In vitro cell-based assay for predicting pharmacokinetics and brain penetration of biologics

TW202630008APending Publication Date: 2026-07-16GENENTECH INC

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Patent Information

Application Number: TW115112156
Authority / Receiving Office: TW · TW
Patent Type: Applications
Current Assignee / Owner
Priority Date: 2021-05-12
Filing Date: 2022-04-12
Publication Date: 2026-07-16

Application Information

Patent Timeline

12 May 2021

Priority

12 Apr 2022

Application

TW115112156

16 Jul 2026

Publication

TW202630008A

IPC: G01N33/50; G01N33/68

Inventors: 劉暢; 劉約翰學寧

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Abstract

The present disclosure relates to methods and compositions useful for measuring the transcytosis or recycling of a molecule. In particular, the present disclosure relates to in vitro receptor-dependent transcytosis or recycling assays for evaluating the clearance rates of therapeutic antibody molecules and Fc-fusion proteins in humans and animals.

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