Treatment of patients with p53 gene mutations or defects-negative cancers and tumors
TW202631155APending Publication Date: 2026-08-01SHENZHEN ASCENTAWITS PHARM TECH CO LTD
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Patent Information
- Authority / Receiving Office
- TW · TW
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2025-01-24
- Publication Date
- 2026-08-01
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Abstract
This invention provides a method for treating patients with p53 gene mutation- or defect-negative cancers or tumors, using a drug containing a DNA alkylating agent prodrug compound as a monotherapy or in combination with other drugs, and its pharmaceutical use. Specifically, the DNA alkylating agent prodrug compound is selected from hypoxia-activated DNA alkylating agent prodrug compounds, AKR1C3-activated DNA alkylating agent prodrug compounds, and DNA alkylating agent prodrug compounds initiated by β-glucosidase (β-D-Glucosidase) or β-galactosidase (β-Galactosidase).
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