Application of aromatic ring-containing biological antagonists in the preparation of drugs for the treatment or prevention of kidney diseases

Abstract

The present invention relates to the application of aromatic ring-containing biological antagonists in the preparation of drugs for the treatment or prevention of kidney diseases. Specifically, it provides the use of 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl-d2)-N-(4-chloro-5-methylisoxazol-3-yl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonamide compounds or their pharmaceutically acceptable salts in the preparation of drugs for the treatment or prevention of kidney diseases, particularly in the preparation of drugs for the treatment or prevention of focal segmental glomerulosclerosis and immunoglobulin A nephropathy. The compound or its pharmaceutically acceptable salt has shown excellent therapeutic effects on focal segmental glomerulosclerosis and immunoglobulin A nephropathy, and has significant clinical application value.