Anti-N3pGlu Aβ antibody and its uses

TW202635719APending Publication Date: 2026-09-01SIMCERE PHARMA CO LTD
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Patent Information

Application Number
TW114141604
Authority / Receiving Office
TW · TW
Patent Type
Applications
Current Assignee / Owner
Priority Date
2025-04-17
Filing Date
2025-10-28
Publication Date
2026-09-01

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Abstract

This invention provides an anti-N3pGlu Aβ antibody, its encoding nucleic acid, and its applications. The thermal stability and immunogenicity of various anti-N3pGlu Aβ antibodies in clinical use have attracted widespread attention in the development of N3pGlu Aβ antibodies. The presence of drug-resistant antibodies in clinical practice is somewhat correlated with their short half-life. The antibody of this invention exhibits higher yield and lower immunogenicity compared to its predecessor, showing better application prospects for the treatment of Alzheimer's disease.
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