Reverse transcription of polynucleotides comprising unnatural nucleotides

TW202635880APending Publication Date: 2026-09-01SYNTHORX INC +1
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Patent Information

Application Number
TW115101363
Authority / Receiving Office
TW · TW
Patent Type
Applications
Current Assignee / Owner
Priority Date
2020-10-23
Filing Date
2021-10-22
Publication Date
2026-09-01

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Abstract

Disclosed herein are methods of reverse transcribing a polynucleotide comprising an unnatural ribonucleotide comprising reverse transcribing the polynucleotide with a reverse transcriptase in the presence of an unnatural dNTP comprising an unnatural nucleobase, wherein the reverse transcriptase polymerizes cDNA into which the unnatural NTP is incorporated. In some embodiments, the polynucleotide is present at a concentration less than or equal to about
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