A live recombinant anguillid herpesvirus 1 useful for the prevention or therapy of a disease caused by anguillid herpes virus 1 and use thereof

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A live recombinant AngHV-1 virus with a dysfunctional ORF35 induces abortive infection, addressing the lack of effective vaccines by providing safe and economical protection against AngHV-1 in eels.

TW202629794APending Publication Date: 2026-07-16VAL

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Patent Information

Application Number: TW114141327
Authority / Receiving Office: TW · TW
Patent Type: Applications
Current Assignee / Owner
Priority Date: 2024-10-25
Filing Date: 2025-10-27
Publication Date: 2026-07-16

Application Information

Patent Timeline

25 Oct 2024

Priority

27 Oct 2025

Application

TW114141327

16 Jul 2026

Publication

TW202629794A

IPC: C12N15/33; A61K39/12; A61P31/12

CPC: C12N7/00; C07K14/005; C12N15/85; A61K39/12; A61P31/14; A61P31/22; C12N2710/16021; C12N2710/16034

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Application Domain

Viral antigen ingredients Antivirals

Technology Topics

Vaccination Open reading frame

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AI Technical Summary

Technical Problem

There is no effective vaccine available to combat eel herpesvirus 1 (AngHV-1), which causes significant mortality and economic losses in eel fisheries, and existing vaccines face challenges such as interference with the host's immune system and stringent environmental release regulations.

Method used

Development of a live recombinant AngHV-1 virus with a dysfunctional open reading frame 35 (ORF35) that induces abortive infection in fish, providing immune protection without replicating and releasing new viral particles, allowing for safe and economical vaccination by immersion.

Benefits of technology

The ORF35-deficient live recombinant AngHV-1 virus effectively confers protection against wild-type AngHV-1 infection in fish, ensuring safety and compliance with environmental regulations while offering a cost-effective vaccination method.

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Abstract

The present invention relates to recombinant eel herpesvirus 1 for use in the prevention or treatment of diseases caused by eel herpesvirus 1. One aspect of the invention provides a live recombinant Eel Herpesvirus 1 (AngHV-1) comprising an open reading frame 35 (ORF35) dysfunctional genome. Further aspects provide products and compositions derived from or comprising live recombinant AngHV-1. Also provided are uses and methods for vaccination and disease treatment in fish, particularly eel, using live recombinant AngHV-1.

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