Bivalent chimeric receptors or chimeric receptor systems and methods of use thereof

Abstract

Provided herein are solid tumor antigen targets for chimeric receptors and chimeric inhibitory receptors. The chimeric antigen receptors (CARs) described herein include a first antigen-binding domain that binds a first antigen; a second extracellular antigen-binding domain; a transmembrane domain; and one or more intracellular signaling domains. The disclosure also provides methods of using the same, such as for the treatment of cancer.