Degradable and porous ceramic container and uses thereof in burying bone tissues

Abstract

and including a main body structure and a coating layer is disclosed. The main body structure includes triaxial clay minerals, alkaline metal inorganic salts, and small molecule proteins, wherein the small molecule proteins includes hydrolysable proteins, or enzymes. The coating is applied to the surface of the main body structure and the coating includes water-soluble organic cellulose.

Description

Biodegradable and porous ceramic containers and their use in burying bone tissue This invention relates to a biodegradable ceramic container, and more particularly to a ceramic container that facilitates the decomposition of biological bone tissue. Bone tissue in organisms, such as fish bones, shrimp shells, or animal bones, is a complex composed of inorganic substances (such as sodium, potassium, calcium, magnesium, zinc, and strontium) and organic substances (such as proteins, fats, and carbohydrates). While the organic matter in biological bone tissue can be decomposed by soil microorganisms, the inorganic matter cannot be converted into smaller molecules through microbial decomposition, thus it is easily retained in the soil. The conventional burial method cannot solve the problem of the inability to decompose the inorganic components of the bone tissue of the organism. To address the aforementioned problems and enable the inorganic components of bone tissue in organisms to be converted into small molecular structures in soil, thus promoting plant growth, this invention proposes a biodegradable and porous ceramic container with a porosity between 10% and 40%. The ceramic container comprises a main structure and a coating. The main structure comprises triaxial preform ceramic clay minerals, alkaline earth metal inorganic salts, and small molecule proteins, including hydrolyzable proteins such as hydrolyzed proteins or enzymes. The coating covers the surface of the main structure and comprises water-soluble organic cellulose. According to one embodiment of the present invention, a biodegradable and porous ceramic container is provided, wherein the triaxial preform ceramic clay mineral comprises clay, feldspar and quartz. According to one embodiment of the present invention, a biodegradable and porous ceramic container is provided, wherein the alkaline earth metal inorganic salt comprises alkaline earth metal sulfate, alkaline earth metal carbonate, or alkaline earth metal acetate. According to one embodiment of the present invention, a biodegradable and porous ceramic container is provided, wherein the content of the alkaline earth metal inorganic salt ranges from 1 wt% to 20 wt%, based on a total amount of 100 wt% of the main structure. According to one embodiment of the present invention, a biodegradable and porous ceramic container is provided, wherein the preferred content of the alkaline earth metal inorganic salt ranges from 3 wt% to 12 wt%. According to one embodiment of the present invention, a biodegradable and porous ceramic container is provided, wherein the small molecule protein comprises protease, plant protein, hydrolyzed collagen, or bone-like protein. According to one embodiment of the present invention, a biodegradable and porous ceramic container is provided, wherein the content of the small molecule protein ranges from 1 wt% to 15 wt%, based on a total amount of 100 wt% of the main structure. According to one embodiment of the present invention, a biodegradable and porous ceramic container is provided, wherein, based on a total amount of 100wt% of the main structure, the preferred content of the small molecule protein is between 2wt% and 8wt%. According to one embodiment of the present invention, a biodegradable and porous ceramic container is provided, wherein the water-soluble organic cellulose comprises carboxymethyl cellulose or hydroxypropyl methyl cellulose. The present invention also proposes the use of a biodegradable and porous ceramic container for burying bone tissue. The porosity of the ceramic container is between 10% and 40%. The ceramic container comprises: a main structure and a coating, wherein the main structure comprises triaxial preform ceramic clay minerals, alkaline earth metal inorganic salts, and small molecule proteins; wherein the small molecule proteins comprise hydrolyzable proteins or enzymes; wherein the total weight of the triaxial preform ceramic clay minerals is 100 wt%, and the weight sum of the alkaline earth metal inorganic salts and the small molecule proteins is 1.5% to 4.5%; the coating covers the surface of the main structure, and the coating comprises water-soluble organic cellulose. 1: Ceramic containers 100: Main Structure 101: Triaxial preform ceramic clay mineral 102: Hole 103: Alkaline Earth Group Metal Inorganic Salts 104: Small molecule proteins 110: Coating Figure 1 is a schematic diagram of the biodegradable and porous ceramic container of the first embodiment of the present invention; Figure 2 is a partial magnified structural schematic diagram of point A in Figure 1; Figure 3 is a flowchart of the manufacturing method of the ceramic container of the present invention; Figure 4 is a schematic diagram of the structural decomposition of apatite under alkaline conditions due to hydration and chelation; Figure 5 is an experimental photograph of the bubbles generated after mixing alkaline earth metal inorganic salt materials with synthetic hydroxyapatite (HAP) and water; Figure 6 is an analysis diagram of the phosphate ion concentration in the solution after immersing hydroxyapatite (HAP) in an alkaline earth metal inorganic salt solution for 6 months; Figure 7 is a schematic diagram of the pH value change in water after mixing alkaline earth metal inorganic salts with synthetic hydroxyapatite (HAP); Figure 8 is a SEM image of the microstructure of alkaline earth metal inorganic salts, synthetic hydroxyapatite (HAP), amino acid proteins, and reacted in water for 14 days. Figure 9 is an experimental photograph showing the changes over time of a ceramic container buried in soil according to one embodiment of the present invention; and Figures 10A to 10C are experimental photographs showing the main structure of the ceramic container of the present invention used to decompose animal bone meal. The present invention will be further described below with reference to specific embodiments, but the following embodiments do not limit the present invention in any way. Referring to Figure 1, which is a schematic diagram of the biodegradable and porous ceramic container of the first embodiment of the present invention. As shown in Figure 1, the biodegradable and porous ceramic container 1 of this embodiment includes a main structure 100 and a coating 110. The main structure 100 is a porous ceramic clay, mainly composed of triaxial preform ceramic clay minerals, alkaline earth metal inorganic salts, and small molecule proteins. The small molecule proteins include hydrolyzable proteins, enzymes, or bacteria. The coating 110 is applied to the surface of the main structure, and the material of the coating 110 includes water-soluble organic cellulose. The ceramic container 1 of this invention is prepared from porous and water-absorbing natural ceramic clay minerals, alkaline earth metal inorganic salts, and small molecule proteins (such as Lactobacillus). It has a certain structural strength and an internal accommodating space. When the ceramic container 1 is placed in a water-containing environment, such as in water or soil, due to the water-absorbing properties of the main structure 100, the alkaline earth metal inorganic salts and small molecule proteins will come into contact with water and undergo dissociation and chemical reactions. This further causes the structure of the ceramic container 1 to disintegrate and releases active factors that facilitate calcium dissolution, thereby solving the problem of difficult-to-decompose inorganic components in food or soil. More specifically, the ceramic container 1 of this invention is used to hold kitchen waste or bone tissue (including inorganic tissues, such as apatite) and bury it in soil. Through a physicochemical reaction between the alkaline earth metal inorganic salts and small-molecule proteins in the main structure 100 and water at room temperature, active factors that readily decompose apatite, such as amino acid molecules and carbonate ions, are released. This causes the kitchen waste or bone tissue (including apatite) contained in the ceramic container 1 to decompose into smaller molecular structures due to the loss of calcium ions. Therefore, the ceramic container 1 of this invention facilitates the natural decomposition of kitchen waste or bone tissue, which is of great significance for environmental protection. Referring also to Figure 2, which is a partially enlarged structural diagram of point A of the ceramic container 1 in Figure 1, showing the cross-sectional structure of the main structure 100 of the ceramic container 1. As shown in Figure 2, the main structure 100 includes triaxial preform ceramic clay mineral 101 (hereinafter referred to as ceramic clay mineral), alkaline earth metal inorganic salt 103, and small molecule protein 104, and a coating 110 is covered on the surface of the main structure 100 to improve the structural strength of the ceramic container 1; wherein, the main structure 100 further includes a plurality of pores 102 distributed among the triaxial preform ceramic clay mineral 101, that is, the ceramic container 1 of the present invention has a porous structure. The following describes the manufacturing method of the ceramic container 1 of the present invention. Referring to Figure 3, it is a flowchart of the manufacturing method of the ceramic container 1 of the present invention. This manufacturing method includes: Step 301, mixing triaxial preform ceramic clay mineral (hereinafter referred to as ceramic clay mineral) with water to prepare a ceramic slurry. According to the present invention, the triaxial preform ceramic clay mineral includes clay, feldspar, and quartz. In this embodiment, a ceramic clay mineral comprising kaolin, quartz, montmorillonite, mica, and feldspar (e.g., potassium feldspar) is mixed with 1.5 to 2 times its weight of water to prepare a ceramic slurry with good fluidity; Step 302: Add alkaline earth metal inorganic salts to the ceramic slurry and mix thoroughly; the content of alkaline earth metal inorganic salts ranges from 1 wt% to 20 wt%, based on a total main structure of 100 wt%. Preferably, in this embodiment, 3-12 wt% alkaline earth metal sulfate (MeSO4) is added. 4) Alkaline earth group metal carbonates (MeCO) 3) or alkaline earth metal acetates (Me(CH) 3COO) 2) or alkaline earth metal carbonates (MeCO) 3) With alkaline earth group metal acetates (Me(CH) 3COO) 2) The mixture is added to the ceramic slurry from step 301 and stirred continuously for 0.5 to 1 hour to obtain a mixed solution. The alkaline earth metal inorganic salts include, for example, magnesium sulfate, magnesium carbonate, calcium bicarbonate, strontium carbonate, calcium acetate, and strontium acetate. All of these inorganic salts are soluble in water. Step 303: Add small molecule protein and stir to form a precursor slurry for ceramic containers; wherein the small molecule protein is a hydrolyzable protein, including hydrolyzed protein or enzyme; wherein the molecular weight of the small molecule protein is between 500 Daltons and 5000 Daltons; and the content of the small molecule protein ranges from 1 wt% to 15 wt% based on the total amount of the main structure being 100 wt%. In this embodiment, 0.5-5 wt% of Lactobacillus is added to the mixed solution obtained in step 302, and the mixture is stirred continuously for 0.5-1 hour to obtain the precursor slurry of the ceramic container of the present invention, and the precursor slurry has good fluidity. The small molecule protein is selected from at least one of Lactobacillus, animal protein (animal small molecule protein), plant protein (plant small molecule protein, i.e., plant protein), and amino acid chain protein. In some embodiments, the small molecule protein includes hydrolyzed collagen or bone morphogenetic protein (BMPs). Due to the small molecular weight of the small molecule protein, it can be hydrated to form a hydrolyzed protein solution. Preferably, the hydrolyzed protein solution can be prepared first, with a concentration of 2.0 mg / ml to 4.5 mg / ml, and then the mixed solution of ceramic slurry and alkaline earth metal inorganic salts from step 302 is added. Step 304: The aforementioned precursor slurry is injected into a mold to form a green mold; in this embodiment, the aforementioned precursor slurry is molded from a plaster mold into a green mold of the desired ceramic container by any of the following methods: mold injection, pressure injection or centrifugal static pressure injection. Step 305: The above-mentioned green body structure is air-dried to obtain the main structure of the ceramic container. In this embodiment, the green mold of the ceramic container is placed on a tray and air-dried at a temperature of 25°C to 26°C for 12 to 24 hours to obtain the main structure of the ceramic container. Step 306: Water-soluble cellulose is coated onto the inner and outer surfaces of the main structure prepared in step 305. In this embodiment, a carboxymethyl cellulose and hydroxypropyl methyl cellulose solution is coated onto the model surface. The carboxymethyl cellulose and hydroxypropyl methyl cellulose powders are added to water and dissolved in water by mechanical stirring to obtain a colloidal solution of 1200 to 1500 mPa·s, which is then coated onto the inner and outer surfaces of the main structure. This strengthens the rigidity and hardness of the ceramic container, as well as providing antibacterial and antifungal properties. Step 307: Allow the above-mentioned water-soluble cellulose coated main structure to stand and dry to complete the ceramic container of the present invention; the porosity of the ceramic container obtained by the above method is between 10% and 40%. In one embodiment, the composition ratio of materials such as ceramic clay minerals, alkaline earth metal carbonates, and lactobacilli, wherein anhydrous alkaline earth metal carbonates (MeCO3) are present. 3. For example, calcium bicarbonate (CaHCO3). 3) The weight ratio of Lactobacillus to the compound is 1:0.2~0.45, and it is mixed with 1 part by weight of ceramic clay mineral (based on a total weight of 100wt% of ceramic clay mineral, and a weight sum of 1.5% to 4.5% of alkaline earth metal inorganic salts and small molecule proteins). The resulting bioceramic composite slurry has a viscosity of 550~750 mPa·s and is malleable. After the model dries, a water-soluble cellulose membrane is coated on the inner and outer surfaces of the main structure to produce the ceramic container of the present invention. Analysis of the degradation rate shows that the ceramic container of the present invention, when immersed in water, achieves 80~100% dissolution within 15 minutes; when buried in soil, the dissolution rate is slower, depending on the water content of the soil. In one embodiment, the materials used contain approximately 960 grams of ceramic clay mineral, approximately 30 grams of calcium carbonate, approximately 10 grams of small molecule protein, and approximately 1500~2000 grams of water. The following examples illustrate the relationship between different components of the ceramic container of the present invention and the dissolution rate, and the experimental results of the time required for bone tissue decomposition when applied to burying bone tissue in soil. According to one example, the alkaline earth metal inorganic salt system uses anhydrous alkaline earth metal acetate (Me(CH3)2) 3COO) 2), and anhydrous alkaline earth metal acetates (Me(CH) 3COO) 2, for example, calcium acetate (Ca(CH) 3COO) 2) The weight ratio of lactobacillus to the compound is 1:0.2~0.8, and then it is mixed with 1 part by weight of ceramic clay mineral (based on the total weight of ceramic clay mineral as 100wt%, the weight sum of the alkaline earth metal inorganic salt and the small molecule protein is 1.5% to 4.5%). The resulting bioceramic composite slurry has a viscosity of 550~750 mPa·s and is malleable. After the model dries, it is coated with a high molecular weight cellulose membrane inside and outside the container. When the ceramic container is immersed in water, it achieves 80~100% dissolution within 5 minutes. When buried in soil, the dissolution effect depends on the water content of the soil, and the rapid dissolution rate is not conducive to chelation. According to another example, in which the alkaline earth metal inorganic salt system uses anhydrous alkaline earth metal carbonates (MeCO3). 3. For example, calcium bicarbonate (CaHCO3). 3)) with anhydrous alkaline earth group metal acetates (Me(CH) 3COO) 2, for example, calcium acetate (Ca(CH) 3COO) 2) A combination of 1:1~2, with the weight ratio of alkaline earth metal inorganic salts to lactobacilli being 1:0.2~0.8, is then mixed with 1 part by weight of ceramic clay (based on a total weight of 100wt% of ceramic clay minerals, the weight sum of the alkaline earth metal inorganic salts and the small molecule protein is 1.5~2.5%). The resulting bioceramic composite slurry has a viscosity of 550~750 mPa·s and is malleable. After the model dries, a high molecular weight cellulose membrane is coated on the inner and outer surfaces of the container to form a ceramic container. When this ceramic container is immersed in water, it achieves an 80~100% dissolution effect within 7 to 15 minutes. When this ceramic container is buried in soil, the dissolution effect depends on the water content in the soil (if the dissolution rate is too fast, it is not conducive to chelation). When this ceramic container is used to bury bone tissue components (apatite) in soil, the bone tissue components dissolve in 8 to 12 months, allowing the apatite to decompose and become a soil resource. According to another example, in which the alkaline earth metal inorganic salt system uses anhydrous alkaline earth metal carbonates (MeCO3). 3. For example, calcium bicarbonate (CaHCO3). 3)) with anhydrous alkaline earth group metal acetates (Me(CH) 3COO) 2, for example, calcium acetate (Ca(CH) 3COO) 2) A combination of 1:1~2, with the weight ratio of alkaline earth metal inorganic salts to lactobacilli being 1:0.2~0.8, is then mixed with 1 part by weight of ceramic clay (based on a total weight of 100wt% ceramic clay minerals, and a weight of 2.0~3.5% for alkaline earth metal inorganic salts and small molecule proteins). The resulting bioceramic composite slurry has a viscosity of 550~750 mPa·s and is malleable. After the model dries, a high-molecular-weight cellulose membrane is coated on the inner and outer surfaces of the container to form a ceramic container. When this ceramic container is immersed in water, it achieves 80~100% dissolution within 7 to 15 minutes. When this ceramic container is buried in soil, the dissolution effect depends on the water content in the soil (if the dissolution rate is too fast, it is not conducive to chelation). When this ceramic container is used to bury bone tissue components (apatite) in soil, the bone tissue components dissolve within 6 to 8 months, allowing the apatite to decompose and become a soil resource. According to another example, in which the alkaline earth metal inorganic salt system uses anhydrous alkaline earth metal carbonates (MeCO3). 3. For example, calcium bicarbonate (CaHCO3). 3)) with anhydrous alkaline earth group metal acetates (Me(CH) 3COO) 2, for example, calcium acetate (Ca(CH) 3COO) 2) A combination of 1:1~2, with the weight ratio of alkaline earth metal inorganic salts to lactobacilli being 1:0.2~0.8, is then mixed with 1 part by weight of ceramic clay (based on a total weight of 100wt% ceramic clay minerals, and a weight sum of 2.5~4.5% for alkaline earth metal inorganic salts and small molecule proteins). The resulting bioceramic composite slurry has a viscosity of 550~750 mPa·s and is malleable. After the model dries, a high-molecular-weight cellulose membrane is coated on the inner and outer surfaces of the container to form a ceramic container. When this ceramic container is immersed in water, it achieves 80~100% dissolution within 7 to 15 minutes. When this ceramic container is buried in soil, the dissolution effect depends on the water content in the soil (if the dissolution rate is too fast, it is not conducive to chelation). When this ceramic container is used to bury bone tissue components (apatite) in soil, the bone tissue components dissolve within 4 to 6 months, allowing the apatite to decompose and become a soil resource. The following are experimental results illustrating the beneficial properties of the ceramic container of this invention for the decomposition of buried bone tissue. According to one embodiment of the invention, the ceramic container is prepared from porous and absorbent natural ceramic clay minerals, alkaline earth metal inorganic salts, and lactobacillus. When the ceramic container containing animal bone meal is buried in soil and subjected to prolonged burial, exposure to light, watering, and dissolution, the ceramic container releases active factors resulting from the hydration and chelation of animal bone meal, alkaline earth metal inorganic salts, and protein amino acid materials. See Figure 4, which illustrates the structural decomposition of apatite under alkaline conditions through hydration and chelation. The principle behind the ceramic container of this invention's ability to decompose the structure of animal bone meal lies in utilizing the hydration reaction of alkaline earth metal inorganic salts with water, followed by the reaction with amino acids and apatite (Ca... 10 (PO 4) 6(OH) 2) Chelation reaction. In the experiments of this invention, synthetic hydroxyapatite (HAP) was used as the apatite, and it was reacted with alkaline earth metal inorganic salts, amino acids, and proteins. See Figures 5, 6, and 7. Figure 5 is an experimental photograph showing the generation of bubbles after mixing alkaline earth metal inorganic salt materials with synthetic hydroxyapatite (HAP) and water (the experimental conditions were 37.4℃, and mixing was carried out in a thermostatic shaker at 60 rpm). In Figure 5, from left to right, the alkaline earth metal inorganic salts used are calcium acetate, calcium sulfate, and calcium bicarbonate; the more obvious the reaction between apatite and inorganic salts, the more turbid the solution becomes. Please also refer to Figure 6, which shows the phosphate ion concentration analysis in the solution of hydroxyapatite (HAP) after immersion in an alkaline earth metal inorganic salt solution for 6 months. In the figure, (a) is a mixed solution of hydroxyapatite (HAP) and calcium acetate; (b) is a mixed solution of hydroxyapatite (HAP) and calcium sulfate; and (c) is a mixed solution of hydroxyapatite (HAP) and calcium carbonate. As shown in Figure 6, after immersion in an aqueous solution of alkaline earth metal inorganic salts for a period of time, hydroxyapatite (HAP) undergoes degradation due to ion exchange reactions, and phosphate ions can be detected in the solution. Figure 7 shows the pH change in water after mixing alkaline earth metal inorganic salts with synthetic hydroxyapatite (HAP). As shown in Figure 7, after mixing alkaline earth metal inorganic salts with synthetic hydroxyapatite (HAP) in water for a period of time, the pH value approaches 7. Figure 8 shows the SEM images of the microstructure of alkaline earth metal inorganic salts, synthetic hydroxyapatite (HAP), amino acid proteins, and other substances after 14 days of reaction in water. The reaction was carried out in a thermostatic shaker at 37°C and 60 rpm in water. The chain reaction formula is as follows (in the following chemical reaction formulas, apatite is called Apatites, and calcium-deficient apatite is called Calcium-deficient apatites): Apatites + H 2O+CO 2→Calcium deficient apatites+CaCO 3 (1) Apatites+6H 2O+NH 3→Calcium deficient apatites+3Ca(OH) 2+(NH 4) 3PO 4 (2) Among them, equation (1) reacts faster, while equation (2) reacts slower. Referring to Figure 9, this is an experimental photograph showing the changes of a ceramic container buried in soil over time according to one embodiment of the present invention. The ceramic container according to one embodiment of the present invention is prepared from a combination of porous and absorbent natural ceramic clay minerals, alkaline earth metal inorganic salts, and lactobacillus. The ceramic containers in the two plastic bottles on the left and right sides of the photograph in Figure 9 are respectively made by adding alkaline earth metal carbonates and alkaline earth metal acetates, and animal bone meal is also added to the ceramic containers. In this experiment, the ceramic container of the present invention was buried in soil 10-15 cm below the surface, placed in sunlight, and watered daily with 100-300 ml of water. The pH value of the soil was tested and photographed at different times. According to the test results, the pH value of the soil changed from 6.8 to between 8.2 and 9.0. Photographs (A) to (E) in Figure 9 represent the changes of the ceramic container in the soil at different times. As can be seen from photographs (C) and (D), after 90 days of burial, grass-like plants covered the soil surface. See also Figures 10A to 10C, which are photographs of the experimental results of using the main structure of the ceramic container of the present invention to decompose animal bone meal. This experiment was conducted to observe the effect of adding alkaline earth metal inorganic salts and small molecule proteins to ceramic clay minerals on the decomposition of animal bone meal. The materials used in this experiment included (1) the experimental group and (2) the control group. The materials of the (1) experimental group were made using the main structure of the ceramic container of the present invention, that is, a combination of ceramic clay minerals, alkaline earth metal inorganic salts and small molecule proteins, and then adding animal bone particles. The materials of the (2) control group were made using only ceramic clay minerals with added animal bone particles. First, as shown in Figure 10A, the materials of the (1) experimental group and the (2) control group were made into clay balls and then buried in the soil. After more than two months of burial in the soil, the buried soil of the (1) experimental group and the (2) control group was dissected, and the photograph is shown in Figure 10B. Furthermore, the materials from experimental group (1) and control group (2), which were buried in the soil, were removed for observation, as shown in Figure 10C. As shown in Figures 10B and 10C, the clay ball structure of the experimental group, which was originally buried in the soil, had disintegrated, with animal bone particles crushed and mixed with the soil, and plant stems embedded inside; in contrast, the clay ball of the control group (2), which was buried in the soil, remained intact. This experiment demonstrates that the ceramic container of the present invention facilitates the decomposition of biological bone tissue (crystalline calcium tissue) in the soil. The biodegradable and porous ceramic container of this invention utilizes the physical properties of ceramic composite materials and polymer materials to develop ceramic containers. By using water in the soil as a medium, the ceramic composite material can release activating factors at room temperature, allowing inorganic salts in bone tissue to undergo physicochemical reactions with it. It can also be biodegraded in the soil, enabling the effective recycling of soil resources. The present invention has the following beneficial effects: 1. The raw materials of the ceramic container of the present invention are triaxial preform ceramic clay minerals, alkaline earth metal inorganic salts (such as alkaline earth metal sulfates, alkaline earth metal carbonates, or alkaline earth metal acetates), and lactobacillus. The production cost is low, the manufacturing process is simple, environmentally friendly, and the raw materials can be recycled and reused; 2. When the bioceramic environmentally friendly container is buried in the soil, through hydration and chelation, when the ceramic container fully absorbs water to a certain extent, the container itself will dissolve and release dissolved calcium components, and release a soil environment that is beneficial to planting, thus building a natural environment; 3. The water-soluble cellulose-coated bioceramic environmentally friendly container provides good container rigidity and shock resistance, and has a good market prospect. The above description is merely illustrative of specific embodiments of the present invention and is not intended to limit the present invention. Equivalent substitutions, modifications, or alterations made by those skilled in the art based on the teachings of the present invention are all included within the scope of the patent application of the present invention and do not depart from the scope of the rights of the present invention. 100: Main Structure 110: Coating 101: Triaxial preform ceramic clay mineral 102: Hole 103: Alkaline Earth Group Metal Inorganic Salts 104: Small molecule proteins

Claims

1. A biodegradable and porous ceramic container, the ceramic container having a porosity between 10% and 40%, the ceramic container comprising: a main structure comprising triaxial preform ceramic clay minerals, alkaline earth metal inorganic salts, and small molecule proteins, wherein, The small molecule protein is a hydrolyzable protein, including hydrolyzed proteins or enzymes; and a coating is applied to the surface of the main structure, the coating comprising water-soluble organic cellulose. Such as the biodegradable and porous ceramic container in claim 1, wherein, Triaxial ceramic clay minerals include at least clay, feldspar, and quartz. Such as the biodegradable and porous ceramic container in claim 1, wherein, The inorganic salts of alkaline earth metals include alkaline earth metal sulfates, alkaline earth metal carbonates, or alkaline earth metal acetates. Such as the biodegradable and porous ceramic container in claim 1, wherein, Based on a total content of 100 wt% for the main structure, the content of the alkaline earth metal inorganic salt ranges from 1 wt% to 20 wt%. Such as the biodegradable and porous ceramic container in claim 1, wherein, Based on a total content of 100 wt% of the main structure, the preferred content range of the alkaline earth metal inorganic salt is 3 wt% to 12 wt%. Such as the biodegradable and porous ceramic container in claim 1, wherein, This small molecule protein includes protease, plant protein, hydrolyzed collagen, or bone-type protein. Such as the biodegradable and porous ceramic container in claim 1, wherein, Based on a total content of 100 wt% for the main structure, the content of the small molecule protein ranges from 1 wt% to 15 wt%. Such as the biodegradable and porous ceramic container in claim 1, wherein, Based on a total content of 100 wt% of the main structure, the preferred content range of the small molecule protein is 2 wt% to 8 wt%. Such as the biodegradable and porous ceramic container in claim 1, wherein, The water-soluble organic cellulose in the coating includes carboxymethyl cellulose or hydroxypropyl methyl cellulose. A biodegradable and porous ceramic container for the burial of bone tissue, the ceramic container having a porosity between 10% and 40%, comprising: a main structure containing triaxial preform ceramic clay minerals, alkaline earth metal inorganic salts, and small molecule proteins, wherein... The small molecule protein comprises a hydrolyzable protein or enzyme; wherein the total weight of the triaxial preform ceramic clay mineral is 100 wt%, the weight of the alkaline earth metal inorganic salt and the small molecule protein is 1.5% to 4.5%; and a coating covering the surface of the main structure, the coating comprising water-soluble organic cellulose.

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