An abiraterone derivative, a pharmaceutical composition, its preparation method and application

Abstract

This invention discloses an abiraterone derivative, a pharmaceutical composition, its preparation method, and its application. The invention provides an abiraterone derivative as shown in formula (1) or formula (2), or a pharmaceutically acceptable salt thereof, which differs from existing abiraterone derivative structures containing one abiraterone molecule per molecule; the compound of this invention contains two abiraterone molecules per molecule. The compound of this invention has a long-acting sustained-release characteristic and can be administered subcutaneously or intramuscularly to maintain blood drug concentrations for 12 weeks (3 months) or longer, for the treatment of prostate cancer.

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