiments. FIG. 7A is a schematic diagram of an application of a detection device according to another embodiment of the present invention. FIG. 7B is a side view of the detection device of FIG. 7A . FIG8A shows the results of detecting a glucose solution using a detection device containing a metainterface. FIG8B shows the results of detecting a glucose solution using a detection device without a metainterface. Implementation Method
[0018] Figure 1 is a schematic perspective view of a detection device according to an embodiment of the present invention. Figure 2 is a schematic perspective view of the metainterface of Figure 1. Figure 3 is a schematic plan view of a pattern in the metainterface of Figure 2.
[0019] Referring to Figures 1 to 3 , the detection device 100 of this embodiment includes a signal source 110, a base plate 120, a container 130, a first metainterface 140, a second metainterface 150, and a detector 160. The detection device 100 of this embodiment can be used to detect the glucose concentration in an analyte 200. In this embodiment, the analyte 200 may be a glucose solution, but is not limited thereto. In some embodiments, the analyte may also be a sample containing glucose, such as a blood sample (e.g., blood (plasma or serum)) or a human body (as shown in Figure 7 ).
[0020] Specifically, the signal source 110 may be, for example, an antenna device for providing the first signal S1, but is not limited thereto. The first signal S1 may travel toward the first metainterface 140 and the second metainterface 150, and the first signal S1 may resonate with the first metainterface 140 and the second metainterface 150, respectively. Specifically, the direction of travel (direction X) of the first signal S1 may be perpendicular to the planes of the first metainterface 140 and the second metainterface 150, thereby achieving an optimal resonance effect between the first signal S1 and the first metainterface 140 (and / or the second metainterface 150). The first metainterface 140 and the second metainterface 150 are substantially parallel to the plane formed by the directions Y and Z. In this embodiment, the frequency of the first signal S1 may be between 0.1 GHz and 10 GHz, but is not limited thereto.
[0021] In this embodiment, direction X, direction Y, and direction Z are different directions. Direction X is, for example, the direction of travel of the first signal S1, and direction Z is, for example, the normal direction of the base plate 120. Direction X is substantially perpendicular to direction Z, and both directions X and Z can be substantially perpendicular to direction Y, but are not limited thereto.
[0022] In this embodiment, a container 130 is disposed on the base plate 120. The container 130 has a recess 131, a first inner wall 132, and a second inner wall 133. The recess 131 can be used to hold a liquid analyte 200. The first inner wall 132 and the second inner wall 133 are the inner walls of the recess 131, and the first inner wall 132 and the second inner wall 133 are opposite to each other. In this embodiment, the analyte 200 has a first side 201 and a second side 202 that face each other. The first side 201 faces the first inner wall 132, and the second side 202 faces the second inner wall 133.
[0023] The first Metainterface 140 is fixed to the first inner wall 132 and disposed on the first side 201 of the object under test 200. The second Metainterface 150 is fixed to the second inner wall 133 and disposed on the second side 202 of the object under test 200. In other words, the first Metainterface 140 and the second Metainterface 150 can be disposed opposite each other, and the first Metainterface 140 and the second Metainterface 150 can be disposed on opposite sides of the object under test 200. The first Metainterface 140 and the second Metainterface 150 can be arranged in the direction X. In some embodiments, the base plate and container can be omitted depending on design or usage requirements. For example, when the object under test is solid, a connector can be used instead of the base plate and container to secure the first and second Metainterfaces, as shown in FIG7 . The first Metainterface 140 and the second Metainterface 150 can resonate with the first signal S1.
[0024] Referring to Figure 2 , the first metainterface 140 includes a first substrate 141 and a plurality of first patterns 142, and the second metainterface 150 includes a second substrate 151 and a plurality of second patterns 152. In this embodiment, the first substrate 141 and the second substrate 151 may be made of, but are not limited to, polyimide (PI). The first patterns 142 and the second patterns 152 may be made of, but are not limited to, metal, such as copper.
[0025] A plurality of first patterns 142 may be disposed on the first substrate 141; the arrangement of the plurality of first patterns 142 may be periodic, but is not limited to this, to enhance the metainterface resonance effect. A plurality of second patterns 152 may be disposed on the second substrate 151; the arrangement of the plurality of second patterns 152 may be periodic, but is not limited to this. The arrangement of the plurality of first patterns 142 is substantially the same as the arrangement of the plurality of second patterns 152. In this embodiment, the plurality of first patterns 142 (or the plurality of second patterns 152) may be disposed on the first substrate 141 (or the second substrate 151) in an array arrangement, for example, but is not limited to this. For example, as shown in FIG. 2 , the plurality of first patterns 142 and the plurality of second patterns 152 are schematically depicted as a 4×6 matrix, but this is not limited to this. In some embodiments, the plurality of first patterns (or the plurality of second patterns) may also be arranged in other matrix configurations.
[0026] The dimensions of the plurality of first patterns 142 are substantially the same as the dimensions of the plurality of second patterns 152. In this embodiment, the dimensions of the plurality of first patterns 142 and the plurality of second patterns 152 may be, for example, 0.5 cm to 10 cm, but are not limited thereto. If the dimensions of the first pattern 142 or the second pattern 152 are smaller than 0.5 cm, the effectiveness of the resonant amplification signal may be reduced. If the dimensions of the first pattern 142 or the second pattern 152 are larger than 10 cm, the effectiveness of the resonant amplification signal may also be reduced.
[0027] A first spacing D1 is defined between two adjacent first patterns 142 in the plurality of first patterns 142, and a second spacing D2 is defined between two adjacent second patterns 152 in the plurality of second patterns 152. The first spacing D1 is substantially the same as the second spacing D2. In this embodiment, the first spacing D1 and the second spacing D2 may be, for example, 0.5 mm to 10 mm, such as 1 mm, but are not limited thereto. When the first spacing D1 or the second spacing D2 is less than 0.5 mm, the effectiveness of the resonant amplification signal may be reduced. When the first spacing D1 or the second spacing D2 is greater than 10 mm, the effectiveness of the resonant amplification signal may also be reduced.
[0028] The shapes of the plurality of first patterns 142 are substantially the same as the shapes of the plurality of second patterns 152. In this embodiment, the shapes of the plurality of first patterns 142 and the plurality of second patterns 152 can be, for example, ring-shaped structures with a gap or split-ring structures. Each first pattern 142 and each second pattern 152 can include at least one ring-shaped structure with a gap or at least one split-ring structure, thereby achieving a better resonance effect between the first signal S1 and the first metainterface 140 (and / or the second metainterface 150), but the present invention is not limited thereto. In this embodiment, in the ring-shaped structure with a gap or the split-ring structure with a gap, the metal on both sides of the gap generates a strong electric field enhancement during resonance, thereby further increasing the detection sensitivity of the detection device.
[0029] For example, as shown in FIG3 , the first pattern 142 and the second pattern 152 may include two square rings (or two C-shaped rings) having gaps: a first square ring SR1 having a first gap G1 and a second square ring SR2 having a second gap G2. The first square ring SR1 surrounds the second square ring SR2, the first gap G1 in the first square ring SR1 does not correspond to the second gap G2 in the second square ring SR2, and the first gap G1 may overlap the second gap G2 in the direction Z.
[0030] The detector 160 may be, for example, an antenna device configured to receive the second signal S2. The second signal S2 may be the result of the interaction between the first signal S1 and glucose. The direction of travel of the second signal S2 may be perpendicular to the planes of the first metainterface 140 and the second metainterface 150. In this embodiment, since the second signal S2 may be a reflected signal of the first signal S1 and its direction of travel may be parallel to and opposite to the direction of travel of the first signal S1, the same antenna device may be used as the signal source 110 and the detector 160, but this is not limited to this. In some embodiments, when the second signal is a transmitted signal of the first signal, the direction of travel of the second signal S2 may be substantially the same as the direction of travel of the first signal S1, and different antenna devices may be used as the signal source and detector, respectively. In this embodiment, the frequency of the second signal S2 may be between 0.1 GHz and 10 GHz, but this is not limited to this.
[0031] In this embodiment, because the first and second metainterfaces 140, 150 resonate with the first signal S1, placing the first and second metainterfaces 140, 150 on opposite sides of the analyte improves the efficiency of the interaction between the input first signal S1 and the glucose in the analyte 200. Consequently, through reflection or transmission, the resonant frequency corresponding to the peak of the output second signal S2 increases with increasing glucose concentration. This design allows the detection device 100 of this embodiment to non-invasively detect the resonant frequency corresponding to the peak of the second signal S2 to determine the glucose concentration in the analyte 200.
[0032] In a preferred embodiment of the present invention, detecting the glucose concentration in the analyte 200 may include, but is not limited to, the following steps: first, providing a relationship graph between the resonance frequency and the known glucose concentration (e.g., FIG. 8A , but not limited thereto); then, comparing the resonance frequency corresponding to the peak value of the second signal S2 with the relationship graph; and finally, calculating, based on the relationship graph, the glucose concentration corresponding to the resonance frequency corresponding to the peak value of the second signal S2, i.e., the glucose concentration in the analyte 200.
[0033] In this embodiment, the detection device 100 can be applied to a wearable device (as shown in FIG. 7 ), and the wearable detection device 100 can detect glucose (ie, blood sugar) in the blood in a non-invasive manner.
[0034] The following examples are provided for illustrative purposes. It is important to note that the following examples share the same component numbers and some of the details as the previous examples, with the same numbers used to represent the same or similar components, and descriptions of the same technical details omitted. For the omitted details, please refer to the previous examples and will not be repeated in the following examples.
[0035] Figures 4 through 6 are schematic plan views of patterns within metainterfaces according to various embodiments. Referring to Figures 4 through 6 in conjunction with Figure 3 , metainterface 140a of Figure 4 , metainterface 140b of Figure 5 , and metainterface 140c of Figure 6 are similar to first metainterface 140 (or second metainterface 150) of Figure 3 , except that pattern 142a of metainterface 140a , pattern 142b of metainterface 140b , and pattern 142c of metainterface 140c are all different from first pattern 142 of first metainterface 140 (or second pattern 152 of second metainterface 150).
[0036] Specifically, referring to FIG. 4 , the pattern 142a of the metainterface 140a includes two circular rings (or two C-shaped rings) with gaps: a first circular ring CR1 having a first gap G1 and a second circular ring CR2 having a second gap G2. The first circular ring CR1 surrounds the second circular ring CR2. The position of the first gap G1 in the first circular ring CR1 does not correspond to the position of the second gap G2 in the second circular ring CR2. Furthermore, the first gap G1 may overlap the second gap G2 in the direction Y.
[0037] 5 , the pattern 142 b of the metainterface 140 b includes a first square ring SR1 having a first gap G1 .
[0038] 6 , the pattern 142 c of the metainterface 140 c includes a first circular ring CR1 having a first gap G1 .
[0039] Figure 7A is a schematic diagram illustrating the application of a detection device according to another embodiment of the present invention. Figure 7B is a side view of the detection device of Figure 7A. Referring to Figures 7A and 7B in conjunction with Figures 1 to 3, detection device 100d of this embodiment is similar to detection device 100 of Figures 1 to 3, with the primary difference being that in detection device 100d of this embodiment, base plate 120 and container 130 of Figure 1 are replaced by connector 130d, and the square ring of Figure 3 is replaced by a circular ring.
[0040] 7A and 7B , the connector 130d (eg, a wristband) can be used to connect the first Metainterface 140d and the second Metainterface 150d to assemble the first Metainterface 140d and the second Metainterface 150d into a wearable device (eg, a wristband).
[0041] The first metainterface 140d is disposed on a first side 201 of a DUT 200d (eg, a wrist), and the second metainterface 150d is disposed on a second side 202 of the DUT 200d, with the first side 201 and the second side 202 facing each other.
[0042] The plurality of first patterns 142d and the plurality of second patterns (not shown) may form a 2×4 matrix. The first pattern 142d (or second pattern) may include two circular rings (or two C-shaped rings) with gaps, namely a first circular ring CR1 and a second circular ring CR2, as shown in FIG4 .
[0043] The following experimental examples are used to describe the detection device of the above embodiment in detail. However, the following experimental examples are not intended to limit the present invention.
[0044] [<] [Testing glucose solution] [>]
[0045] [Example] [1]
[0046] First, glucose solutions of varying known concentrations were loaded into the recess 131 of the detection device 100 shown in FIG1 . Next, the signal source 110 shown in FIG1 was used to provide a first signal S1. The reflected second signal S2 was then received by the detector 160 shown in FIG1 . The resonant frequencies corresponding to the peaks of the received second signal S2 when detecting glucose solutions of varying known concentrations were plotted as a graph of resonant frequencies and known glucose concentrations, as shown in FIG8A . The concentrations of the glucose solutions ranged from 0 mg / dl to 230 mg / dl.
[0047] [Comparative Example] [1]
[0048] Comparative Example 1 uses the same steps as Example 1 to test glucose solutions of varying concentrations. The difference is that the detection device used in Comparative Example 1 does not include a metainterface. The test results for Comparative Example 1 are plotted as a graph of the relationship between the resonant frequency and the known glucose concentrations, shown in Figure 8B.
[0049] As can be seen from the results of Figures 8A and 8B , compared to the results of Figure 8B , which uses a detection device without a metainterface to detect glucose solutions of different known concentrations, when Figure 8A uses a detection device with a metainterface to detect glucose solutions of different known concentrations, it can be found that the resonant frequency increases with the increase in the concentration of the glucose solution.
[0050] Furthermore, the graph of resonant frequencies and known glucose concentrations shown in FIG8A shows that each resonant frequency corresponds to a specific glucose concentration. Therefore, when using a detection device with a metainterface to detect a glucose solution of unknown concentration, the resonant frequency corresponding to the peak value of the measured second signal can be compared with the graph shown in FIG8A to calculate the glucose concentration corresponding to the resonant frequency in FIG8A , which is the concentration of the glucose solution.
[0051] The sensitivity of the detection device is defined as the ratio of the change in resonant frequency divided by the change in glucose solution concentration. The results in Figures 8A and 8B show that when the concentration of the glucose solution changes by 220 mg / dl, the change in resonant frequency detected by the detection device with a metainterface is greater than 100 MHz (i.e., 2700 MHz - 2583 MHz = 117 MHz), while the change in resonant frequency detected by the detection device without a metainterface is less than 10 MHz (i.e., 2808 MHz - 2800 MHz = 8 MHz). Calculations show that the detection sensitivity of the detection device with a metainterface is approximately 0.53 MHz / (mg / dl) (i.e., 120 MHz / 220 mg / dl), while the detection sensitivity of the detection device without a metainterface is approximately 0.038 MHz / (mg / dl) (i.e., 8 MHz / 220 mg / dl). Therefore, compared to a detection device without a metainterface, the detection device of this embodiment with a metainterface can detect a larger change in the resonance frequency, has better sensitivity, and can measure blood glucose levels more sensitively.
[0052] In summary, in a detection device according to one embodiment of the present invention, by disposing the first and second metainterfaces on opposite sides of the analyte, the frequency of the detected second signal increases with increasing glucose concentration. Furthermore, the detection device according to this embodiment can non-invasively detect the frequency of the second signal to determine the glucose concentration in the analyte.
[0053] Although the present invention has been disclosed above with reference to the embodiments, they are not intended to limit the present invention. Anyone with ordinary skill in the art may make slight changes and modifications without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention shall be determined by the scope of the appended patent applications.
[0054] 100, 100d: Detection device 110:Signal Source 120: bottom plate 130:Container 130d: Connector 131: Groove 132: First inner wall 133: Second inner wall 140: First Metainterface 140a, 140b, 140c: Metainterface 141: first substrate 142, 142d: First pattern 142a, 142b, 142c: Pattern 150: Second Metainterface 151: Second substrate 152: Second pattern 160: Detector 200, 200d: Object to be tested 201: First side 202: Second side CR1: First circular ring CR2: Second circular ring D1: first spacing D2: Second spacing G1: First Gap G2: Second gap S1: First signal S2: Second signal SR1: First Square Ring SR2: Second Square Ring X, Y, Z: direction
Claims
1. A detection device for detecting the glucose concentration in an analyte, comprising: A signal source, configured to provide a first signal; a first metainterface disposed on a first side of the DUT and comprising a first substrate and a plurality of first patterns arranged on the first substrate; a second metainterface disposed on a second side of the DUT and comprising a second substrate and a plurality of second patterns arranged on the second substrate; and a detector for receiving a second signal, wherein the second signal is a signal resulting from an interaction between the first signal and the glucose; wherein the first signal travels toward the first metainterface and the second metainterface, and the first signal resonates with the first metainterface and the second metainterface, respectively; and wherein detecting the glucose concentration in the analyte comprises the following steps: calculating the glucose concentration in the analyte based on a peak value of the second signal.
2. The detection device as described in claim 1, wherein calculating the glucose concentration in the analyte based on the peak value of the second signal includes the following steps: providing a relationship graph between the resonance frequency and the known glucose concentration; comparing the resonance frequency corresponding to the peak value of the second signal with the relationship graph; and calculating the glucose concentration corresponding to the resonance frequency corresponding to the peak value based on the relationship graph.
3. The detection device according to claim 1, wherein the frequencies of the first signal and the second signal are 0.1 GHz to 10 GHz.
4. The detection device according to claim 1, wherein the traveling direction of the first signal is perpendicular to the first metainterface and the second metainterface.
5. The detection device according to claim 1, wherein the sizes of the plurality of first patterns and the plurality of second patterns are 0.5 cm to 10 cm.
6. The detection device according to claim 1, wherein the plurality of first patterns and the plurality of second patterns have the same size and shape.
7. The detection device according to claim 1, wherein the plurality of first patterns and the plurality of second patterns are shaped as ring structures with gaps.
8. The detection device of claim 1, wherein two adjacent first patterns among the plurality of first patterns have a first spacing therebetween, two adjacent second patterns among the plurality of second patterns have a second spacing therebetween, and the first spacing is substantially the same as the second spacing.
9. The detection device of claim 8, wherein the first spacing and the second spacing are 1 mm.
10. The detection device according to claim 1, wherein the material of the plurality of first patterns and the plurality of second patterns is metal.
11. A use of the detection device according to claim 1, which is a wearable device for detecting blood sugar in a non-invasive manner.