Imidazotriazine derivatives as il-17 modulators

Abstract

3-Cyclopropyl-N-[(S)-[3-[1-(2,2-difluoropropylaminomethyl)-3-hydroxy-3-methyl-cyclobutyl]imidazo[1,2-b][1,2,4]tris(6-yl)-[4-(trifluoromethyl)cyclohexyl]methyl]isoazol-4-methylamine or pharmaceutically acceptable salts and / or solvates thereof are potent modulators of human IL-17 activity and are therefore beneficial for the treatment and / or prevention of various human diseases, including inflammatory and autoimmune disorders. 3-cyclopropyl-N-[(S)-[3-[1-(2,2-difluoropropylcarbamoyl)-3-hydroxy-3-methyl-cyclobutyl]imidazo[1,2-b][1,2,4]triazin-6-yl]-[4-(trifluoromethyl)cyclohexyl]methyl]isoxazole-4-carboxamide or a pharmaceutically acceptable salt and / or solvate thereof, being a potent Modulator of human IL-17 activity, is accordingly of benefit in the treatment and / or prevention of various human illnesses, including inflammatory and autoimmune disorders.