Heteroaryl macrocyclic compounds, their preparation methods and applications

TW202631633APending Publication Date: 2026-08-01BEIJING AVISTONE BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
TW · TW
Patent Type
Applications
Current Assignee / Owner
Filing Date
2025-10-31
Publication Date
2026-08-01

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Abstract

This invention relates to a heteroaryl macrocyclic compound, its preparation method, pharmaceutical compositions containing this compound, and its use as a therapeutic agent. The structure of the heteroaryl macrocyclic compound is shown in Formula I: where A, E, M, L1, L2, X1, X2, and X3 are defined as described in the specification. This heteroaryl macrocyclic compound exhibits good inhibitory activity against epidermal growth factor receptor (EGFR) and can be used to treat diseases related to abnormal EGFR induction, particularly cancer.
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