Lipidated tlr7 / 8 modulators as adjuvants and uses thereof

Abstract

The disclosure relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, and Y are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds of Formula (I) may modulate the activity of antigens of interest and may be useful in inducing or enhancing an immune response against diseases, disorders and conditions mediated by antigens of interest. In a particular embodiment, the compounds of Formula (I) may be useful as a component of a liposomal adjuvant formulation.