Cyclic compounds, their pharmaceutical compositions and their applications

Abstract

This invention discloses a cyclic compound, its pharmaceutical composition, and its applications. Specifically, this invention discloses a compound as shown in formula (I), its pharmaceutically acceptable salt, its solvate, or a solvate of a pharmaceutically acceptable salt thereof. The cyclic compound of this invention has one or more of the following advantages: novel structure, good agonistic activity against APJ receptors, effective inhibition of cAMP production, weak recruitment ability against β-arrestin, good pharmacokinetic properties, ability to reduce drug dosage, reduction of possible toxic side effects, increased patient compliance, and improved therapeutic efficacy.